Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50901-46-7,1-(Pyridazin-4-yl)ethanone,as a common compound, the synthetic route is as follows.

To a solution of 1-pyridazin-4-ylethanone (0.3 g) in 1 ,4-dioxane (1.5 ml_) was added (0920) tert- butyl /V-aminocarbamate (0.327 g) and the reaction heated at 70C for 90 minutes. The reaction mixture was concentrated to give tert- butyl A/-[(E)-1-pyridazin-4-ylethylideneamino]carbamate which was used without further purification. (0921) NMR (400 MHz, CDCIs) 9.59 (dd, 1 H), 9.19 (dd, 1 H), 8.00 (s, 1 H), 7.77 (dd, 1 H), 2.21 (s, 3H), 1.57 (s, 9H), 50901-46-7

As the paragraph descriping shows that 50901-46-7 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; SCUTT, James, Nicholas; WILLETTS, Nigel, James; SONAWANE, Ravindra; PHADTE, Mangala; KANDUKURI, Sandeep, Reddy; SASMAL, Swarnendu; ARMSTRONG, Sarah; MCGRANAGHAN, Andrea; (155 pag.)WO2019/185875; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1837-55-4, 3,5-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[01040] Sodium methoxide (5.84 g, 0.108 mol) was added to a stirred solution of 3,5-dichloropyridazine (8 g, 0.054 mol) in 350 mL of THF at 0C. After the addition, the mixture was stirred at room temperature for 16 h. The mixture was quenched with water (100 mL), extracted with EA (300 mL X 2). The combined organic solvents were dried over anhydrous Na2S04, concentrated and purified by silica gel chromatography (0-40% EtO Ac/petroleum ether) which gave 1.5 g of 5-chloro-3-methoxypyridazine as yellow solid (17% yield). LCMS: m/z 145.1 [M+H]+; = 1.42 min., 1837-55-4

As the paragraph descriping shows that 1837-55-4 is playing an increasingly important role.

Reference£º
Patent; SKYHAWK THERAPEUTICS, INC.; LUZZIO, Michael; MCCARTHY, Kathleen; HANEY, William; (470 pag.)WO2019/28440; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66346-87-0,6-Chloro-5-methylpyridazin-3-amine,as a common compound, the synthetic route is as follows.

The reaction is performed underan argon-atmosphere. 6-Chloro-5-methylpyridazin-3-amine (3.00 g; 20.90 mmol), ie/f-butyl 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 ,2,3,6- tetrahydropyridine-1 -carboxylate (7.1 1 g; 22.98 mmol) and sodium carbonate (2 mol/L, aq. solution; 41 .79 mL; 83.58 mmol) in 1 ,4-dioxane (150 mL) is purged with argon. After 5 minutes Xphos 2nd Gen. (0.49 g; 0.63 mmol) is added and the mixture is stirred over night in a sealed vial at 100C. The reaction mixture is concentrated under reduced pressure. The residue is taken up in water and extracted several times with EtOAc. The combined organic layers are washed with brine, dried over Na2S04, filtered and concentrated under reduced pressure. The residue is purified by silica gel chromatography (DCM/MeOH). (1086) Yield: 5.20 g (86%) ESI-MS: m/z = 291 [M+H]+ Rt(HPLC): 0.79 min (method 10), 66346-87-0

The synthetic route of 66346-87-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; SMITH KEENAN, Lana Louise; LOWE, Michael D.; RAZAVI, Hossein; SARKO, Christopher Ronald; SURPRENANT, Simon; TAKAHASHI, Hidenori; TURNER, Michael Robert; WU, Xinyuan; (182 pag.)WO2019/81637; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

A solution of 3,4,5-trichloropyridazine (470 mg, 2.56 mmol) in ethanol (30 ml) was cooled to 0C and saturated with ammonia gas and stirred at room temperature for 4 days. The reaction mixture was then purged with nitrogen for 2 h, and filtered to remove ammonium chloride. The filter cake was washed with anhydrous ethanol, the filtrate and washes were used directly in the next step.MS (electrospray): m/z [M+H]+ = 164, 165, 166, 167, 168, 69 4- Pyridazinamine (D11)A solution of 3,5-dichloro-4-pyridazinamine and 5,6-dichloro-4-pyridazinamine (may be prepared as described in Description 0; 419.8 mg, 2.56 mmol), sodium hydroxide (246 mg, 6.14 mmol) and Pd/C (136 mg, 0.128 mmol) in ethanol (20 ml) was hydrogenated overnight. The reaction mixture was purged with nitrogen and filtered. The filtrate was concentrated to a residue and triturated with ethyl acetate. The mixture was filtered again to collect a solid which was dried to yield the title compound as a yellow solid. 98 mg.MS (electrospray): m/z [M+H]+ = 96

14161-11-6, As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele; WO2011/38572; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To ie/f-butyl 3-(4,4 5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1 ]-oct-2-ene-8- carboxylate (1 .93 g, 5.75 mmol) and 6-bromopyridazin-3-amine (1 .00 g, 5.75 mmol) in 1 ,4- dioxane (25 mL) is added 2M aq. Na2C03 solution (11 .5 mL, 23.0 mmol) and Xphos 2nd generation catalyst (136 mg, 0.17 mmol). The reaction mixture is degassed with argon and stirred at 100C for 2 h. All volatiles are evaporated under reduced pressure. The crude material is purified by normal phase chromatography to obtain the title compound. (0913) Yield: 0.80 g (46%) ESI-MS: m/z = 303 (M+H)+, 88497-27-2

The synthetic route of 88497-27-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; SMITH KEENAN, Lana Louise; LOWE, Michael D.; RAZAVI, Hossein; SARKO, Christopher Ronald; SURPRENANT, Simon; TAKAHASHI, Hidenori; TURNER, Michael Robert; WU, Xinyuan; (182 pag.)WO2019/81637; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-64-3, 3,6-Dichloro-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 3,6-Dichloro-4-methyl-pyridazine (3.0 g, 18.40 mmol) in Ammonia (28-30% ; 150 ml_) was heated at 130 C in a pressurised reaction vessel for 16 hrs. The reaction mixture was cooled to ambient temperature and extracted with dichloromethane (10 x 100 ml.) The organic layers were combined, dried (MgSO4), filtered and concentrated to give a mixture of the titled compounds (853 mg; 32%). LCMS: (Method A) RT = 0.45 min; m/z = 144 [M+H]+.1H NMR: (400 MHz, DMSO-d6) delta 2.07 (s, 3H), 2.18 (s, 3H), 6.47 (bs, 2H), 6.49 (bs, 2H), 6.74 (s, 1H), 7.31 (s, 1H).

19064-64-3, 19064-64-3 3,6-Dichloro-4-methylpyridazine 87923, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; VERNALIS (R&D) LTD.; WO2009/109743; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

932-22-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.

A mixture of 4,5-dichloropyridazinone (5.0 g, 30 mmol) and water (30 mL) was heated with bromine (1.9 mL, 36 mmol) at 180 0C for 30 min in a microwave oven. Upon cooling the mixture was diluted with water (50 mL) and the solid was collected by filtration and washed with water (10 mL) to give the title compound as an off- white solid (6.75 g) after drying.

As the paragraph descriping shows that 932-22-9 is playing an increasingly important role.

Reference£º
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2009/86041; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141-30-0,3,6-Dichloropyridazine,as a common compound, the synthetic route is as follows.

To a 1000 mL single-necked round bottom flask was added 3,6-dichloropyridazine (29.80 g, 200 mmol), hydrazine hydrate (15.00 g, 300 mmol), DMF and acetonitrile (280 ml of DMF). The reaction mixture was stirred at 90 C for 10 hours. TLC and GC were determined to complete the reaction. After the reaction, the solvent was removed by steaming, get the crude product, the pure product was isolated by silica gel column chromatography 3-chloro-6-hydrazinopyridazine, after drying, the calculated yield was 83.65%. Purity 98.69% (HPLC)., 141-30-0

The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong Youbang Biochemical Technology Co., Ltd.; Geng Xuanping; Lai Chao; Lai Ziteng; Lai Xinsheng; (4 pag.)CN106632069; (2017); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141-30-0,3,6-Dichloropyridazine,as a common compound, the synthetic route is as follows.

Synthesis of Compound J.1. A flask was charged with 3,6-dichloropyridazine (1.49 g, 0.01 mol, 1.0 equiv), silver nitrate (0.17 g, 0.001 mol, 0.1 equiv), water (30 mL), pivalic acid (3.57 g, 0.035 mol, 3.5 equiv), and sulfuric acid (1.6 mL, 0.03 mol, 3.0 equiv). The mixture was heated to 70 C. and a solution of ammonium persulfate (2.28 g, 0.01 mol, 1.0 equiv) in water (10 mL) was added dropwise over ten minutes. The reaction was stirred at 70 C. for one hour and then cooled to RT. The reaction mixture was poured into ice water and then adjusted to pH 8 with aqueous ammonium hydroxide. The aqueous mixture was extracted with CH2Cl2 (2¡Á250 mL). The combined organic extracts were filtered through a cotton plug, washed with aqueous 1 N NaOH (70 mL), dried over anhydrous MgSO4 and concentrated under reduced pressure. Purification by flash column chromatography (20% EtOAc/hexanes) afforded the title compound (1.32 g, 64%) as a white solid. 1H NMR: (CDCl3, 400 MHz) delta: 7.5 (s, 1H), 1.5 (s, 9H); Rf=0.5 (80% EtOAc/hexanes)., 141-30-0

As the paragraph descriping shows that 141-30-0 is playing an increasingly important role.

Reference£º
Patent; Sunesis Pharmaceuticals, Inc; US2009/5359; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a microwave vial were mixed: 1,1-dimethylethyl 1-piperazinecarboxylate (135 mg, 0.725 mmol, available from Fluke), 3,6-dichloropyridazine (90 mg, 0.604 mmol, available from Alfa Aesar) and DIPEA (0.137 mL, 0.785 mmol) in Tert-Butanol (2 mL). The reaction was stirred and heated in an Emrys Optimizer microwave at 100 C. for 20 mins then for 30 mins at 150 C. The reaction mixture was partitioned between EtOAc (20 mL) and water (20 mL) and the organic layer washed with brine (20 mL) before being dried through an hydrophobic frit and concentrated. The residue was dissolved in DCM and purified by SP4 on a 12+M silica cartridge using a gradient of 10-50% EtOAc in cyclohexane. The appropriate fractions were collected and concentrated to yield the desired product as a white solid, 1,1-dimethylethyl 4-(6-chloro-3-pyridazinyl)-1-piperazinecarboxylate (114.2 mg). LCMS (Method C): Rt=0.85, MH+=299

141-30-0, 141-30-0 3,6-Dichloropyridazine 67331, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Demont, Emmanuel Hubert; Garton, Neil Stuart; Gosmini, Romain Luc Marie; Hayhow, Thomas George Christopher; Seal, Jonathan; Wilson, David Matthew; Woodrow, Michael David; US2012/208798; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem