Tag: M.W:100-200

51149-08-7, 3,6-Dichloropyridazine-4-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 3,6-dichloropyridazine-4-carboxylic acid (5.5 g, 28.5 mmol) in DCM (50.0 ml) and MeOH (10 ml) was added trimethylsilyldiazomethane (2 M in hexane, 15 ml, 30.0 mmol) slowly at 0 C. It became a clear solution after the addition. It was stirred for 30 min and was added another 15 mL of trimethylsilyldiazomethane and stirred for 30 min. It was quenched with (0170) 2 mL of acetic acid, concentrated and purified by ISCO (80g, 0-40% ethyl acetate in hexane) to give the title compound. MS (ESI): m/z 206 (M+H) +, 51149-08-7

51149-08-7 3,6-Dichloropyridazine-4-carboxylic acid 433804, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; BURGEY, Christopher, S.; FRITZEN, Jeffrey, F.; BALSELLS, Jaume; PATEL, Mehul; (59 pag.)WO2015/153304; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

19064-64-3, 3,6-Dichloro-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of compound 3,6-dichloro-4-methylpyridazine (20.0 g, 122.7 mmol) and ammonium hydroxide in water (86.60 g, 245 mmol) was refluxed for about 30 h. The mixture was concentrated and used in the next step without purification, 19064-64-3

The synthetic route of 19064-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1120-95-2,3-Chloropyridazine,as a common compound, the synthetic route is as follows.

Preparation of tert-butyl 4-(pyridazin-3-yloxy)piperidine-l-carboxylate. To a solution of tert-butyl 4-hydroxy-4-methylpiperidine-l-carboxylate (140 mg, 0.696 mmol) in DMF (2.3 mL) was added sodium hydride (60% w/w, 56 mg, 1.39 mmol). The reaction was stirred for 10 min at ambient temperature. Then 3-chloropyridazine (159 mg, 1.39 mmol) was added and reaction stirred 3 h at 95C. The reaction was cooled to ambient temperature and diluted with water and extracted with EtOAc. Combined organics were washed with saturated NaHC03(aq), water, and brine. The combined organic extracts were dried over anhydrous Na2S04(S), filtered and concentrated in vacuo to afford the title compound (assumed quantative yield, 194 mg) in sufficient purity for step 2. MS (apci) m/z = 280.2 (M+H)., 1120-95-2

The synthetic route of 1120-95-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

120276-59-7, 3-Chloro-6-(chloromethyl)pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of (6-(4-hydroxy-2-oxopyridin-l(2H)-yl)-7,8-dihydronaphthalen-2-yl)methyl acetate (2 g, 6.42 mmol), 3-chloro-6-(chloromethyl)pyridazine (1.047 g, 6.42 mmol) and potassium carbonate (0.888 g, 6.42 mmol) in Nu,Nu-dimethylformamide (DMF) (40 mL) was heated to 80 C for 6 hr, then the mixture was filtered and concentrated to give the residue which was purified by a flash column to give (6-(4-((6-chloropyridazin-3-yl) methoxy)-2- oxopyridin- l(2H)-yl)-7,8-dihydronaphthalen-2-yl)methyl acetate (2.4 g, 4.93 mmol, 77% yield): 1H NMR (400 MHz, CDC13) delta ppm 7.65 (d, J = 8.8 Hz, 1H), 7.58 (d, J = 8.8 Hz, 1H), 7.25-7.23 (m, 1H), 7.17-7.16 (m, 2H), 7.06 (dd, J = 4.8, 3.2 Hz, 1H), 6.45 (s, 1H), 6.04-5.98 (m, 2H), 5.37 (s, 2H), 5.06 (s, 2H),3.04 (t, J = 8.4 Hz, 2H), 2.73 (t, J = 8.4 Hz, 2H), 2.1 1 (s, 3H); ES-LCMS m/z 438 ( +H)+.

120276-59-7, 120276-59-7 3-Chloro-6-(chloromethyl)pyridazine 22498639, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, IV, Siegfried Benjamin; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing; LIN, Xiaojuan; XU, Shanli; LV, Maoyun; YAO, Chen; LI, Lei; HUANG, Xing; GAO, Min; WO2013/166621; (2013); A1;,
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Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-50-8,Methyl 6-chloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.,65202-50-8

:p 3: Methyl 6-(3- { [2-(trifluoromethyl)benzylloxyl azetidin- 1 -yl)pyridazine-3- carboxylate; A suspension of 3-{[2-(trifluoromethyl)benzyl]oxy}azetidine (595 mg, 2.58 mmol), methyl beta-chloropyridazine-S-carboxylate (450 mg, 2.58 mmol), potassium carbonate (715 mg, 5.15 mmol) and tetrabutylammonium iodide (20 mg, 0.052 mmol) in dioxane (10 mL) was heated to 95 ¡ãC for 16 h. The cooled reaction mixture was poured into a 125 mL separatory funnel containing water (50 mL) and extracted with ethyl acetate (3 x 30 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated. Purification by column chromatography through silica gel gave the title compound.1H NMR (J6-acetone, 400 MHz) delta 7.86-7.80 (2H, m), 7.75-7.51 (3H, m), 6.79 (IH, d, J= 9.5 Hz), 4.78-4.76 (3H, m), 4.49 (2H, dd, J= 10.0, 6.5 Hz), 4.15 (2H, dd, J= 10.0, 4.0 Hz), 3.88 (3H, s).MS (ESI, Q+) m/z 368 (M+ 1).

As the paragraph descriping shows that 65202-50-8 is playing an increasingly important role.

Reference£º
Patent; MERCK FROSST CANADA LTD.; WO2007/143823; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

88491-61-6,88491-61-6, 3-Bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Zinc powder (0.12 g, 1.8 mmol) was added to a dry flask purged with nitrogen. Dry DMF (1.0 ml) was added followed by iodine (43 mg, 0.2 mmol). The solution changed from colourless to yellow and then back to colourless. Methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3- lodopropanoate (0.20 g, 0.60 mmol) was added, followed by iodine (43 mg, 0.2 mmol). The solution was stirred at ambient temperature, with an exotherm observed. To this solution was added Pd2(dba)3(28 mg, 0.04 mmol), SPhos (25 mg, 0.12 mmol) and 3-bromopyridazine (0.25 g, 1.6 mmol). The RM was stirred at rt under nitrogen for 18 h. The RM was filtered twice and purified by FCC (silica, EtOAc / hexane) to give the desired product.Y = 43 % MS ES+: 282

As the paragraph descriping shows that 88491-61-6 is playing an increasingly important role.

Reference£º
Patent; NODTHERA LIMITED; HARRISON, David; WATT, Alan Paul; BOUTARD, Nicolas; FABRITIUS, Charles-Henry; GALEZOWSKI, Michal; KOWALCZYK, Piotr; LEVENETS, Oleksandr; WOYCIECHOWSKI, Jakub; (161 pag.)WO2018/167468; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred suspension of 2,2-dimethylpropanoic acid (0.288 g, 2.82 mmol) and 3,6-dichloropyridazine (0.299 g, 2 mmol) in water (3 ml_) at 55C was added AgN03 (0.068 g, 0.4 mmol) as a solution in water (0.3 ml_) followed by TFA (0.046 g, 0.4 mmol). (NH4)2S208 (0.778 g, 3.19 mmol) was added dropwise as a solution in water (1.5 ml_). The reaction mixture was then heated to 75C for 1 h. Upon cooling the reaction mixture was poured into NaHC03 solution (15 ml_) and extracted with CH2CI2 (15 ml) twice. The combined organic fractions were dried over MgS04, filtered and the solvent removed by evaporation in vacuo. Purification by silica gel column chromatography, 3:1 CH2CI2/hexane elution, yielded intermediate 1 (0.33 g, 80%). LCMS (ESI): Found 205.0 [M+Hf.

141-30-0, 141-30-0 3,6-Dichloropyridazine 67331, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; KARUS THERAPEUTICS LIMITED; SHUTTLEWORTH, Stephen Joseph; GATLAND, Alice Elizabeth; FINNEMORE, Daniel John; ALEXANDER, Rikki Peter; SILVA, Franck; CECIL, Alexander; (233 pag.)WO2019/166824; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6082-66-2,3,4,6-Trichloropyridazine,as a common compound, the synthetic route is as follows.

6082-66-2, Example 24A 3,6-dichloropyridazin-4-amine 3,4,6-Trichloropyridazine (25 g, 136 mmol) was added to 14. 8 N ammonium hydroxide (200 mL) in a 500 mL stainless steel pressure bottle. The mixture was stirred for 16 hours at 75 C. The mixture was cooled to ambient temperature, and 17 g (76%) of the title compound was collected by filtration as a solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 7.16 (s, 2H), 6.82 (s, 1H); MS (ESI+) m/z 164 (M+H)+.

6082-66-2 3,4,6-Trichloropyridazine 95123, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; AbbVie S.a.r.l.; Galapagos NV; Altenbach, Robert J.; Bogdan, Andrew; Cowart, Marlon D.; Esmieu, William Ramesh; Gfesser, Gregory A.; Greszler, Stephen N.; Koenig, John R.; Kym, Philip R.; Liu, Bo; Malagu, Karine Fabienne; Patel, Sachin V.; Scanio, Marc J.; Searle, Xenia B.; Voight, Eric; Wang, Xeuqing; Yeung, Ming C.; (202 pag.)US2017/15675; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

15456-86-7, 4-Bromo-1,2-dihydropyridazine-3,6-dione is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b 4-Bromo-3,6-dichloropyridazine A solution of 4-bromo-1,2-dihydropyridazine-3,6-dione (10 g, 52 mmol) in phosphorus oxychloride (100 ml) was stirred and heated at 100 C. under nitrogen for 16 h. Upon cooling the excess phosphorus oxychloride was removed in vacuo. The residue was azeotroped with toluene (*2), then taken up in dichloromethane/water. The mixture was carefully basified with sodium hydrogen carbonate (solid). It was necessary to dilute the mixture further to get two clear layers. The two layers were separated and the aqueous was extracted with dichloromethane (*3). The combined extracts were dried (Na2SO4), filtered and evaporated. The residue was purified by chromatography on silica gel, eluding with dichloromethane to afford the title pyridazine (5.0 g, 42%) as a colourless solid. 1H NMR (250 MHz, CDCl3) 7.68 (br s). MS (ES30) 230 [MH]+, 228 [MH]+.

15456-86-7, 15456-86-7 4-Bromo-1,2-dihydropyridazine-3,6-dione 254942, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Sharp & Dohme Limited; US6291460; (2001); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6082-66-2,3,4,6-Trichloropyridazine,as a common compound, the synthetic route is as follows.

(b) 2-[(3,6-Dichloro-4-pyridazinyl)oxy]ethanol; A solution of ethylene glycol (55 ml) in tetrahydrofuran (200 ml) was treated at around O0C (ice bath cooling) with sodium hydride (60% dispersion in oil, 5.9 g) over 40 minutes. After the addition was complete, 3,4,6-trichloropyridazine (27 g) containing isomers of bromo-dichloropyridazine as impurity was added portionwise and washed in with more dry THF (50ml) and the mixture was stirred at O0C for 1 hour and then at room temperature overnight. The mixture was concentrated (to 1/3 volume) then diluted with aqueous sodium bicarbonate solution and extracted with chloroform (5x) and ethyl acetate (3x). The combined organic extracts were washed with water, dried over sodium sulphate and evaporated and the solids filtered off and washed with CHCI3 (x3) and dried in a vacuum oven overnight at 4O0C affording a white solid (25.5 g, 83%), containing some bromo-derivative (10-15%). MS (+ve ion electrospray) m/z 209/211 (MH+). MS (+ve ion electrospray) m/z 255/7 (MH+), bromo-derivative.

6082-66-2, As the paragraph descriping shows that 6082-66-2 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2008/9700; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem