Tag: M.W:200-300

84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84956-71-8, Synthesis of 2-tert-butyl-4-chloro-5-(2-tert-butyldimethylsilyloxy-1-(4-tert-butylphenyl)-1-ethyl)oxy-3(2H)-pyridazinone To a solution of 2-tert-butyl-4,5-dichloro-3(2H)-pyridazinone (0.5 g, 2.27 mmol) in DMF (10 ml) were added anhydrous cesium carbonate (0.74 g, 2.27 mmol) and 1-tert-butyldimethylsilyloxy 2-hydroxy 2-(4-tertbutylphenyl) ethane (0.7 g, 2.27 mmol). The mixture is stirred for 2 hours at 70 C. and then cooled to room temperature and ethyl acetate is added to it. The solution is then washed with water, dried and concentrated and the residue subjected to purification by flash chromatography (silica gel; ethyl acetate/hexanes) to give the above compound.

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Casebier, David S.; Robinson, Simon P.; Purohit, Ajay; Radeke, Heike S.; Azure, Michael T.; Dischino, Douglas D.; US2005/191238; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: A solution of the substituted pyridazinone and either a benzylic alcohol or benzylic bromide in dimethylformamide was treated with cesium carbonate then optionally heated to 55-80 C. After cooling to ambient temperature, the crude product was isolated as a solution in ethyl acetate, washed with water and aqueous sodium chloride then dried, filtered and concentrated. Subsequent purification by chromatography on silica afforded the title compound.

The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Lantheus Medical Imaging, Inc.; Cesati, Richard R.; Radeke, Heike S.; Pandey, Suresh K.; Purohit, Ajay; Robinson, Simon P.; US2015/196672; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4-((tetrahydro-2H-thian-4-yl) oxy) aniline 45c (200 mg, 0.955 mmol)And 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (200 mg, 0.97 mmol) in ethanol (10 mL),Heat to 90 C in a sealed tube and stir for 12 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 1/1 to 1/2),The target product 6-chloro-4-((4-((tetrahydro-2H-thian-4-yl) oxy) phenyl) amino) pyridazine-3-carboxylic acid methyl ester 45d (240 mg, yellow solid ),Yield: 66%.

372118-01-9, The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135034-10-5,3-Chloro-6-iodopyridazine,as a common compound, the synthetic route is as follows.

b) Ethyl (?)-3-(3-Chloro-6-pyridazinyl)-2-propenoate.; A suspension of 3- chloro-6-iodopyridazine (2.4 g, 10 mmol), ethyl acrylate (4.4 mL, 40 mmol), palladium(II) acetate (90 mg, 0.40 mmol) and tri(o-tolyl)phosphine (366 mg, 1.20 mmol) in DMF (10 mL) and diisopropylethyl amine (5 mL) was stirred with heating (1 1 1 C oil-bath) for 3.5 h, cooled to room temperature, diluted with H20 (50 mL) and extracted with EtOAc (300 mL). The extract was washed (brine) and dried. After solvent removal at reduced pressure, the residue was chromatographed (14% to 20% EtOAc/hexane) to give 174 mg (8%) of ethyl (E)-3- (3-chloro-6-pyridazinyl)-2-propenoate as a brown solid, mp 106-1 10 C. IR 2928, 1715, 1 186 cm”1; 1H NMR (CDC13) delta 1.38 (t, J= 7.5 Hz, 3H, CH2G?), 4.33 (q, J= 7.5 Hz, 2H, CH2CH3), 7.98 (d, J = 16.2 Hz, 1H, CH=CHCO), 7.57 (d, J= 8.4 Hz, 1H, 4-ArH), 7.63 (d, J = 8.4 Hz, 1H, 5-ArH), 7.86 ppm (d, J= 16.2 Hz, 1H, CH=CHCO). HRMS calcdC9H9C1N202 [M + H]+ 213.0425, found 213.0431., 135034-10-5

As the paragraph descriping shows that 135034-10-5 is playing an increasingly important role.

Reference£º
Patent; WAYNE STATE UNIVERSITY; SANDFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; FONTANA, Joseph, A.; DAWSON, Marcia; XIA, Zebin; WO2011/79305; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

EXAMPLE 8 Synthesis of 2-tert.-butyl-4-chloro-5-[4-(1,1,2-trifluoro-2-trifluoromethoxy-ethoxy)-benzyloxy]-3(2H)-pyridazinone [Compound (3)] 1.16 g of 4-(1,1,2-trifluoro-2-trifluoromethoxy-ethoxy)-benzyl alcohol (Example 3) and, 15 minutes later, 0.95 g of 2-tert.-butyl-4,5-dichloro-3(2H)-pyridazinone are added to a suspension of 0.2 g of sodium hydride at 50% in 10 cc of dimethylformamide. The resulting reaction mixture is stirred for 1 hour at room temperature, is diluted with ether, is washed with diluted HCl and brine; the washed solution is thoroughly dehydrated, the solvent is evaporated off and the so obtained raw reaction product is chromatographed on silica gel with 9/1 hexane/ethyl acetate. 1.3 g of pure product is obtained. Melting point 68-69 C.

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Presidenza del Consiglio dei Ministri-Ufficio del Ministro per il coordinamento delle iniziative per la ricerva Scientifica e Tecnologica; US5169848; (1992); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17973-86-3,3,6-Dibromopyridazine,as a common compound, the synthetic route is as follows.

Example 24 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(6-(4-(trifluoromethyl)phenyl)pyridazin-3-yl)propan-2-ol (56) To a stirred solution of 3,6-dibromopyridazine (200 mg, 0.84 mmol) and 4-(trifluoromethyl)phenylboronic acid (159.7 mg, 0.84 mmol) in 1,2-dimethoxyethane (DME; 12 mL) was added 1M sodium carbonate (Na2CO3; 1.2 mL, 1.26 mmol) at RT, and the mixture was degassed by purging with argon for 30 min. To the resulting reaction mixture was added tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4; 29.1 mg, 0.025 mmol), and the mixture was further degassed for 5 min at RT. The reaction mixture was stirred at reflux for 18 h. After complete consumption of the starting material (by TLC), the reaction mixture was cooled to RT, diluted with H2O (50 mL) and extracted with EtOAc (2*50 mL). The combined organic extracts were washed with H2O (40 mL) and brine (40 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude material. Purification by silica gel column chromatography (eluting with 12% EtOAc/hexane) afforded a mixture of mono and bis-coupled products BC (150 mg, 2:1 ratio), which was taken to the next step without separation. (Note: Both compounds eluted at same Rf; all the characteristic protons were seen in the 1H NMR spectrum.) MS (ESI): 303 [M+H]+. To a stirred suspension of copper powder (0.75 g, 11.81 mmol) in DMSO (3 mL) was added ethyl 2-bromo-2,2-difluoroacetate (1.2 g, 5.92 mmol) at RT, and the mixture was stirred for 1 h. A solution of compound BC (0.9 g, mixture) in DMSO (7 mL) was added to the reaction mixture, and stirring was continued for another 18 h at RT. After completion of reaction (by TLC), the reaction mixture was quenched with satd NH4Cl solution (100 mL) and extracted with EtOAc (2¡Á200 mL). The combined organic extracts were washed with H2O (50 mL) and brine (50 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude product. Purification by silica gel column chromatography (eluting with 15% EtOAc/hexane) afforded crude BD (0.7 g, as a mixture) which was taken for the next step without separation. (Note: All the characteristic protons were seen in the 1H NMR spectrum.) LC-MS: 347.8 [M+H]+ at 4.99 RT (73.75% purity).

17973-86-3, As the paragraph descriping shows that 17973-86-3 is playing an increasingly important role.

Reference£º
Patent; VIAMET PHARMACEUTICALS, INC.; US2012/329802; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5788-58-9,5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred suspension of 4,5-dibromopyridazmn-3(2H)-one (4.00 g, 15.8 mmol) in methanol (40 mL, 990 mmol), was added potassium carbonate (4.00 g, 28.9 mmol) and the mixture was stirred at 80t for 67 hours. The solvent was removed in vacuum. Water was added to the residue and acetic acid was added until acidic pH was reached. A solid precipitated and wascollected by filtration, washed with water, and dried to give 2.23 g (69 % yield) of the title compound as a crude product.LC-MS (Method 5): R = 0.57 mm; MS (ESIpos): mlz = 205 [M+H]

As the paragraph descriping shows that 5788-58-9 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; HEINRICH, Tobias; PRINZ, Florian; LEFRANC, Julien; SCHROeDER, Jens; MENGEL, Anne; BONE, Wilhelm; BALINT, Joszef; WENGNER, Antje; EIS, Knut; IRLBACHER, Horst; KOPPITZ, Marcus; BOeMER, Ulf; BADER, Benjamin; BRIEM, Hans; LIENAU, Philip; CHRIST, Clara; STOeCKIGT, Detlef; HILLIG, Roman; (1256 pag.)WO2017/102091; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

41933-33-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41933-33-9,2-Benzyl-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

To a mixture of 2-benzyl-4,5-dichloropyridazin-3(2H)-one (30.6 g, 120 mmol), prepared as described in Example 244A, 4-chlorophenyl boronic acid (20.6 g, 132 mmol) and tetrakis(triphenylphosphine)palladium (5 g, 4.3 mmol) in toluene (300 mL) under an atmosphere of argon, and was added an aqueous Na2CO3 solution (2M, 66 mL, 132 mmol). The reaction mixture was stirred at 100 C. under argon for 16 h. The reaction was then allowed to cool to RT and was subsequently poured into water (200 mL). The resulting mixture was extracted with EtOAc (3¡Á150 mL). The combined organic layers were washed with saturated aqueous NaCl. The organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure. The obtained thick syrup was dissolved in MeOH (100 mL) and the resulting solution kept at 0 C. until white solid precipitated. The solid was collected by filtration, washed with hexanes, and then triturated with EtOAc-hexanes to give the title compound, 2-benzyl-5-chloro-4-(4-chlorophenyl)pyridazin-3(2H)-one (12 g, 30%) as a white powder. LC/MS (method A, general procedure): RT=3.81 min, (M+H)+=331.

The synthetic route of 41933-33-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yu, Guixue; Ewing, William R.; Mikkilineni, Amarendra B.; Pendri, Annapurna; Sher, Philip M.; Gerritz, Samuel; Ellsworth, Bruce A.; Wu, Gang; Huang, Yanting; Sun, Chongqing; Murugesan, Natesan; Gu, Zhengxiang; Wang, Ying; Sitkoff, Doree; Johnson, Stephen R.; Wu, Ximao; US2005/143381; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.914349-19-2,4-(6-Chloropyridazin-3-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

4- (6-chloropyridazin-3-yl) benzaldehyde (40 mg, 0.18 mmol)Was dissolved in methanol / dichloromethane (4: 1, 2 mL), sodium borohydride (NaBH4, 10 mg, 0.26 mmol) was gradually added at 0 C and the mixture was stirred at room temperature for 2 hours. After the reaction, ethyl acetate was added thereto, washed with brine, and the organic layer was dried over anhydrous sodium sulfate,Concentrated to give (4- (6-chloropyridazin-3-yl) phenyl) methanol(39 mg, 98%) as a yellow solid.

914349-19-2, The synthetic route of 914349-19-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Korea Research Institute of Chemical Technology; Handok Co., Ltd.; Jeong Hui-jeong; Kim Hyeong-rae; Ha Jae-du; Lee Jeong-ok; Cho Seong-yun; Choi Sang-un; Lee Jong-guk; Park Ji-hun; (45 pag.)KR101869534; (2018); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Z-re-Bromo-a-pyridazinyll-?S^S^delta-te/if-butoxycarbonyl-Z.delta-diazabicvclo-rZ.Z.Il- heptane (Intermediate compound)A mixture of te/tauf-butyl-(1S,4S)-2,5-diazabicyclo-[2.2.1]-heptane-2- carboxylate (3.0 g; 15.1 mmol), 3,6-dibromopyridazine (3.6 g; 15.1 mmol) and dioxane (15 ml) was stirred for 3 days at 90C. The crude product salt was filtered. Aqueous sodium hydroxide (50 ml; 1 M) was added to the solid material. The mixture was extracted with dichloromethane (3 x 50 ml). Chromatography on silica gel with dichloromethane, methanol and cone, ammonia (89:10:1 ) gave the title compound as free base. Yield 1.71 g (32%).

17973-86-3, 17973-86-3 3,6-Dibromopyridazine 248852, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; NeuroSearch A/S; WO2006/87305; (2006); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem