Tag: M.W:200-300

5788-58-9,5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4,5-dibromo-pyridazin-3-one (2.00 g, 7.88 mmol) was dissolved N, N-dimethylformamide (10 mL), potassium carbonate (1.31 g, 9.46 mmol), iodomethane (736 muL, 11.8 mmol) and the mixture was stirred for 2 hours at 50 . The reaction mixture was concentrated under reduced pressure, the residue was diluted with water, and extracted with ethyl acetate. The organic phase was dried anhydrous sodium sulfate and concentrated under reduced pressure, the resulting residue was dissolved in ethyl acetate / methanol was added to give the title compound precipitated solid by filtered and dried (755 mg). Further, to give the title compound (1.20 g) by purifying the residue and the filtrate was concentrated under reduced pressure, and the resulting by silica gel column chromatography.

The synthetic route of 5788-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AJINOMOTO COMPANY INCORPORATED; UENO, HIROKAZU; HAYAKAWA, NOBUHIKO; YOKOYAMA, RYOHEI; IWASAKI, KANA; YAMAMOTO, TAKASHI; (67 pag.)JP2016/37467; (2016); A;,
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187973-60-0, 6-Iodopyridazin-3-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example B.72-Cyclopropyl-6-iodo-3-methyl-imidazo[1,2-b]pyridazine A mixture of 2-bromo-1-cyclopropylpropan-1-one (0.72 g, 2.03 mmol) and 6- iodopyridazin-3-amine (449 mg, 2.03 mmol) in 1,2-dimethoxyethane (10 ml) was refluxed under an argon atmosphere for 20 hrs. After cooling to r.t, the solvent was evaporated. The crude product was taken up in water (1 5m1) and extracted with EtOAc The organic s were dried overMgSO4, filtered and evaporated. The aqueous layer was neutralized by addition of iN NaOH and then extracted extracted with CH2C12. The organic layer was dried over MgSO4, filtered and evaporated. The two organic extracts were combinated and concentrated. The crude product was purified by silica gel chromatography using a heptane/EtOAc gradient as eluent to provide the title compound (30 mg, 5%; not clean) as light brown solid. MS (mle): 300.3 (M+H)., 187973-60-0

The synthetic route of 187973-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; WO2015/113980; (2015); A1;,
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Pyridazine | C4H4N2 – PubChem

17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1) In a 250ml three-vial bottle,Weigh 0.05 mol of 3,6-dibromopyridazine,0.06 mol (3,5-di-tert-butylphenyl) boric acid,100ml toluene,Stir and dissolve,Under nitrogen protection,Add 0.0025mol Pd(PPh3)4,0.1mol potassium carbonate,50 ml water and ethanol volume ratio of 1:1 mixture,Stir and warm up to 120C,Reflux reaction for 12 hours,Sampling point board,Shows no remaining 3,6-dibromopyridazine,Complete reaction;Naturally cool to room temperaturefilter,Layered filtrate,Take the organic phase and vortex it to zero fraction.Over neutral silica gel column,Intermediate 2-1 is obtained,HPLC purity 99.3%,Yield 61.2%;

17973-86-3, As the paragraph descriping shows that 17973-86-3 is playing an increasingly important role.

Reference£º
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Xu Kai; Li Chong; Zhang Xiaoqing; Zhang Zhaochao; (45 pag.)CN107880028; (2018); A;,
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5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5788-58-9

To a stirred solution of tert-butyl (3R)-3-methylpiperazine-1-carboxylate(500 mg, 2.50 mmol, 1 equiv.) and DIEA(645.3 mg, 4.99 mmol, 2 equiv.) in DMF(5 mL) was added 4,5- dibromo-2,3-dihydropyridazin-3-one (760.6 mg, 3.00 mmol, 1.2 equiv.) in portions at 100 degrees C overnight. The residue product was purified by reverse phase flash with the following conditions: MeCN/H2O(35%-75%,45min) to afford tert-butyl (3R)-4-(5-bromo-6-oxo-1,6- dihydropyridazin-4-yl)-3-methylpiperazine-1-carboxylate(150mg,16.10%) as a yellow oil

5788-58-9 4,5-Dibromopyridazin-3(2H)-one 236181, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; GOLDFINCH BIO, INC.; YU, Maolin; DANIELS, Matthew, H.; HARMANGE, Jean-christophe, P.; TIBBITTS, Thomas, T.; LEDEBOER, Mark, W.; WALSH, Liron; MUNDEL, Peter, H.; MALOJCIC, Goran; (860 pag.)WO2019/55966; (2019); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.187973-60-0,6-Iodopyridazin-3-amine,as a common compound, the synthetic route is as follows.

General procedure: Method H: to a solution of compound 12a (788 mg, 3.24 mmol)in n-butanol (12 mL) was added compound 3 (717 mg, 3.24 mmol).The mixture was refluxed for 16 h, evaporated to dryness, and theresidue was suspended in CHCl3. The solution was made alkalinewith a 30% ammonium hydroxide solution and extracted withCHCl3. The combined organic layers were dried over MgSO4,filtered, and evaporated under reduced pressure to give the desiredimidazo[1,2-b]pyridazine 13a (1.20 g, 100%) as a brown solid., 187973-60-0

As the paragraph descriping shows that 187973-60-0 is playing an increasingly important role.

Reference£º
Article; Moine, Esperance; Dimier-Poisson, Isabelle; Enguehard-Gueiffier, Cecile; Loge, Cedric; Penichon, Melanie; Moire, Nathalie; Delehouze, Claire; Foll-Josselin, Beatrice; Ruchaud, Sandrine; Bach, Stephane; Gueiffier, Alain; Debierre-Grockiego, Francoise; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 105; (2015); p. 80 – 105;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5788-58-9,4,5-Dibromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.,5788-58-9

General procedure: To a solution of 4,5-dichloro-2,3-dihydropyridazin-3-one (65.6 mg, 0.40 mmol, 1 equiv.) in DMA(2 mL) were added 1-[(2,4-difluorophenyl)methyl]piperazin-2-one (90 mg, 0.40 mmol, 1 equiv.) and DIEA(102.8 mg, 0.80 mmol, 2 equiv.) at room temperation. The resulting mixture was stirred for 16 h at 100 degrees C. The reaction was monitored by LCMS. The product was purified by reverse phase flash with the following conditions (Column: spherical C18, 20-40 um,120g; Mobile Phase A: Water(5mmol/L NH4HCO3), Mobile Phase B: MeCN; Flow rate:45mL/min; Gradient: 20% B to 40% B in 25min; 220 nm) to afford 4-chloro-5-[4-[(2,4- difluorophenyl)methyl]-3-oxopiperazin-1-yl]-2,3-dihydropyridazin-3-one (28.6 mg, 20.27%) as a yellow solid

As the paragraph descriping shows that 5788-58-9 is playing an increasingly important role.

Reference£º
Patent; GOLDFINCH BIO, INC.; YU, Maolin; DANIELS, Matthew, H.; HARMANGE, Jean-christophe, P.; TIBBITTS, Thomas, T.; LEDEBOER, Mark, W.; WALSH, Liron; MUNDEL, Peter, H.; MALOJCIC, Goran; (860 pag.)WO2019/55966; (2019); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

90766-97-5,90766-97-5, 5-Bromo-6-phenylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-6-phenylpyridazin-3(2H)-one (1.522 g, 6.06 mmol) in DMF (90 mL) was added tert-buty 2-(((ls,4s)-4-(tosyloxymethyl)cyclohexyl)methoxy)acetate (2.50 g, 6.06 mmol), potassium 2-methylpropan-2-olate (1.360 g, 12.12 mmol) and 18-crown-6 (0.320 g, 1.212 mmol). The reaction was stirred at 40 0C for 16 h, quenched with water (40 mL), extracted with EtOAc (4 x 50 mL), and washed with brine. The combined organic phases were dried over MgSO4, filtered, and concentrated to give a brown oil. The brown oil was purified by silica gel column chromatography to give the title compound as a yellow oil (1.346 g). LCMS mlz = 491.3 [M+Eta]+; 1H NMR (400 M Hz, CDCl3) delta ppm, 1.37-1.64 (m, 17H), 1.80-1.90 (m, IH), 2.23 (bs, IH), 3.42 (d, J= 7.07 Hz, 2H), 3.94 (s, 2H), 4.17 (d, J = 7.71 Hz, 2H), 7.44-7.49 (m, 4H), 7.50-7.55 (m, 2H).

As the paragraph descriping shows that 90766-97-5 is playing an increasingly important role.

Reference£º
Patent; ARENA PHARMACEUTICALS, INC.; TRAN, Thuy-Anh; HAYASHI, Rena; IBARRA, Jason B.; ULLMAN, Brett; ZOU, Ning; WO2010/77275; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.286946-24-5,Methyl 3,6-dichloropyridazine-4-carboxylate,as a common compound, the synthetic route is as follows.

Example 71; Preparation of Compound 71; Step A; A solution of 3,6-dichloro pyridazine-4-carboxylic acid methyl ester (2.0 mmol, 0.41 g), diethylisopropyl amine (3.0 mmol, 0.52 mL) and piperazine-1- carboxylic acid te/t-butyl ester (2 mmol, 0.37 g) in dioxane (2 mL) was irradiated using microwave for 20 minutes at a temperature of 80 C. The reaction mixture was concentrated in vacuo, and the resulting residue was purified using flash column chromatography on silica gel (eluent: ethyl acetate) to provide compound 71 A as a yellow solid in quantitative yield. HPLC-MS RT= 1.9 min, mass calculated for formula C15H2ICIN4O4 356.13, observed LCMS m/z 357.1 (M+H).

286946-24-5, 286946-24-5 Methyl 3,6-dichloropyridazine-4-carboxylate 17861811, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING CORPORATION; WO2008/54749; (2008); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5788-58-9,4,5-Dibromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

5788-58-9, EXAMPLE 1 4-bromo-5-(3-n-propoxy-4-methoxy-N-methylbenzylamino)-3(2H)pyridazinone (Compound No. 6) STR28 A mixture comprising 300 mg of 4,5-dibromo-3(2H)pyridazinone, 740 mg of 3-n-propoxy-4-methoxy-N-methylbenzylamine and 10 ml of ethanol, was refluxed under stirring for 7 hours. Then, ethanol was distilled off under reduced pressure, dilute hydrochloric acid was added to the residue thereby obtained, and the mixture was extracted with ethyl acetate. The extract was washed twice with water and dried over sodium sulfate. Then, the solvent was distilled off to obtain a yellow solid substance. The product was crystallized from ethyl acetate, to obtain 310 mg of the above identified compound having a melting point of from 149 to 150 C. as light yellow crystals. NMR delta: 7.53(1H, s), 6.75(3H, s), 4.53(2H, s), 3.91(2H, t), 3.81(3H, s), 3.01(3H, s), 1.84(2H, hexalet), 1.01(3H, t). MS (m/e): 302(M+ -Br,100%), 179, 137.

As the paragraph descriping shows that 5788-58-9 is playing an increasingly important role.

Reference£º
Patent; Nissan Chemical Industries Ltd.; US4978665; (1990); A;,
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Pyridazine | C4H4N2 – PubChem

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (100 mg, 0.483 mmol) and 6- (methylthio) pyridin-3-amine (101 mg, 0.724 mmol) were dissolved in ethanol (2 mL), It was heated to 110 C in a microwave reactor and stirred for 1 hour.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 2/1 to 1/1),The target product 6-chloro-4-((6- (methylthio) pyridin-3-yl) amino) pyridazine-3-carboxylic acid methyl ester 13a (100 mg, yellow solid) was obtained,Yield: 66%.

372118-01-9, As the paragraph descriping shows that 372118-01-9 is playing an increasingly important role.

Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
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Pyridazine | C4H4N2 – PubChem