Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123696-02-6,3-Chloro-5-methoxypyridazine,as a common compound, the synthetic route is as follows.

A degassed solution of 3-chloro-5-methoxypyridazine (473 mg, 3.27 mmol), 3,5-difluoro-4-trimethylstannanylpyridine (1.0 g, 3.6 mmol), copper [(I)] iodide (31 mg, 0.2 mmol) and lithium chloride (416 mg, 9.8 mmol) was formed in 1,4-dioxane (10 ml). Tetrakis (triphenylphosphine)- palladium [(0)] (100 mg) was added and the mixture heated to [80C] for 16 h. The solvent was removed and the residue was purified by flash column chromatography over silica using 40% isohexane: 60% ethyl acetate to give 3- (3, 5-difluoropyridin-4-yl)-5-methoxypyridazine as a pale yellow solid (220 mg): 8H (400 MHz, [CDCL3)] 7.10-7. 12 [(1H,] m), 8. 54 (2H, s), 9.02 [(1H,] d, [J 3.] 1); [7NLZ] (ES+) 224.

123696-02-6, 123696-02-6 3-Chloro-5-methoxypyridazine 10975612, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2004/14865; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6082-66-2,3,4,6-Trichloropyridazine,as a common compound, the synthetic route is as follows.

6082-66-2, Example 18A 5,6-dichloropyridazin-3(2H)-one [0749] 3,4,6-Trichloropyridazine (12 g, 65.4 mmol) in acetic acid (45 mL) was heated at 130¡ã C. for two hours. After cooling to room temperature, the reaction mixture was poured into ice water (200 mL). The solid was collected by filtration to give 3.7 g of the title compound.

As the paragraph descriping shows that 6082-66-2 is playing an increasingly important role.

Reference£º
Patent; HUBBARD, Robert D.; WANG, Le; PARK, Chang H.; SUN, Chaohong; McDANIEL, Keith F.; PRATT, John K.; SOLTWEDEL, Todd N.; WENDT, Michael D.; HOLMS, John H.; LIU, Dachun; SHEPPARD, George S.; US2013/331382; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13327-27-0,6-Methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

13327-27-0, 6-Methylpyridazin-3(2H)-one (Alfa, 2.5 g, 22.70 mmol) and phosphorus oxybromide (Aldrich, 16.27 g, 56.8 mmol) were heated at 90 C under a nitrogen atmosphere for 1.5 hours. After cooling, the mixture was poured onto ice (100 g), neutralized with sodium bicarbonate, and the aqueous phase was extracted with CH2Cl2 (3chi30 mL). The combined organic phase was washed with 5% NaHCO3, brine, dried (Na2SO4) and concentrated. The residue was dissolved in hot ethyl acetate and washed through a plug of silica gel, eluting with ethyl acetate and concentrated. MS (DCI/NH3) m/z 172 (M+H)+, 190 (M+NH4)+.

13327-27-0 6-Methylpyridazin-3(2H)-one 83346, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ABBOTT LABORATORIES; SCHRIMPF, Michael R.; LEE, Chih-Hung; LI, Tao; GFESSER, Gregory A.; MORTELL, Kathleen H.; FAGHIH, Ramin; NERSESIAN, Diana L.; SIPPY, Kevin B.; BUNNELLE, William H.; SCANIO, Marc; SHI, Lei; GOPALAKRISHNAN, Murali; DONNELLY-ROBERTS, Diana; HU, Min; WO2010/36998; (2010); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

Example 157 4-Isopropylamino-3,5-dichloropyridazine 3,4,5-Trichloropyridazine (9.2 g 0.05 mol) is dissolved in toluene (24 ml). Isopropylamine (16.5 g, 0.28 mol) is added and the mixture refluxed three hrs. The solution is cooled, diluted with chloroform and sodium hydroxide (1N). The organic phase is separated, washed with water and saline, then dried over sodium sulfate, filtered and concentrated. The concentrate is chromatographed (silica gel, 300 g; ethyl acetate/hexane (30/70)) to give the title compound, NMR (300 MHz, CDCl3) 8.50, 4.74, 4.47 and 1.20delta., 14161-11-6

The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pharmacia & Upjohn Company; US5866589; (1999); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Coupling according to general procedure II:Amine intermediate: {(3S,4R)-3-(4-Chloro-phenyl)-4-[1-((S)-5-chloro-pyridin-2-yloxy)-ethyl]pyrrolidin-1-yl}-piperidin-4-yl-methanone (VIII-B-1)Heteroaryl: 6-Chloro-pyridazine-3-carbonitrile (commercially available),ES-MS m/e: 551.3 (M+H+). General Procedure II: Aromatic Nucleophilic SubstitutionTo a stirred solution of an amine of type VIII (1 mmol) in DMF (5 mL) was added EtNiPr2 (1.5 mmol) and a substituted chloropyridine, chloropyrimidine, or chloropyridazine (1.3 mmol). The reaction mixture was heated at 60 until completion (reaction monitored by TLC or LCMS). Thereaction mixture was concentrated under vacuo, taken up in EtOAc and washed with H2O several times. The organic phase was dried over Na2SO4, concentrated under vacuo and then purified by preparative HPLC or column chromatography to yield the title product., 35857-89-7

As the paragraph descriping shows that 35857-89-7 is playing an increasingly important role.

Reference£º
Patent; Jablonski, Philippe; Knust, Henner; Nettekoven, Matthias; Patiny-Adam, Angelique; Ratni, Hasane; Riemer, Claus; US2011/53948; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

51149-08-7, 3,6-Dichloropyridazine-4-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

51149-08-7, 3-[6-Bromo-2-fluoro-3-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)-phenoxy]-5-chloro-benzonitrile (R-73) step 1-To a solution of 3,6-dichloro-4-carboxy-pyridazine (R-74a, 7.5 g, 38.9 mmol, Aldrich) in DCM (30 mL) and MeOH (10 mL) cooled to 0 C. was added a solution of (trimethylsilyl)diazomethane (2.0 M in hexane), slowly via pipette, until a persistent yellow color is observed. After addition was complete, the solvents were removed in vacuo. The crude product was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient (10 to 25% EtOAc) to afford 3.89 g (86%) of R-74b as a brown oil that solidifies on standing.

51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Billedeau, Roland Joseph; Sweeney, Zachary Kevin; US2009/170856; (2009); A1;,
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Pyridazine | C4H4N2 – PubChem

6082-66-2, 3,4,6-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of substituted phenol (5 mmol) in dimethyl formamide (20 mL) was added 60% sodium hydride (5 mmol) under ice-water bath. After further stirring for 30 min, 3,4,6-trichloropyridazine (6, 5 mmol) was added and reacted at room temperature for 1-24 h. The reaction solution was poured into cold water, then the formed solid was filtered, washed with water and dried to give intermediate 7, which didn?t need any further purification. Intermediate 7 (5 mmol) with substituted aniline (5 mmol) and a few drops of 12 M hydrochloric acid was added and boiled with 50 ml ethanol for 12-48 h under reflux. The reaction solution was poured into cold water, then alkalized to pH 8 with 4 M NaOH solution. Then the solid was filtered, washed with water, dried and recrystallized from DMF/H2O to obtain pyridazine derivatives 8a-l. (0017) Pyridazine derivatives (2 mmol) was boiled with 10 mL acetic acid under reflux overnight. The reaction solution was poured into cold water, then alkalized to pH 8 with 4 M NaOH solution. Then the solid was filtered, washed with water, dried and recrystallized from DMF/H2O to obtain pyridazinone derivatives 9a-l. To a mixture of 9e (2 mmol) in DMF (10 mL) was added absolute potassium carbonate (4 mmol) followed by iodomethane (2 mmol). The solution was refluxed overnight, then poured into cold water, filtered, washed with water, dried and recrystallized from DMF/H2O to obtain 9m. To a mixture of 9e (2 mmol) in DMF (10 mL) was added absolute potassium carbonate (8 mmol) followed by iodomethane (4 mmol). The solution was refluxed overnight, then poured into cold water, filtered, washed with water, dried and recrystallized from DMF/H2O to obtain 9n., 6082-66-2

6082-66-2 3,4,6-Trichloropyridazine 95123, apyridazine compound, is more and more widely used in various fields.

Reference£º
Article; Li, Dongyue; Zhan, Peng; Liu, Huiqing; Pannecouque, Christophe; Balzarini, Jan; De Clercq, Erik; Liu, Xinyong; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 2128 – 2134;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-50-8,Methyl 6-chloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.

65202-50-8, Methyl 6-{3-r(2-bromophenyl)oxylazetidin-l-yl}pyridazine-3-carboxylate; Into a flame-dried 100 mL round-bottom flask equipped with a magnetic stirring bar and under N2 was added methyl 6-chloropyridazine-3-carboxylate (848 mg, 4.91 mmol), 3- [(2-bromophenyl)oxy]azetidine hydrochloride (1.3 g, 4.91 mmol) and potassium carbonate (2.04 g, 14.7 mmol) in dioxane (30 mL). The reaction mixture was heated to reflux for 16 h overnight. The reaction mixture was cooled to room temperature and quenched with water (10 mL). The reaction mixture was concentrated and a beige solid precipitated out of solution. The solid was diluted with water (20 mL) and filtered through WhatmanNo.l paper on a Hirsch funnel, washing with water. The resulting beige solid was dried on the vacuum pump overnight, giving the desired product.MS (ESI, Q+) m/z 364 (M + 1, 79Br), 366 (M + 1, 81Br).

65202-50-8 Methyl 6-chloropyridazine-3-carboxylate 12379801, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/143823; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63001-30-9,Methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.,63001-30-9

To a solution of methyl 6-oxo-lH-pyridazine-3-carboxylate (2.59 g, 1.0 eq, 16.64 mmol, from Combi-Blocks) and potassium acetate, KOAc (6.60 g, 4.0 eq) in 50 mL of acetic acid, glacial, cooled at 0 C, bromine, Br2 (2.54 mL, 2.96 eq), is added. After the addition the mixture is stirred at 80 C for 5 h. The mixture is poured on 200 mL of saturated Na2S203 water solution. The mixture is extracted with EtOAc (10 % THF, 3 times, 150 mL in total). The gathered organic layers are washed with 200 mL of 0.01 N HC1 water solution and 200 mL of brine and dried over Na2S04. After filtration the solvent is evaporated and the resulting crude is purified by flash column chromatography (Si02, DCM / EtOAc 95:5 to 0: 100) to afford the desired compound. LCMS: MW (calcd): 233; m/z MW (obsd): 235 (M+H).

The synthetic route of 63001-30-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GALAPAGOS NV; MAMMOLITI, Oscar; JANSEN, Koen, Karel; PALISSE, Adeline, Marie, Elise; JOANNESSE, Caroline, Martine, Andree-Marie; MENET, Christel, Jeanne, Marie; ALLART, Brigitte; EL BKASSINY, Sandy; (186 pag.)WO2017/148787; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5096-73-1,5096-73-1, 6-Chloropyridazine-3-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-(4-Chloro-phenylamino)-pyridazine-3-carboxylic acidA mixture of 6-chloro-pyridazine-3-carboxylic acid (80% pure, 400 mg, 2.02 mmol) and 4- chloro-aniline (523 mg, 4.06 mmol) in 1 ,2-DME (10 ml) was heated to 80 0C for 90 min in the microwave oven. The mixture was allowed to cool to RT and then concentrated in vacuo. Purification by flash chromatography (Hex/EtOAc 100:0 to 0:100) gave 6-(4-chloro- phenylamino)-pyridazine-3-carboxylic acid (50% pure, 330 mg, 33 %). UPLC (5-100% CH3CN): tR = 0.915 min, MS (ES-): 248 [M-1].

As the paragraph descriping shows that 5096-73-1 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; WO2008/128968; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem