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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 181355-92-0, name is 6-Chloro-4-iodo-3-methoxypyridazine, introducing its new discovery. Quality Control of 6-Chloro-4-iodo-3-methoxypyridazine

Compounds of Formula (I) that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula (I), together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/ or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3222 – PubChem

 

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Related Products of 187973-60-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.187973-60-0, Name is 6-Iodopyridazin-3-amine, molecular formula is C4H4IN3. In a Patent,once mentioned of 187973-60-0

The present invention relates to compounds of formula (I), wherein A, B, R1 and R2 are as defined herein before.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2927 – PubChem

 

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A new method for the traceless solid phase synthesis of 3(2H)-pyridazinones has been developed employing dihydropyran-functionalized resin. The procedure has permitted the preparation of several diarylpyridazinones through a Suzuki cross-coupling reaction and cleavage conditions that promoted a retro-ene fragmentation.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3182 – PubChem

 

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The present invention relates to radiolabeled compounds of formula (I) wherein either A, B, R1, R2, is labeled with a radionuclide selected from 3H, 11C and 18F and its use for imaging alpha synuclein and/or Abeta deposits in mammals.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2923 – PubChem

 

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The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3192 – PubChem

 

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This paper presents the synthesis of some alkyl or aryl pyridazinyl ethers from 2-alkyl-4-halo-5-hydroxy-and 2-alkyl-4,5-dichloropyridazin-3(2H)-ones or 3,6-dichloropyridazine. Reaction of 2-alkyl-4-halo-5-hydroxypyridazin-3(2H)-ones 1 with 1,2-dibromoethane or 1,3-dibromopropane gave the corresponding monopyridazin-5-yl ethers 2 and alpha,omega-[di(pyridazin-5-oxy)]alkanes 3. Treatment of 4 with 4-substituted-phenol afforded 5-(4-substituted-phenoxy)-2- (4-substituted-phenoxymethyl) derivatives 5. Reaction of 2-alkyl-4,5-dichloro derivatives 7 with 1 gave the corresponding di(pyridazin-5-yl) ethers 8 in good yields. Compound 10 was reacted with catechol to give monopyridazin-3-yl ether 11 and/or di(pyridazin-3-yl) ether 12. Also we described the results for the reaction of 2-alkyl-4-chloro-5-(4-substituted-phenoxy)pyridazin-3(2H)-ones with nucleophiles.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3204 – PubChem

 

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A novel ring contraction for the conversion of 2,7-disubstituted 10H-dipyridazino<4,5-b:4',5'-e><1,4>thiazine-1,6-(2H,7H)-diones (4’a-c) into the corresponding 2,6-disubstituted 9H-dipyridazino<4,5-b:4',5'-d>pyrrole-1,5(2H,6H)-diones (7’a-c), through a base-induced extrusion of sulfur, is described.Heating of 4’a-c in dimethylformamide in the presence of potassium carbonate smoothly afforded 7’a-c, respectively, in good yields, although neither 2,8-dimethyl-10H-dipyridazino<4,5-b:4',5'-e><1,4>thiazine-1,9(2H,8H)-dione (5’a), nor 3,7-dimethyl-10H-dipyridazino<4,5-b:4'5'-e><1,4>thiazine-4,6(3H,7H)-dione (6’a) was susceptible to similar reaction conditions.The mechanism of the ring contraction, which may involve an intermediate (anion, C-) containing a thiirane ring, is also discussed.Keywords – pyridazine; dipyridazino<1,4>thiazine; dipyridazino<4,5-b:4'5'-d>pyrrole; sulfur extrusion; ring contraction; Smiles rearrangement; photochemical cyclization.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3209 – PubChem

 

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The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3191 – PubChem

 

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The present invention relates to ethynyl derivatives of formula (I) as allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5). The variables in formula (I) are defined in the specification.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3049 – PubChem

 

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Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3164 – PubChem