Tag: M.W:200-300

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 4,5-Dichloro-2-phenylpyridazin-3(2H)-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1698-53-9

The reaction of 2-substituted-4,5-dichloro-3(2H)-pyridazinones 1a-b with alkoxides and alkylthiolates was investigated.Regiospecific displacement of either the 4 or 5 chlorine atom could be achieved in most cases by appropriate selection of the reaction solvent.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3104 – PubChem

Electric Literature of 90766-97-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 90766-97-5, Name is 5-Bromo-6-phenylpyridazin-3(2H)-one, molecular formula is C10H7BrN2O. In a Article，once mentioned of 90766-97-5

A series of 6-phenyl-3(2H)-pyridazinones bearing different substitution at the 5 position of the pyridazinone ring were prepared in the search for new platelet aggregation inhibitors. The structure of the final compounds was determined on the basis of spectroscopics methods.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 90766-97-5. In my other articles, you can also check out more blogs about 90766-97-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3139 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of Perchloropyridazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 20074-67-3

The present invention belongs to the field of antibacterial agents, more specifically to antibacterials for treating Acinetobacter baumannii infections. The invention provides arylhydrazides containing a 2-pyridone moiety, according to formula (I), which show selective antibacterial activity against A. baumannii. The invention also relates to their use as medicaments and specifically as antibacterials for the treatment of A. baumannii infections, as well as to a process for their preparation and to pharmaceutical compositions containing them.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2906 – PubChem

Application of 20074-67-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 20074-67-3, Name is Perchloropyridazine,introducing its new discovery.

A morphinan derivative represented by the following general formula (I): (wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc., R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group, Y binds to a carbon atom as a ring-constituting atom of R2, R3, R4, and R5 represent hydrogen; hydroxy, etc., R6a and R6b represent hydrogen, etc., R7 and R8 represent hydrogen, etc., R9 and R10, which are the same or different, represent hydrogen, etc., X represents O or CH2, and Y represents C(=O)), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 20074-67-3, and how the biochemistry of the body works.Application of 20074-67-3

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2907 – PubChem

Reference of 492431-11-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.492431-11-5, Name is 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, molecular formula is C13H19ClN4O2. In a Patent，once mentioned of 492431-11-5

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group -OR5; a group -CH2OR5; a group -NR6R7; a group -NR8COR9; a group -NR8CONR10R11; a group -CH2NR12R13; a group -CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group -CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 492431-11-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3234 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C4H4IN3. Introducing a new discovery about 187973-60-0, Name is 6-Iodopyridazin-3-amine

Vascular endothelial growth factor (VEGF) plays important roles in tumor angiogenesis, and the inhibition of its signaling pathway is considered an effective therapeutic option for the treatment of cancer. In this study, we describe the design, synthesis, and biological evaluation of 2-acylamino-6-phenoxy-imidazo[1,2-b]pyridazine derivatives. Hybridization of two distinct imidazo[1,2-b]pyridazines 1 and 2, followed by optimization led to the discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (23a, TAK-593) as a highly potent VEGF receptor 2 kinase inhibitor with an IC50 value of 0.95 nM. The compound 23a strongly suppressed proliferation of VEGF-stimulated human umbilical vein endothelial cells with an IC50 of 0.30 nM. Kinase selectivity profiling revealed that 23a inhibited platelet-derived growth factor receptor kinases as well as VEGF receptor kinases. Oral administration of 23a at 1 mg/kg bid potently inhibited tumor growth in a mouse xenograft model using human lung adenocarcinoma A549 cells (T/C=8%).

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C4H4IN3, you can also check out more blogs about187973-60-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2946 – PubChem

Reference of 492431-11-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 492431-11-5, 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine, introducing its new discovery.

The purpose of the present invention is to provide a compound that has excellent CDK4/6 inhibitory activity. The present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt of the compound.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 492431-11-5. In my other articles, you can also check out more blogs about 492431-11-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3236 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C11H8Cl2N2O. Introducing a new discovery about 41933-33-9, Name is 2-Benzyl-4,5-dichloropyridazin-3(2H)-one

The present disclosure is directed to pyridazin-3(2H)-one compounds of formula (I), pharmaceutical compositions thereof and methods for modulating or activating a Parkin ligase The present disclosure is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase, R21, R22, R23, R24 and R25 are as defined herein.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C11H8Cl2N2O, you can also check out more blogs about41933-33-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3194 – PubChem

Related Products of 22808-29-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.22808-29-3, Name is 4-tert-Butyl-3,6-dichloropyridazine, molecular formula is C8H10Cl2N2. In a article，once mentioned of 22808-29-3

There is increasing evidence that compounds with selectivity for gamma-aminobutyric acidA (GABAA) alpha2- and/or alpha3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect profile. Herein we describe a novel series of GABAA alpha2/alpha3 subtype-selective agonists leading to the identification of the development candidate 17, a nonsedating anxiolytic in preclinical animal assays.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 22808-29-3

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2889 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 3-Iodo-6-isopropoxypyridazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 17321-38-9

The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3221 – PubChem