Tag: M.W:100-200

Application In Synthesis of 3-Chloro-4-methylpyridazine, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 68206-04-2, Name is 3-Chloro-4-methylpyridazine, molecular formula is C5H5ClN2. In a Patent，once mentioned of 68206-04-2

Novelcompounds of formulae (II, III) and pharmaceutical compositions have been found to inhibit inducible NOS synthase wherein: R 4, R5, R6 and R7 are independently selected from the group consisting of hydrogen lower alkyl, and halogen; and, R8 has the structure whrein X1, X 2, X3, X4, X5, X6, R9, R13,R14 and n are as described herein.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N535 – PubChem

Application of 1114563-58-4, When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. 1114563-58-4, Name is 6-Chloro-2,4-dimethylpyridazin-3(2H)-one, molecular formula is C6H7ClN2O. In a Patent，once mentioned of 1114563-58-4

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R9, X1 and X2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, e.g. cancer, pharmaceutical preparations containing such compounds and their uses as a medicament.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2079 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Synthetic Route of 20375-65-9. Introducing a new discovery about 20375-65-9, Name is 3-Phenyl-6-chloropyridazine

The peptide compound represented by the formula: STR1 which is useful as a germicide or disinfectant, is produced by reducing a compound of the formula: STR2 wherein Y is amino group which may optionally be protected; R1 is hydrogen or protective group; and R2 is hydrogen or protective group; and subjecting the reduction product compound to deprotection reaction when required. A compound of the formula: STR3 wherein Z is amino group which may optionally be protected; R1 is hydrogen or protective group; and R2 is hydrogen or protective group, is a useful as intermediate for production of the first-mentioned compound.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2563 – PubChem

Application of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article，once mentioned of 141-30-0

The proton sponge-triethylamine tris(hydrogen fluoride) mixture provides a mild and efficient fluorinating – reagent for the selective introduction of a fluorine atom, by halogen exchange, into dichlorodiazines. (C) 2000 Elsevier Science Ltd.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1667 – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, HPLC of Formula: C4H2Cl2N2, molecular formula is C4H2Cl2N2, introducing its new discovery. HPLC of Formula: C4H2Cl2N2

Direct amination of heteroarenes and arenes has been achieved in a one-pot C-H zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using C-H amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines. Direct amination of heteroarenes and arenes has been achieved in a one-pot zincation/Cu(OAc)2-catalyzed amination sequence using O-acylhydroxylamines. The method provides a rapid and efficient approach to a range of aromatic and heteroaromatic amines, including those which were previously inaccessible by using C-H amination methods. tmp=2,2,6,6- tetramethylpiperidide.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1819 – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. Quality Control of 3-Chloro-6-methylpyridazine

Guided by computational analysis, herein we report the design, synthesis and evaluation of four novel diazine-based histone deacetylase inhibitors (HDACis). The targets of interest (TOI) are analogues of panobinostat, one of the most potent and versatile HDACi reported. By simply replacing the phenyl core of panobinostat with that of a diazine derivative, docking studies against HDAC2 and HDAC8 revealed that the four analogues exhibit inhibition activities comparable to that of panobinostat. Multistep syntheses afforded the visualized targets TOI1, TOI2, TOI3-rev and TOI4 whose biological evaluation confirmed the strength of HDAC8 inhibition with TOI4 displaying the greatest efficacy at varying concentrations. The results of this study lay the foundation for future design strategies toward more potent HDACis for HDAC8 isozymes and further therapeutic applications for neuroblastoma.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N647 – PubChem

Quality Control of 3,6-Dichloropyridazine, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent，once mentioned of 141-30-0

The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or diabetes/metabolic syndrome via inhibition of HDAC4.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. A catalyst does not appear in the overall stoichiometry of the reaction it catalyzes. “Quality Control of 3,6-Dichloropyridazine

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1338 – PubChem

Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. Reference of 141-30-0

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1560 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of 3-Phenyl-6-chloropyridazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 20375-65-9, name is 3-Phenyl-6-chloropyridazine. In an article，Which mentioned a new discovery about 20375-65-9

A novel macrobicycle featuring an amidopyridine unit as a carboxylic acid binding site, and amide functionality to provide further hydrogen bonding interactions with suitable guests has been prepared. The ability of this novel macrobicycle to bind peptide derivatives has been investigated.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2766 – PubChem

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. Recommanded Product: 141-30-0

Compounds of formula (I)wherein n is 0, 1, or 2; X is O, S, ¿NH¿, and ¿N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by alpha7nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 141-30-0 is helpful to your research. Recommanded Product: 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1368 – PubChem