5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5096-73-1
Intermediate 36-Oxazol -5-yl -ryridazine-3-carboxyl ic acid: A mixture of 6-chloro-pyridazine-3-carboxylic acid (350 mg), 5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-2-triisopropylsilanyl-oxazole (1 .00 g), PdCI2[1 ,1 ?-bis(diphenylphosphino)ferrocene]*CH2Cl2 complex (200 mg), and aqueous Na2003solution (2 M; 3.0 mL) in 1 ,4-dioxane (5 mL) and water (1 mL) is stirred overnight at80C under an argon atmosphere. After cooling to room temperature, the reaction mixture is acidified with hydrochloric acid (4 N; 3 mL) and extracted with ethyl acetate. The combined extracts are washed with brine, dried over MgSO4 and concentrated in vacuo. The residue is dissolved in tetrahydrofuran, hydrochloric acid(4N; 4 mL) is added, and the mixture is stirred for 2 h at room temperature. The solvent is evaporated in vacuo and the residue is mixed with ethyl acetate and water. The aqueous phase is extracted with ethyl acetate and the combined extracts are washed with brine, dried over MgSO4, and concentrated in vacuo. The residue is triturated with diethyl ether, filtered off and dried to give the title product. LC (method2): tR = 0.45 mm; Mass spectrum (ESI): mlz = 192 [M+H]
The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; NOSSE, Bernd; ECKHARDT, Matthias; HIMMELSBACH, Frank; LANGKOPF, Elke; ASHWEEK, Neil J.; HARRIOTT, Nicole; WO2014/19967; (2014); A1;,
Pyridazine – Wikipedia
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