Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17973-86-3,3,6-Dibromopyridazine,as a common compound, the synthetic route is as follows.

Step 1: 3,6-Dibromopyridazine (500 mg, 2.1 mmol), 4-(3-methoxy-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)-l-(tetrahydro-2H-pyran-2-yl)-lH-pyrazole (970 mg, 2.52 mmol), Pd(dppf)Ci2 (77 mg, 0.11 mmol), K2CO3 (870 mg, 6.3 mmol) were mixed in a Schlenk tube. The reaction was degassed with N2 for 15 min and dioxane (8 mL) and water (1 mL) were added and the reaction was heated to 90 C for 16 h. The reaction was cooled to room temperature, partitioned between EtOAc and water. The organic layers were dried over Na2S04, concentrated under vacuum, purified via column chromatography: eluting with gradient hexanes/EtOAc (0% to 40% EtOAc), column: silica 4 g, to provide 3-bromo-6-(2-methoxy-4-(l-(tetrahydro-2H-pyran- 2-yl)-lH-pyrazol-4-yl)phenyl)pyridazine (690 mg, 79%) as an off-white fluffy solid .

17973-86-3, As the paragraph descriping shows that 17973-86-3 is playing an increasingly important role.

Reference£º
Patent; PTC THERAPEUTICS, INC.; BABU, Suresh; BHATTACHARYYA, Anuradha; HWANG, Seongwoo; JANI, Minakshi; MOON, Young-choon; SYDORENKO, Nadiya; (214 pag.)WO2017/100726; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.286946-24-5,Methyl 3,6-dichloropyridazine-4-carboxylate,as a common compound, the synthetic route is as follows.

Methyl 3,6-dichloropyridazine-4-carboxylate (2 g, 9.66 mmol) was weighted into a clean dry flask charged with a magnetic stirring bar. It was sealed and purged with nitrogen twice and dissolved in anhydrous THF (40 ml). The solution was cooled in an ice-water bath and added sodium methoxide (0.69 g, 12.77 mmol) in one portion. It was stirred for 30 min. LC-MS showed the completion of the reaction. It was quenched with saturated aqueous ammonium chloride (20 mL). The mixture was extracted with ethyl acetate (3×40 mL). The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated. The residue was purified by ISCO (80g, 0-30% ethyl acetate in hexane) to give the title compound. MS (ESI): m/z 203 (M+H) +, 286946-24-5

286946-24-5 Methyl 3,6-dichloropyridazine-4-carboxylate 17861811, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; BURGEY, Christopher, S.; FRITZEN, Jeffrey, F.; BALSELLS, Jaume; PATEL, Mehul; (59 pag.)WO2015/153304; (2015); A1;,
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Pyridazine | C4H4N2 – PubChem

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (1.22 g, 5.95 mmol),4- (3-methoxyoxetane-3-yl) aniline 69e (760mg, 4.25mmol),Diisopropylethylamine (1.65 g, 12.75 mmol) and acetonitrile (15 mL) were mixed, heated to 90 C. in a microwave reactor, and stirred for 3 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 50/1 to 1/2),The target product 6-chloro-4-((4- (3-methoxyoxetan-3-yl) phenyl) amino) pyridazine-3-carboxylic acid methyl ester 69f (850 mg, yellow solid) was obtained. yield: 57%., 372118-01-9

372118-01-9 Methyl 4,6-dichloropyridazine-3-carboxylate 17848322, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1206487-35-5,4,6-Dibromopyridazin-3-amine,as a common compound, the synthetic route is as follows.

To a stirred solution of 4-bromo-6-bromopyridazin-3-amine (3a), (0.20 g, 0.79 mmol) in DML (5 mL) were ethyl 2-(3,8-diazabicyclo[3.2.1]octan-8-yl)acetate hydrochloride (0.278 g, 1.11 mmol ) and DIPEA (0.7 mL, 3.95 mmol) at RT and stirred for 16 h at 90 C under nitrogen atmosphere. Then the reaction mixture was quenched with cold water (20 mL) and the brown solid obtained was washed with diethyl ether, filtered and dried under vacuum. The same procedure was repeated four times to afford pure title compound (0.155 g, Yield : 55 %). 1H NMR (400 MHz, DMSO-d6): d 6.96 (s, 1H), 5.76 (s, 2H), 4.15-4.03 (m, 2H), 3.37-3.29 (m, 2H), 3.19 (s, 2H), 3.16-3.14 (m, 2H), 2.83-2.80 (m, 2H), 1.85 (s, 4H), 1.23-1.13 (m, 3H); LC-MS: m/z 371.1 (M+l)+., 1206487-35-5

Big data shows that 1206487-35-5 is playing an increasingly important role.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SASMAL, Sanjita; SAMAJDAR, Susanta; MUKHERJEE, Subhendu; ABBINENI, Chandrasekhar; (260 pag.)WO2019/207538; (2019); A1;,
Pyridazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.825633-94-1,5-Iodo-2,3-dihydropyridazin-3-one,as a common compound, the synthetic route is as follows.

5-Iodopyridazin-3 (2H) -one (200 mg, 0.90 mmol) , potassium carbonate (249 mg, 1.80 mmol) , and anhydrous acetonitrile (4.5 mL) were charged to a round-bottom flask equipped with a rubber septum and magnetic stirbar. Methyl iodide (62.0 muL, 0.991 mmol) was charged dropwise via syringe. The flask was then equipped with a reflux condenser and heated at reflux for 1 hour. The reaction mixture was filtered through. The filtrate was evaporated to give the crude product, which was purified by silica gel column chromatography (0-10 MeOH/DCM) to afford 5-iodo-2-methylpyridazin-3 (2H) -one. LC/MS: (M+1) +: 236.80., 825633-94-1

The synthetic route of 825633-94-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; SHI, Zhi-Cai; WALSH, Shawn P.; WU, Zhicai; YU, Yang; FERGUSON II, Ronald; GUO, Zhiqiang; FRIE, Jessica; SUZUKI, Takao; BLIZZARD, Timothy A.; FU, Qinghong; VANGELDER, Kelsey F.; (118 pag.)WO2016/65582; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 8: 4-(6-Bromo-3-pyridazinyl)morpholine. 3,6-Dibromopyridazine (1.34g, 5.63mmol) was dissolved in acetonitrile (8ml), to this mo?holine(0.74ml, 8.45mmol) and triethylamine (1.22ml, 8.45mmol) were added and the suspension was irradiated in the microwave to 1600C for 80 minutes. The sample was then extracted between water(100ml) and dichloromethane (100ml). The mixture was poured through a hydrophobic frit collecting the dichloromethane layer which was evaporated to as dry as possible. The sample was then purified by chromatography (4* 10g of silica) eluting with 10% ethyl acetate/ dichloromethane to obtain the title compound (1.23g)1H-NMR (CDCl3) ? 3.59-3.61 (4H, m), 3.82-3.85 (4H, m), 6.79 (IH, d, J= 10), 7.35 (IH, d, J =10).LC/MS m/z [MH+] 246 consistent with molecular formula C8H1081BrN3O, 17973-86-3

17973-86-3 3,6-Dibromopyridazine 248852, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/22937; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1206487-35-5, 4,6-Dibromopyridazin-3-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-bromo- 1 -((lr,3 r)-3- (quinolin-2-yl)cyclobutyl)ethanone (1.56 g, 4.62 mmol, prepared using themethod described in Example 1, step C) and 4,6-dibromopy-ridazin-3-amine (1.17 g, 4.62 mmol) in DMF (10 mE) wasstirred at rt for 3 days. The reaction mixture was poured intowater (200 mE), and extracted with EtOAc (2×200 mE). The combined organic layers were washed with saturated NaHCO3 and brine, dried over Na2 SO4, filtered, and concentrated. The residue obtained was purified by flash chromatography on silica gel (0-40% EtOAc/heptane) to obtain 2-((lr, 3r)-3-(6,8-dibromoimidazo[ 1 ,2-b]pyridazin-2-yl)cyclobutyl)quinoline as a yellow oil. ?H-NMR (400 MHz, CDC13) oe (ppm): 8.10 (dd, J=8.3, 4.8 Hz, 2H), 7.98 (s, 1H), 7.79 (d, J=8.1 Hz, 1H), 7.70 (t, J=7.8 Hz, 1H), 7.47-7.53 (m, 1H), 7.44 (s, 1H), 7.38 (d, J=8.6 Hz, 1H), 4.01-4.10 (m, 1H),3.89-3.99 (m, 1H), 2.96-3.08 (m, 2H), 2.75-2.86 (m, 2H).

1206487-35-5, The synthetic route of 1206487-35-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Janssen Pharmaceutica, NV; Player, Mark R.; Meegalla, Sanath K.; Illig, Carl R.; Chen, Jinsheng; Wilson, Kenneth J.; Lee, Yu-Kai; Parks, Daniel J.; Cheung, Wing S.; Huang, Hui; Patch, Raymond J.; US2014/364413; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4,5-dibromopyridazin-3(2H)-one (0.30 g, 1.182 mmol), 2-(piperidin-4- yl)benzonitrile hydrochloride (0.289 g, 1.300 mmol), and DIPEA (0.454 ml, 2.60 mmol) in DMA (2.498 ml) was heated to 100C for 16h. The reaction was cooled and diluted with saturated sodium bicarbonate to give a tan precipitate that was filtered and dried to give 2-(l-(5-bromo-6-oxo-l,6-dihydropyridazin-4-yl)piperidin-4- yl)benzonitrile (0.434 g, 100%). LCMS: Rt = 0.85 min, (M+H)+ = 359.7. The material was used without purification, 5788-58-9

5788-58-9 4,5-Dibromopyridazin-3(2H)-one 236181, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17973-86-3,3,6-Dibromopyridazine,as a common compound, the synthetic route is as follows.

[00207] To a solution of 3,6-dibromopyridazine (400 mg, 1.68 mMol, 1.0 eq.) in dry THF (19 ml_) at 10 C was added NaH (8.1 mg, 2.02 mMol, 1.2 eq., 60 % in mineral oil) and the reaction was stirred at 10 C for 10 min. A solution of (1-methyl-piperidin-4-yl)-methanol (239 mg, 1.85 mMol, 1.1 eq.) in dry THF (1 ml_) was added and the reaction was allowed to warm to RT and stirred at RT for 4.5 h then at 40 C for 16 h. The reaction was quenched with NaHCC>3 (aq.) and the THF removed under reduced pressure. The aqueous phase was extracted with ethyl acetate (3x) and the combined organic phases washed with brine, dried (MgSCU) and concentrated to give a white solid. The crude material was purified by silica column chromatography eluting with 0-10 % methanol/DCM to give the desired product as a white solid (183 mg, 0.64 mMol, 38 %). AnalpH9_MeOH_4MIN: Rt: 2.45 min, m/z 286.2/288.1 [M+H]+

17973-86-3, The synthetic route of 17973-86-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; RABBITTS, Terrence; QUEVEDO, Camilo; CRUZ, Abimael; PHILIPS, Simon; FALLON, Philip Spencer; DUNN, Jonathan Neil; FREEM, Joshua Robert; LEE, Lydia Yuen-Wah; TRAORE, Tenin; WILLIAMS, Sophie Caroline; (219 pag.)WO2019/145718; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84956-71-8, Preparation Example 23 Preparation of 2-t-butyl-4-chloro-5[{6-(4-fluorobenzyloxy)-3-pyridyl}-methyloxy]-3(2H)-pyridazinone (Compound No. 1011) To a solution of 2.3 g of 6-(4-fluorobenzyloxy)-3-pyridine methanol in 20 ml of N,N-dimethylformamide was added under stirring at 0C 0.5 g of 55% sodium hydride (in mineral oil). After stirring for 30 minutes at room temperature, thereto was added 2.2 g of 2-t-butyl-4,5-dichloro-3(2H)-pyridazinone. The reaction mixture was stirred at room temperature for additional 8 hours, poured into 50 ml of ice water and extracted twice with 50 ml of benzene. The organic layer was washed with water, dried over anhydrous sodium sulfate and then freed of solvent by distillation under reduced pressure to give 4.1 g of a crude product. The crude product was added with isopropyl ether and recrystallized therefrom to obtain 3.2 g of 2-t-butyl-4-chloro-5-[{6-(4-fluorobenzyloxy)-3-pyridyl}-methyloxy]-3(2H)-pyridazinone, m.p. 121.0 124.0C.

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; NISSAN CHEMICAL INDUSTRIES LTD.; EP199281; (1991); B1;,
Pyridazine – Wikipedia
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