Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63001-30-9,Methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.

63001-30-9, To a solution of methyl 6-oxo-1 ,6-dihydropyridazine-3-carboxylate (1 .1 g, 7.14 mmol) in A/,A/-dimethylformamide (20 ml_) at room temperature was added potassium carbonate (1 .97 g, 14.3 mmol) and iodoethane (2.23 g, 14.3 mmol). The reaction mixture was stirred at 70 C for 16 h, cooled to room temperature, diluted with water (300 ml_) and extracted with ethyl acetate (80 ml_ c 3). The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated to afford methyl 1 -ethyl-6-oxo-1 ,6-dihydropyridazine-3-carboxylate (1 .0 g, 5.49 mmol, 76.9%) as a white solid. LCMS (ESI) m/z: 183.1 [M+H]+.

The synthetic route of 63001-30-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YUMANITY THERAPEUTICS, INC.; LE BOURDONNEC, Bertrand; LUCAS, Matthew; OZBOYA, Kerem; PANDYA, Bhaumik; TARDIFF, Daniel; TIVITMAHAISOON, Parcharee; WRONA, Iwona; (475 pag.)WO2019/183587; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15456-86-7,4-Bromo-1,2-dihydropyridazine-3,6-dione,as a common compound, the synthetic route is as follows.

The solid, divided into two batches, was treated with phosphorus oxychloride (2×200 ml) and heated to reflux for 3.5 h. The mixture was cooled, evaporated and azeotroped with toluene. The residue was partitioned between dichloromethane and saturated aqueous sodium bicarbonate solution and extracted with DCM twice more. The organic extracts were dried and evaporated. This residue was re-dissolved in dichloromethane, and chromatographed on silica gel (300 g) (DCM as eluent) to give a white solid (101.5 g, 87%). (LC/MS analysis showed ca. 20-30% impurity, isomers of bromo-dichloropyridazine)., 15456-86-7

The synthetic route of 15456-86-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2008/6648; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7252-84-8,3-Amino-6-methoxypyridazine,as a common compound, the synthetic route is as follows.

Example 62: Preparation of 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-l-phenyl-2- sulfanylideneimidazolidin-4-yl}-N-(6-methoxypyridazin-3-yl)acetamide. TBTU (253.3 mg; 0.77 mmol; 1.5 eq) and DIPEA (179 mu 1-03 mmol; 2 eq) were added to a solution of 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-l-phenyl-2- sulfanylideneimidazolidin-4-yl} acetic acid (1-3) (200 mg; 0.51 mmol; 1 eq) in dioxane (5 mL). After 20 minutes, 6-methoxypyridazin-3-amine (128.9 mg; 1.03 mmol; 2 eq) in dimethylformamide (0.1 mL) was added. The reaction mixture was stirred at room temperature over the week-end. After concentration to dryness, saturated ammonium chloride (30 mL) was added and the aqueous layer was extracted with ethyl acetate (3 x 30 mL). The combined organic layers were washed with saturated sodium chloride (3 x 30 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude was precipitated in methanol. The title compound, the title compound 2-{3-[2-(4-chlorophenyl)ethyl]-5-oxo-l-phenyl- 2-sulfanylideneimidazolidin-4-yl } -N-(6-methoxypyridazin-3-yl)acetamide was obtained in 22% yield (55.8 mg) as a grey-white powder. 1H-NMR (CDC13): delta (ppm) 2.9 (m, 1H), 3.03 (m, 1H), 3.22 (m, 1H), 3.45 (m, 1H), 3.74 (m, 1H), 3.98 (s, 3H), 4.17 (m, 1H), 4.8 (t, 1H, J = 4.2 Hz), 7.38 (m, 10H), 8.17 (m, 1H), 11.19 (s, 1H); MS (ESI+): m/z = 495.9, 497.8 [M+H]+ ., 7252-84-8

As the paragraph descriping shows that 7252-84-8 is playing an increasingly important role.

Reference£º
Patent; VIVALIS; GUEDAT, Philippe; BERECIBAR, Amaya; CIAPETTI, Paola; VENKATA PITHANI, Subhash; TROUCHE, Nathalie; WO2013/171281; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-65-4,3-Methoxypyridazine,as a common compound, the synthetic route is as follows.

Step 1: A mixture of 3-methoxypyridazine (12.0 mL, 130 mmol) and oxirane-2,2,3,3- tetracarbonitrile (20 g, 140 mmol) in THF (240 mL) was stirred at 0 oC for 2 h and at 4 oC for 40 h. The reaction was concentrated to afford crude dicyano(3-methoxypyridazin-1-ium-1- yl)methanide as a solid, which was taken to the next step without further purification. 1H NMR (DMSO-d6, 400 MHz): delta 8.56 (d, J = 6.0 Hz, 1H), 7.94 (m, 1H), 7.14 (d, J = 9.2 Hz, 1H), 3.97 (s, 3H)., 19064-65-4

19064-65-4 3-Methoxypyridazine 292493, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LIM, Jongwon; ALTMAN, Michael, D.; BRUBAKER, Jason, D.; GIBEAU, Craig, R.; (94 pag.)WO2016/144847; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.

To a solution of 2H-tetrazole (1.83 1 g, 26.1 mmol) in DMF (30 ml) was added Cs2CO3(8.52 g, 26.1 mmol) at 0 C. The resulting solution was stirred at 0 C for 15 mm followed byaddition of 6-chloropyridazine-3-carbonitrile (Liu, et al., I Med. Chem. 2007, 50, 3086-3 100) (3.04 g, 21.79 mmol). The resulting solution was stirred at rt for 30 mm, then heated at 90 C for 30mm. The mixture was cooled to rt, and partitioned between EtOAc and sat. NaHCO3. The organic layer was washed with sat.NaHCO3 three times, dried over Na2504, and concentrated.The residue was stirred with DCM. The solid was collectted by filtration to give the title compound., 35857-89-7

As the paragraph descriping shows that 35857-89-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; BISWAS, Dipshikha; DING, Fa-Xiang; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; PASTERNAK, Alexander; SUZUKI, Takao; VACCA, Joseph; XU, Shouning; WO2015/103756; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-65-4, 3-Methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reagent 53-Methoxy-4-(tributylstannyl)pyridazine2,2,6,6-Tetramethylpiperidine (10.4 mL, 61.51 mmol) in ether (125 mL) was cooled to -30 C. and treated with n-BuLi (24.6 mL, 61.51 mmol). The reaction solution was warmed to room temperature for 30 minutes, and then cooled to -75 C. 3-Methoxypyridazine (3.10 g, 26.75 mmol) in ether (10 mL) was added slowly at -75 C. After ten minutes, tributylchlorostannane (10.45 g, 32.09 mmol) was added all at once and stirred at -75 C. for another forty-five minutes. The reaction was queched with a mixture of wet ether (50 mL)/saturated NH4Cl (50 mL), warmed to RT, diluted with ether (1000 mL) and washed with half-saturated NH4C twice The organic layer was dried through MgSO4, filtrated and evaporated to dry to give a yellow oil. The crude material was added to a silica gel column and was eluted with 0-20% ethyl acetate in hexane to give a blue liquid (2.09 g, 19.58% yield) as the title compound. 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 8.68 (d, J=4.2 Hz, 1 H) 7.43 (d, J=4.2 Hz, 1 H) 4.09 (s, 3 H) 1.44-1.57 (m, 6 H) 1.31 (sextet, J=7.3 Hz, 6 H) 0.99-1.23 (m, 6 H) 0.88 (t, J=7.2 Hz, 8 H. MS APCI, m/z=397/399/401 (M+H). HPLC 4.04 min.

19064-65-4, The synthetic route of 19064-65-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; US2008/318943; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

120276-59-7, 3-Chloro-6-(chloromethyl)pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

120276-59-7, A mixture of 3-chloro-6- (chloromethyl)pyridazine (835 mg, 5.12 mmol) and NaN3 (433 mg, 6.66 mmol) in DMF (10 mL) was stirred overnight at RT. Water was added and the mixture was extracted with EtOAc (3x). The combined organic layers were washed with brine, dried over anh. Na2S04, filtered and concentrated. The crude material was purified by silica gel chromatography (0-50% EtOAc in hexanes) to provide 3-(azidomethyl)-6- chloropyridazine (700 mg, 4.13 mmol, 81% yield) as an off-white solid. MS (ESI, pos. ion) m/z: 170.0 (M+l). .H NMR (400 MHz, CDC13) delta ppm 7.57 (s, 2 H), 4.76 (s, 2 H).

The synthetic route of 120276-59-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; D’AMICO, Derin C.; HERBERICH, Bradley J.; JACKSON, Claire L.M.; PETTUS, Liping H.; TASKER, Andrew; WANG, Hui-Ling; WU, Bin; WURZ, Ryan; WO2012/148775; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

A suspension of 3,6-dichloro-4-methyl-pyridazine (3 g, 18.40 mmol) in concentrated ammonia (20 mL, 1.057 mol) in a sealed vessel was heated to 130 C for 15 h. After cooling to rt, it was diluted with water and filtered. The solid was dried under reduced pressure and used directly in the next step (2.2 g). NMR showed it contained two isomers; 6-chloro-4-methyl-pyridazin-3-amine and 6-chloro-5-methyl-pyridazin-3-amine in about 1:1.8 ratio., 19064-64-3

The synthetic route of 19064-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; FARMER, Luc J.; FOURNIER, Pierre-Andre; LESSARD, Stephanie; LIU, Bingcan; ST-ONGE, Miguel; STURINO, Claudio; SZYCHOWSKI, Janek; YANNOPOULOS, Constantin; WO2015/48245; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE l; EPO 2-(6-(4-[2-(rTrifluoromethyl’)benzoyl1piperazin-l-v?pyridazin-3-yl)-l,3-benzothiazole; Step 1; 6-Chloropyridazine-3 -carboxylic acid; To concentrated sulfuric acid (175 mL) in a flask equipped with a mechanical stirrer was added 3-chloro-6-methylpyridazine (25 g, 194 mmol). To the resulting solution was added K2Cr2O7 (69 g, 234 mmol) portionwise over 40 min, using a cold water bath to maintain the internal temperature below 65 0C. The reaction was then maintained at 60 0C for 3 h. The mixture was cooled and quenched by the addition of ice, then poured onto 200 g ice and extracted eight times with EtOAc. The combined organic layers were washed with brine, dried over MgSO4 and evaporated to give the title compound., 1121-79-5

1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/9236; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5469-69-2, 3-Amino-6-chloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-amino-6-chloropyridazine (19.2 g,148 mmol; CASNo. 5469-69-2) in EtOH (500 mL) was added 10% Pd catalyst on 1940 carbon (unreduced, 55% water). Triethylamine (50 mL) was added and the mixture was hydrogenated under 500 psi/mole for 1.9 h. The reaction was filtered and the ethanol was washed with aqueous NH4CI. The organic layer was concentrated to give pyridazin-3-amine as a white solid (11 g, 78% yield). MS (APCI 10V) AP+1 96.2. To a suspension of pyridazin-3-amine (5 g, 50 mmol) in THF (50 mL) and CH3CN (70 mL) was added pyridine (5.10 mL, 63.1 mmol) followed by phenyl chloroformate (6,95 mL, 55.2 mmol) slowly. The reaction was stirred overnight. The reaction was filtered to remove the precipitate. The filtrate was concentrated and then taken up in CH2CI2 which was washed with water. The organic layer was dried using SPE phase separators and concentrated. The residue was purified by silica gel column chromatography (0-5% MeOH/CH2CI2). An undesired side product eluted first followed by the title compound which was concentrated to give a white solid (7.5 g, 70% yield). MS (APCI 10V) AP+1 216.12; 1H NMR (400 MHz1 DMSO-d6) delta ppm 7.20 – 7.24 (m, 2 H) 7.25 – 7.28 (m, 1 H) 7.39 – 7.44 (m, 2 H) 7.64 – 7.69 (m, 1 H) 8.05 (dd, 1 H) 8.94 (dd, 1 H) 11.34 (s, 1 H)., 5469-69-2

5469-69-2 3-Amino-6-chloropyridazine 21643, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; WO2009/127946; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem