Tag: M.W:100-200

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. 141-30-0In an article, authors is Abouzid, Khaled, once mentioned the new application about 141-30-0.

Pyridazinone derivatives: Design, synthesis, and in vitro vasorelaxant activity

In an attempt to identify potential vasodilator-cardiotonic lead compounds, three series of pyridazinones were designed using three-dimensional pharmacophore developed with CATALYST software from a set of potent cyclic nucleotide phosphodiesterase III, cAMP PDEIII inhibitors. The features of the target compounds were based on the structures of many biologically active lead compounds with cAMP phosphodiesterase III inhibiting activity such as Milrinone and others. Compounds with higher fit scores to the developed pharmacophore were synthesized namely; 6-(3-ethoxycarbonyl-4-oxo-1,4-dihydroquinolin-6-yl)-4,5-dihydro-3(2H)-pyridazinones (3a and 3b), 6-[4-(2,6-disubstituted-quinolin-4-ylamino)phenyl]-4,5-dihydropyridazin-3(2H)-ones (5a-f), and 6-[3-(5-cyano-6-oxo-4-aryl-1,6-dihydro-2-pyridyl)phenylamino]-3(2H)pyridazinone (8a and 8b). The vasodilator activity of the newly synthesized compounds was examined on the isolated main pulmonary artery of the rabbit. Some of the tested compounds showed moderate vasorelaxant activity compared with standard drug, Milrinone.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1587 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 5096-73-1, name is 6-Chloropyridazine-3-carboxylic acid, introducing its new discovery. 5096-73-1

Pd/Cu bimetallic co-catalyzed direct 2-arylation of benzoxazole with aryl chloride

An efficient Palladium/Copper bimetallic co-catalyzed direct 2-arylation of benzoxazoles with aryl chlorides is presented. The Pd(OAc)2/CuI/NiXantphos-based catalyst enables the installation of various aryl and heteroaryl groups in good to excellent yields (75?99%). Preliminary mechanism investigation indicates that Pd/Nixantphos complex activates C-Cl bond of aryl chlorides via oxidative addition, and Cu/Nixantphos complex chelates with nitrogen atom to lower the pKa of the 2-H in benzoxazoles.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5096-73-1 is helpful to your research. 5096-73-1

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2076 – PubChem

 

In an article, published in an article,authors is Betti, Laura, once mentioned the application of 932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone,molecular formula is C4H2Cl2N2O, is a conventional compound. this article was the specific content is as follows. 932-22-9

alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus.

Our previous work on pyridazinone-arylpiperazine derivatives suggested some structural features that a compound should have to show high affinity and good selectivity for alpha(1) adrenoceptors (AR) with respect to alpha(2)-AR. Accordingly, two classes of new alkoxyphenylpiperazinylheptylpyridazinones were designed and synthesized to evaluate the effect of the alkoxy substituent on affinity and selectivity. As expected, affinity increased with larger alkoxy groups. Affinity values are all comparable with that of the reference compound (prazosin), with the exception of compound 1c found 4.5-fold more active than prazosin.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2295 – PubChem

 

In an article, published in an article,authors is Bissell, Eugene R., once mentioned the application of 20375-65-9, Name is 3-Phenyl-6-chloropyridazine,molecular formula is C10H7ClN2, is a conventional compound. this article was the specific content is as follows. 20375-65-9

Synthesis and Chemistry of 7-Amino-4-(trifluoromethyl)coumarin and Its Amino Acid and Peptide Derivatives

The synthesis and purification of 7-amino-4-(trifluoromethyl)coumarin, a novel fluorescent marker for the sensitive detection of proteinases, were investigated.Two byproducts, 7-hydroxy-4-(trifluoromethyl-2-quinolone and 2-ethoxy-7-hydroxy-4-(trifluoromethyl)quinoline, were isolated and identified. 7-Methoxy-4-(trifluoromethyl)-2-quinolone was also prepared.Amino acid and peptide derivatives prepared by solution methods using the stepwise approach included 7-(L-leucinamido)-, 7-(D-alanyl-L-leucyl-L-lysinamido)-, 7-(D-valyl-L-leucyl-L-lysinamido)-, and 7-(Nalpha-Z-glycylglycyl-L-argininamido)-4-(trifluoromethyl)coumarins

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2597 – PubChem

 

141-30-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 141-30-0, molcular formula is C4H2Cl2N2, introducing its new discovery.

3-QUINUCLIDINYL HETEROATOM BRIDGED BIARYL DERIVATIVES

Compounds ol formula:(I) or pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, wherein: A and G are each independently N or N+?0-; m and n are each independently 0, 1, or 2; X1 and X3 are each independently O, S, and ?N(R1)?; X2 is O, S, ?N(R1)?, ?N(Ar2)?, and ?N(R2)C(0)?; Ar1 is a six-membered aromatic ring; Ar2 is cyclohexyl or a monoor bicyclic aromatic ring, and R13 is hydrogen, alkyl, or halogen, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formulas (I) and (II) and methods for using such compounds and compositions.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 141-30-0, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 141-30-0

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1369 – PubChem

 

64068-00-4, Name is 6-Chloro-4-methylpyridazin-3-amine, belongs to pyridazine compound, is a common compound. 64068-00-4In an article, authors is Barlin, Gordon B., once mentioned the new application about 64068-00-4.

Imidazo<1,2-b>pyridazines. I Some 3-Alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl)inidazo<1,2-b>pyridazines and 3-Methoxy-2,6-diphenylimidazo<1,2-b>pyridazine

A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl)imidazo<1,2-b>pyridazines (1) and 3-methoxy-2,6-diphenylimidazo<1,2-b>pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O-alkylation of the corresponding imidazo<1,2-b>pyridazin-3(5H-ones with diazoalkanes. 6-Chloro-3-methoxy-2-phenylimidazo<2,1-a>phthalazine was prepared similarly.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1058 – PubChem

 

37444-46-5, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 37444-46-5

Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction

Compounds of the formulae (IA) and (IB): wherein R1 is C1 to C3 alkyl optionally substituted with phenyl, Het or a N-linked heterocyclic group selected from piperidinyl and morpholinyl; wherein said phenyl group is optionally substituted by one or more substitutents selected from C1 to C4 alkoxy; halo; CN; CF3; OCF3 or C1 to C4 alkyl wherein said C1 to C4 alkyl group is optionally substituted by C1 to C4 haloalkyl or haloalkoxy either of which is substituted by one or more halo atoms; R2 is C1 to C6 alkyl and R13 is OR3 or NR5R6, or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity are potent and selective inhibitors of type 5 cyclic guanosine 3?,5?-monophosphate phosphodiesterase (cGMP PDE5) and have utility in the treatment of, inter alia, male erectile dysfunction (MED) and female sexual dysfunction (FSD).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N342 – PubChem

 

932-22-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 932-22-9, molecular formula is C4H2Cl2N2O, introducing its new discovery.

Pyridazinylurea plant regulators

Pyridazinylurea plant regulators of the formula STR1 and acid addition salts thereof; wherein R is alkyl or cycloalkyl, R1 is hydrogen or alkyl, each X independently is halogen, alkoxy, alkylthi or alkylsulfonyl, and p is 0, 1 or 2.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.932-22-9, you can also check out more blogs about932-22-9

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2248 – PubChem

 

141-30-0, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 141-30-0, C4H2Cl2N2. A document type is Article, introducing its new discovery.

Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine

A series of 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine derivatives were synthesized. In initial screening and quantitative evaluation, compound 2r was among the most active agents, exhibiting in the same time the lowest toxicity. In the anti-maximal electroshock test, it showed median effective dose (ED50) of 17.3 mg/kg and median toxicity dose (TD50) of 380.3 mg/kg, and the protective index (PI) of 22.0, which is much better than PI of the reference drugs. In a subsequent test, compound 2r had median hypnotic dose (HD50) of 746.6 mg/kg, thus demonstrating much better margin of safety compared to reference drugs. Compound 2r also showed oral activity against MES-induced seizures and lower oral neurotoxicity. For explanation of the putative mechanism of action, compound 2r was tested in chemical induced models.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1714 – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Filp, Ulrike and a compound is mentioned, 20375-65-9, 3-Phenyl-6-chloropyridazine, introducing its new discovery. 20375-65-9

Stereocontrolled [11C]Alkylation of N-Terminal Glycine Schiff Bases To Obtain Dipeptides

The use of various quaternary ammonium salts as chiral phase-transfer catalysts allowed effective and stereoselective radiochemical [11C]alkylation to obtain functionalized dipeptides. We herein report a broadly applicable procedure for the asymmetric [11C]alkylation of dipeptides to give labeled N-terminal peptides by using different [11C]alkyl halides. Contended stereoselectivities of the reactions were observed by using 11C-labeled alkyl halides, [11C]methyl iodide and [11C]benzyl iodide, and diastereomeric ratios with different specialized catalysts of 95:5 and 90:10 were achieved, respectively. Accordingly, the straightforward synthesis of enantioenriched compounds should play a vital role in peptide-based radiopharmaceutical development and positron emission tomography imaging.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2621 – PubChem