Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

Potassium dichromate (3.3 g, 11.2 mmol) was added in portions to a solution of 3-Chloro-6-methyl-pyridazine (1.2 g, 9.3 mmol) in [H2SO4] (10 ml). After addition the mixture is stirred at 50 [C] on. The reaction was pored on ice and the mixture was extracted three times with diethyl ether. The combined organic phases were dried and concentrated to give the title compound (840 mg, 57%). [LC-MS] [(M++1)] : 159 and 161 (3: 1).

1121-79-5, As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.

tert- butyl bis(4-hydroxybutyl)carbamate(0.39 g)Was dissolved in N, N-dimethylformamide (4.5 mL). Sodium hydride (0.16 g) was added thereto,Then 6-chloropyridazine-3-carbonitrile(0.46 g) was added. This was stirred at room temperature for 22 hours. A saturated aqueous solution of ammonium chloride was added thereto, and then extracted with ethyl acetate. The organic layer was concentrated. The obtained residue was purified by silica gel column chromatography to give the title compound (0.24 g). The NMR analysis result of the obtained compound was as follows.

35857-89-7, The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NIPPON SODA COMPANY LIMITED; IHORI, YOICHI; SHIBAYAMA, KOTARO; INOUE, SHUJI; KANG, CHANG-KYUNG; SHIINOKI, YASUYUKI; NISHIMURA, SATOSHI; (60 pag.)JP2016/222655; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1211591-88-6,5-(Trifluoromethyl)pyridazin-3-amine,as a common compound, the synthetic route is as follows.

To a solution of 2-[6-(2-bromoacetyl)-5-ethylsulfonyl-3-pyridyl]-2-methyl-propanenitrile (300 mg, 0.84mmol, 1.00 equiv.) [compound 12 prepared as described in step 2, example P1] in acetonitrile (6.3 mL)were added 5-(trifluoromethyl)pyridazine-3-amine (150 mg, 0.88 mmol, 1.00 equiv.) [prepared asdescribed in W02016/051193) and magnesium oxide (67 mg, 1.70 mmol, 2.00 equiv.) at roomtemperature under argon atmosphere. The resulting mixture was heated to 90 C overnight. The reaction mixture was cooled down at room temperature, filtered and concentrated. The crude material was diluted with ethyl acetate and satuared ammonium chloride solution. The aqueous layer was separated and extracted twice with ethyl acetate. The organic layers were combined, dried overanhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by flash chromatography over silica gel (ethyl acetate in cyclohexane) to obtain the title compound. LCMS (method 4): 424 (M+H) retention time: 0.97 mm., 1211591-88-6

The synthetic route of 1211591-88-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; RENDLER, Sebastian; EDMUNDS, Andrew; MUEHLEBACH, Michel; EMERY, Daniel; RAWAL, Girish; SEN, Indira; SIKERVAR, Vikas; (105 pag.)WO2019/53182; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1837-55-4, 3,5-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of tert-butyl 5-(5-chlororyridazin-3-yl)thiorhene-2-carboxylateA solution of 3,5-dichloropyridazine (2.00 g, 13.4 mmol) and tert-butyl 5-(tributylstannyl)thiophene-2-carboxylate (6.35 g, 13.4 mmol, synthesis see above) in 1,4-dioxane (25 mL) was degassed with Ar. CsF(6.12 g, 40.3 mmol), CuCl (0.133 g, 1.34 mmol) and PdCl2(dppf) (0.491 g, 0.671 mmol) were added andthe mixture was heated at7O C for2 h. KF (3.12 g, 53.7 mmol) in 50 mL water was added and themixture was stirred at RT for 2 h. The mixture was filtered over Celite and rinsed with DCM (15 mL) and brine (15 mL). The organic layer was dried over Na2SC4, filtered and concentrated in vacuo. FC (EtOAc/ DCM 0:1 – 1:1) afforded tert-butyl 5-(5-chloropyridazin-3-yl)thiophene-2-carboxylate (2.14 g, 6.65 mmol, 49%). LCMS: calc. for [M+H] = 297.04, found 297.0.

1837-55-4, The synthetic route of 1837-55-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GRUeNENTHAL GMBH; NARDI, Antonio; RATCLIFFE, Paul; CRAAN, Tobias; HERTRAMPF, Thorsten; LESCH, Bernhard; KIME, Robert; STEINHAGEN, Henning; WO2015/161928; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Hydrazine hydrate (0.25 mol, 2.5 equiv) was added dropwise to a solution of 4,6 dichloro pyrimidine 3,6 dichloro pyridazine (0.1 mol, 1 equiv) in ethanol (100 mL) for 30 C at room temperature. After stirring at 30 C for 1 h, the reaction mixture after 1 h produced a creamy precipitate. After filtering the product (78% yield), it was used for the next step in the synthesis.

141-30-0, As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.

Reference£º
Article; Rajput, Jamatsing D.; Bagul, Suresh D.; Bendre, Ratnamala S.; Research on Chemical Intermediates; vol. 43; 11; (2017); p. 6601 – 6616;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.

4,5-dichloropyridazin-3-one (20.06 g, 122.3 mmol)And POCl3 (117 mL, 1280 mmol)The mixture was stirred at reflux for 3 hours.After the reaction,The mixture was cooled to room temperature.A mixed suspension of water and ice (100 mL) was then added.The resulting mixture was adjusted to pH = 10 with saturated aqueous Na 2CO 3.It was then extracted with EtOAc (250 mL x 3).The combined organic layers were washed with brine brine (250 mL)Filter and concentrate under reduced pressure.The residue was purified by silica gel column chromatography (EtOAc /EtOAcThe title compound was obtained as a white solid (17.80 g, yield: 79.3%)., 932-22-9

The synthetic route of 932-22-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141-30-0,3,6-Dichloropyridazine,as a common compound, the synthetic route is as follows.

Intermediate L6-((6-Chloro-[1 ,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Acetic acid, 500C 3-Chloro-6-hydrazinylpyridazine (i) A mixture of 3,6-dichloropyridazine (3 g, 20.14 mmol) and hydrazine monohydride(1 g, 20.14 mmol) was heated in a sealed tube to 80 0C for 5 hours. Solvent was evaporated and the crude was used in the next step without purification (3.56 g, 100%). LCMS (method B): [MH]+ = 145.1 , tR = 0.57 min.

141-30-0, The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; FU, Xingnian; HE, Feng; LI, Yue; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YU, Zhengtian; ZHANG, Ji Yue (Jeff); DAI, Miao; WO2011/18454; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34584-69-5,3,6-Dichloro-4,5-dimethylpyridazine,as a common compound, the synthetic route is as follows.

A suspension of 3,6-dichloro-4,5-dimethyl-pyridazine (3.0 g, 17 mmol) in aqueous NaOH (3.3 N, 28 mL) is stirred at reflux for 2 h. The reaction is cooled to room temperature and acetic acid (50percent solution in water, 19 mL) is added. The formed precipitate is extracted with 9: 1 ethyl acetate :THF (3 x 100 mL). The combined organic extracts are dried over Na2S04 and concentrated under reduced pressure to afford the desired compound. (1292) [0343] LCMS: MW (calcd): 159; m/z MW (obsd): 160 (M+H). 1.66

34584-69-5, As the paragraph descriping shows that 34584-69-5 is playing an increasingly important role.

Reference£º
Patent; GALAPAGOS NV; MAMMOLITI, Oscar; JANSEN, Koen, Karel; PALISSE, Adeline, Marie, Elise; JOANNESSE, Caroline, Martine, Andree-Marie; MENET, Christel, Jeanne, Marie; ALLART, Brigitte; EL BKASSINY, Sandy; (186 pag.)WO2017/148787; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

51149-08-7, Production Example 16 (1) [0971] A mixture of 693 mg of N2-methyl-5-trifluoromethylpyridine-2,3-diamine, 700 mg of 3,6-dichloropyridazine-carboxylic acid, 1.04 g of EDCI hydrochloride, 50 mg of HOBt and 2.5 ml of pyridine was stirred at room temperature for 4 hours and then allowed to stand at room temperature overnight. Water was poured to the reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.19 g of 3, 6-dichloropyridazine-4-carboxylic acid (2-methylamlno-5-trifluoromethylpyridin-3-yl)-amide. 3,6-Dichloropyridazine-4-carboxylic acid (2-methylamino-5-trifluoromethylpyridin-3-yl)-amide 1H-NMR (CDCl3) delta: 8.44 (1H, s), 8.01(1H, s), 7.78 (1H, s), 4.99(1H, brs), 3.10(3H, d).

The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company Limited; TAKAHASHI, Masaki; ITO, Mai; NOKURA, Yoshihiko; TANABE, Takamasa; SHIMIZU, Chie; EP2857397; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

A suspension of 3,6-dichloro-4-methylpyridazine (3.38 g, 20.74 mmol) in ammonium hydroxide (55 mL, 1412 mmol) was heated in a reactor at 130 C during for about 16 h. The reaction mixture was cooled to room temperature. A precipitate appeared which was filtered, washed with water and dried under vacuum to give an inseparable mixture of 6-chloro-4-methylpyridazin- -amine and 6-chloro-5- methylpyridazin-3 -amine (ratio 57/43) (2.25 g, 76%). NMR (DMSO-d6, 300MHz,) delta 7.30 (s, 1H), 6.45 (broad, 2H), 2.08 (s, 3H) and 6.74 (s, 1H), 6.47 (broad, 2H), 2.19 (s, 3H)., 19064-64-3

19064-64-3 3,6-Dichloro-4-methylpyridazine 87923, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ABBVIE INC.; ARGIRIADI, Maria A.; BREINLINGER, Eric; CUSACK, Kevin P.; HOBSON, Adrian, D.; POTIN, Dominique; BARTH, Martine; AMAUDRUT, Jerome; POUPARDIN, Olivia; MOUNIER, Laurent; KORT, Michael, E.; (392 pag.)WO2016/198908; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem