Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

2 M Aqueous Na2CO3 solution (1.13 ml.) is added to a mixture of (2R.6R, 11 S)-6, 11 -dimethyl- 8-(4.4.5.5-tetramethyl-[1 .3.2]dioxaborolan-2-yl)-1 .2.5.6-tetrahydro-4H-2,6-methano- benzo[d]azocine-3-carboxylic acid tert-butyl ester (483 mg) and 3-chloro-6-methyl-pyridazine (218 mg) in dimethylformamide (2 ml_). The resulting mixture is flushed with argon and then 1 ,1 ‘-bis(diphenylphosphino)ferrocene-palladium dichloride dichloromethane complex (73 mg) is added. The mixture is heated to 100 0C and stirred at this temperature overnight. After cooling to room temperature, water is added and the resulting mixture is extracted with ethyl acetate. The combined organic extracts are washed with water and brine and dried (MgSO4). The solvent is removed under reduced pressure and the residue is taken up in CH2CI2 (3 ml.) and treated with F3CCO2H (0.5 ml.) for 1 h. Then, the solution is concentrated and the residue is purified by HPLC on reversed phase (MeCN/H2O/NH3) to afford the title compound.Yield: 225 mg (68% of theory) Mass spectrum (ESI+): m/z = 294 [M+H]+, 1121-79-5

1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/63061; (2009); A2;,
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33471-40-8, 4-Methylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The product of step c) (12.2 g, 0.112 mol) in phosphorus oxychloride (125 ML) was heated at 90C for 3 h. The mixture was cooled to room temperature and concentrated almost to dryness. The residue was poured into ice/water, made basic by careful addition of 4N NAOH and extracted with ether. The aqueous phase was re-extracted with DCM. The organic phases were combined, washed with water, dried over sodium sulphate, filtered and concentrated to dryness. The residue was purified by flash chromatography on silica gel in 2: 1 ethyl acetate- isohexane to give an orange solid (11.2 g, 78%). LH NMR (400 MHz, CDCIs) 8 8.97 (1 H, d, J = 4. 9 HZ), 7.35 (1 H, d, J = 4. 9 HZ), 2.44 (3 H, s) ppm., 33471-40-8

33471-40-8 4-Methylpyridazin-3(2H)-one 11412358, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2004/74290; (2004); A1;,
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932-22-9, 4,5-Dichloro-3(2H)-pyridazinone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of dichloropyridazinone (50.0 g, 303.0 mmol) in DMF (200 mL) was added K2CO3 (50.3 g, 364.0 mmol) at RT under vigorous stirring. Benzylbromide (40.0 mL, 336.0 mmol) was added in rapid drops via a syringe. The resulting suspension was stirred at 50 C. for 1 h until all the pyridazinone was consumed as judged by HPLC. The reaction mixture was then poured into water (400 mL). The resultant suspension was stirred for 15 min at RT, and then filtered. The collected solid was rinsed thoroughly with water until no color was apparent in the filtrate. The solid was dried in a vacuum oven at 50 C. overnight to give the title compound, 2-benzyl-4,5-dichloropyridazin-3(2H)-one, (73.1 g, 95%) as pale yellow solid. HPLC: 3.17 min; MS, M+H=255., 932-22-9

932-22-9 4,5-Dichloro-3(2H)-pyridazinone 73247, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Yu, Guixue; Ewing, William R.; Mikkilineni, Amarendra B.; Pendri, Annapurna; Sher, Philip M.; Gerritz, Samuel; Ellsworth, Bruce A.; Wu, Gang; Huang, Yanting; Sun, Chongqing; Murugesan, Natesan; Gu, Zhengxiang; Wang, Ying; Sitkoff, Doree; Johnson, Stephen R.; Wu, Ximao; US2005/143381; (2005); A1;,
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38956-79-5, 3-Hydrazinyl-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of corresponding hydrazinylpyridazine 1 or 5 (1 mmol) and aldehyde 2 (1.1 mmol) in ethanol (5 mL) was heated at 60 C for 0.5 h. The formation of hydrazone was checked by TLC and the reaction mixture was cooled to rt. Oxone (1.5 mmol) was added to the mixture at rt followed by tetramethyl ammonium bromide (0.2 mmol) and the resulting mixture was heated at 60 C for another 5 h. The mixture was cooled to rt and extracted with dichloromethane (2 ¡Á 25 mL), dried over anhydrous sodium sulfate and concentrated to obtain a residue which was purified by column chromatography using hexane/ethyl acetate as eluent to furnish the desired triazolopyridazines 4 and 7 (See reference no; 7 for supporting information).

38956-79-5, As the paragraph descriping shows that 38956-79-5 is playing an increasingly important role.

Reference£º
Article; Ruso, Jayaraman Sembian; Rajendiran, Nagappan; Srinivas, Chowdappa; Murthy, Konappa Narasimha; Soumya, Krishnamurthy; Journal of the Korean Chemical Society; vol. 58; 4; (2014); p. 377 – 380;,
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88497-27-2,88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of ethyl 4-chloro-3-oxobutanoate (1.99 g, 811.49 mmol) and 6-bromopyridazin-3 -amine (1.0 g, 6.90 mmol, PharmaBlock) in EtOH (15 mL) was heated in a microwave at 120 C for 2 h. The reaction was concentrated under reduced pressure. The residue was dissolved in EtOAc (about 250 mL) and washed with water, sat. sodium bicarbonate, and then brine. The organics were collected, dried over MgS04, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica (EtOAc /heptane 0-50 %) to give the title compound (1.06 g, 65%) LC/MS (Table 1, Method i) = 0.73 min; MS m/z: 284, 286 (M+H)+ .

As the paragraph descriping shows that 88497-27-2 is playing an increasingly important role.

Reference£º
Patent; ABBVIE INC.; BREINLINGER, Eric, C.; COX, Phil, B.; DAANEN, Jerome; DIETRICH, Justin; DJURIC, Stevan; DOMBROWSKI, Amanda, W.; FRANK, Kristine, E.; FRIEDMAN, Michael, M.; GOMTSYAN, Arthur; LI, Huan-Qui; LONGENECKER, Kenton; OSUMA, Augustine; ROWLEY, Ann, Marie; SCHMIDT, Robert; VASUDEVAN, Anil; WILSON, Noel; (378 pag.)WO2016/168641; (2016); A1;,
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88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,88497-27-2

To a mixture comprising 285 g (1638 mmol) 6-bromopyridazin-3-amine which was prepared according to intermediate example 1 h,275 g (3276 mmol) NaHC03 and 2815 mL MeOH was dropwise added 85 mL (1638 mmol) bromine at rt and it was stirred at rt overnight. After further addition of 34 mL (655 mmol) bromine and 55 g (655 mmol) NaHC03,the mixture was stirred overnight again. The solvent was reduced to about 1000 mL and the mixture was poured on 5 L of water. The precipitate was filtered off, washed with water and dried give 411 g (99%) of the title compound. 1 H-NMR (CDCls): delta= 6.14 (1 H), 9.92 (2H) ppm.

The synthetic route of 88497-27-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; WENGNER, Antje Margret; NEUHAUS, Roland; SIEMEISTER, Gerhard; BRUeNING, Michael; WO2014/131739; (2014); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1211591-88-6,5-(Trifluoromethyl)pyridazin-3-amine,as a common compound, the synthetic route is as follows.

82 mg of 5-(trifluoromethyl)pyridazin-3-amine was dissolved in 5 ml of chlorobenzene, and 20 mg of 2-bromo-1-[3-(ethylsulfonyl)-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]ethanone was added at room temperature. After the addition, the reaction mixture was stirred under reflux with heating for 3 hours. After the reaction, the reaction mixture was mixed with 10 ml of a 1M sodium hydroxide aqueous solution and extracted with ethyl acetate (10 ml*2). The obtained organic layer was dehydrated with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by preparative medium pressure liquid chromatography using n-hexane/ethyl acetate (with a gradient of from 10:0 to 0:10) as the eluent to obtain 142 mg of the desired product as a brown solid. Melting point: 214-218 C. 1H-NMR (CDCl3): delta9.40 (d, J=7.5 Hz, 1H), 8.94 (s, 1H), 8.58 (d, J=2.0 Hz, 1H), 8.34-8.30 (m, 1H), 8.11-8.09 (m, 1H), 7.24 (dd, J=7.5, 2.0 Hz, 1H), 3.79 (q, J=7.4 Hz, 2H), 1.36 (t, J=7.4 Hz, 3H)., 1211591-88-6

1211591-88-6 5-(Trifluoromethyl)pyridazin-3-amine 67123099, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Nissan Chemical Industries, Ltd.; KUDO, Takao; MAIZURU, Yukihiro; TANAKA, Ayano; NOTO, Kenkichi; MATSUI, Hiroto; KOBAYASHI, Masaki; (260 pag.)US2018/22760; (2018); A1;,
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65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

65202-50-8, In a nitrogen atmosphere, a mixture of methyl 6-chloropyridazine-3-carboxylate (900 mg), 4-methoxy-4-(4-(pentafluorosulfanyl)phenyl)piperidine hydrochloride (2.030 g), potassium carbonate (3604 mg), TBAI (385 mg) and dehydrated THF (80 mL) was stirred overnight at 80¡ãC. The mixture was poured to water at room temperature, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated brine, dried over magnesium sulfate and then concentrated. The obtained residue was crystallized from ethyl acetate and hexane to obtain the title compound (2.25 g). MS: [M+H]+ 454.0

The synthetic route of 65202-50-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; IMAMURA Keisuke; TOMITA Naoki; ITO Yoshiteru; ONO Koji; MAEZAKI Hironobu; NII Noriyuki; (123 pag.)EP3118200; (2017); A1;,
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1837-55-4, 3,5-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

131.1 3-chloro-5-methoxypyridazine To a solution of 3,5-dichloropyridazine (300 mg) in MeOH (2 mL) was added a 5.4 M solution of sodium methoxide in MeOH (0.410 mL) and the reaction mixture was stirred for 1 h at 90 C. It was quenched with H2O and extracted with EtOAc. The organic phase was washed with a 5% solution of KHSO4, a sat. solution of NaHCO3 and brine, dried over MgSO4 and concentrated in vacuo to give the crude titled compound as an orange solid. 1H NMR ((CD3)2SO) delta: 9.01 (d, J=2.4 Hz, 1H), 7.55 (d, J=2.4 Hz, 1H), 3.96 (s, 3H), 1837-55-4

As the paragraph descriping shows that 1837-55-4 is playing an increasingly important role.

Reference£º
Patent; Actelion Pharmaceuticals Ltd.; Hilpert, Kurt; Hubler, Francis; Murphy, Mark; Renneberg, Dorte; US2014/73651; (2014); A1;,
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15456-86-7, 4-Bromo-1,2-dihydropyridazine-3,6-dione is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Essentially as previously described (/. Neuroinflamm. 2007, 4, 21 ; herein incorporated by reference in its entirety), compound 1-1 (2 g, 10.4 mmol, 1 eq) and pyridin-4-yI boronic acid (14,3 mmol, 1.76 g, 1.37 eq) were suspended in dimeihoxyeihane and water (10: 1 v/v) in a heavy wall pressure vessel and purged with argon for 15 min. Tetrakis(triphenylphosphine)palladium (0.1 eq) and sodium carbonate (3eq) were added, the vessel immediately capped, the reaction mixture heated (1 10 C ) for 18 h, then cooled to ambient temperature and subjected to filtration on a medium frit sintered glass funnel containing Ceiite 545. The filtrate was concentrated in vacuo and the concentrate triturated with hexane. The yellow product 1 -2 (2.2 g) exhibited a mass (ESI) of m/z (MeOH) =190.06 (MET), and was taken to the next step without further purification., 15456-86-7

As the paragraph descriping shows that 15456-86-7 is playing an increasingly important role.

Reference£º
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; ARANCIO, Ottavio; WATTERSON, Daniel, Martin; PELLETIER, Jeffrey, Claude; ROY, Saktimayee, Mitra; WO2014/145485; (2014); A2;,
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