Tag: M.W:200-300

Application of 5788-58-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5788-58-9, Name is 4,5-Dibromopyridazin-3(2H)-one, molecular formula is C4H2Br2N2O. In a Patent，once mentioned of 5788-58-9

PYRIDO[3,2-d]PYRIDAZINE-2(1H)-ONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula (I) wherein R1, R2, R3, R4, R5, W and X are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5788-58-9, and how the biochemistry of the body works.Application of 5788-58-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3156 – PubChem

 

187973-60-0, Name is 6-Iodopyridazin-3-amine, belongs to pyridazine compound, is a common compound. Computed Properties of C4H4IN3In an article, once mentioned the new application about 187973-60-0.

PYRROLIDINO HETEROCYCLES

The invention relates to compounds of formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2931 – PubChem

 

Synthetic Route of 90766-97-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 90766-97-5, Name is 5-Bromo-6-phenylpyridazin-3(2H)-one,introducing its new discovery.

Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones

A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)- pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-oxo-propenyl fragment or a phenylthio group at position 5 of the heterocyclic ring.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 90766-97-5, and how the biochemistry of the body works.Synthetic Route of 90766-97-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3125 – PubChem

 

Synthetic Route of 492431-11-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, molecular formula is C13H19ClN4O2. In a Patent，once mentioned of 492431-11-5

FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4 mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 492431-11-5, and how the biochemistry of the body works.Synthetic Route of 492431-11-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3230 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 5788-58-9, name is 4,5-Dibromopyridazin-3(2H)-one, introducing its new discovery. Quality Control of 4,5-Dibromopyridazin-3(2H)-one

A one-pot synthesis of […] method (by machine translation)

The present invention discloses a one-pot synthesis of […] new method, the structure of formula (I) indicated by the […], having a structure of formula (III) as shown by a tri-substituted tertiary amine, added in a reaction vessel, for 20 – 130 C temperature by the trifluoro methane directly into the high temperature generated from the decomposition of carbon dioxide and hydrogen fluoride gas, and the temperature in the stirring reaction, for thin layer chromatography tracking after the reaction, cooling, of added dichloromethane dilution, for column chromatography separation to obtain the structure shown in formula (II) of the […], Wherein formula (I), (II) in the formula (III) R in theR1, R2, R3said carbon atom number is 1 – 10 alkyl, or the carbon atom number is 6 – 10 containing various substituted aryl, X chlorine atom or bromine atom. The invention not only provides a one-pot synthesis of […] new method, and the use of renewable energy sources. (by machine translation)

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5788-58-9, and how the biochemistry of the body works.Quality Control of 4,5-Dibromopyridazin-3(2H)-one

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3154 – PubChem

 

Related Products of 1698-53-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1698-53-9, Name is 4,5-Dichloro-2-phenylpyridazin-3(2H)-one, molecular formula is C10H6Cl2N2O. In a Article，once mentioned of 1698-53-9

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

Novel small molecule antagonists of NPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl) pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, synthesis and structure-activity relationships study of the HTS-derived hit led to the identification of 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one lead molecule with submicromolar antagonist activity at the target receptor and high selectivity against a panel of therapeutically relevant off-target proteins. This lead molecule may provide a pharmacological tool to clarify the molecular basis of the in vivo physiological function and therapeutic utility of NPBWR1 in diverse disease areas including inflammatory pain and eating disorders.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1698-53-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3115 – PubChem

 

Reference of 34127-22-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.34127-22-5, Name is Ethyl 3,6-dichloropyridazine-4-carboxylate, molecular formula is C7H6Cl2N2O2. In a Patent，once mentioned of 34127-22-5

The disclosure generally relates to compounds of formula (I), including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 34127-22-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2956 – PubChem

 

Reference of 135034-10-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 135034-10-5, Name is 3-Chloro-6-iodopyridazine,introducing its new discovery.

Smectic liquid crystals with ‘de Vries-like’ properties are characterized by a maximum layer contraction of ?1% upon transition from the non-tilted SmA phase to the tilted SmC phase. We show herein that one can systematically increase the ‘de Vries-like’ character of a smectic liquid crystal by tuning the frustration between SmA- and SmC-promoting elements according to established structure-property relationships. The Royal Society of Chemistry 2011.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 135034-10-5, and how the biochemistry of the body works.Reference of 135034-10-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3069 – PubChem

 

10344-42-0, Name is 4-Bromo-3,6-dichloropyridazine, belongs to pyridazine compound, is a common compound. Product Details of 10344-42-0In an article, once mentioned the new application about 10344-42-0.

Some new 3-(alkylsulfanyl)-7-chloro-1-phenyl-1H-pyridazino [4,3-e][1,3,4]thiadiazine were synthesized by treatment of the alkyl-2-phenylhydrazinecarbodithioates with 4-bromo-3,6-dichloropyridazine in alkaline acetonitrile. Orientation of the reaction has been determined by X-ray crystallography technique. The chlorine atom on the number 7 position of these products was replaced by secondary amines at reflux condition.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3021 – PubChem

 

Application of 135034-10-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 135034-10-5, 3-Chloro-6-iodopyridazine, introducing its new discovery.

Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors

Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from leptin deficiency-induced and diet-induced obesity, with greater whole body insulin sensitivity than wild-type animals. In this work, we have discovered a series of potent, selective, orally bioavailable SCD1 inhibitors based on a known pyridazine carboxamide template. The representative lead inhibitor 28c also demonstrates excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 135034-10-5. In my other articles, you can also check out more blogs about 135034-10-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3067 – PubChem