Tag: M.W:200-300

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is C11H19ClN4, belongs to pyridazines compound, is a common compound. In a patnet, author is Becker, Christian, once mentioned the new application about 73963-42-5, HPLC of Formula: C11H19ClN4.

Determination of liquid chromatography/flame ionization detection response factors for N-heterocycles, carboxylic acids, halogenated compounds, and others

Many gas chromatography-flame ionization detection (GC/FID) studies are dealing with response behavior of analytes such as alcohols and alkanes. Studies in the field of liquid chromatography (LC)/FID mainly focused on volatile analytes. In contrast, studies on LC/FID by conveyor type interface covered high molecular weight non-volatile biopolymers, whereby no response factors were calculated. With this study, we fill the gap and present response factors of volatile and non-volatile analytes by LC/FID in terms of flow injection (FIA) measurements of the single compounds without an analytical separation by an LC column. In the present study, 56 different compounds such as carboxylic acids, N-heterocycles, halogenated acids, pharmaceuticals, and other compounds were investigated. In some cases, the obtained response factor data confirmed aspects known from GC/FID studies. But this study also disproves several assumptions done in previous response studies as well as the prediction models based upon the experimental data and literature. Especially the response factors and effective carbon number (ECN) values of structural isomers such as pyrazine, pyridazine, and pyrimidine are assumed to be equal in current response prediction models. Contradictory to these assumptions, the experimental response factors and ECN values of, e.g., the structural isomers pyrazine (RFExp = 0.59; ECNExp = 3.66), pyridazine (RFExp = 0.66; ECNExp = 4.1), and pyrimidine (RFExp = 0.63; ECNExp = 3.93) reveal different experimental response factors and ECN than proposed by response factor prediction models (RFExp = 0.64; ECNExp = 4). Graphical abstract

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 73963-42-5. The above is the message from the blog manager. HPLC of Formula: C11H19ClN4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of N,N’-Diphenylthiourea, 102-08-9, Name is N,N’-Diphenylthiourea, molecular formula is C13H12N2S, belongs to pyridazines compound. In a document, author is Vajekar, Shailesh N., introduce the new discover.

Choline hydroxide promoted sustainable one-pot three-component synthesis of 1H-pyrazolo[1,2-a]pyridazine-2-carbonitriles under solvent-free conditions

A sustainable one-pot three-component synthesis of novel 1H-pyrazolo[1,2-a]pyridazine-2-carbonitrile derivatives employing a highly efficient, biodegradable, and recyclable choline hydroxide catalyst under solvent-free conditions is demonstrated. The salient features of this protocol are simple workup, mild reaction conditions, short reaction time (10 min), excellent yields (up to 97%), high atom economy, column chromatography-free protocol, and eco-friendliness. Interestingly, the choline hydroxide was recycled up to five cycles without any considerable loss of efficiency. The structures of the products were deduced by their H-1 NMR, C-13 NMR, and HRLC-MS spectra.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 102-08-9. Application In Synthesis of N,N’-Diphenylthiourea.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a document, author is Bhatt, Ashish, introduce the new discover, Product Details of 73963-42-5.

Facile one-pot synthesis of N-fused 1,2,4-triazoles via oxidative cyclization using manganese dioxide

A facile one-pot synthesis of N-fused 1,2,4-triazoles from heterocyclic hydrazines and aldehydes is reported. The reaction is efficiently promoted by manganese dioxide to afford the desired products mostly in high yields and in relatively short times. The mild nature of the synthesis, cheap oxidizing agent, and short reaction time are notable advantages of the developed protocol. This protocol is effective toward various substrates having different functionalities.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 73963-42-5 is helpful to your research. Product Details of 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

Reference of 73963-42-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Lv, Lina, introduce new discover of the category.

A structural and thermodynamic study of the complexes of U(vi) with azinecarboxylates

Complexation of U(vi) with pyridazine-3-carboxylate (PDZ) and pyrazine-2-carboxylate (PAZ) was studied by spectrophotometry, potentiometry and microcalorimetry in 1.0 mol dm(-3) NaClO4. Three complexes, [UO2L](+), UO2L2(aq) and [UO2L3](-), were identified and their stability constants (log) and the corresponding formation enthalpies were determined. The thermodynamic parameters indicate that the formation of the three complexes is endothermic and driven exclusively by entropy. H-1 and C-13-NMR data provide insight into the coordination modes of the complexes which corroborate with the thermodynamic data. Ligands chelate to U(vi) via (2)(N,O) coordination mode in complexes [UO2L](+) and UO2L2(aq). The crystal structures of four U(vi) complexes, [(UO2)(PAZ)(2)(H2O)]H2O(i), [(UO2)(PDZ)(2)(H2O)](ii), [(UO2)(PDZ)(3)Na2ClO4]2H(2)O(iii), and [(UO2)(2)(PDZ)(4)(H2O)(2)]2H(2)O(iv), were determined by single-crystal X-ray diffraction and compared with the U(vi) complex with picolinate (PA) (CH6N3)[UO2(PA)(3)] in the literature. The structure data suggest that the carboxylates coordinate with uranium in O?C-O-U mode. The strengths of the U-O-C-C-N chelate cycles in the U(vi)/L complexes decrease with the trend of PA > PDZ > PAZ, which is in great agreement with the trend of thermodynamic parameters in aqueous solutions. It is interesting that in compound II two PDZ molecules coordinate with U(vi) in cis-planar positions via (2)(N,O) mode, but in other metal complexes of the three ligands having the same (2)(N,O) coordination mode the two ligand molecules are all in trans-arrangement. In the dimeric complex IV, one ligand coordinate with U(vi) in (2)(N,O) mode, while the other does it in (2)-L-(2)(O:O) mode respectively.

Reference of 73963-42-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

Chemistry, like all the natural sciences, Category: pyridazines, begins with the direct observation of nature¡ª in this case, of matter.102-08-9, Name is N,N’-Diphenylthiourea, SMILES is S=C(NC1=CC=CC=C1)NC2=CC=CC=C2, belongs to pyridazines compound. In a document, author is Javed, Athar, introduce the new discover.

Synthesis, antimicrobial activity, and docking study of some N-3, N-6-diphenylpyridazine-3,6-diamine derivatives as dihydrofolate reductase inhibitors

Objective: The present study focussed on the synthesis of pyridazine analogs to explore broad-spectrum antimicrobial study. Since pyridazine analogs are not conventionally found in nature, and hence, its analogs are studied later. Materials and Methods: All the synthesized compounds were characterized by spectroscopic techniques, namely, UV, IR,(HNMR)-H-1, and mass spectrometry. Antimicrobial activity was screened by serial dilution method and absorbance was recorded using ELISA reader, subsequently minimum inhibitory concentrations were determined. Docking study was done into the active site of dihydrofolate reductase using Auto Dock 4.2. Results: The present investigation about synthesis, characterization, and biological studies of some new pyridazine analogs were carried out to obtain potent and pharmacologically active compounds. The free energy of binding was in the range of 5.12 to 8.97 kcal/mole. In silico study report was in good tune with laboratory experiments. Conclusions: Most of the compounds were moderate-to-good toward the antimicrobial activity. Compound AJ27 was found to be most active. Results of anti-microbial activity establishes the importance of N-3, N-6-diphenylpyridazine-3,6-diamine as the basic skeleton required for the antimicrobial activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 102-08-9. Category: pyridazines.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

In an article, author is Avdeev, Ya. G., once mentioned the application of 102-08-9, Name is N,N’-Diphenylthiourea, molecular formula is C13H12N2S, molecular weight is 228.31, MDL number is MFCD00004921, category is pyridazines. Now introduce a scientific discovery about this category, Computed Properties of C13H12N2S.

Nitrogen-containing six-membered heterocyclic compounds as corrosion inhibitors for metals in solutions of mineral acids – A review

The current state of studies on metal protection from corrosion in mineral acid solutions by six-membered N-containing heterocyclic compounds is reviewed. Literature data on the protection of various metals in acid solutions by these compounds are summarized. The specific features of their protective action mechanism are discussed. The feasibility of metal protection by formulations containing these compounds, even in high-temperature corrosion, is noted. N-Containing six-membered heterocyclic compounds are prone to adsorption on metal surfaces from mineral acid solutions. Based on the free adsorption energy values of these corrosion inhibitors (CIs) on metal surfaces, it can be deemed with high probability that they are mostly bound to a metal by physical forces, but upon adsorption on its surface they slow down the cathodic and anodic reactions, and eventually inhibit its corrosion. Compounds containing S atoms or bulky substituents are most interesting. These compounds are adsorbed on metals more strongly and behave as more efficient CIs. It often happens that such CIs hinder metal corrosion in HCl solutions but do it much more weakly in H2SO4, HClO4, and H3PO4. A known method for improving the protective effect of N-containing six-membered heterocyclic CIs in these media involves combining them with anionic additives, e. g., halide or rhodanide anions. The heterocycles discussed behave as CIs in cold solutions but lose these properties at higher temperatures. Examples of the use of six-membered N-containing heterocycles as CIs of various steels and non-ferrous metals (Al, Cu, Sn, Zn and their alloys) are available in literature. The industrial application of individual six-membered N-containing heterocycles and their derivatives for metal protection in acid media is of little promise and is unjustified. It is more appropriate to use these compounds as components of inhibitor mixtures. Mixed CIs containing these compounds can hinder corrosion even in such corrosive media as high-temperature HCl solutions or hot H3PO4 solutions. The base for creating prospective mixed corrosion inhibitors for metals in acids should be searched for among six-membered heterocyclic compounds containing two or more nitrogen atoms or compounds obtained from natural raw materials. The bibliography includes 150 references.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem