Tag: M.W:200-300

SDS of cas: 89284-10-6, In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In a article, 89284-10-6, molcular formula is C5H4Br2N2, introducing its new discovery.

The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3141 – PubChem

Recommanded Product: 1698-53-9, In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In a article, 1698-53-9, molcular formula is C10H6Cl2N2O, introducing its new discovery.

The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3079 – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. Product Details of 825633-94-1

Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of (S)-14k, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, (S)-14k was selected for further preclinical evaluation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 825633-94-1. In my other articles, you can also check out more blogs about 825633-94-1

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2988 – PubChem

Synthetic Route of 679406-03-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 679406-03-2, Name is Ethyl 4,6-dichloropyridazine-3-carboxylate, molecular formula is C7H6Cl2N2O2. In a Patent，once mentioned of 679406-03-2

The present invention relates to the use of novel compounds of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2961 – PubChem

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. Related Products of 1698-53-9. Introducing a new discovery about 1698-53-9, Name is 4,5-Dichloro-2-phenylpyridazin-3(2H)-one

4-Amino(alkylamino)-5-chloro-2-substituted-3-oxo-2H-pyridazines and 5-amino(alkylamino, dialkylamino)-4-chloro-2-substituted-3-oxo-2H-pyridazines have been prepared by nucleophilic substitution reactions of 4,5-dichloro-2-substituted-3-oxo-2H-pyridazines with amines in aprotic solvent.Structure of the compounds prepared has been proved by IR and UV spectra.Fungicidal and herbicidal activity of the compounds prepared have been tested.None of the compounds prepared exceeds the standard Vitavax in the fungicidal activity tests.Compounds VIII and XII show equal or better activity on the Hill reaction as compared with the standard pyrazone.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 1698-53-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1698-53-9, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3101 – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. Computed Properties of C10H6Cl2N2O

Substituted 5-hydrazinopyridazin-3(2H)-ones, e.g., 4-chloro-2-(3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H)-one or 4-chloro-2-(2-fluoro-5-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H)-one, are prepared by treating halogenated pyridazin-3-(2H)-ones with hydrazine and substituted hydrazines and are useful as central nervous system depressants and sleep inducers.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3085 – PubChem

Related Products of 41933-33-9, In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In a article, 41933-33-9, molcular formula is C11H8Cl2N2O, introducing its new discovery.

A 3(2H)pyridazinone of the formula: STR1 wherein R1 is hydrogen, methyl, C3 -C6 alkenyl, C5 or C6 cycloalkyl, benzyl, phenyl, –(CH2)m CO2 R3 (wherein R3 is hydrogen or C1 -C5 alkyl, and m is an integer of from 1 to 4), –(CH2)n A (wherein A is –OH or –N(R4)2 wherein R4 is C1 -C3 alkyl, and n is an integer of from 2 to 6) or –CH2 CF3 ; R2 is chlorine or bromine; each of Y1 and Y2 which may be the same or different, is hydrogen, C1 -C5 alkyl, C2 -C8 alkenyl, halogen, –OR5 (wherein R5 is hydrogen, C1 -C8 alkyl or STR2 wherein q is an integer of from 1 to 4), –CO2 R6 (wherein R6 is hydrogen or C1 -C5 alkyl), –N(R7)2 (wherein R7 is C1 -C4 alkyl) or –SR8 (wherein R8 is C1 -C4 alkyl); and Y3 is C1 -C5 alkyl, C2 -C8 alkenyl, halogen, –OR5 (wherein R5 is as defined above), –CO2 R6 (wherein R6 is as defined above), –N(R7)2 (wherein R7 is as defined above) or –SR8 (wherein R8 is as defined above), or a pharmaceutically acceptable salt thereof.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3195 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Synthetic Route of 5788-58-9, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 5788-58-9, name is 4,5-Dibromopyridazin-3(2H)-one. In an article，Which mentioned a new discovery about 5788-58-9

High-throughput screening of a small-molecule library identified a 5-triazolo-2-arylpyridazinone as a novel inhibitor of the important glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3) Such inhibitors are of interest due to PFKFB3’s control of the important glycolytic pathway used by cancer cells to generate ATP A series of analogues was synthesized to study structure-activity relationships key to enzyme inhibition Changes to the triazolo or pyridazinone rings were not favoured, but limited-size substitutions on the aryl ring provided modest increases in potency against the enzyme Selected analogues and literature-described inhibitors were evaluated for their ability to suppress the glycolytic pathway, as detected by a decrease in lactate production, but none of these compounds demonstrated such suppression at non-cytotoxic concentrations

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 5788-58-9Synthetic Route of 5788-58-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3168 – PubChem

Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. Application of 5788-58-9

Alpha 4 integrin inhibitory action of compound [a] is new. The sulfonamide derivative or its pharmaceutically acceptable salt [a], particular substituents used A B and, (I) having the structure represented by the following general formula. [Drawing] no (by machine translation)

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3161 – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. Related Products of 5788-58-9

The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R6, R7, m and n are described herein.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3146 – PubChem