Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-64-3,3,6-Dichloro-4-methylpyridazine,as a common compound, the synthetic route is as follows.

To a suspension of 10 g (61 .4 mmol) 3,6-dichloro-4-methylpyridazine in 33 mL ethanol were added 33.3 mL (6750 mmol) of an aqueous ammonia solution (26% v/v). The mixture was heated in an autoclave (Berghof RHS175) to 120′ C/20 bar over night. After cooling to room temperature, the solvent was evaporated to give 12 g of a crude material which was used directly in step 2.

19064-64-3, The synthetic route of 19064-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER INTELLECTUAL PROPERTY GMBH; KNUT, Eis; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark; BOeMER, Ulf; GUeNTHER, Judith; FANGHAeNEL, Joerg; KORR, Daniel; WO2012/163942; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

63910-43-0, 4-Chloro-5-methoxypyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63910-43-0, Synthesis of 4-chloro-2-(2-chlorobenzylV5-methoxypyridazin-3(2HVone (11) 10 1 1 To a solution of compound 10 (1 g, 6,25 mmol), compound 2 (1,5 g, 7.50 mmol) and K2C03 (1.7 g, 12.5 mrnol) in DMF (15 mL) was added KI (104 mg, 0.63 mmol). The solution was stirred at 90 C for 2h. The mixture was cooled to room temperature and quenched with water, extracted with EtOAc for 3 times, combined the organic layer, washed with brine, dried over Na2S04, filtered, concentrated under reduced pressure, purified by column chromatography [eluting with PE to PE/EtOAc (4: 1)] to give compound 1 1 (700 mg, 44%) as a white solid.

As the paragraph descriping shows that 63910-43-0 is playing an increasingly important role.

Reference£º
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; BECKWITH, Jonathan Roger; DUTTON, Rachel; ESER, Markus; LANDETA, Cristina; BLAZYK, Jessica L.; MEEHAN, Brian M.; HATAHET, Feras; BOYD, Dana; WO2015/143164; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

6082-66-2, 3,4,6-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6082-66-2

(a) 4-Bromo-2-{[4-(methyloxy)phenyl]methyl}-6-({[4-(methyloxy)phenyl]methyl}oxy)-3(2/-/)-pyridazinone and 5-bromo-2-{[4-(methyloxy)pheny|]methyl}-6-({[4-(methyloxy)pheny|]methyl}oxy)-3(2H)- pyridazinone; A solution of 4-methoxybenzyl alcohol (6.2ml, 50 mmol) in dry ether (120ml) was treated dropwise with phosphorus tribromide (2.07ml, 22 mmol). The mixture was heated under reflux for 1 hour, cooled, washed twice with water, dried and the solvent was evaporated. The 4-methoxybenzyl bromide thus produced was added to a mixture of 4-bromo-1 ,2-dihydro-3,6-pyridazinedione (for a synthesis, see Example 3(a) above) (4g, 21 mmol) and potassium carbonate (8.28g, 60 mmol) in dry DMF (60ml) and stirred overnight at RT. The mixture was diluted with ethyl acetate, washed 3 times with water, dried over magnesium sulfate and evaporated to low volume. Some solid was filtered off and washed with ethyl acetate. The filtrate was evaporated to dryness and the residue chromatographed on silica, eluting with 20% ethyl acetate/hexane and then 100% ethyl acetate.. This gave the less polar of the two desired products (3.233g), the more polar of the two desired products (1.626g) and a mixture of these (1.351g). Total yield 6.3Og, 70%.Less polar product MS (+ve ion electrospray) m/z 431 and 433 (MH+, 15%), 121 (100%). More polar product MS (+ve ion electrospray) m/z 431 and 433 (MH+, 15%), 121 (100%).

As the paragraph descriping shows that 6082-66-2 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/115947; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65202-50-8

Example 87 [0264] Formula 88] [0265] 1) In tetrahydrofuran (100 mL) was dissolved methyl 6-chloropyridazin-3-carboxylate (1.726 g), the solution was cooled to 0¡ãC, 1M diisobutyaluminum hydride-tetrahydro- furan solution (20 mL) was added dropwise to the solution, and the mixture was stirred at the same temperature for 20 minutes. To the reaction mixture were successively added water (10 mL) and IN hydrochloric acid (20 mL) at 0¡ãC. After adding a saturated aqueous sodium bicarbonate solution to the mixture at room temperature, the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the residue obtained by concentrating the extract under reduced pressure was purified by silica gel column chromatography (n-hexane: ethyl acetate=90: 10 to 25:75) to obtain (6-chloropyridazin-3-yl)methanol (177 mg).MS (m/z): 147/145 [M+H]+

As the paragraph descriping shows that 65202-50-8 is playing an increasingly important role.

Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; SAKURAI, Osamu; SARUTA, Kunio; HAYASHI, Norimitsu; GOI, Takashi; MOROKUMA, Kenji; TSUJISHIMA, Hidekazu; SAWAMOTO, Hiroaki; SHITAMA, Hiroaki; IMASHIRO, Ritsuo; WO2012/81736; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-67-6,6-Chloro-3-hydroxypyridazine,as a common compound, the synthetic route is as follows.

To a 1000-mL round-bottom flask purged and maintained with an inert atmosphere of nitrogen was placed a solution of 6-chloro-2,3- dihydropyridazin-3-one (5 g, 38.30 mmol) and (3-methoxyphenyl)boronic acid (7.6 g, 50.01 mmol) in dioxane (300 mL)/water (15 mL) then Pd(dppf)Cl2 (1.41 g) and K2C03 (15.9 g, 115.04 mmol) were added. The reaction was stirred at 110C for 15 h, quenched by the addition of 100 mL of water, and extracted with EtOAc (3×150 mL). The organic extracts were combined, washed with brine (3×200 mL), dried over anhydrous Na2S04, and concentrated under reduced pressure. The residue was purified by column chromatography eluting with EtO Ac/petroleum ether (9: 1) affording 5.6 g (72%) of the title compound as a white solid. Mass Spectrum (LCMS, ESI pos): Calcd. for CnHnN202+: 203.1 (M+H); Found: 203.1., 19064-67-6

As the paragraph descriping shows that 19064-67-6 is playing an increasingly important role.

Reference£º
Patent; PROTEOSTASIS THERAPEUTICS, INC.; PARKS, Daniel; MUNOZ, Benito; (66 pag.)WO2018/81378; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 30 6-(5-((5-chloro-2-((l -methyl- lH-pyrazol-4-yl)amino)pyrimidin-4-yl)amino) hexahvdrocvclopentarc1pyrrol-2(lH)-yl)pyridazine-3-carbonitrile [0458] To a solution of 5-chloro-N2-(l -methyl- lH-pyrazol^-y -N4- (octahydrocyclopenta[c]pyrrol-5-yl)pyrimidine-2,4-diamine (85.8 mg, 0.26 mmol) and Et3N (80.4 mg, 0.80 mmol) in EtOH (10 mL) was added 6-chloropyridazine-3-carbonitrile (72.8 mg, 0.52 mmol). The reaction mixture was stirred at rt overnight, quenched with water (30 mL), and extracted with DCM (100 mL chi 3). The combined organic phases were washed with brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v) = 1/50) to give the title compound as a beige solid (109.6 mg, yield 97.6%). LC-MS (ESI, pos. ion) m/z: 437.4 [M+H]+; NMR (600 MHz, OMSO-d6) delta (ppm): 9.03 (s, 1H), 7.85 (m, 2H), 7.75 (s, 1H), 7.45 (s, 1H), 7.02 (d, J = 9.6 Hz, 1H), 6.93 (d, J = 7.8 Hz, 1H), 4.59 (m, 1H), 3.79 (s, 3H), 3.72 (m, 4H), 2.84 (s, 2H), 2.33 (m, 2H), 1.62 (m, 2H); 13C NMR (150 MHz, CDCb) delta (ppm): 158.2, 157.5, 131.1, 130.1, 128.2, 124.2, 118.2, 111.8, 72.7, 60.7, 52.9, 40.8, 39.1, 37.6., 35857-89-7

35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; LI, Xiaobo; CHEN, Wuhong; ZHANG, Tao; HU, Haiyang; DAI, Weilong; WU, Yanjun; (192 pag.)WO2017/44434; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

88497-27-2,88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference example 197 4- ( (4-Chlorobenzyl) oxy) -1- ( 2-cyclopropyl-3-methylimidazo [1, 2- b] pyridazin-6-yl ) pyridin-2 ( 1H) -one A) 6-Bromo-2-cyclopropyl-3-methylimidazo [1, 2-b] pyridazine To a solution of 6-bromopyridazin-3-amine (1.0 g) in DMA (10 ml) were added 2-bromo-l-cyclopropylpropan-l-one (2.04 g) and NaHCC>3 (0.966 g) at room temperature, and the mixture was stirred at 80C for 16 h. The mixture was partitioned between EtOAc and water, and the organic layer was washed with brine, dried over MgS04, concentrated – in vacuo, and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (1.10 g) as yellow crystals. MS (ESI+) : [M+H]+ 252.0.

88497-27-2 3-Amino-6-bromopyridazine 2794779, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; MAEKAWA, Tsuyoshi; KAKEGAWA, Keiko; YASUMA, Tsuneo; KINA, Asato; AIDA, Jumpei; KHAMRAI, Uttam; KUNDU, Mrinalkanti; WO2013/105676; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

932-22-9, 4,5-Dichloro-3(2H)-pyridazinone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,932-22-9

4.5- dichloro-2-methyl-pyridazin-3-one To a stirred solution of 4,5-dichloro-lH-pyridazin-6-one (25.0 g, 152 mmol) in N,N-dimethylformamide (152 ml) was added potassium carbonate (25.4 g, 182 mmol) and iodomethane (25.8 g, 182 mmol, 11.3 ml). The resulting mixture was stirred at room temperature overnight. The reaction mixture was then poured onto ice-water (300ml) and the mixture stirred for 15 mins. The resulting precipitate was collected by filtration, then dissolved in dichloromethane and passed through a phase separation cartridge. The organics were concentrated in vacuo to give 19.7 g of a pale brown solid. 1H NMR (400 MHz, Chloroform) d ppm 3.83 (s, 3 H) 7.77 (s, 1 H)

932-22-9 4,5-Dichloro-3(2H)-pyridazinone 73247, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SYNGENTA LIMITED; BHONOAH, Yunas; ELLIOTT, Alison Clare; GAULIER, Steven; LING, Kenneth; MITCHELL, Glynn; MORRIS, James Alan; RZEPA, Paula Rocha; VINER, Russell Colin; WO2013/50421; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

51355-94-3, 6-Bromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 250-mL round-bottom flask was placed a solution of 2- chloro-N-[4-(trifluoromethyl)phenyl]propanamide (3 g, 11.92 mmol, as prepared in Example 1, step A) in acetone (120 mL) then K2CO3 (4.93 g, 35.67 mmol) and 6-bromo-2,3-dihydropyridazin-3-one (2.48 g, 14.17 mmol) were added. The reaction was heated to reflux for 16 h then the solids were filtered out and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography eluting with EtOAc/petroleum ether (1:20 up to 1: 1) affording 3.8 g (82%) of the title compound as a white solid. Mass Spectrum (LCMS, ESI pos): Calcd. for Ci4Hi2BrF3N302+: 390.0 (M+H); Found: 390.0., 51355-94-3

The synthetic route of 51355-94-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROTEOSTASIS THERAPEUTICS, INC.; PARKS, Daniel; MUNOZ, Benito; (66 pag.)WO2018/81378; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50901-46-7,1-(Pyridazin-4-yl)ethanone,as a common compound, the synthetic route is as follows.

To a mixture of ethyl 2,2,2-trifluoroacetate (0.256 g) and sodium methoxide (25% by wt in methanol, 0.449 mL) in tert- butyl methyl ether (0.409 mL) was added a suspension of 1-pyridazin-4-ylethanone (0.200 g) in tert- butyl methyl ether (2.87 mL) at room temperature and the mixture stirred at room temperature overnight. The reaction mixture was adjusted to pH 4 with 10% aqueous citric acid solution, diluted with water and extracted with dichloromethane (x3). Both liquid phases were concentrated, combined, then purified by preparative reverse phase HPLC to afford 4,4,4-trifluoro-1- pyridazin-4-yl-butane-1 ,3-dione as a brown gum. The product was a 2: 1 mixture of the enofketo tautomers. (0765) 1 H NMR (400MHz, CDsCN) (0766) peaks for keto tautomer 9.57 (s, 1 H) 9.51-9.43 (m, 1 H) 8.04-7.98 (m, 1 H) 3.52 (s, 2H) (0767) peaks for enol tautomer (shown below) 9.64 (s, 1 H) 9.5-9.44 (m, 1 H) 8.10-8.04 (m, 1 H) 6.96 (s, 1 H)

50901-46-7, 50901-46-7 1-(Pyridazin-4-yl)ethanone 14452005, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; SCUTT, James, Nicholas; WILLETTS, Nigel, James; SONAWANE, Ravindra; PHADTE, Mangala; KANDUKURI, Sandeep, Reddy; SASMAL, Swarnendu; ARMSTRONG, Sarah; MCGRANAGHAN, Andrea; (155 pag.)WO2019/185875; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem