Extracurricular laboratory:new discovery of 4,5-Dibromopyridazin-3(2H)-one

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The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof, which can inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3151 – PubChem

 

Awesome Chemistry Experiments For 4,5-Dichloro-2-phenylpyridazin-3(2H)-one

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Commercially available anilines were converted by a two step, one-pot process to the corresponding pyridazinones in good to excellent yields. During the process research, a significant halogen exchange was confirmed and prevented which allowed the process to be scaled to multikilogram quantities.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3117 – PubChem

 

Awesome and Easy Science Experiments about 4,5-Dichloro-2-phenylpyridazin-3(2H)-one

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Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3078 – PubChem

 

Can You Really Do Chemisty Experiments About 6-Iodopyridazin-3-amine

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Application of 187973-60-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 187973-60-0, Name is 6-Iodopyridazin-3-amine,introducing its new discovery.

A series of compounds containing the triazole structure disclosed by the invention have GLS1 a glutaminase inhibitory activity and can be, used for treating diseases and, disorders related to an abnormal or glutaminase activity rise, and the in-vitro experiments show, that the compound disclosed by the invention has good inhibitory activity for various transglutaminase-dependent cancer, cells . such as colon cancer, tri-negative breast cancer, and lung cancer. (by machine translation)

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2935 – PubChem

 

Final Thoughts on Chemistry for 4,5-Dichloro-2-phenylpyridazin-3(2H)-one

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1698-53-9, name is 4,5-Dichloro-2-phenylpyridazin-3(2H)-one, introducing its new discovery. Recommanded Product: 4,5-Dichloro-2-phenylpyridazin-3(2H)-one

Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson’s disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3088 – PubChem

 

Top Picks: new discover of 825633-94-1

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Product Details of 825633-94-1, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 825633-94-1, name is 5-Iodo-2,3-dihydropyridazin-3-one. In an article,Which mentioned a new discovery about 825633-94-1

The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer’s disease, schizophrenia, pain, sleep disorder, Parkinson’s disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.

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Properties and Exciting Facts About 41933-33-9

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 41933-33-9. In my other articles, you can also check out more blogs about 41933-33-9

Application of 41933-33-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 41933-33-9, Name is 2-Benzyl-4,5-dichloropyridazin-3(2H)-one, molecular formula is C11H8Cl2N2O. In a Article,once mentioned of 41933-33-9

Ring contraction of 7-substituted 2-phenyl-4H-pyridazino<4,5-e><1,3,4>thiadiazin-8(7H)-ones (5a-d) to 5-substituted 3-phenyl-1H-pyrazolo<3,4-d>pyridazin-4(5H)-ones (7a-d), through base-induced extrusion of sulphur, is described.Similar reactions proceed, not only on the 4-acetyl derivatives (4a-d) in basic media, but on 5a and the 4-methyl derivative (6a) thermally.Probable mechanism of these reactions are discussed.A comparable approach to the ring contraction, photochemical cyclisation of 2-substituted 5-(1-alkyl-2-benzylidenehydrazino)-4-chloro-3(2H)-pyridazinones (9a-e) to the corresponding 1-alkylpyrazolo<3,4-d>-pyridazinone derivatives (8a-e) is also performed.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3210 – PubChem

 

Discovery of 22808-29-3

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Reference of 22808-29-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.22808-29-3, Name is 4-tert-Butyl-3,6-dichloropyridazine, molecular formula is C8H10Cl2N2. In a article,once mentioned of 22808-29-3

This invention describes novel pyridazinylimidazolidinone compounds, which are useful as herbicides.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2880 – PubChem

 

Archives for Chemistry Experiments of 825633-94-1

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 5-Iodo-2,3-dihydropyridazin-3-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 825633-94-1, Name is 5-Iodo-2,3-dihydropyridazin-3-one, molecular formula is C4H3IN2O

Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of (S)-14k, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, (S)-14k was selected for further preclinical evaluation.

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Reference:
Pyridazine – Wikipedia,
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More research is needed about 5788-58-9

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5788-58-9, Name is 4,5-Dibromopyridazin-3(2H)-one, belongs to pyridazine compound, is a common compound. name: 4,5-Dibromopyridazin-3(2H)-oneIn an article, once mentioned the new application about 5788-58-9.

Six novel photochromic bisarylpyridazinones containing 2,5-dimethylthiophene or 5-methyl-2-phenylthiazole unit were synthesized, and their photochromic and fluorescence properties were investigated. The bisarylpyridazinones underwent reversible color change upon irradiation with UV or visible light. The effect of solvents on the absorption spectra of the bisarylpyridazinones was investigated. The closed-ring forms of bisarylpyridazinones displayed negative solvatochromism which was attributed to the high dipolar characters of the molecule. The open-ring forms of bisarylpyridazinones showed fluorescence at 400-480 nm upon excitation at 302 nm, and the intensities of emission bands gradually decreased during the ring-closing photoreactions. Among the synthesized bisarylpyridazinones, 4,5-bis(5-methyl-2-phenylthiazol-4-yl)-2-methyl(or 2-phenyl) pyridazin-3(2H)-ones (5O and 6O) displayed rather large absorption and emission spectral change, higher quantum efficiency during the photoreaction compared to others. A high conversion ratio (94%) to the closed form was observed for 5O.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3176 – PubChem