Tag: M.W:300-400

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Molecular, vibrational (FT-IR and FT-Raman), NMR and UV spectral analysis of imidazo[1,2-b]pyridazine using experimental and DFT calculations

A combined experimental and theoretical study on molecular and vibrational structure of imidazo[1,2-b]pyridazine (IP) was carried out. In this work, molecular geometry and vibrational frequencies of IP in the ground state have been calculated using the density functional method, B3LYP/6-311++G (d,p) level. The vibrational spectra (FT-IR and FT-Raman) H-1 NMR, C-13 NMR and UV of IP have been experimentally recorded. The optimized geometry was in good agreement with the reported experimental values obtained from the X-ray crystal structure of IP in IP monohydrate. The scaled down vibrational frequencies calculated at 6-311++G(d,p) level correlated well with the experimental values. The theoretical spectrograms of FT-IR, FT-Raman, H-1 NMR, C-13 NMR and UV of the title compound have been constructed and compared with experimental spectra.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Related Products of 375-72-4, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 375-72-4, Name is 1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-sulfonyl fluoride, SMILES is O=S(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(F)=O, belongs to pyridazines compound. In a article, author is Jaballah, Maiy Youssef, introduce new discover of the category.

Pyridazine Based Scaffolds as Privileged Structures in anti-Cancer Therapy

Pyridazines, their oxo derivatives; pyridazinone as well as fused bi- or tricyclic pyridazine containing scaffolds are key structural features of many biologically active compounds with diverse pharmacological applications, including cancer therapy. Since protein kinases play prominent role in tumor biology, the inhibition of its signaling pathway is considered an effective therapeutic option for the treatment of cancer. Based on the various advantages of pyridazines in drug design including modulation of the physico-chemical properties, improving ADME and toxicity profile as well as easy and diverse synthetic methods of access, makes them an invaluable tool for designing compounds as future drugs for targeted cancer treatment. In this review, we have compiled and discussed the anticancer potential of pyridazine based scaffold, with special focus on those targeting protein kinase inhibition.

Related Products of 375-72-4, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 375-72-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Othman, Ismail M. M., once mentioned the application of 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, molecular formula is C21H19O2P, molecular weight is 334.35, MDL number is MFCD00008455, category is pyridazines. Now introduce a scientific discovery about this category, Computed Properties of C21H19O2P.

Synthesis, characterization, and biological studies of some novel pyrazole carboxamide, pyridazine and thienopyridazine derivatives

The arylhydrazones 3a, b were prepared and reacted with various reagents to yield the target compounds pyrazoles 6a-f, 1,6-dihydropyridazine-3-carboxamide derivatives 9a,b and thieno[3,4-d]pyridazine-1-carboxamide derivatives 10a,b. The structures of the synthesized compounds were confirmed by various spectral data and elemental analyses. Furthermore, all target derivatives were tested for their antibacterial bioactivity against different types of Gram+ve and Gram-ve strains and for antifungal activity against two fungi micro-organisms by well diffusion method. Thus, the observed results showed that the 5-cyano-6-imino-N-(4-methoxyphenyl)-4-methyl-1-phenyl-1,6-dihydropyridazine-3-carboxamide (9b) displayed the best antimicrobial activity (with MIC values ranged from 0.49 +/- 0.2 to 3.9 +/- 0.6 mu g/mL).

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1799-84-4, Name is 3,3,4,4,5,5,6,6,6-Nonafluorohexyl methacrylate, SMILES is CC(C(OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F)=O)=C, in an article , author is Lin, Feng, once mentioned of 1799-84-4, HPLC of Formula: C10H9F9O2.

Construction of Vesicles, Micro/Nanorods and Ultralong Nanotubes through the Self-Assembly of Non-Classical Amphiphiles with Rigid Conformation

Amphiphilic molecules have long been regarded as an important class of supramolecular building blocks for the fabrication of nanomaterials. While most previous researches have mainly focused on amphiphlies with flexible structures, in this work, four novel amphiphiles possessing wholly-rigid skeletons have been designed and synthesized. These molecules were built by using 4,4′-bipyridin-1-ium or viologen as hydrophilic moieties and phenyl or biphenyl as hydrophobic segments, bridged by a pyridazine unit. Their self-assembly behavior has been investigated by scanning electron microscopy (SEM), atomic force microscopy (AFM) and transmission electron microscopy (TEM), which revealed they could self-assemble into well-ordered nanoarchitectures with various morphologies such as vesicles, micro/nanorods and nanotubes in water or methanol, depending on their hydrophilic/hydrophobic fraction ratios.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem