Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34231-77-1,Methyl pyridazine-4-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of methyl pyridazine-4-carboxylate (0.4 g) in methanol (4.92 ml_) was added hydrazine hydrate (1.16 g) and the mixture was heated at reflux overnight. The reaction mixture was cooled and concentrated to afford pyridazine-4-carbohydrazide as a brown solid. (0715) NMR (400MHz, CDsOD) 9.52-9.48 (m, 1 H) 9.36 (dd, 114) 8.00 (dd, 1 H) (three NH protons missing), 34231-77-1

34231-77-1 Methyl pyridazine-4-carboxylate 12439252, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; SCUTT, James, Nicholas; WILLETTS, Nigel, James; SONAWANE, Ravindra; PHADTE, Mangala; KANDUKURI, Sandeep, Reddy; SASMAL, Swarnendu; ARMSTRONG, Sarah; MCGRANAGHAN, Andrea; (155 pag.)WO2019/185875; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

932-22-9, 4,5-Dichloro-3(2H)-pyridazinone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,932-22-9

0495-1 ((Chloromethoxy)methyl)benzene (2.17 mL) was added to a mixture of 4,5-dichloropyridazin-3(2H)-one (2.00 g), 1,8-diazabicyclo[5.4.0]undeca-7-ene (1.85 mL), and N-methylpyrrolidone (24 mL) under ice-cooling, followed by stirring at room temperature for 1 hour. After water and ethyl acetate were added to the reaction mixture, the organic layer was collected by separation, washed sequentially with water and a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure, thereby obtaining 2-((benzyloxy)methyl)-4,5-dichloropyridazin-3(2H)-one (2.82 g). MS m/z (M+H): 285.

As the paragraph descriping shows that 932-22-9 is playing an increasingly important role.

Reference£º
Patent; FUJIFILM Corporation; FURUYAMA, Hidetomo; KURIHARA, Hideki; TERAO, Takahiro; NAKAGAWA, Daisuke; TANABE, Shintaro; KATO, Takayuki; YAMAMOTO, Masahiko; SEKINE, Shinichiro; MASHIKO, Tomoyuki; INUKI, Shinsuke; UEDA, Satoshi; US2015/322063; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(3) N-ethyl 2-propoxy-5-bromobenzylamine hydrochloride 2 (5.17 g, 16.8 mmol) and 3-chloro-6-cyanopyridazine (2.65 g, 16.8 mmol) were dissolved in NMP (25 ml) and sodium hydrogen carbonate added (3.54 g, 42.1 mmol). The mixture was heated at 110 C. under argon for 7.5 hours and then allowed to cool to ambient temperature. The mixture was poured into ethyl acetate (200 ml) washed with water (5*200 ml) and brine (200 ml), the organic phase dried over MgSO4 and concentrated in vacuo. The residue was purified by MPLC (20%ethyl acetate/hexane) and then crystallized from ether/hexane to give the title product (4.80 g, 76%). MS (ESP): 272 (MH+), 227 (M-EtNH2)+. NMR (250 MHz, DMSO-d6) delta: 0.99 (t, J=6 Hz, 3H); 1.26 (t, J=7 Hz, 3H); 1.78 (m, 2H); 2.92 (q, J=7 Hz, 2H); 3.95 (t, J=6 Hz, 2H); 4.02 (s, 2H); 7.02 (d, J=8 Hz, 1H); 7.52 (dd, J=8, 2 Hz, 1H); 7.75 (d, J=2 Hz, 1H); 9.32 (brs, 2H)., 35857-89-7

As the paragraph descriping shows that 35857-89-7 is playing an increasingly important role.

Reference£º
Patent; Zeneca Limited; US5994353; (1999); A;,
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19064-67-6, 6-Chloro-3-hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A) 6-Chloro-2-(2-dimethylamino-ethyl)-2H-pyridazin-3-one:To a solution of 6-chloro-pyridazin-3-one (500 mg, 3.83 mmol) in 5 mL N,N- dimethylformamide was added 2-dimethylaminoethyl chloride hydrochloride (828 mg, 5.75 mmol), potassium carbonate (1.59 g, 11.5 mmol) and sodium iodide (632 mg, 4.21 mmol). The mixture was stirred over night at 65 0C. The solvent was evaporated. The crude product was purified by preparative HPLC using a gradient of acetonitrile / 5 % acetonitrile-water phase containing 0.1 M ammonium acetate, to give 174 mg of the desired sub-title product as light brown solids after freeze drying (22 % yield). 1H NMR (400 MHz, methanol-d4 as solvent and internal reference) delta (ppm) 2.35 (s, 6H), 2.82 (t, 2H, J = 6.4 Hz), 4.26 (t, 2H, J = 6.5 Hz), 6.9S (d, IH, J = 9.7 Hz), 7.44 (d, IH. J = 9.7 Hz)., 19064-67-6

The synthetic route of 19064-67-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2007/8144; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

932-22-9, 4,5-Dichloro-3(2H)-pyridazinone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4,5-dichloropyridazin-3-one (20.06 g, 122.3 mmol)And POCl3 (117 mL, 1280 mmol)The mixture was stirred at reflux for 3 hours.After the reaction,The mixture was cooled to room temperature.A mixed suspension of water and ice (100 mL) was then added.The resulting mixture was adjusted to pH = 10 with saturated aqueous Na 2CO 3.It was then extracted with EtOAc (250 mL x 3).The combined organic layers were washed with brine brine (250 mL)Filter and concentrate under reduced pressure.The residue was purified by silica gel column chromatography (EtOAc /EtOAcThe title compound was obtained as a white solid (17.80 g, yield: 79.3%)., 932-22-9

932-22-9 4,5-Dichloro-3(2H)-pyridazinone 73247, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3,4,5-trichloropyridazine (0.50 g, 2.73 mmol), 4-(2,4- difluorophenyl)piperidine (0.538 g, 2.73 mmol), and potassium carbonate (0.791 g, 5.72 mmol) in dioxane (9 ml) and water (1 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (4.94 ml, 54.5 mmol) was added. The mixture was heated to reflux for 16 h. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water and concentrated to give 4- chloro-5-(4-(2,4-difluorophenyl)piperidin-l-yl)-3-hydrazinylpyridazine as a brown oil. LCMS: Rt = 0.74 min, (M+H)+ = 340.0. The material was used without purification., 14161-11-6

14161-11-6 3,4,5-Trichloropyridazine 70111, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

64068-00-4, 6-Chloro-4-methylpyridazin-3-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

64068-00-4, 6-Chloro-4-methyl-pyridazin-3-amine (3.5 g, 24 mmol) was combined with ethanol (40 mL), triethylamine (8.7 mL, 62 mmol) and chloroacetone (4 mL, 49 mmol) in a 100 mL high pressure flask. The flask was sealed and heated behind a blast shield at 150 C for 45 min. The mixture was concentrated and chromatographed on silica gel, eluting with 30-80% EtOAc in CH2C12 to yield 6-chloro-2,8-dimethylimidazo[l,2-b]pyridazine (2.2 g, 49%). MS m/z 182.3, 184.3 [M+H]+.

The synthetic route of 64068-00-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PTC THERAPEUTICS, INC.; WOLL, Matthew, G.; AMEDZO, Lukiana; BABU, Suresh; BARRAZA, Scott, J.; BHATTACHARYYA, Anuradha; KARP, Gary, Mitchell; MAZZOTTI, Anthony, R.; NARASIMHAN, Jana; PATEL, Jigar; TURPOFF, Anthony; XU, Zhenrong; (251 pag.)WO2018/226622; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5096-73-1

Intermediate 36-Oxazol -5-yl -ryridazine-3-carboxyl ic acid: A mixture of 6-chloro-pyridazine-3-carboxylic acid (350 mg), 5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-2-triisopropylsilanyl-oxazole (1 .00 g), PdCI2[1 ,1 ?-bis(diphenylphosphino)ferrocene]*CH2Cl2 complex (200 mg), and aqueous Na2003solution (2 M; 3.0 mL) in 1 ,4-dioxane (5 mL) and water (1 mL) is stirred overnight at80C under an argon atmosphere. After cooling to room temperature, the reaction mixture is acidified with hydrochloric acid (4 N; 3 mL) and extracted with ethyl acetate. The combined extracts are washed with brine, dried over MgSO4 and concentrated in vacuo. The residue is dissolved in tetrahydrofuran, hydrochloric acid(4N; 4 mL) is added, and the mixture is stirred for 2 h at room temperature. The solvent is evaporated in vacuo and the residue is mixed with ethyl acetate and water. The aqueous phase is extracted with ethyl acetate and the combined extracts are washed with brine, dried over MgSO4, and concentrated in vacuo. The residue is triturated with diethyl ether, filtered off and dried to give the title product. LC (method2): tR = 0.45 mm; Mass spectrum (ESI): mlz = 192 [M+H]

The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; NOSSE, Bernd; ECKHARDT, Matthias; HIMMELSBACH, Frank; LANGKOPF, Elke; ASHWEEK, Neil J.; HARRIOTT, Nicole; WO2014/19967; (2014); A1;,
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Pyridazine | C4H4N2 – PubChem

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3-chloro-6-methyl-pyridazine (4 g, 31.2 mmol) in CHCI3 (80 mL) was added l ,3,5-trichloro-[l ,3,5]triazinane-2,4,6-trione (2.47 g, 10.4 mmol) at room temperature. The mixture was refluxed till the reaction was over. The mixture was concentrated to give the residue, which was purified by column to give 3-chloro-6-chloromethyl-pyridazine (2.5 g, 49.3% yield). 1H NMR(400 MHz, CDC13) delta ppm 7.69 (d, J = 8.8 Hz, 1H), 7.56 (d, J = 8.8 Hz, 1H), 4.86 (s, 2H), ES-LCMS m/z 163 (M+ )+.

1121-79-5, The synthetic route of 1121-79-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, IV, Siegfried Benjamin; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing; LIN, Xiaojuan; XU, Shanli; LV, Maoyun; YAO, Chen; LI, Lei; HUANG, Xing; GAO, Min; WO2013/166621; (2013); A1;,
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Pyridazine | C4H4N2 – PubChem

1122-63-0, 1-(Pyridazin-3-yl)ethanone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1122-63-0, [Referential Example 13] Lithium 1-(6-methoxy-3-pyridyl)-5-(3-pyridazinyl)-1H-pyrazole-3-carboxylate; [Show Image] 1) Methyl 4-(3-pyridazinyl)-2,4-dioxobutanoate; A 1.0M solution of lithium bis(trimethylsilyl)amide in tetrahydrofuran (19 ml) was added dropwise to a solution of 3-acetylpyridazine (2.097 g) in tetrahydrofuran (50 ml) under argon atmosphere at -78C, and the mixture was stirred for 1 hour. A solution of dimethyl oxalate (4.055 g) in tetrahydrofuran (35 ml) was added dropwise to the reaction liquid, and the mixture was stirred at 0C for 2 hours. The reaction solvent was evaporated under reduced pressure, and water and diethylether were added to the residue, then the aqueous layer was separated. The aqueous layer was then acidified with 1N aqueous hydrochloric acid, and the solution was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give methyl 4-(3-pyridazinyl)-2,4-dioxobutanoate (2.63 g, 73%) as a solid. 1H-NMR (400 MHz, CDCl3)delta: 3.97 (3H, s), 7.73 (1H, dd, J = 8.5, 5.1 Hz), 7.96 (1H, s), 8.28 (1H, dd, J = 8.5, 1.8 Hz), 9.38 (1H, dd, J = 5.1, 1.8 Hz). ESI-MSm/z: 209 (M+H)+.

The synthetic route of 1122-63-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1698626; (2006); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem