Tag: M.W:200-300

Synthetic Route of 5788-58-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5788-58-9, Name is 4,5-Dibromopyridazin-3(2H)-one, molecular formula is C4H2Br2N2O. In a Article，once mentioned of 5788-58-9

Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors

The p38 mitogen-activated protein kinase (MAPK) plays an important role in the production of proinflammatory cytokines, making it an attractive target for the treatment of various inflammatory diseases. A series of pyridazinopyridinone compounds were designed as novel p38 kinase inhibitors. A Structure-activity investigation identified several compounds possessing excellent potency in both enzyme and human whole blood assays. Among them, compound 31 exhibited good pharmacokinetic properties and showed excellent selectivity against other related kinases. In addition, 31 demonstrated efficacy in a collagen-induced arthritis disease model in rats.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 5788-58-9. In my other articles, you can also check out more blogs about 5788-58-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3185 – PubChem

 

Application of 286946-24-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.286946-24-5, Name is Methyl 3,6-dichloropyridazine-4-carboxylate, molecular formula is C6H4Cl2N2O2. In a article，once mentioned of 286946-24-5

PRODRUGS OF HIV REVERSE TRANSCRIPTASE INHIBITORS

Compounds of Formula I are described: wherein R1 and R2 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV, and the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 286946-24-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2893 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C4H2ClIN2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 135034-10-5, name is 3-Chloro-6-iodopyridazine. In an article，Which mentioned a new discovery about 135034-10-5

CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30

The present invention relates to a class of substituted-cyanopyrrolidines of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction. (Formula (I))

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 135034-10-5, help many people in the next few years.Computed Properties of C4H2ClIN2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3060 – PubChem

 

Synthetic Route of 1698-53-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1698-53-9, molcular formula is C10H6Cl2N2O, introducing its new discovery.

Synthesis of Pyrazolo<3,4-d>pyridazines from 5-(1-Methylhydrazino)-pyridazines by Means of the Vilsmeier-Haack Reaction

Reaction of 2-substituted 5-(1-methylhydrazino)-3(2H)-pyridazinones (2a-d) with dimethylformamide-phosphorus oxychloride afforded 5-substituted 1,5-dihydro-1-methyl-4H-pyrazolo<3,4-d>pyridazin-4-ones (3a-d) in good yields.However, concurrent formation of 5-substituted 2,5-dihydro-2-(2-substituted 1-chlorovinyl)-4H-pyrazolo<3,4-d>pyridazin-4-ones (6a-c, 12, 13) (minor products) and the 1-methyl-4H-derivatives (3a-c) (major ones) was observed, when starting with the corresponding 2-substituted 5-(2-acetyl-1-methylhydrazino)-3(2H)-pyridazinones (5a-c, 9, 10) under similar conditions.A plausible mechanism for the reaction is proposed.Keywords – pyridazine; pyrazolo<3,4-d>pyridazine; Vilsmeier reagent; tri-n-butyltin chloride; sodium borohydride; stereoisomer; photoisomerization; vinyl radical

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1698-53-9 is helpful to your research. Synthetic Route of 1698-53-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3097 – PubChem

 

Reference of 1698-53-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1698-53-9, Name is 4,5-Dichloro-2-phenylpyridazin-3(2H)-one, molecular formula is C10H6Cl2N2O. In a article，once mentioned of 1698-53-9

Process for obtaining 4,5-dichloro-2-phenyl-3(2H)-pyridazinone from 5-chloro-4-amino-2-phenyl-3(2H)-pyridazinone

In a process for obtaining 4,5-dichloro-2-phenyl-3(2H)-pyridazinone from 5-chloro-4-amino-2-phenyl-3(2H)-pyridazinone the 5-chloro-4-amino-2-phenyl-3(2H)-pyridazinone is diazotized in a first stage in accordance with the following reaction: STR1 the compound (I) being obtained by dilution with water and filtration. In a second stage of the process the compound (I) is reacted with thionyl chloride in accordance with the following reaction: STR2 the 4,5-dichloro-2-phenyl-3(2H)-pyridazinone being obtained by dilution with water and filtration.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1698-53-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3087 – PubChem

 

Synthetic Route of 1698-53-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 1698-53-9, 4,5-Dichloro-2-phenylpyridazin-3(2H)-one, introducing its new discovery.

Preparation of Novel Tricyclic Ring Systems Containing the Pyridazinone Ring

Novel tricyclic ring systems, imidazo<3,4-d>pyridazino<4,5-b><1,4>thiazines 3, imidazo<2,1-b>pyridazino<4,5-e><1,3,4>thiadiazines 15 and 18 were prepared by the reaction of 5-amino-4-chloropyridazin-3(2H)-ones 1 and 5(4)-(1-methylhydrazino)-4(5)-chloropyridazin-3(2H)-ones 13 (16) with isothiocyanates 2 and 7.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 1698-53-9. In my other articles, you can also check out more blogs about 1698-53-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3116 – PubChem

 

492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, belongs to pyridazine compound, is a common compound. Application In Synthesis of 1-Boc-4-(6-Chloropyridazin-3-yl)piperazineIn an article, once mentioned the new application about 492431-11-5.

AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 492431-11-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3237 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of 6-Chloro-4-iodo-3-methoxypyridazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 181355-92-0

Metalation of diazines XVII. Very hindered bases as new metalating agents, improvement of regioselectivity for the metalation of 3-chloro-6-methoxypyridazine

The different factors governing the regioselectivity of the metalation of 3-chloro-6-methoxypyridazine with alkylamides were studied. Very hindered bases were used as new metalating agents and a very good regioselectivity was obtained.

If you are interested in 181355-92-0, you can contact me at any time and look forward to more communication. Safety of 6-Chloro-4-iodo-3-methoxypyridazine

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3227 – PubChem

 

Related Products of 1698-53-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1698-53-9, Name is 4,5-Dichloro-2-phenylpyridazin-3(2H)-one, molecular formula is C10H6Cl2N2O. In a Patent，once mentioned of 1698-53-9

A one-pot synthesis of […] method (by machine translation)

The present invention discloses a one-pot synthesis of […] new method, the structure of formula (I) indicated by the […], having a structure of formula (III) as shown by a tri-substituted tertiary amine, added in a reaction vessel, for 20 – 130 C temperature by the trifluoro methane directly into the high temperature generated from the decomposition of carbon dioxide and hydrogen fluoride gas, and the temperature in the stirring reaction, for thin layer chromatography tracking after the reaction, cooling, of added dichloromethane dilution, for column chromatography separation to obtain the structure shown in formula (II) of the […], Wherein formula (I), (II) in the formula (III) R in theR1, R2, R3said carbon atom number is 1 – 10 alkyl, or the carbon atom number is 6 – 10 containing various substituted aryl, X chlorine atom or bromine atom. The invention not only provides a one-pot synthesis of […] new method, and the use of renewable energy sources. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1698-53-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3089 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C10H6Cl2N2O, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1698-53-9, Name is 4,5-Dichloro-2-phenylpyridazin-3(2H)-one, molecular formula is C10H6Cl2N2O

A “click and activate” Approach in one-pot synthesis of a triazolyl-pyridazinone library

A “click and activate” strategy was designed and executed in a four-component, stepwise condensation that led to a trisubstituted triazolyl-pyridazinone library. This one-pot process included regioselective azide substitution at 2-substituted-4,5-dichloropyridazinones, followed by a Cu(I) catalyzed triazole formation which triggered subsequent nucleophilic substitution at the neighboring position to achieve three points of diversity.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, HPLC of Formula: C10H6Cl2N2O, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1698-53-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3109 – PubChem