Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1722-10-7,3-Chloro-6-methoxypyridazine,as a common compound, the synthetic route is as follows.

Example 24 6,6′-dimethoxy-3,3′-bipyridazine 15 In a 100 ml two-necked flask, 1.55 g (2.1 mmol) of dichlorobis(triphenylphosphine)nickel(II), 452 mg (6.95 mmol) of zinc and 2.23 g (6.95 mmol) of tetrabutylammonium bromide are solubilized in 40 ml of freshly distilled DMF. After degassing, the solution is stirred at ambient temperature for 30 min (the green starting solution turns brown). 1 g (6.95 mmol) of 3-chloro-6-methoxypyridazine 14 is added to this solution, and the reaction mixture is heated at 55 C. for 8 hours. After the solvent has been evaporated off under reduced pressure, the residue is taken up in a saturated solution of ammonium chloride, the suspension is extracted with 4*40 ml of dichloromethane and the organic phase is dried over MgSO4 and then concentrated under reduced pressure. The reaction crude is chromatographed on silica gel (eluent:ethyl acetate/petroleum ether=4/6), to give the bipyridazine 15 with a yield of 96%. 1H NMR (CDCl3) deltappm: 4.16 (s, 6H, OCH3); 7.10 (d, 2H, J=9.3, Hpyridazine); 8.59 (d, 2H, J=9.3, Hpyriazine). 13C NMR (CDCl3) deltappm: 54.96, 118.07, 127.25, 152.40, 165.35. MS, m/z (I %): 218 (M+, 100%), 189 (M+-N2, 22%), 175 (M+t-(N2+CH3), 31%)., 1722-10-7

1722-10-7 3-Chloro-6-methoxypyridazine 74403, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.); US2010/298562; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123169-25-4,6-Bromo-2-methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

1123169-25-4, In the reaction vessel RuPhos Indoline Precatalyst (0.058 g, 0.079 mmol) and sodium tert-butoxide (0.305 g, 3.17 mmol) were combined, followed by 6-bromo-2-methylpyridazin-3 (2H) -one (0.300 g, 1.587 mmol) and tert-butyl 1-oxa-4, 9-diazaspiro [5.5] undecane-9-carboxylate (0.488 g, 1.905 mmol) . This mixture was then evacuated and backfilled with N2 (3 times) . Then dry, degassed tetrahydrofuran (7.9 mL) was added to this flask. This mixture was heated at 80 overnight. The mixture was cooled and solvent was removed on a rotavapor. The residue was dissolved in 40 mL of EtOAc and 20 mL of water. After separation, aqueous layer was extracted with EtOAc (20mL x 2) . The organic layers were combined and washed with 20 mL brine. Then it was dried over Na2SO4. Removing solvent gave the crude product, wich was purifed by column chromatography (40g slica gel column, eluted with 100 EtOAc) to afford the title compound. LC-MS (IE, m/z) : 365 (M+1) +.

As the paragraph descriping shows that 1123169-25-4 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; SHI, Zhi-Cai; WALSH, Shawn P.; WU, Zhicai; YU, Yang; FERGUSON II, Ronald; GUO, Zhiqiang; FRIE, Jessica; SUZUKI, Takao; BLIZZARD, Timothy A.; FU, Qinghong; VANGELDER, Kelsey F.; (118 pag.)WO2016/65582; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5096-73-1,6-Chloropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.

5096-73-1, Step 1:A solution of carbonyldiimidazole (CDI, 165 ??, 1.0 M in N,N-dimethylformamide, 0.165 mmol) was added to a solution of 3-chloropyridazine-6-carboxylic acid (300 ??,, 0.5 M in N,N-dimethylformamide, 0.15 mmol) in a vial. The mixture was shaken at room temperature for 2 hours. A solution of the relevant amine (300 ??, 0.5 M in N,N-dimethylformamide, 0.15 mmol) was added and the vials shaken at room temperature for 20 hours. The reaction was evaporated to dryness under vacuum. The residue was partitioned between ethyl acetate (2.5 mL) and water (2 mL). The layers were separated and the organic layer was evaporated and the residue used without further purification in the subsequent step.

The synthetic route of 5096-73-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER LIMITED; Gibson, Karl Richard; Owen, Dafydd Rhys; WO2013/61297; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5096-73-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5096-73-1,6-Chloropyridazine-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 4 2-[6-((1R,2R)-1-Benzyl-2-carboxy-2-hydroxy-ethylcarbamoyl)-pyridazin-3-yl]-benzoic Acid (R1=-OH; R41=H) 6-Chloropyridazine-3-carboxylic acid (78.9 mg, 497 mumol, 1.0 eq.), DIPEA (273 muL, 3.2 eq.), HATU (189 mg, 497 mumol, 1.0 eq.), and (2R,3R)-3-amino-2-hydroxy-4-phenyl-butyric acid ethyl ester (129 mg, 497 mumol, 1.0 eq.) were combined in DCM (2 mL) and stirred for 1 hour. The crude reaction was chromatographed using a gradient (0-80% EtOAc/Hex) to obtain (2R,3R)-3-[(6-chloro-pyridazine-3-carbonyl)-amino]-2-hydroxy-4-phenyl-butyric acid ethyl ester.

As the paragraph descriping shows that 5096-73-1 is playing an increasingly important role.

Reference£º
Patent; THERAVANCE, INC.; US2012/309724; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

54709-94-3, 5-Methylpyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

54709-94-3, Example 386-Oxo-1,6-dihydro-pyridazine-4-carboxylic acid The title compound from Example 37 (0.90 g, 8.2 mmol) was stirred in concentrated sulfuric acid (13 mL) and heated to 45 C. Potassium permanganate (3.6 g, 12 mmol) was added portion wise over 30 min to avoid letting the temperature rise. The reaction was allowed to stir for a further 30 min at 45 C. The reaction was then cooled to room temperature and ice was added to the reaction mixture. The resulting precipitate was collected by vacuum filtration, washing with cold water and diethyl ether to give 0.98 g (87%) of the title compound as the a pale green solid.1H NMR (300 MHz, CDCl3): delta (ppm) 13.39 (broad s, 1H), 8.12 (s, 1H), 7.22 (s, 1H).

The synthetic route of 54709-94-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AstraZeneca AB; NPS PHARMACEUTICALS, INC.; US2007/259860; (2007); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.933-76-6,4,5-Dichloro-2-methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.,933-76-6

4,5-dichloro-2-methylpyridazin-3(2H)-one (200 mg, 1.1 17 mmol), 3-aminoazocan-2-one (155 mg, 1.09 mmol), N,N-diisopropylehtylamine (0.289 g, 2.23 mmol) and DMAc (1.3 mL) were charged in a sealable vial. The reaction was heated to 120 C for 2 hours. The reaction mixture was partitioned between EtOAc and NaHC03 (aq., sat.). The crude product was purified by flash chromatography (10% to 100% 1 :10:90 NH4OH:MeOH:DCM in DCM, 24g-silica gel column) to afford to sets of fractions containing regioisomers. The later eluting fractions (most polar isomer) was isolated after evaporation under reduced pressure to afford 3-((5-chloro-l -methyl-6- oxo-l ,6-dihydropyridazin-4-yl)amino)azocan-2-one (0.235 g, 0.84 mmol) in 77% yield. LCMS (ESI+): 285 / 287 (M+H, CI pattern).

The synthetic route of 933-76-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; BURDICK, Daniel, J.; COTE, Alexandre; DUPLESSIS, Martin; NASVESCHUK, Christopher, G.; TAYLOR, Alexander, M.; (117 pag.)WO2016/112298; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53180-92-0,5-Chloropyridazin-4-amine,as a common compound, the synthetic route is as follows.,53180-92-0

Preparation 9.2: 5-(2-methylpyridin-3-yl)pyridazin-4-amine 7v [00288] A mixture of 5-chloropyridazin-4-amine (50 mg, 0.386 mmol), (2-methyl-3- pyridyl)boronic acid (63.43 mg, 0.463 mmol), palladium triphenylphosphane (22.3 mg, 0.0193 mmol) and a2C03 (386 mu^ of 2M, 0.772 mmol) in dioxane (2 mL) was heated at 140C for lh. The mixture was then cooled to room temperature and partitioned between DCM and water. The organic layer was filtered through a SCX column, eluting with a 2M solution of H3 in MeOH. The eluate was concentrated in vacuo to give the title compound 7v (72 mg, 100% Yield).

The synthetic route of 53180-92-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; BRENCHLEY, Guy; CHARRIER, Jean-damien; DAVIS, Chris; DURRANT, Steven; JARDI, Gorka, Etxebarria I; FRAYSSE, Damien; JIMENEZ, Juan-miguel; KAY, David; KNEGTEL, Ronald; PIERARD, Francoise; PINDER, Joanne; SHAW, David; STORCK, Pierre-henri; STUDLEY, John; TWIN, Heather; WO2014/143241; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. To a mechanically stirred solution of 3-chloro-6-methylpyridazine (155.6 mmol) in 140 mL of concentrated sulfuric acid, finely powdered potassium dichromate (55.40 g) was added slowly, the temperature being kept below 50 C. When the addition was complete, stirring was continued for another 4 hours at 50 C. The viscous, dark green liquid was then cooled and crushed ice was added cautiously. The reaction mixture was extracted with ethyl acetate (6*400 mL). The ethyl acetate extracts were combined, dried over anhydrous Na2SO4. The solvent was concentrated in vacuo to yield slightly red colored 6-chloropyridazine-3-carboxylic acid (106.6 mmol). This material was used for next reaction without further purification. Yield 69%. m.p. 145 C. (dec). 1H NMR (300 MHz, DMSO-d6) delta 13.1, 8.20, 8.05., 1121-79-5

As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; XENON PHARMACEUTICALS INC.; US2008/125434; (2008); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example XIV; 3-iodo-6-methyl-pyridazine2.5 g 3-chloro-6-nnethyl-pyridazine are dissolved in 10 ml of 57 % hydrogen iodide solution and heated for 2 hours to 1200C. Then the mixture is cooled to 00C and carefully neutralised with 1 N sodium hydroxide solution. The aqueous phase is extracted twice with ethyl acetate and the combined organic phases are washed twice with water and once with saturated sodium chloride solution. After drying with magnesium sulphate the solvent is eliminated in vacuo.Yield: 3.6 g (84 % of theory)Mass spectrum (ESI+): m/z = 221 [M+H]+

1121-79-5, 1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/16118; (2009); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

51149-08-7,51149-08-7, 3,6-Dichloropyridazine-4-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of a portion (10 g) of the material so obtained, concentrated sulphuric acid(10 drops) and anhydrous ethanol (50 ml) was heated to reflux for 24 hours. The mixture was evaporated and the residue was partitioned between ethyl acetate and water. The organic phasewas dried over magnesium sulphate and evaporated. The residue was dissolved in phosphorylchloride (70 ml) and the solution was heated to 70C for 2 hours. The resultant mixture wascooled to ambient temperature, poured onto a mixture of ice and water and extracted with ethylacetate. The organic layer was washed with a saturated aqueous sodium bicarbonate soluiton,dried over magnesium sulphate and evaporated. The residue was purified by columnchromatography on silica using a 4:1 mixture of petroleum ether (b.p 40-60C) and ethylacetate as eluent. There was thus obtained ethyl 3,6-dichloropyridazine-4-carboxylate as an oil (5.7 g); NMR Spectrum: (CDC13) 1.45 (t, 3H), 4.49 (q, 2H), 7.87 (s,1H); Mass Spectrum: M+H4 221.

As the paragraph descriping shows that 51149-08-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/108707; (2004); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem