Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.492431-11-5,1-Boc-4-(6-Chloropyridazin-3-yl)piperazine,as a common compound, the synthetic route is as follows.

A mixture of tert-butyl 4- (6-chloropyridazin-3-yl)piperazine-l-carboxylate (0.060 g, 0.20 mmol), compound 83 (0.054 g, 0.20 mmol), Xantphos (0.017 g, 0.030 mmol), Pd2(dba)3 (0.014 g, 0.015 mmol), and sodium tert-butoxide (0.029 g, 0.30 mmol) in dioxane was purged with nitrogen gas for 1 minute. The reaction was heated at 12O0C for 6 hours and then cooled to room temperature. The solvent was removed by filtration. The residue was washed with 2 x ImI dioxane. The product was then dissolved in 1OmL methanol/DCM (1 :1) and concentrated. The crude material was re-dissolved in 4mL methanol and purified on a C-18 reversephase column (150 x 30 mm, 4 micro) using Mass directed preperative HPLC and gradient elution of acetonitrile in water containing 0.1%TFA to give the title compound 162. LCMS-ESI (POS), M/Z, M+l: 532.3

492431-11-5, 492431-11-5 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine 21925370, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN INC.; WO2009/85185; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 250 g (1 .05 mol) 3,6-dibromopyridazine in 1 .2 L 25% aqueous ammonia was heated to 100C at 11.7 bar overnight in an autoclave. After cooling, the precipitate was filtered off, washed with water and dried to give 137 g (75%) of the title compound. 1 H-NMR (DMSO-d6): delta= 6.58 (1 H), 6.69 (2H), 7.41 (1 H) ppm., 17973-86-3

The synthetic route of 17973-86-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SIEMEISTER, Gerhard; BADER, Benjamin; WENGNER, Antje, Margret; MUMBERG, Dominik; KOPPITZ, Marcus; KLAR, Ulrich; KROEMER, Guido; VITALE, Ilio; JEMAA, Mohamed; WO2014/20041; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

187973-60-0, 6-Iodopyridazin-3-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of tert-butyl l-(but-3-ynyl)-lH-l,2,3-triazole-4-carboxylate (15 g, 68 mmol), 6-iodopyridazin-3 -amine (15 g, 68 mmol), Pd(PPh3)2Ci2 (4.77 g, 6.80 mmol), Cul (1.29 g, 6.8 mmol) and TEA (34.2 g, 339 mmol) in 300 mL anhydrous THF was heated at 60 C under 2 for 12 h. The mixture was cooled to rt, DCM/MeOH (500 mL, 10 : 1) was added, filtered off and concentrated under reduced pressure to give a yellow oil. The oil was purified by silica gel column (0 to 9% DCM in MeOH) to give the title compound as a yellow solid (18.0 g, 84%). MS (ES+) CisHisNeCh requires: 314, found: 315 [M+H]+., 187973-60-0

As the paragraph descriping shows that 187973-60-0 is playing an increasingly important role.

Reference£º
Patent; BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM; DI FRANCESCO, Maria, Emilia; JONES, Philip; HEFFERNAN, Timothy; SOTH, Michael, P.; LE, Kang; CARROLL, Christopher, Lawrence; MCAFOOS, Timothy; BURKE, Jason, P.; THEROFF, Jay; ZANG, Zhijun; (155 pag.)WO2016/4413; (2016); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

135034-10-5, 3-Chloro-6-iodopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

XlV.i .a [3-(6-Chloro-pyridazin-3-yl)-prop-2-vnyl1-carbamic acid tert-butyl ester; 19.2 g (80.0 mmol) 3-Chloro-6-iodo-pyridazine (Tetrahedron 55, 1999, 15067) and 13.7 g (88.0 mmol) prop-2-ynyl-carbamic acid tert-butyl ester are dissolved in 200 ml THF and 2.50 g (4.0 mmol) bis-(triphenylphosphine)palladiumdichloride, 2.80 g (14.8 mmol) copper-(l)- iodide and finally 60 ml diisopropylamine are added at 0C. The mixture is stirred for 2 hours at 0C. After that time ice-water is added and the mixture is extracted with ethylacetate. The organic phase is separated and dried over sodium sulphate. The solvent is evaporated and the residue is purified by silica gel column chromatography with methylene chloride/ethyl acetate (5:1 ) as eluent. The product is dried in vacuo at 50C. Yield: 12.8 g (60% of theory), Rf value: 0.50 (silica gel, methylene chloride/ethyl acetate = 5:1 ) Ci2H12CIN3O2EII Mass spectrum: m/z = 268/270 [M+H]+ M. p. 102-105 C

135034-10-5, 135034-10-5 3-Chloro-6-iodopyridazine 15418839, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/48802; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

187973-60-0, 6-Iodopyridazin-3-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Method H: to a solution of compound 12a (788 mg, 3.24 mmol)in n-butanol (12 mL) was added compound 3 (717 mg, 3.24 mmol).The mixture was refluxed for 16 h, evaporated to dryness, and theresidue was suspended in CHCl3. The solution was made alkalinewith a 30% ammonium hydroxide solution and extracted withCHCl3. The combined organic layers were dried over MgSO4,filtered, and evaporated under reduced pressure to give the desiredimidazo[1,2-b]pyridazine 13a (1.20 g, 100%) as a brown solid., 187973-60-0

As the paragraph descriping shows that 187973-60-0 is playing an increasingly important role.

Reference£º
Article; Moine, Esperance; Dimier-Poisson, Isabelle; Enguehard-Gueiffier, Cecile; Loge, Cedric; Penichon, Melanie; Moire, Nathalie; Delehouze, Claire; Foll-Josselin, Beatrice; Ruchaud, Sandrine; Bach, Stephane; Gueiffier, Alain; Debierre-Grockiego, Francoise; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 105; (2015); p. 80 – 105;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17973-86-3,3,6-Dibromopyridazine,as a common compound, the synthetic route is as follows.

3,6-Dibromopyridazine (1.34g, 5.63mmol) was dissolved in acetonitrile (8ml), to this morpholine (0.74ml, 8.45mmol) and triethylamine (1.22ml, 8.45mmol) were added and the suspension was irradiated in the microwave to 1600C for 80 minutes. The sample was then extracted between water (100ml) and dichloromethane (100ml). The mixture was poured through a hydrophobic frit collecting the dichloromethane layer which was evaporated to as dry as possible. The sample was then purified by chromatography (4×1 Og of silica) eluting with 10% ethyl acetate/ dichloromethane to obtain the title compound (1.23g)1H-NMR (CDCl3) delta 3.59-3.61 (4H, m), 3.82-3.85 (4H, m), 6.79 (IH, d, /= 10), 7.35 (IH, d, J = 10). LC/MS m/z [MH+] 246 consistent with molecular formula C8H1081BrN3O, 17973-86-3

As the paragraph descriping shows that 17973-86-3 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2008/116816; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5788-58-9, To a stirred solution of (3S)-3-methyl-1-[(2-methylphenyl)methyl]piperazine (500 mg, 2.45 mmol, 1 equiv.) and DIEA(632.6 mg, 4.89 mmol, 2 equiv.) in DMA(5 mL) was added 4,5- dibromo-2,3-dihydropyridazin-3-one (745.6 mg, 2.94 mmol, 1.2 equiv.) in portions at 100 degrees C overnight

The synthetic route of 5788-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GOLDFINCH BIO, INC.; YU, Maolin; DANIELS, Matthew, H.; HARMANGE, Jean-christophe, P.; TIBBITTS, Thomas, T.; LEDEBOER, Mark, W.; WALSH, Liron; MUNDEL, Peter, H.; MALOJCIC, Goran; (860 pag.)WO2019/55966; (2019); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 4 6-Chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid methyl ester A mixture of 4,6-dichloro-pyridazine-3-carboxylic acid methyl ester (1.0 g, 4.83 mmol) and 5,6-dimethoxypyridin-2-amine (968 mg, 6.28 mmol) was dissolved in acetonitrile (5 mL) and heated at 70 C. for 16 h. The mixture was concentrated in vacuo and the crude mass obtained was purified by chromatography (silica, 100-200 mesh, 10-70% ethyl acetate in hexane) to give 6-chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid methyl ester (830 mg, 53%) as a yellow solid. LC-MS: 325.2 [M+H]+., 372118-01-9

As the paragraph descriping shows that 372118-01-9 is playing an increasingly important role.

Reference£º
Patent; Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael; US2013/178478; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5788-58-9,4,5-Dibromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

5788-58-9, A mixture of 25 g (0.1 mol) of 4,5-dibromo-3 (2H) -pyridazinone, 93 g (0.5 mol) of tributylamine,(HFC-23) at room temperature, and the mixture was stirred at 80 C, and the reaction was carried out. After the reaction was followed by thin layer chromatography, the reaction mixture was cooled with 10 ml of methylene chloride And purified by column chromatography (the stationary phase was silica gel GF254, eluent ethyl acetate / petroleum ether V / V = 1: 1) to give 17.2 g of a white solid product as a white powder,Yield 90%.

As the paragraph descriping shows that 5788-58-9 is playing an increasingly important role.

Reference£º
Patent; Pei, Qing; (6 pag.)CN106083731; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

90766-97-5,90766-97-5, 5-Bromo-6-phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 5-bromo-6-phenyl-2,3-dihydropyridazin-3-one (0.500 g, 1.99 mmol) and N,N-dimethylformamide dimethyl acetal (0.397 mL, 2.978 mmol) in DMF (20 mL) was refluxed for 2 h. The mixture was diluted with EtOAc and washed with water and then several times with brine. The organic phase was dried over sodium sulfate and the solvent was removed. The crude was purified by flash chromatography on silica gel Biotage cartridge (cyclohexane:EtOAc=90:10 to 50:50) to afford title compound as a white solid (0.279 g, 1.05 mmol, 53% yield). MS/ESI+ 265.0-267.0 [MH]+, Rt=0.92 min (Method A).

As the paragraph descriping shows that 90766-97-5 is playing an increasingly important role.

Reference£º
Patent; CHIESI FARMACEUTICI S.p.A.; BIAGETTI, Matteo; Capelli, Anna Maria; Guala, Matilde; (42 pag.)US2016/75710; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem