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20375-65-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.20375-65-9, Name is 3-Phenyl-6-chloropyridazine, molecular formula is C10H7ClN2. In a Article, authors is Sanchez, J. Domingo£¬once mentioned of 20375-65-9

Synthesis of 5-N-acetylardeemin seco-analogues

Piperazinediones derived from ethyl N-indolylmethyl- glicinate or L- alaninate and different alpha-amino esters were cyclized with anthranilic acid in two steps with retention of configuration of the stereocenters to afford compounds which are analogues of 5-N-acetylardeemin, a MDR reversal agent.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2732 – PubChem

 

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Self-assembly of noncyclic bis-D- and L-tripeptides into higher order tubular constructs: Design, synthesis, and X-ray crystal superstructure

(Figure Presented) Trans (1R,2R)-diaminocyclohexane was used as a semirigid vicinal diamine to anchor two N-protected tripeptides consisting of L-D-L amino acids as carboxy terminal amides. The bis-tripeptide consisting of L-Ser (OBn)-D-Ser (OBn)-L-Ser (O-p-bromobenzyl) Boc afforded X-ray quality crystals containing benzene and chloroform solvent molecules. Analysis of the solid-state structure revealed a highly H-bonded helical open-ended tubular superstructure. The tripeptide strands intertwine like a pair of self-embracing arms, held together by a gamma-turn and a 14-membered antiparallel H-bonded macroring spanning the first and third amino acid residues within each strand. Whereas the tripeptide from the R,R anchor gave beautiful crystals from benzene and chloroform, the analogous construct from the S,S-anchored diamine gave a gel. Related bis-tripeptides with different amino acids showed extensive intramolecular H-bonding based on NMR titration and dilution experiments.

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19064-67-6, Name is 6-Chloro-3-hydroxypyridazine, belongs to pyridazine compound, is a common compound. 19064-67-6In an article, authors is Allerton, Charlotte M.N., once mentioned the new application about 19064-67-6.

Design and synthesis of pyridazinone-based 5-HT2C agonists

The SAR of a series of pyridazinone derived 5-HT2C agonists has been explored and resulted in identification of a compound with excellent levels of 5-HT2C functional agonism and selectivity over 5-HT2A and 5-HT2B. This compound displayed good in vivo efficacy in pre-clinical models of stress urinary incontinence, despite having physiochemical properties commensurate with impaired CNS penetration.

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ARYL, HETEROARYL, AND HETEROCYCLE SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF

Novel aryl, heteroaryl, and non-aromatic heterocyle substituted tetrahydroisoquinolines are described in the present invention. These compounds are used in the treatment of various neurological and physiological disorders. Methods of making these compounds are also described in the present invention.

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Pyridazine | C4H4N1438 – PubChem

 

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1121-79-5, molcular formula is C5H5ClN2, introducing its new discovery. 1121-79-5

Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobepine derivatives having formulae I(A-E) and formula (II): [image] where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.

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20375-65-9, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 20375-65-9, name is 3-Phenyl-6-chloropyridazine. In an article£¬Which mentioned a new discovery about 20375-65-9

Total syntheses of (¡À)-spiroquinazoline, (-)-alantryphenone, (+)-lapatin A, and (-)-quinadoline B

Quick access: The aza-Diels-Alder reaction of unprecedented aminal-embodied olefins with azadienes provides quick access to indoline-containing spiroquinazoline alkaloids. This approach was utilized in the total syntheses of the title compounds (see figure). Copyright

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SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS

Use of compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R, R1 and X have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin Il and/or HIV protease inhibitors.

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Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists

This letter describes the synthesis and structure activity relationship (SAR) studies of structurally novel M4 antagonists, based on a 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazine core, identified from a high-throughput screening campaign. A multi-dimensional optimization effort enhanced potency at human M4 (hM4 IC50s?141-30-0

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Pyridazine | C4H4N1615 – PubChem

 

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Delta 1-pyrrolines used as pesticides

Novel Delta1-pyrrolines of the formula (I) 1in which R1, R2, R3, m and Q have the meanings given in the description, a plurality of processes for preparing these substances and their use for controlling pests.

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Pyridazine | C4H4N1211 – PubChem

 

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Pyridazines. L <1>. Syntheses and Reactions of Phenyl(3-pyridazinyl)methane Derivatives

A convenient approach to phenyl(3-pyridazinyl)ketone (6) and phenyl(3-pyridazinyl)methanol (7) is proposed.Reactions of the related diarylmethyl chloride 8 with various N- and S-nucleophiles were found to afford the expected amines 9a-c, 10a-c and thioethers 11a,b in satisfactory yields.

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