Tag: M.W=200-250

Zhao, Hong; Jin, Jian published the artcile< Visible Light-Promoted Aliphatic C-H Arylation Using Selectfluor as a Hydrogen Atom Transfer Reagent>, COA of Formula: C9H8ClN3O2, the main research area is alkane heteroarene selectfluor hydrogen atom transfer light arylation; heteroaryl alkyl derivative preparation.

A mild, practical method for direct arylation of unactivated C(sp3)-H bonds with heteroarenes has been achieved via photochem. Selectfluor is used as a hydrogen atom transfer reagent under visible light irradiation A diverse range of chem. feedstocks, such as alkanes, ketones, esters, and ethers, and complex mols. readily undergo intermol. C(sp3)-C(sp2) bond formation. Moreover, a broad array of heteroarenes, including pharmaceutically useful scaffolds, can be alkylated effectively by the protocol presented here.

Organic Letters published new progress about Alkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, COA of Formula: C9H8ClN3O2.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Luraschi, Elena; Arena, Francesca; Sacchi, Antonia; Laneri, Sonia; Abignente, Enrico; Avallone, Lucia; D’amico, Michele; Berrino, Libero; Rossi, Francesco published the artcile< Research on heterocyclic compounds. XXXVIII. Synthesis and pharmacological activity of imidazo[1,2-b]pyridazine-2-carboxylic derivatives>, Recommanded Product: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate, the main research area is imidazopyridinecarboxylic acid derivative preparation antiinflammatory structure.

A series of imidazo[1,2-b]pyridazine-2-carboxylic acids, esters and amides was synthesized and tested for antiinflammatory, analgesic and ulcerogenic activities. The Et esters were prepared by cyclocondensation of some 3-aminopyridazines with Et bromopyruvate, followed by hydrolysis or ammonolysis to obtain the corresponding acids and amides. The inhibitory activity on the carrageenan-induced edema in the rat paw and on writhes induced by acetic acid in mice was evaluated, as well as the ulcerogenic action on the rat gastric mucosa. The pharmacol. activity was discussed in terms of structure-activity relationships. In particular, the analgesic activity shown by these carboxylic derivatives was compared with that found in other series of imidazo[1,2-b]pyridazine analogs previously examined

Farmaco published new progress about Analgesics. 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Recommanded Product: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Joshi-Pangu, Amruta; Cohen, Ryan D.; Tudge, Matthew T.; Chen, Yonggang published the artcile< Dearomatization of Electron-Deficient Nitrogen Heterocycles via Cobalt-Catalyzed Asymmetric Cyclopropanation>, Recommanded Product: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate, the main research area is dearomatization electron deficient nitrogen heterocycle cobalt catalyst stereoselective cyclopropanation.

The dearomatization of a series of electron-deficient nitrogen heterocycles has been achieved through a cobalt-catalyzed asym. cyclopropanation reaction. This reaction proceeds with high levels of enantio- and diastereoselectivity to afford unique cyclopropanes that can be further functionalized to provide complex heterocyclic building blocks.

Journal of Organic Chemistry published new progress about Cyclopropanation catalysts, stereoselective. 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Recommanded Product: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

El Akkaoui, Ahmed; Berteina-Raboin, Sabine; Mouaddib, Abderrahim; Guillaumet, Gerald published the artcile< Direct Arylation of Imidazo[1,2-b]pyridazines: Microwave-Assisted One-Pot Suzuki Coupling/Pd-Catalyzed Arylation>, Related Products of 64067-99-8, the main research area is imidazo pyridazine microwave preparation; microwave Suzuki coupling aryl heterocyclic halide arylboronic acid.

Direct intermol. C-H arylation of 6-chloroimidazo[1,2-b]pyridazine in its 3-position was achieved, and the tolerance to reaction conditions in the presence of chloro groups was investigated. Various 3-(hetero)arylimidazo[1,2-b]pyridazines were synthesized in good to excellent yields. This methodol. was successfully applied to the synthesis of 3,6-di- and 2,3,6-trisubstituted imidazo[1,2-b]pyridazines by a microwave-assisted, one-pot, two-step Suzuki cross-coupling/palladium-catalyzed arylation process.

European Journal of Organic Chemistry published new progress about Arylation. 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Related Products of 64067-99-8.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Xiao, Fang; Lin, Jin-Hong; Hao, Fei; Zheng, Xing; Guo, Yu; Xiao, Ji-Chang published the artcile< Visible light mediated C-H trifluoromethylation of (hetero)arenes>, Application In Synthesis of 64067-99-8, the main research area is trifluoromethyl heteroarene preparation; aromatic heterocycle visible light trifluoromethylation.

A protocol for visible light mediated C-H trifluoromethylation of unactivated (hetero)arenes under blue LED irradiation has been developed. The reaction enables the rapid construction of a range of CF3-containing (hetero)arenes in moderate to high yields from the readily accessible trifluoromethylsulfonyl-pyridinium salt (TFSP). This protocol is also suitable for nitrogen-containing aromatic heterocycles, which are potentially useful in medicinal chem.

Organic Chemistry Frontiers published new progress about Heterocyclic aromatic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Application In Synthesis of 64067-99-8.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Kosary, Judit; Kasztreiner, Endre; Rabloczky, Gyorgy; Kurthy, Maria published the artcile< Synthesis and cardiotonic activity of 2,4-diamino-1.3,5-triazines>, Safety of Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate, the main research area is aminotriazine heteroaryl preparation cardiotonic; triazine diaminoheteroaryl preparation cardiotonic.

Thirty-two diaminotriazine derivatives, e.g., I (R = NH2, NHBu, NMe2, morpholino, 4-methylpiperazino; R1 = indol-3-yl, imidazo[1,2-a]pyridin-2-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-a]pyrazin-2-yl, etc.] were prepared and tested for cardiotonic activity in cats. There was no correlation between the cardiotonic activity of these compounds and their inhibitory effect on cardiac phosphodiesterase.

European Journal of Medicinal Chemistry published new progress about Cardiotonics. 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Safety of Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Xiao, Fang; Lin, Jin-Hong; Hao, Fei; Zheng, Xing; Guo, Yu; Xiao, Ji-Chang published the artcile< Visible light mediated C-H trifluoromethylation of (hetero)arenes>, Reference of 64067-99-8, the main research area is trifluoromethyl heteroarene preparation; aromatic heterocycle visible light trifluoromethylation.

A protocol for visible light mediated C-H trifluoromethylation of unactivated (hetero)arenes under blue LED irradiation has been developed. The reaction enables the rapid construction of a range of CF3-containing (hetero)arenes in moderate to high yields from the readily accessible trifluoromethylsulfonyl-pyridinium salt (TFSP). This protocol is also suitable for nitrogen-containing aromatic heterocycles, which are potentially useful in medicinal chem.

Organic Chemistry Frontiers published new progress about Heterocyclic aromatic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Reference of 64067-99-8.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Kosary, Judit; Kasztreiner, Endre; Rabloczky, Gyorgy; Kurthy, Maria published the artcile< Synthesis and cardiotonic activity of 2,4-diamino-1.3,5-triazines>, Formula: C9H8ClN3O2, the main research area is aminotriazine heteroaryl preparation cardiotonic; triazine diaminoheteroaryl preparation cardiotonic.

Thirty-two diaminotriazine derivatives, e.g., I (R = NH2, NHBu, NMe2, morpholino, 4-methylpiperazino; R1 = indol-3-yl, imidazo[1,2-a]pyridin-2-yl, imidazo[1,2-b]pyridazin-2-yl, imidazo[1,2-a]pyrazin-2-yl, etc.] were prepared and tested for cardiotonic activity in cats. There was no correlation between the cardiotonic activity of these compounds and their inhibitory effect on cardiac phosphodiesterase.

European Journal of Medicinal Chemistry published new progress about Cardiotonics. 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Formula: C9H8ClN3O2.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Tong, Chao-Lai; Xu, Xiu-Hua; Qing, Feng-Ling published the artcile< Nucleophilic and Radical Heptafluoroisopropoxylation with Redox-Active Reagents>, Product Details of C9H8ClN3O2, the main research area is heptafluoroisopropyl ether preparation; hydroxylamine oxidative heptafluoroisopropyl silver heptafluoroisopropylation; conformation; heptafluoroisopropoxylation; nucleophilic reactions; radical reactions; redox-active reagents.

The practical and efficient heptafluoroisopropoxylation reactions through the invention of a series of redox-active N-OCF(CF3)2 reagents e.g., I were described. These reagents were readily prepared from the oxidative heptafluoroisopropylation of hydroxylamines e.g., II with AgCF(CF3)2. The substitutions on the nitrogen atom significantly affected the properties and reactivities of N-OCF(CF3)2 reagents. Accordingly, two types of N-OCF(CF3)2 reagents including I and III were used as OCF(CF3)2 anion and radical precursors, resp. This protocol enables the direct heptafluoroisopropoxylation of a range of substrates, delivering the corresponding products in moderate to excellent yields.

Angewandte Chemie, International Editionpublished new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Product Details of C9H8ClN3O2.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Dong, Jianyang; Yue, Fuyang; Xu, Wentao; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published the artcile< Visible-light-mediated Minisci C-H alkylation of heteroarenes with 4-alkyl-1,4-dihydropyridines using O2 as an oxidant>, SDS of cas: 64067-99-8, the main research area is alkylated heteroarene green preparation; heteroarene alkyl dihydropyridine alkylation iridium photocatalyst.

A protocol for direct visible-light-mediated Minisci C-H alkylation reactions of N-heteroarenes with 4-alkyl-1,4-dihydropyridines for synthesis of alkylated N-heteroarenes such as I at room temperature with mol. oxygen as an oxidant was reported. The protocol permitted efficient functionalization of various N-heteroarenes with a broad range of cyclic and acyclic primary, secondary and tertiary alkyl groups and was scalable to the gram level. This mild protocol used an inexpensive, green oxidant and was suitable for late-stage C-H alkylation of complex nitrogen-containing mols. Its utility was demonstrated by preparing or functionalizing several pharmaceuticals and natural products.

Green Chemistrypublished new progress about Dihydropyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, SDS of cas: 64067-99-8.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem