Tag: M.W:100-200

51149-08-7, 3,6-Dichloropyridazine-4-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 3,6-dichloropyridazine-4-carboxylic acid (15.0 g, 78 mmol) in THF (150 mL) was added ethanol (18.15 mL, 311 mmol) and DMAP (0.950 g, 7.77 mmol). EDC (16.39 g, 85 mmol) was then added in portions over 1 min. The reaction was mildly exothermic. The reaction was stirred at room temperature for 16 h. The reaction mixture was transferred to a separatory funnel containing saturated aqueous NaHCCb solution (150 mL). The aqueous layer was extracted with ether (3 x 250 mL). The combined organic layers were washed with brine (100 mL), dried over MgSCn, filtered, and concentrated. The residue was purified by column chromatography on silica gel (20%? 40% ethyl acetate in hexanes; 300 g column) to afford ethyl 3,6-dichloropyridazine-4- carboxylate (13.2 g, 59.7 mmol, 77% yield) as a colorless oil: NMR (400MHz, CDCh) delta 7.88 (s, 1H), 4.50 (q, J=7.0 Hz, 2H), 1.46 (t, J=7.2 Hz, 3H); LCMS (ESI) m/e 221.1 [(M+H)+, calcd for C7H7CI2N2O2 221.0].

51149-08-7, 51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARTZ, Richard A.; AHUJA, Vijay T.; SIVAPRAKASAM, Prasanna; DUBOWCHIK, Gene M.; MACOR, John E.; (104 pag.)WO2018/98411; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dissolve 25.Og (0.229 moles) of 3-chloro-6-methylpyridazine in 250 ml of NH4OH and heat to 1700C. in a sealed container for 24 h. Evaporate solvents. Triturate in methylene chloride and filter solid. Repeat with filtrate 4 x. Combine all filtered solids and dry in vacuum oven over night to obtain product as off-white solid 4.32 g (0.040 moles, 20.4 %). H1NMR (DMSO-d6): delta 7.1 (d, J = 8.9 Hz, IH); 6.67 (d, J = 6.67 Hz, IH); 6.04 (s, br, 2H); 2.33 (s, 3H) ppm. ES+ = 110 (100%, M + 1).

1121-79-5, The synthetic route of 1121-79-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2006/107784; (2006); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

3-Chloro-6-methylpyridazine (3.00 g, 23.3 mmol) was dissolved in concentrated sulfuric acid (23 mL), and potassium dichromate (8.24 g, 28.0 mmol) was added little by little under ice cooling. The mixture was stirred at room temperature for 1.5 hours, and the mixture was further stirred at 50C for 60 hours. The reaction mixture was slowly poured into ice water, and the mixture was extracted with diethyl ether (x 3). The organic layer was washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to give the title compound (1.27 g; yield, 34%) as a white solid. 1H NMR (CDCl3, 400 MHz): delta 7.80 (1H, d, J = 7.8 Hz), 8.32 (1H, d, J = 7.8 Hz). MS (ESI) m/z: 159 (M+H) +.

1121-79-5, 1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2409977; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the compound of preparation 92 (30mg, 0.057mmol) in acetonitrile (1 OmL) were added 3-chloro-6-cyanopyridazine (12mg, 0.086mmol) and N,N-diisopropylethylamine (40muL, 0.23mmol). The reaction mixture was stirred at reflux for 3h. The reaction was concentrated in vacuo and residue diluted by adding sodium hydrogen carbonate solution (1 OmL) and extracted with EtOAc (3 x 1 OmL). The combined organic extracts were washed with brine (15ml_), dried with sodium sulphate, filtered and concentrated in vacuo to give the crude residue. Purification by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (95:5:0.5) gave 25mg (78%) of the title compound as a mixture of epimers as a white solid. 1H NMR (400 MHz, CD3OD) delta 1.19 -2.47 (1 OH, m), 2.87-4.49 (12H, m), 4.80- 4.85 (1 H, m), 6.52-6.69 (3H, m), 6.92-6.94 (2H, m), 7.09-7.37 (3H, m), 7.42- 7.47 (1 H, m). LRMS: APCI+ m/z 627 [MH+]., 35857-89-7

35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER LIMITED; ANDREWS, Mark, David; BARBER, Christopher, Gordon; WO2010/15972; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

63001-30-9, Methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63001-30-9, B. A mixture of 6-hydroxypyridazine-3-carboxylic acid methyl ester obtained above and phosphorous oxychloride were carefully heated to reflux and maintained there for 2.5 h. The reaction mixture was then cooled and evaporated in vacuo to remove excess phosphorylchloride, and the residue was then poured into ice water. The precipitate was collected by filtration, washed with saturated NaHCO3 and water, and dried under vacuum to yield the product as a yellow solid (4.359 g, 79% yield).

The synthetic route of 63001-30-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; XENON PHARMACEUTICALS INC.; WO2006/34440; (2006); A2;,
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Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred suspension of 2,2-dimethylpropanoic acid (0.288 g, 2.82 mmol) and 3,6-dichloropyridazine (0.299 g, 2 mmol) in water (3 ml_) at 55C was added AgN03 (0.068 g, 0.4 mmol) as a solution in water (0.3 ml_) followed by TFA (0.046 g, 0.4 mmol). (NH4)2S208 (0.778 g, 3.19 mmol) was added dropwise as a solution in water (1.5 ml_). The reaction mixture was then heated to 75C for 1 h. Upon cooling the reaction mixture was poured into NaHC03 solution (15 ml_) and extracted with CH2CI2 (15 ml) twice. The combined organic fractions were dried over MgS04, filtered and the solvent removed by evaporation in vacuo. Purification by silica gel column chromatography, 3:1 CH2CI2/hexane elution, yielded intermediate 1 (0.33 g, 80%). LCMS (ESI): Found 205.0 [M+Hf.

141-30-0, 141-30-0 3,6-Dichloropyridazine 67331, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; KARUS THERAPEUTICS LIMITED; SHUTTLEWORTH, Stephen Joseph; GATLAND, Alice Elizabeth; FINNEMORE, Daniel John; ALEXANDER, Rikki Peter; SILVA, Franck; CECIL, Alexander; (233 pag.)WO2019/166824; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

Step 9.1. 6-Chloro-4-methylpyridazin-3-ylamine and 6-chloro-5-methylpyridazin-3-ylamine A mixture of 50.0 g (307 mmol) of 3,6-dichloro-4-methylpyridazine in 170 ml of aqueous ammonia (30%) is heated at 120 C. for 16 h in a steel reactor at the internal pressure of bar.The reactor is cooled and the reaction mixture is poured into 200 ml of water. The solid formed is isolated by filtration and dried under vacuum, to give 38.5 g of a mixture containing approximately 45% of 6-chloro-4-methylpyridazin-3-ylamine (CAS 64068-00-4) and 55% of 6-chloro-5-methylpyridazin-3-ylamine (CAS 66346-87-0).1H NMR (CDCl3) delta: 7.20 and 6.75 (2s, 1H): (d, 0.55H), 4.9 (sl, 2H), 2.40 and 2.25 (2s, 3H) ppm., 19064-64-3

As the paragraph descriping shows that 19064-64-3 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS; US2011/312934; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-chl oro-Af2-(3,8-di methyl i mi dazo[ l ,2-c/]pyridin-7-yl)-A – (piperidin-4-yl)pyrimidine-2, 4-diamine (100 mg, 0.2689 mmol) in ethanol (10 mL) were added 6-chloropyridazine-3-carbonitrile (56.5 mg, 0.405 mmol) and TEA (54.5 mg, 0.539 mmol). The mixture was stirred at room temperature overnight. The mixture was filtered and the filter cake was washed with EtOH (50 mL x 3) to give the title product as a light yellow solid (98 mg, yield 76.73%).MS(ESI,pos.ion)m/z: 475.2 [M+H]+;1H NMR (400 MHz, DMSO-d6) d (ppm): 8.78 (s, 1H), 8.10 (d, j = 7.2 Hz, 1H), 7.91 (s, 1H), 7.85 (d, j = 9.6 Hz, 1H), 7.38 (t, j= 8.7 Hz, 2H), 7.32 (s, 1H), 6.89 (d, j= 7.7 Hz, 1H), 4.56 (d, j = 12.3 Hz, 2H), 4.21 (s, 1H), 3.05 (t, j = 12.5 Hz, 2H), 2.43 (s, 3H), 2.41 (s, 3H), 1.94 (d, j =I I .8 Hz, 2H), 1.69-1.53 (m, 2H)., 35857-89-7

35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-67-6, 6-Chloro-3-hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6-chloropyridazin-3 (2H)-one (0.140 g, 1.07 mmol), (3 -methylquinolin-7-yl)boronic acid, (0.221 g, 1.18 mmol), Cu(OAc)2 (0.0390 g, 0.215 mmol) and pyridine(0.191 ml, 2.36 mmol) in DCM (10.7 mL, 1.07 mmol) was stirred at room temperature overnight. The reaction mixture was partitioned between EtOAc and water. The organic extracts were washed with brine, then dried over anhydrous Na2SO4(), filtered and concentrated under vacuum. The resulting residue was purified by silica chromatography to afford the title compound (25 mg, 8.6% yield). MS (apci) m/z = 274.0 [(M+H)+2], 272.0 (M+H) with Cl pattern.

19064-67-6, 19064-67-6 6-Chloro-3-hydroxypyridazine 252828, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; COOK, Adam; GUNAWARDANA, Indrani W.; HUNT, Kevin W.; METCALF, Andrew T.; MORENO, David; REN, Li; TANG, Tony P.; (263 pag.)WO2017/70708; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

Preparation 9.1: 5-(4-methylpiperazin-l-yl)pyridazin-4-amine 7o Step 1: 3,4-dichloro-5-(4-methylpiperazin-l-yl)pyridazine [00283] 3,4,5-Trichloropyridazine (3 g, 16.36 mmol) was dissolved in dry NMP (18 mL) and cooled in an ice-bath. DIPEA (2.326 g, 3.135 mL, 18 mmol) was added, followed, dropwise, by 1-methylpiperazine (1.721 g, 1.906 mL, 17.18 mmol). The resulting mixture was stirred at RT overnight. The reaction mixture was concentrated under reduced pressure to give an brown solid whichwas partitioned between 10% MeOH in DCM and saturated NaHC03. The aqueous layer was extracted with further 10% MeOH in DCM (5x20mL) and the combined organics were dried over Na2S04, filtered and concentrated under reduced pressure to give a brown oil which was purified by column chromatography (7.5% MeOH in DCM, ~300mL silica, loaded in DCM) to provide 3,4-dichloro-5-(4-methylpiperazin-l- yl)pyridazine as a light yellow solid (2.36g, 58% Yield)., 14161-11-6

The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; BRENCHLEY, Guy; CHARRIER, Jean-damien; DAVIS, Chris; DURRANT, Steven; JARDI, Gorka, Etxebarria I; FRAYSSE, Damien; JIMENEZ, Juan-miguel; KAY, David; KNEGTEL, Ronald; PIERARD, Francoise; PINDER, Joanne; SHAW, David; STORCK, Pierre-henri; STUDLEY, John; TWIN, Heather; WO2014/143241; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem