Extracurricular laboratory:new discovery of 4-Bromo-6-chloro-2-methylpyridazin-3(2H)-one

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Structure-based drug design was used to guide the optimization of a series of selective BTK inhibitors as potential treatments for Rheumatoid arthritis. Highlights include the introduction of a benzyl alcohol group and a fluorine substitution, each of which resulted in over 10-fold increase in activity. Concurrent optimization of drug-like properties led to compound 1 (RN486) (J. Pharmacol. Exp. Ther. 2012, 341, 90), which was selected for advanced preclinical characterization based on its favorable properties.

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Discovery of 5-Bromo-6-phenylpyridazin-3(2H)-one

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The synthesis and anti-platelet activity of several 5-alkylidene-6-phenyl-3(2H)-pyridazinones are described. The most active compounds are those that contain oxygenated functions (COOR, COMe) on the alkylidene fragment (6a, 6b and 6c).

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Some scientific research about 3-Chloro-6-iodopyridazine

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Application of 135034-10-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.135034-10-5, Name is 3-Chloro-6-iodopyridazine, molecular formula is C4H2ClIN2. In a article,once mentioned of 135034-10-5

Compounds of the formula (I), in which R1, R2, R3, R3?, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumours.

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Archives for Chemistry Experiments of 5-Bromo-6-phenylpyridazin-3(2H)-one

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A series of 6-phenyl-3(2H)-pyridazinones with a diverse range of substituents in the 5-position have been prepared and evaluated in the search for new antiplatelet agents. A significant dependence of the substituent on the inhibitory effect has been observed. The pharmacological study of these compounds confirms that modification of the chemical group at position 5 of the 6-phenyl-3(2H)-pyridazinone system influences both variations in the antiplatelet activity and the mechanism of action.

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New explortion of 1698-53-9

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Reference of 1698-53-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1698-53-9, Name is 4,5-Dichloro-2-phenylpyridazin-3(2H)-one,introducing its new discovery.

In a process for preparing 4-amino-5-chloro-1-phenylpyridazin-6-one by reacting 4,5-dichloro-1-phenylpyridazin-6-one with aqueous ammonia in the presence of a catalyst, the catalyst used is soluble in the aqueous alkaline reaction medium but is essentially insoluble in the reaction medium which has been acidified after removal of the 4-amino-5-chloro-1-phenylpyridazin-6-one.The process of the present invention makes it possible for the catalyst to be recovered and reused in a simple manner.

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Simple exploration of 5-Bromo-6-phenylpyridazin-3(2H)-one

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Application of 90766-97-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 90766-97-5, 5-Bromo-6-phenylpyridazin-3(2H)-one, introducing its new discovery.

A series of diversely substituted 3(2H)-pyridazinones were efficiently N-methylated at position 2 by treatment with N,N-dimethylformamide dimethylacetal in DMF.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3137 – PubChem

 

Awesome Chemistry Experiments For 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine

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492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, belongs to pyridazine compound, is a common compound. COA of Formula: C13H19ClN4O2In an article, once mentioned the new application about 492431-11-5.

The present invention provides a compound of formula IA or a pharmaceutically acceptable salt thereof; 5 (IA) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

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Properties and Exciting Facts About 135034-10-5

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Related Products of 135034-10-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.135034-10-5, Name is 3-Chloro-6-iodopyridazine, molecular formula is C4H2ClIN2. In a Article,once mentioned of 135034-10-5

A first principle study of the cross-coupling reaction between 3-chloro-6-iodopyridazine and triphenylbismuth under palladium catalysis has been carried out. The approach selected for this investigation is the density functional theory within the framework of the PBE0 and B3LYP hybrid exchange?correlation functionals, with and without including empirical corrections for the dispersion forces at the GD3 level. For this reaction, a three-step mechanism including an oxidative addition, a transmetalation and a reductive elimination has been proposed. All intermediates and transition states have been fully characterized. The energy profile is deduced in gas phase and in solvent. Calculations suggest that the oxidative addition is the rate-determining step for the entire cross-coupling reaction.

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The important role of 4,5-Dibromopyridazin-3(2H)-one

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The synthesis of selected 4-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones and alkane-bridged dimers of 4-, 5- and 6-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones is reported. The blocking activity of these compounds was deterrnined on the pre- and postsynaptic alpha-adrenoreceptors of isolated rat vas deferens.

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Extracurricular laboratory:new discovery of 492431-11-5

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Tetrahydroquinoline compounds of Formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

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