Tag: M.W:100-200

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step H: A round bottomed flask was charged with the triflate (0.20 g, 0.44 mmol) from step G above, bis(pinacolato)diboron (0.12 g, 0.48 mmol) and potassium acetate (0.13 g, 1.33 mmol) and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (36 mg, 0.04 mmol) in DMF (3 mL). The mixture was refilled with nitrogen three times and then stirred at 80 C. for 1 hour. The mixture was cooled to room temperature. Cesium carbonate (0.43 g, 1.33 mmol), 3-chloro-6-methylpyridazine (0.10 g, 0.67 mmol) and water (2 mL) were added. The mixture was refilled with nitrogen three times and then stirred at 60 C. for 2 hours. After cooling, the mixture was partitioned between methylene chloride and water. The aqueous phase was extracted with methylene chloride. The combined extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (10:1 methylene chloride/methanol) to yield the desired benzazepine (70 mg, 46%) as an off-white solid.

1121-79-5, The synthetic route of 1121-79-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMR Technology, Inc.; US2007/21408; (2007); A1;,
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Pyridazine | C4H4N2 – PubChem

6082-66-2, 3,4,6-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6082-66-2

1.2. 2-[4-(3,6-dichloropyridazin-4-yl)-piperazin-1-yl]-ethanol In a 50mL round bottom flask, 9.18g (0.05 mol) of 3,4,6-trichloro-pyridazine, 5.30g (0.05 mol) of anhydrous sodium carbonate and 20mL of N,N-dimethylacetamide (DMA) were added, stirred at room temperature, then 6.54g (0.05mol) of 2-(piperazin-1-yl)-ethanol (dissolved in 10ml DMA) was added dropwise slowly, stirred overnight, filtered on the next day. 100mL of distilled water was added into the filter cake and stirred, then filtered again to obtain 10.20g of a white solid, yield: 73.6%, m.p.139~ 141C. 1H-NMR(400MHz, CDCl3) deltappm: 2.57(br, 1H), 2.66~2.68(t, 2H, J=5.12Hz), 2.73~2.76(t, 4H, J=4.76Hz), 3.36~3.38(t, 4H, J=4.52Hz), 3.68~3.71(t, 2H, J=5.04Hz), 6.88(s, 1H). 13C-NMR(400MHz, DMSO-d6) deltappm: 155.14, 149.43, 148.70, 116.64, 60.00, 58.49, 52.44, 48.90. EI-MS m/e: 276.1[M+, 100], 280{[M+4]+, 100}, 245.0, 207.1, 175.1, 100.1, 70.1.

The synthetic route of 6082-66-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China; EP1900735; (2008); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66346-87-0,6-Chloro-5-methylpyridazin-3-amine,as a common compound, the synthetic route is as follows.

66346-87-0, Example 65 Preparation of Intermediate 66 [0664] [0665] A mixture of intermediate 58 (293 mg, 0.958 mmol) and 6-chloro-5-methylpyridazin-3-amine (195 mg, 1.35 mmol) in 16 mL of ethanol was heated at 77 C. overnight. After cooling to room temperature the reaction mixture was concentrated under reduced pressure and the residue was purified via silica gel column chromatography (5-100% ethyl acetate in hexanes) to yield intermediate 66 (125 mg, 38%) as a white solid. [0666] LCMS m/z [M+H]+ C17H23ClN4O2 requires: 351.15. Found 351.12. [0667] 1H-NMR (CDCl3, 400 MHz): delta 7.76 (s, 1H), 7.62 (s, 1H), 5.57 (m, 1H), 4.09 (m, 1H), 2.89 (m, 1H), 2.52 (m, 1H), 2.45 (s, 3H), 1.86 (m, 1H), 1.70-1.30 (m, 4H), 1.47 (s, 9H).

66346-87-0 6-Chloro-5-methylpyridazin-3-amine 12353663, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Siegel, Dustin; Sperandio, David; Yang, Hai; Sangi, Michael; Parrish, Jay P.; Hui, Hon Chung; US2013/273037; (2013); A1;,
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932-22-9, 4,5-Dichloro-3(2H)-pyridazinone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

932-22-9, Example 35; 5-(3-Cyclobutyl-2,3,4,5-tetrahydro-lH-benzo[d]azepin-7-yloxy)-2-methyl-2H-pyridazin- 3 -one; General synthesis of Example 35:; Step 1: Synthesis of 5-iodo-2H-pyridazin-3-one.; A round-bottom flask contained 4,5-dichloro-2H-pyridazin-3-one (10.0 g, 60.6 mmol) and hydriodic acid (57% in H2O, 80 mL, 606 mmol) was heated at 145 0C for 27 h. After cooled to room temperature, the black precipitation was collected by filtration and was washed with water. The black solid was stirred in water (50 mL) and was added solid sodium thiosulfate (Na2O3S2) in portion until the black color turned grey. The solid material was collected by filtration and was dissolved in 150 mL solvent (MeOH/CH2Cl2 1 :1). It was filtered and the filtrate was concentrated and dried to give 6.13 g (46%) of 5- iodo-2H-pyridazin-3one. 1HNMR (400 MHz, OMS0-d6) delta 13.25 (s, IH), 8.08 (s, IH), 7.54 (s, IH) ; MS (m/z) = 222 (M + 1).

As the paragraph descriping shows that 932-22-9 is playing an increasingly important role.

Reference£º
Patent; CEPHALON, INC.; WO2009/142732; (2009); A2;,
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63910-43-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63910-43-0,4-Chloro-5-methoxypyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

Example 2 5.0 g (0.03 mol) of 5-chloro-4-methoxy-pyridazine-6-one and 5.0 g of potassium carbonate are initially charged in 50 ml of dimethyl sulphoxide, and 4.7 g (0.03 mol) of 2,4,5-trifluoro-benzonitrile are added at room temperature (about 20 C.). The mixture is stirred at room temperature for 2 hours and then poured into water, and precipitated product is filtered off with suction, washed with water and dried. 7.7 g (86% of theory) of 2-(2,5-difluoro-4-cyano-phenyl)-4-chloro-5-methoxy-pyridazin-3-one of melting point 182 C. are obtained.

63910-43-0 4-Chloro-5-methoxypyridazin-3(2H)-one 819793, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Aktiengesellschaft; US6551963; (2003); B1;,
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Pyridazine | C4H4N2 – PubChem

51149-08-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 3,6-dichloro-4-carboxy-pyridazine (7.5 g, 38.9 mmol, Aldrich) in DCM (30 mL) and MeOH (10 mL) cooled to 0 C. was added a solution of (trimethylsilyl)diazomethane (2.0 M in hexane), slowly via pipette, until a persistent yellow color is observed. After addition was complete, the solvents were removed in vacuo. The crude product was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient (10 to 25% EtOAc) to afford 3.89 g (86%) of 116b as a brown oil that solidifies on standing.

The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Roche Palo Alto LLC; US2008/45511; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21141-03-7,3-Amino-4-pyridazinecarboxylic acid,as a common compound, the synthetic route is as follows.

3-Aminopyridazine-4-carboxylic acid (200 mg, 1.43 mmol) and benzaldehyde(0.18 mL, 1.73 mmol) were stirred in DMF (3 mL) at 90 C for four days. The reaction mixture was allowed to cool tort and sodium triacetoborohydride (605 mg, 2.86 mmol) was added. The reaction was stirred for 16 h. The reaction was quenched with water and extracted with EtOAc. The extracts were dried (Na2S04) and concentrated. The residuewas purified by column chromatography (0-20% MeOH/DCM). The relevant fractionswere concentrated to give 6.3 mg (4%) of the title compound. 1H NMR (500 MHz, DMSO-d6): 8 8.51 (d, 1H, 5Hz), 7.63 (d, 1H, J = 5.0 Hz), 7.30-7.39 (m, 4H), 7.22-7.25 (m, 1H), 4.72 (br s, 2H). [M+H] calc’d for C1zHuN302, 230; found 230.

21141-03-7, The synthetic route of 21141-03-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; QUANTICEL PHARMACEUTICALS, INC.; CHEN, Young, K.; KANOUNI, Toufike; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan; WO2014/100818; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7252-84-8,3-Amino-6-methoxypyridazine,as a common compound, the synthetic route is as follows.

7252-84-8, To a solution of 3-amino-6-methoxypyridazine (250 mg, 2.0 mmol) in acetonitrile (50 mL) was added 2-bromo-4?-nitroacetophenone (970 mg, 3.99 mmol), and then the reaction mixture was refluxed for 5.0 hours. The resulting mixture was filtered and the filter cake was dried under vacuum to give the title product (408 mg, 75.7%). The compound was characterized by the following spectroscopic data: ESI-MS (positive ion mode) m/z: 271.2 [M+1]+.

7252-84-8 3-Amino-6-methoxypyridazine 81673, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CHENG, Changchung; LIU, Bing; ZHANG, Yingjun; LONG, Bohua; ZHANG, Weihong; WO2015/43492; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

6082-66-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6082-66-2,3,4,6-Trichloropyridazine,as a common compound, the synthetic route is as follows.

(a) 2-[(3,6-Chloro-4-pyridazinyl)thio]ethanol A solution of 3,4,6-trichloropyridazine (25 g) in tetrahydrofuran (200 ml) and triethylamine (19 ml) was treated at 0 C. (ice bath cooling) with 2-mercaptoethanol (8.33 ml) over 5 minutes. After the addition was complete, the mixture was stirred at room temperature for 72 hours. The mixture was stirred with aqueous sodium bicarbonate solution and dichloromethane and the solid was collected, washed with water, ether and pentane and dried in vacuo, giving (22.9 g). The combined aqueous and organic fraction was evaporated to half volume giving further solid, which was washed and dried as above (5.0 g). The total yield of solid (27.9 g; 91%) contained some bromo-analogue (5-10%) by NMR.

6082-66-2 3,4,6-Trichloropyridazine 95123, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Cailleau, Nathalie; Davies, David Thomas; Esken, Joel Michael; Hennessy, Alan Joseph; Kusalakumari Sukumar, Senthil Kumar; Markwell, Roger Edward; Miles, Timothy James; Pearson, Neil David; US2008/221110; (2008); A1;,
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Pyridazine | C4H4N2 – PubChem

7252-84-8,7252-84-8, 3-Amino-6-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method 2: (0084) Dissolve 2-chloro-4-(1-cyclopropyl-3-tetrahydropyran-4-yl-pyrazol-4-yl)oxy-pyridine (400 mg, 1.2 mmol) in 1,4-dioxane (15 mL) in a vial. Add 2-(4-amino-2-pyridyl)propan-2-ol (266.5 mg, 1.6 mmol), cesium carbonate (568.5 mg, 1.7 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (134.6 mg, 0.23 mmol) and purge with nitrogen for 5 minutes. Add palladium(II)acetate (26.1 mg, 0.12 mmol) and purge with nitrogen for 5 minutes. Seal the vial and stir at 100 C. overnight. Cool the reaction to room temperature, filter through a CELITE plug and wash with 5% MeOH in DCM. Concentrate and purify by reverse phase chromatography (Redisep Rf Gold High Performance C18 Reverse Phase Column, 0-100% formic acid/acetonitrile (ACN) in formic acid/water). Concentrate appropriate fractions and dry under vacuum to give the title compound (341 mg; 67.3% yield). MS (m/z): 436 (M+1).

7252-84-8 3-Amino-6-methoxypyridazine 81673, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ELi Lilly and Company; MCMILLEN, William T.; JOSEPH, Sajan; PARTHASARATHY, Saravanan; PEI, Huaxing; SAWYER, Jason Scott; BEIGHT, Douglas W.; ZHAO, Gaiying; COATES, David A.; WOLFANGEL, Craig D.; (43 pag.)US2016/96823; (2016); A1;,
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Pyridazine | C4H4N2 – PubChem