Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

A mixture of 3,4,5-trichloropyridazine (0.250 g, 1.363 mmol), (2,3-dihydro-1H-inden-2-yl)methanamine hydrochloride (0.250 g, 1.363 mmol), and potassiumcarbonate (0.396 g, 2.86 mmol) in dioxane (10 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (2.469 ml, 27.3 mmol) was added. The mixture was heated to reflux for 16 h overnight. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water, dried over5 magnesium sulfate, and concentrated to give 5-chloro-N-((2,3-dihydro-1H-inden-2- yl)methyl)-6-hydrazinylpyridazin-4-amine. LCMS: Rt = 1.85 mi (M+H7 = 290.1. The material was used without purification.

14161-11-6, As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

144294-43-9, 3-Amino-5-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0388-1 A mixture of 6-chloro-N-(pyrimidin-5-yl)-1,5-naphthyridine-3-amine (10 mg), 5-methylpyridazine-3-amine (6.4 mg), tris(dibenzylideneacetone)dipalladium(0) (3.5 mg), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (4.5 mg), cesium carbonate (25 mg), and 1,4-dioxane (1 mL) was stirred at 140 C. for 30 minutes using a microwave reaction apparatus. The reaction mixture was cooled to room temperature, and the solid matter was collected by filtration, thereby obtaining N2-(5-methylpyridazin-3-yl)-N7-(pyrimidin-5-yl)-1,5-naphthyridine-2,7-diamine (1.6 mg). 1H-NMR(CDCl3/CD3OD=4/1) delta: 8.81 (1H, s), 8.75 (2H, s), 8.73 (1H, brs), 8.64 (1H, brs), 8.51 (1H, d, J=2.4 Hz), 8.12 (1H, d, J=9.0 Hz), 7.83 (1H, d, J=2.4 Hz), 7.36 (1H, d, J=9.0 Hz), 2.45 (3H, s). MS m/z (M+H): 331.

144294-43-9, The synthetic route of 144294-43-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FUJIFILM Corporation; FURUYAMA, Hidetomo; KURIHARA, Hideki; TERAO, Takahiro; NAKAGAWA, Daisuke; TANABE, Shintaro; KATO, Takayuki; YAMAMOTO, Masahiko; SEKINE, Shinichiro; MASHIKO, Tomoyuki; INUKI, Shinsuke; UEDA, Satoshi; US2015/322063; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1120-95-2,3-Chloropyridazine,as a common compound, the synthetic route is as follows.

Example 4-5 (Trans)-8-({[6-(3,5-dimethylphenyl)-3-pyridazinyl]amino}methyl)-3-(3-pyridazinyl)-1-oxa-3-azaspiro[4.5]decan-2-one dihydrochloride (Trans)-8-({[6-(3,5-dimethylphenyl)-3-pyridazinyl]amino}methyl)-1-oxa-3-azaspiro[4.5]decan-2-one (Intermediate 46, 20 mg, 0.055 mmol), trans-1,2-diaminocyclohexane (0.013 ml, 0.109 mmol), 3-chloropyridazine (prepared according to WO/0107416, 12.50 mg, 0.109 mmol), K3PO4 (34.8 mg, 0.164 mmol), copper(I) iodide (10.39 mg, 0.055 mmol) were suspended in 1,4-dioxane (4 ml) and shaken at 120 C. in a closed vial overnight. The resulting dark mixture was concentrated under vacuum, taken up with DCM (20 ml) and filtered over a separation tube. The organic solution was concentrated and purified with Biotage SP1 over a 12S NH2 Varian cartridge, eluding with a gradient of cyclohexane and EtOAc. (Trans)-8-({[6-(3,5-dimethylphenyl)-3-pyridazinyl]amino}methyl)-3-(3-pyridazinyl)-1-oxa-3-azaspiro[4.5]decan-2-one was eluted with ca 70% EtOAc and recovered as a colourless oil (12 mg, 0.027 mmol, 49%). 1H NMR (400 MHz, CDCl3): delta 8.97 (dd, 1H), 8.58 (dd, 1H), 7.63-7.61 (m, 3H), 7.50 (dd, 1H), 7.07 (br s, 1H), 6.73 (d, 1H), 4.86 (br t, 1H), 4.23 (s, 2H), 3.46 (t, 2H), 2.41 (s, 6H), 2.12-1.07 (m, 9H); HPLC-MS: 1.69 min, 445 [M+H]+., 1120-95-2

As the paragraph descriping shows that 1120-95-2 is playing an increasingly important role.

Reference£º
Patent; Biagetti, Matteo; Contini, Stefania Anna; Genski, Thorsten; Guery, Sebastien; Leslie, Colin Philip; Mazzali, Angelica; Pizzi, Domenica Antonia; Sabbatini, Fabio Maria; Seri, Catia; US2009/203705; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.

5-Chloro–N2- (1,5- dimethyl -1H- pyrazol-3-yl) -N4- (3- ethyl-piperidin-4-yl) pyrimidine-2,4-diamine (0.12g , 0.34mmol) was suspended (10.OmL) at EtOH, to which was added 6-chloro-pyridazin-3-carbonitrile (96mg, 0.69mmol) and triethylamine (0.15mL, 1.10mmol). The reaction system was stirred at 40 overnight, then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (MeOH solution of DCM / 3M NH3 in the (v / v) = 100/1 to 75/1 to 50/1) to give the title compound as a yellow solid (45mg, yield 29% ).

35857-89-7, The synthetic route of 35857-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (105 pag.)CN105461694; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1837-55-4, 3,5-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In analogy to the preparation of the intermediate 8-1 (step 1) from tert-butyl N- [(lR,5S,8S)-3-azabicyclo[3.2.1]octan-8-yl]carbamate (2.00 g, 8.84 mmol) and 3,5- dichloropyridazine (2.0 g, 13.4 mmol) in a sealed tube at 90 C using EtOH as solvent in the presence of Et3N (3.63 g, 5.0 mL, 35.9 mmol), tert-butyl N-[(lR,5S,8S)-3-(6-chloropyridazin-4- yl)-3-azabicyclo[3.2.1]octan-8-yl]carbamate (1.71 g, 54%) was obtained as a white solid. MS (ES+) m/z: 339.2 [(M+H)+]., 1837-55-4

As the paragraph descriping shows that 1837-55-4 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; JAKOB-ROETNE, Roland; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; SARIE, Jerome Charles; VASTAKAITE, Greta; (61 pag.)WO2018/83050; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

51149-08-7, 2,5-Dichloro-pyridizine-3-carboxylate (0.40 g, 2.07 mmol) in toluene (8 ML) was reacted with triethylamine (0.72 ML, 5.20 mmol) and benzyl amine (0.23 ML, 2.07 mmol) at 90 C. for 8 hours.The solution was partitioned between water and ethyl acetate.The organic layer was dried over sodium sulfate, filtered, and concentrated to yield the title compound (0.257 g, 47%). MS (DCI/NH3) m/z 264 (M+H+)+.

The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pratt, John K.; Betebenner, David A.; Donner, Pemela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong; US2004/87577; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

70952-62-4, 3,6-Dichloro-4-methoxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a mixed solvent of 1,4-dioxane (2.5 mL) and dimethylsulfoxide (2.5 mL) was dissolved 190 mg (1.16 mmol) of 2-cyclopropyl-3-methoxyphenol, 146 mg (1.30 mmol) of potassium tert-butoxide was added to the solution and the resulting mixture was stirred for 10 minutes. To the mixture was added 170 mg (0.950 mmol) of 3,6-dichloro-4-methoxypyridazine and the resulting mixture was stirred overnight. The reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layers were combined, washed successively with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed, and the obtained residue was purified by silica gel chromatography (Wakogel C-100, hexane-ethyl acetate, gradient) to obtain 90.1 mg (0.293 mmol, Yield: 30.8%) of 6-chloro-3-(2-cycloprcpyl-3-methoxyphenoxy)-4-methoxypyridazine and 114 mg (0.371 mmol, Yield: 39.1%) of 3-chloro-6-(2-cyclopropyl-3-methoxyphenoxy)-4-methoxypyridazine., 70952-62-4

As the paragraph descriping shows that 70952-62-4 is playing an increasingly important role.

Reference£º
Patent; Sankyo Agro Company, Limited; EP1426365; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932-22-9,4,5-Dichloro-3(2H)-pyridazinone,as a common compound, the synthetic route is as follows.

932-22-9, 4.5- dichloro-2-methyl-pyridazin-3-one To a stirred solution of 4,5-dichloro-lH-pyridazin-6-one (25.0 g, 152 mmol) in N,N-dimethylformamide (152 ml) was added potassium carbonate (25.4 g, 182 mmol) and iodomethane (25.8 g, 182 mmol, 11.3 ml). The resulting mixture was stirred at room temperature overnight. The reaction mixture was then poured onto ice-water (300ml) and the mixture stirred for 15 mins. The resulting precipitate was collected by filtration, then dissolved in dichloromethane and passed through a phase separation cartridge. The organics were concentrated in vacuo to give 19.7 g of a pale brown solid. 1H NMR (400 MHz, Chloroform) d ppm 3.83 (s, 3 H) 7.77 (s, 1 H)

As the paragraph descriping shows that 932-22-9 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA LIMITED; BHONOAH, Yunas; ELLIOTT, Alison Clare; GAULIER, Steven; LING, Kenneth; MITCHELL, Glynn; MORRIS, James Alan; RZEPA, Paula Rocha; VINER, Russell Colin; WO2013/50421; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1211587-01-7,5-Chloropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.

The carboxylic acid (243 mg, 1.53 mmol) was dissolved in ~15 mL of ethanol and treated with 24 mg (0.2 mmol) of dimethylaminopyridine (DMAP) followed by 324 mg (1.69 mmol) 1-(3-dimethylaminopropyl-3-ethylcarbodiimide hydrochloride (EDCl). The reaction was stirred at ambient temperature for 4 hours and then worked up by the procedure described in Example 166A. The crude product was purified by flash chromatography on silica gel to give 150 mg (52%) of the title compound as a white crystalline solid. 1 H NMR (CDCl3, 300 MHz) delta 1.45 (t, 3H), 4.55 (q, 2H), 7.65 (d, 1H), 8.15 (d, 1H). MS (DCl/NH3) m/e 187/189 (M+H)+, 204/206 (M+H+NH3)+., 1211587-01-7

1211587-01-7 5-Chloropyridazine-3-carboxylic acid 19792063, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Abbott Laboratories; US5250548; (1993); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.

5-chloro -N2- (1,3- dimethyl -1H- pyrazol-4-yl) -N4- (3- ethyl-piperidin-4-yl) – pyrimidine-2,4-diamine ( 202.7mg, 0.58mmol) in EtOH (10mL) was added 6-chloro-pyridine-3-carbonitrile (162.3mg, 1.17mmol) and triethylamine (0.35mL, 2.5mmol) in solution. IncomeThe mixture was warmed to reflux and stirred overnight, then concentrated under reduced pressure. MeOH solution was purified by preparative thin layer chromatography, the residue of ammonia (3M in / DCM(V / v) = 1/20) to give the title compound as a white solid (91.9mg, 35.1% yield)., 35857-89-7

35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (105 pag.)CN105461694; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem