Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.

To a solution of N4 – ((3R, 6S) -6-aminohexahydrofuro [3,2-b] furan-3-yl) -5-chloro-N2- (1-methyl- Yl) pyrimidine-2,4-diamine (32 mg, 0.091 mmol) in n-butanol (20 mL) was added 6-chloropyridazine-3-carbonitrile (25 mg, 0.179 mmol) and triethylamine (42 mg, Mg).The reaction was allowed to warm to 120 C for 20 hours,And then concentrated under reduced pressure.The resulting residue was purified by silica gel column chromatography (MeOH / DCM (v / v) = 1/30)The title compound was obtained as a yellow solid(17 mg, 0.037 mmol, yield 41%).

35857-89-7, 35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Sunshine Lake Pharma Co., Ltd.; Xi, Ning; Dai, Weilong; Li, Minxiong; Chen, Wuhong; Zhang, Tao; Hu, Haiyang; Li, Xiaobo; Liu, Jun; Wang, Tingjin; (146 pag.)CN106478651; (2017); A;,
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53896-49-4, Pyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,53896-49-4

To a solution of the intermediate from Step B (5.96 g, 56.7 mmol) in MeOH (35 mL) was added 6N HCl (20.89 mL, 125 mmol) followed by Pd/C (0.905 g, 8.51 mmol). The reaction mixture was kept on Parr shaker for 2 hours at 40 psi hydrogen. The reaction mixture was filtered through celite and washed with 600 mL of MeOH and the filtrate concentrated. The residue was azeotroped several times with toluene. A dark brown solid was obtained. LC1 rt = 0.36 min, m/z = 110 (M+H).

53896-49-4 Pyridazine-3-carbonitrile 13642940, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Sharp & Dohme Corp.; BROCKUNIER, Linda, L.; GUO, Jian; PARMEE, Emma, R.; RAGHAVAN, Subharekha; ROSAUER, Keith; STELMACH, John, E.; SCHMIDT, Darby Rye; (87 pag.)EP2373317; (2016); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16401-70-0,N-Methylpyridazin-4-amine,as a common compound, the synthetic route is as follows.

To a solution of N-methylpyridazin-4-amine (83 mg, 0.76 mmol), triethylamine (0.42 ml, 3.04 mmol)and a catalytic amount of DMAP in 15 ml THE was added a solution in CH2Cl2 (5 ml) of 1-(6-chloro-3-methyl-2-pyridyl)-5-methyl-pyrazole-4-carbonyl chloride (0.21 g, 0.76 mmol), prepared from thecorresponding acid (oxalyl chloride 5 eq., CH2Cl2, cat. DMF, 40C,5 h). The mixture was stirred at rtovernight. After evaporation of the solvents, the residue was taken up in ethyl acetate and washedwith a solution of sodium bicarbonate. After drying (MgSO4) and evaporating the organic phase, theresidue was purified by flash chromatography to give the title compound as white crystals. Mp: 190-4C, LCMS: 0.69 min, 343-5 (MH)., 16401-70-0

As the paragraph descriping shows that 16401-70-0 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; HALL, Roger Graham; EDMUNDS, Andrew; JEANGUENAT, Andre; WO2014/166795; (2014); A1;,
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51149-08-7, 3,6-Dichloropyridazine-4-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

51149-08-7, Preparation 36; 3,6-Dichloropyridazine-4-carboxyiic acid ((J?)-1 soprapyIpIperidm~3~ yhnethyl)amide To 3,6-dichloropyridazine-4-carboxylic acid (Ig, 5.2mmol) in DCE (20mL) at 0C was added oxalyl chloride (1.36mL, 15.6mmoi) and DMF (2 drops). After 0.5h the solvent was removed in vacuo. The residue in DCE (lOmL) was added to C-((i?)-l- isopropylpiperidin-3-yl)methylamine phthalazinedione salt (Preparation 5) (1.5g, 4.7inmol) and NEt3 (0.66mL, 4.7mmol) in DCE (lOmL). After 0,5h the mixture was filtered and the solvent removed from the filtrate in vacuo. The residue was added to an MP-TsOH column, washed with MeOH and then crude product eluted with 2M NH3 in MeOH and the solvent was removed in vacuo. The residue was purified on a Biotage Isoiera (KP:NH column, Hexane to 100% EtOAc) to give, after removal of the solvent in vacuo, the title compound: RT- 1.70min; m/z (ES+) = 331.0 [M + llf.

The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROSIDION LIMITED; BLOXHAM, Jason; BRADLEY, Stuart Edward; SAMBROOK-SMITH, Colin Peter; SMYTH, Donald; KEILY, John; DAWSON, Graham John; RASAMISON, Chrystelle Marie; BELL, James Charles; WO2011/117254; (2011); A1;,
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6082-66-2, 3,4,6-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6082-66-2, General procedure: To a stirred solution of substituted phenol (5 mmol) in dimethyl formamide (20 mL) was added 60% sodium hydride (5 mmol) under ice-water bath. After further stirring for 30 min, 3,4,6-trichloropyridazine (6, 5 mmol) was added and reacted at room temperature for 1-24 h. The reaction solution was poured into cold water, then the formed solid was filtered, washed with water and dried to give intermediate 7, which didn?t need any further purification. Intermediate 7 (5 mmol) with substituted aniline (5 mmol) and a few drops of 12 M hydrochloric acid was added and boiled with 50 ml ethanol for 12-48 h under reflux. The reaction solution was poured into cold water, then alkalized to pH 8 with 4 M NaOH solution. Then the solid was filtered, washed with water, dried and recrystallized from DMF/H2O to obtain pyridazine derivatives 8a-l. (0017) Pyridazine derivatives (2 mmol) was boiled with 10 mL acetic acid under reflux overnight. The reaction solution was poured into cold water, then alkalized to pH 8 with 4 M NaOH solution. Then the solid was filtered, washed with water, dried and recrystallized from DMF/H2O to obtain pyridazinone derivatives 9a-l. To a mixture of 9e (2 mmol) in DMF (10 mL) was added absolute potassium carbonate (4 mmol) followed by iodomethane (2 mmol). The solution was refluxed overnight, then poured into cold water, filtered, washed with water, dried and recrystallized from DMF/H2O to obtain 9m. To a mixture of 9e (2 mmol) in DMF (10 mL) was added absolute potassium carbonate (8 mmol) followed by iodomethane (4 mmol). The solution was refluxed overnight, then poured into cold water, filtered, washed with water, dried and recrystallized from DMF/H2O to obtain 9n.

The synthetic route of 6082-66-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Dongyue; Zhan, Peng; Liu, Huiqing; Pannecouque, Christophe; Balzarini, Jan; De Clercq, Erik; Liu, Xinyong; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 2128 – 2134;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

To a solution of 3,4,5-trichloropyridazine (880 mg, 4.80 mmol) in EtOH (10 mL) was slowly added a solution of Intermediate I-57 (2 g, 5.76 mmol) and DIPEA (2.5 mL, 14.40 mmol) in EtOH (10mL). The reaction mixture was refluxed for 6h and evaporated. The residue was dissolved in DCM and washed with water. The organic layer was dried, filtered and evaporated. The residue was purified by column chromatography (Biotage, DCM/MeOH 100:0 to 80:20) to yield Intermediate 1-58 (1.3 g, 55%) as yellow solid. It was used in later experiments without further purification.1H NMR (300 MHz, CDCI3) delta 8.67 (s, 1H), 7.36 – 7.16 (m, 15H), 3.84 (m, 4H), 3.64 (t, J = 5.4 Hz, 2H), 3.33 (t, J = 5.1 Hz, 2H).

14161-11-6, As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.

Reference£º
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; BLANCO-APARICIO, Carmen; RODRIGUEZ-ARISTEGUI, Sonsoles; GOMEZ DE LA OLIVA, Cristina Ana; HERNANDEZ HIGUERAS, Ana Isabel; GONZALEZ CANTALAPIEDRA, Esther; AJENJO DIEZ, Nuria; WO2013/5057; (2013); A1;,
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1114563-58-4, 6-Chloro-2,4-dimethylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1114563-58-4, Example 1 3-{(S)-1-[4-(1,5-Dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one 2 M aqueous Na2CO3 solution (0.31 mL) was added to a solution of (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-[(S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl]-1,3-oxazinan-2-one (0.15 g) and 6-chloro-2,4-dimethyl-2H-pyridazin-3-one (75 mg) in N,N-dimethylformamide (1 mL). The resulting mixture was sparged with argon for 10 min, before [1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(II) dichloromethane complex (15 mg) was added. The mixture was heated to 100 C. and stirred at this temperature overnight. After cooling to ambient temperature, water was added and the resulting mixture was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO4), and concentrated. The residue was purified by chromatography on silica gel (CH2Cl2/MeOH 98:2->80:20) to afford the title compound. Yield: 0.10 g (67% of theory); LC (method 1): tR=3.17 min; Mass spectrum (ES+): m/z=476 [M+H]+.

The synthetic route of 1114563-58-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VITAE PHARMACEUTICALS, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/108578; (2012); A1;,
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15456-86-7, 4-Bromo-1,2-dihydropyridazine-3,6-dione is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a degassed solution of 4-bromo-1,2-dihydropyridazine-3,6-dione (100 mg, 0.5 mmol), (4-fluoro-1H-indol-2-yl)boronic acid (131 mg, 0.7 mmol) and K3P04 (279 mg, 1.1 mmol) in DMF (2 mL) and H20 (0.2 mL) was added Pd(dppf)Cl2 (5 mg) under N2. The mixture was stirred at 80 C for 12 h. After the solvent was removed, the residue was purified by prepTLC (DCM : EtOAc = 10: 1) to give the product of 4-(4-fluoro-1H-indol-2-yl)-1,2-dihydropyridazine-3,6-dione (50 mg, yield: 39%). ?H-NMR (DMSO-d6, 400 MHz,) 11.95 (br.s, 1H), 7.47-7.68 (m, 3H), 7.35 (d, J= 8.0 Hz, 1H), 7.1 1-7.19 (m, 1H), 6.81 (dd, J= 8.0, 10.4Hz, 1H). MS (M+H): 246., 15456-86-7

The synthetic route of 15456-86-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; BROCKUNIER, Linda, L.; NARGUND, Ravi; MARCANTONIO, Karen; ZORN, Nicolas; XIAO, Dong; PENG, Xuanjia; LI, Peng; GUO, Tao; WO2014/123793; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-50-8,Methyl 6-chloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.

65202-50-8, Step 5; Methyl 6-(4-[2-(trifluoromethyl)benzoyl]piperazin-l-yUpyrida2ine-3-carboxylate; To a mixture of methyl -chloropyridazine-S-carboxylate (3.9 g, 22.6 mmol), l-[2- (trifluoromethyl)benzoyl]piperazine (7.0 g, 27.1 mmol) and potassium carbonate (6.5 g, 47 mmol) was added 100 mL of dioxane and the mixture was heated to reflux for 71 h. The mixture was cooled to room temperature and the solid filtered and swirled in 4: 1 ethepiethyl acetate at reflux for 45 min. The solid was filtered to provide the title compound.

The synthetic route of 65202-50-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/9236; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

PREPARATION 16; 3-Bromo-6-chloro-7-methylimidazo[1,2- )]pyridazine a) 6-Chloro-5-methylpyridazin-3-amine (+ 6-chloro-4-methylpyridazin-3-amine) Ammonia (32% solution in water, 54 mL) was added to a solution of 3,6-dichloro-4- methylpyridazine (5.0 g, 30.67 mmol) in ethanol (25 mL) in a sealed tube. The resulting mixture was stirred at 100 C for 70 hours, cooled down and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (3:2 hexanes/ethyl acetate to 100% ethyl acetate) to yield the title compound (3.8 g, 57%) as a mixture of two isomers which was used in the next step without further purification.LRMS (m/z): 144 (M+1)+.

19064-64-3, 19064-64-3 3,6-Dichloro-4-methylpyridazine 87923, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; ALMIRALL,S.A.; GONZALEZ RODRIGUEZ, Jacob; VIDAL JUAN, Bernat; VIDAL GISPERT, Laura; BACH TANA Jordi; WO2012/69202; (2012); A1;,
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