Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.187973-60-0,6-Iodopyridazin-3-amine,as a common compound, the synthetic route is as follows.

General procedure: A 10 mL round-bottomed flask containing a magnetic stirbar was charged with CuI (0.1 mmol) followed by L-hydroxyproline (0.2 mmol),6-iodopyridazin-3-amine (1.3 mmol) and K3PO4 (3.0 mmol). The flask wasflushed with N2 and a solution of the appropriate amine (1.0 mmol) inanhydrous DMSO (1.5 mL) was then added. The mixture was stirred under N2at 50 C for 24 h. MeOH (5 mL) and H2O (5 mL) were added and the stirredmixture was neutralised by dropwise addition of AcOH. The resultant solidswere allowed to settle out and the supernatant solution added to the top of astrong cation exchange (SCX) column. The remaining solid was washed withfurther MeOH (5 mL), and the washings also added to the SCX column. Thesolution was allowed to elute slowly through the column, which was thenflushed with further MeOH. These MeOH washings were discarded. A 1 Msolution of NH3 in MeOH was flushed through until elution of the product wascomplete and the solvent was evaporated under reduced pressure to yield acrude material. Purification was done by flash silica chromatography, elutiongradient typically 0-10% MeOH in CH2Cl2. Relevant fractions were evaporatedto dryness to afford the desired product., 187973-60-0

The synthetic route of 187973-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bethel, Paul A.; Roberts, Bryan; Bailey, Andrew; Tetrahedron Letters; vol. 55; 37; (2014); p. 5186 – 5190;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135034-10-5,3-Chloro-6-iodopyridazine,as a common compound, the synthetic route is as follows.

To a stirred solution of Intermediate 2 (0.25 g, 0.8 mmol) in dry DMF (5 mL), TEA (0.36 ml,2.85 mmol) and 3-chloro-6-iodopyridazine (0.123 g, 0.99 mmol) were added at rt and the reaction mixture was stirred at 90 C overnight. The resulting reaction mixture was cooled to rt and DMF was evaporated under reduced pressure. To the resulting crude mixture, water (20 mL) was added and the product was extracted with EtOAc (2 x 30 mL). Theresulting organic layer was dried over Na2SO4 and concentrated. This crude product waspurified by flash column chromatography to afford the title compound ( off white solid). 1HNMR (400 MHz, CDCI3): 68.86-8.84 (m, 2H), 8.11 (d, J = 8.8 Hz, IH), 8.03 (d, J = 2.0 Hz,I H), 7.90 (dd, J = 8.8, 2.0 Hz, I H), 7.45 (d, J = 9.6 Hz, I H), 6.60 (d, J = 9.6 Hz, I H), 3.65-3.58 (m, 5H), 2.73-2.67 (m, 2H), 2.59-2.54 (m, 2H), 1.51 (d, J = 6.8 Hz, 3H). LCMS:(Method A) 447.0 (M +H), Rt. 2.13 mm, 99.59% (Max). HPLC: (Method A) Rt. 2.16 mm,98.99% (Max).

135034-10-5, As the paragraph descriping shows that 135034-10-5 is playing an increasingly important role.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20074-67-3,Perchloropyridazine,as a common compound, the synthetic route is as follows.,20074-67-3

1.69 g (10.10 mmol) of carbazole was added to a 250 ml three-necked flask, Then, 100 mL of N,N-dimethylformamide was added as a reaction solvent, Stirred for 10 min on a magnetic stirrer. Under ice-cooling, 0.49 g (20.19 mmol) of NaH was added portionwise to the reaction flask and stirring was continued for 1 h. 0.50 g (2.30 mmol) of 3,4,5,6-tetrachloropyridazine was dissolved in 20 ml of N,N-dimethylformamide was added dropwise to the reaction system. After completion of the addition, the reaction was carried out at 60 C for 15 hours under nitrogen atmosphere. After the reaction, The reaction solution was poured into 150 ml of dilute hydrochloric acid at a concentration of 10% Decompression pumping, washing, drying, The crude product was treated with petroleum ether and ethyl acetate (PE:EA=10:1) The mobile phase was subjected to column chromatography to remove impurities, and then pure methylene chloride (DCM) The column was evaporated to give 1.16 g of a pale yellow solid in 68.0% yield.

As the paragraph descriping shows that 20074-67-3 is playing an increasingly important role.

Reference£º
Patent; Dalian University of Technology; LI, JIUYAN; SUI, KAI; LIU, DI; (19 pag.)CN106243091; (2016); A;,
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84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84956-71-8, Example 3 Synthesis of 2-tert-butyl-4-chloro-5-[2-(2-methyl-4-n-pentylphenoxy)ethylthio]-3(2H)-pyridazinone (Compound No. 12) In 20 ml of methanol were dissolved 1.8 g of 2-tert-butyl-4,5-dichloro-3(2H)-pyridazinone and 1.9 g of 2-(2-methyl-4-n-pentylphenoxy)ethylmercaptan, and then to the mixture was added dropwise a solution of 0.5 g of sodium methoxide dissolved in 5 ml of methanol. After dropwise addition, the mixture was stirred at room temperature for 1 hour to complete the reaction. Then, methanol was distilled off under reduced pressure, and an oily product which was separated by adding water was extracted with ethyl acetate The extract was washed with water, dried over anhydrous sodium sulfate, and then ethyl acetate was distilled off under reduced pressure. The oily product obtained was isolated by column chromatography (Wako Gel C-200, eluted with toluene: ethyl acetate = 9: 1) to give 2.8 g of the title compound as colorless oily liquid.

The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UBE INDUSTRIES, LTD.; RIKAGAKU KENKYUSHO; EP283271; (1990); A3;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.187973-60-0,6-Iodopyridazin-3-amine,as a common compound, the synthetic route is as follows.

Reference Example 54 Production of (6-iodoimidazo[1,2-b]pyridazin-2-yl)methanol To a solution of 3-amino-6-iodopyridazine (2.0 g, 9.0 mmol) in ethanol (40 mL) was added 3-chloro-2-oxopropyl acetate (2.73 g, 18.1 mmol), and the mixture was heated under reflux for 24 hr. After cooling the mixture to room temperature, saturated aqueous sodium hydrogencarbonate solution was added to the mixture, and the mixture was extracted with ethyl acetate/tetrahydrofuran. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and filtrated. The solvent was evaporated under reduced pressure, and the residue was collected by filtration and washed with ethyl acetate/hexane to give the title compound (498 mg, 20%) as a white powder. 1H-NMR (DMSO-d6, 300 MHz) delta 4.62 (2H, d, J=5.6 Hz), 5.33 (1H, t, J=5.6 Hz), 7.49 (1H, d, J=9.3 Hz), 7.80 (1H, d, J=9.3 Hz), 8.14 (1H, s).

187973-60-0, The synthetic route of 187973-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/137595; (2009); A1;,
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17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3. Preparation of 3-(4-(benzyloxy)cyclohexyloxy)-6-bromopyridazine To a stirred suspension of 4-(benzyloxy)cyclohexanol (50.0 mg, 0.242 mmol) and KO’Bu (40.8 mg, 0.364 mmol) in THF (3.00 mL) was added 3,6-dibromopyridazine (115 mg, 0.485 mmol) at room temperature. The reaction mixture was stirred at 70 C. for 15 hours. The residue was diluted with EtOAc and washed with water and brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by column chromatography on SiO2 (Hex:EtOAc=3:1) to give the desired product as a white solid. 1H-NMR (400 MHz, CDCl3) delta 1.58 (3H, m), 1.78 (2H, m), 2.04 (2H, m), 2.23 (1H, m), 3.46, 3.57 (1H, m), 4.55 (2H, s), 5.27, 5.36 (1H, m), 6.81 (1H, m), 7.26-7.37 (5H, m), 7.45 (1H, m). LC-MS Calcd. 362.06, Found 362.80 [M+H]+., 17973-86-3

17973-86-3 3,6-Dibromopyridazine 248852, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.; US2012/53180; (2012); A1;,
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1591827-16-5, Methyl 6-chloro-3-methoxypyridazine-4-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of methyl 6-chloro-3-methoxypyridazine-4-carboxylate (2.0 g, 0.01 mol) in 20 mL of THF was added MeMgBr (7.4 ml, 0.022 mol) at -30 C under a nitrogen atmosphere. The resulting mixture was stirred at 0 C for 1 hr. After finished, the mixture was poured into water and acidified with sat. aq. NH4C1, extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 5: 1) to afford 2-(6-chloro-3-methoxypyridazin-4-yl)propan-2-ol (550 mg). MS (ESI): m/z 203, 205 (M+H)+., 1591827-16-5

The synthetic route of 1591827-16-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ARRINGTON, Kenneth, L.; BURGEY, Christopher; GILFILLAN, Robert; HAN, Yongxin; PATEL, Mehul; LI, Chun Sing; LI, Yaozong; LUO, Yunfu; LEI, Zhiyu; XU, Jiayi; WO2014/58747; (2014); A1;,
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17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 26 A mixture of 5 parts of 1-(3-methylphenyl)piperazine dihydrochloride, 10.6 parts of sodium carbonate and 180 parts of N,N-dimethylformamide was stirred for 1 hour at 65 C. Then there were added 7.2 parts of 3,6-dibromopyridazine and the whole was stirred overnight at about 65 C. The reaction mixture was poured into ice water. The product was filtered off and dissolved in dichloromethane. The solution was washed twice with water, dried, filtered and evaporated. The residue was crystallized from ethanol. The product was filtered off and dried, yielding 4.1 parts (61.5%) of 3-bromo-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine; mp. 145.7 C. (compound 136).

17973-86-3, 17973-86-3 3,6-Dibromopyridazine 248852, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Janssen Pharmaceutica N.V.; US5001125; (1991); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

84956-71-8, 2-(t-butyl)-4,5-dichloro-2-hydro-pyridazin-3-one (1.66 g, 7.50 mmol) and (4-(2-methyl-1,3-dioxolan-2-yl)phenyl) methanol (0.971g, 5.00mmol; for example, Takebayashi, S;. Dabral, N;. Miskolzie, M;.. Bergens, S.H.J.Am.Chem.Soc, 2011,133,25, 9666-9669, )solution in dry dimethylformamide (50.0 mL) to a it was treated at ambient temperature at a time by cesium carbonate (3.26g, 10.0mmol). Then, the resulting suspension was immersed in a preheated oil bath , and maintained at 65 C., with vigorous stirring, for 4 hours. After cooling to ambient temperature, the suspension was maintained for a further 12 hours,and then, is transferred to a separation funnel, and ethyl acetate (each 50 ml) and divided into water. Furthermore, these layers are separated, washed with ethyl acetate aqueous layer (2¡Á50mL). A saturated aqueous sodium chloride in combination with ethyl acetate (5¡Á50mL) washing and cleaning, then, dried with magnesium sulfate, filtering, in reduced pressure to concentrate the yellow solid. Subsequently, coarse material, 7:3 hydroxypentanoic/ethyl acetate is purified by using silica chromatography (40¡Á220mm). The main product is recovered at peak 400-700mL eluent, pools, in reduced pressure concd. white solid. Subsequently, the material is purified hot ethyl acetate/aminopentanenitrile by recrystallization from a colorless needle is obtained (1. 33g, 3. 51mmol; 70. 1%).1H NMR : (300MHz, DMSO-d6) delta8. 27 (1H, s), 7. 52-7. 36 (4H, m), 5. 44 (2H, s), 4. 07-3. 93 (2H, m), 3. 76-3. 60 (2H, m), 1. 57 (9H, s), 1. 55 (3H, s).13C NMR : (75MHz, DMSO-d6) delta157. 8,153. 9,143. 6,134. 9,127. 7,126. 2,125. 4,115. 5,107. 9, 71. 2, 65. 4, 64. 1, 27. 5, 27. 2. HRMS C19H2335ClN2O4to calculated value (M+H): 379. 1419 ; measured value: 379. 1416. TLC: Rf0. 39 (silica gel, 7:3 hydroxypentanoic/ethyl acetate, uv).

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; LANTHEUS MEDICAL IMAGING INCORPORATED; CESATI, RICHARD R; RADEKE, HEIKE S; PANDEY, SURESH K; PUROHIT, AJAY; ROBINSON, SIMON P; (297 pag.)JP2015/531760; (2015); A;,
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492431-11-5,492431-11-5, 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 10.5 g of the compound obtained in the preceding step and 2.5 g of 10% palladium-on-charcoal in 30 ml of DMF and 250 ml of EtOH is hydrogenated overnight at RT and atmospheric pressure. The catalyst is filtered off and the filtrate is concentrated under vacuum. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture of from (97/3; v/v) to (90/10; v/v). 9.1 g of the expected product are obtained, and are used without further purification.

492431-11-5 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine 21925370, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Di Malta, Alain; Garcia, Georges; Roux, Richard; Schoentjes, Bruno; Serradeil-Le Gal, Claudine; Tonnerre, Bernard; Wagnon, Jean; US2004/180878; (2004); A1;,
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