With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.187973-60-0,6-Iodopyridazin-3-amine,as a common compound, the synthetic route is as follows.
Example B.26-Iodo-3-methyl-2-(trifluoromethyl)imidazo[1,2-b]pyridazine A mixture of 6-iodopyridazin-3-amine (CAS 187973-60-0; 2 g, 9.05 mmol) and 3- bromo-1,1,1-trifluorobutan-2-one (2.41 g, 11.8 mmol) in ethanol (40 ml) under an argon atmosphere was heated to 85C and stirred for 18 hrs. The brown solution was cooled to r.t. and con25 centrated to leave a brown orange sticky paste which was triturated in a mixture of 10 % aq.Na2CO3 (20 ml) and EtOH (20 ml). The suspension was stirred at r.t. for 30 mm. The product was collected by filtration, washed with H20 and dried., 187973-60-0
187973-60-0 6-Iodopyridazin-3-amine 10867834, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; WO2015/113980; (2015); A1;,
Pyridazine – Wikipedia
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