With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10344-42-0,4-Bromo-3,6-dichloropyridazine,as a common compound, the synthetic route is as follows.
c 3,6-Dichloro-4-(pyrrolidin-1-yl)pyridazine To a slurry of 4-bromo-3,6-dichloropyridazine (115 g, 0.51 mol) and potassium carbonate (209 g, 1.5 mol) in DMF (1) was added pyrrolidine (46 ml, 0.56 mol) at 0 C. with stirring. The mixture was allowed to warm to room temperature and then stirred under nitrogen overnight. Water (1.5) was added and the resultant slurry was filtered. The residue was washed thoroughly with water and diethyl ether, yielding the title compound (110 g, 100%) as a fine white powder. 1H NMR (250 MHz, CDCl3) delta2.03 (4H, m), 3.64 (4H, m), 6.46 (1H, s). MS (ES+) m/e 218 [MH]+, 220 [MR]+.
10344-42-0, The synthetic route of 10344-42-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Merck Sharp & Dohme Ltd.; US6699859; (2004); B1;,
Pyridazine – Wikipedia
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