Tag: M.W:100-200

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C5H3ClN2O2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 5096-73-1, name is 6-Chloropyridazine-3-carboxylic acid. In an article£¬Which mentioned a new discovery about 5096-73-1

An efficient palladium-catalyzed synthesis of 1-heteroaryl-4-aminopiperidine derivatives from heteroaryl chlorides

An efficient protocol for the synthesis of 1-heteroaryl-4-(N-methyl)aminopiperidines starting from heteroaryl chloride derivatives is described. A broad range of 1-heteroaryl-4-(N-Boc-N-methyl)aminopiperidine derivatives were obtained in good to excellent yields using DavePhos as optimal ligand for Pd-catalyzed Buchwald-Hartwig amination reaction. After a mild and efficient acidolysis the amination products could be obtained successfully.

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Pyridazine | C4H4N2074 – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. name: 4,5-Dichloro-3(2H)-pyridazinone. Introducing a new discovery about 932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone

Synthesis of organic carbonates with alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates and ROH/AlCl3under ambient condition

We demonstrated the synthesis of organic carbonates using alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates and alcohol in the presence of aluminum chloride. Alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates were reacted with alcohol in the presence of AlCl3 in toluene at room temperature to afford the corresponding unsymmetric and symmetric organic carbonates in good to excellent yields. These are efficient and convenient processes. Alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates are solid, stable and non-toxic CO2/CO2R(Ar) source. It is noteworthy that the reaction is carry out under an ambient and acidic conditions, the easy-to prepare and readily available starting materials and the quantitative isolation of reusable 4,5-dichloropyridazin-3(2H)-one.

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Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 3,6-Dichloropyridazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 141-30-0

FUSED BICYCLOHETEROCYCLE SUBSTITUTED QUINUCLIDINE DERIVATIVES

Compounds of formula (I)wherein n is 0, 1, or 2; X is O, S, ?NH?, and ?N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by alpha7nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 13327-27-0, name is 6-Methylpyridazin-3(2H)-one, introducing its new discovery. name: 6-Methylpyridazin-3(2H)-one

Malononitrile compounds as pesticides

The present invention provides a malononitrile compound represented by the formula (I):The malononitrile compound has an efficient pesticidal activity and can control effectively pests.

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: pyridazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 141-30-0, name is 3,6-Dichloropyridazine. In an article£¬Which mentioned a new discovery about 141-30-0

Intramolecular hydrogen bonding between 2-cyanoguanidine and 3-chloro-6-(pyrazol-1-yl)pyridazines in copper(II) complexes

Treatment of copper(II) salts with 3-chloro-6-(pyrazol-1-yl)pyridazine (cppd)-2-cyanoguanidine (enge) mixtures yielded [Cu(cppd)2(H2O)2[NO3]2, [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4], Cu(cppd)2Cl2¡¤2H2O and Cu(cppd)2Br2¡¤ 2H2O. The corresponding 3-chloro-6-(3,5-dimethylpyrazol-1-yl)pyridazine (cmppd) systems gave Cu(cmppd)-(cnge)2(NO3)2¡¤6H2O, [Cu(cmppd)2(cnge)][BF4]2, [Cu(cmppd)(cnge)Cl2]¡¤H2O and Cu(cmppd)(cnge)Br2¡¤H2O. Four of the complexes have been structurally characterised. Whereas the copper atoms in [Cu(cppd)2(H2O)2][NO3]2 and [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4] have tetragonally elongated distorted octahedral geometry, those in [Cu(cmppd)2(cnge)][BF4]2 and [Cu(cmppd)(cnge)Cl2]¡¤H2O adopt trigonal-bipyramidal geometries. The centrosymmetric [Cu(cppd)2(H2O)2]2+ cation comprises two equatorial bidentate chelating cppd ligands and two axial water molecules while [Cu(cppd(cnge)2(H2O)(FBF3)]+ comprises one cppd and two monodentate cnge molecules as equatorial ligands and one water molecule and one BF4- anion as axial ligands. In the [Cu(cmppd)(cnge)Cl2] molecule the chlorine atoms occupy equatorial sites, the cnge an axial position and the cmppd ligand straddles equatorial and axial sites, while in the [Cu(cmppd)2(cnge)]2+ cation the cnge ligand is located equatorially and the two cmppd ligands straddle equatorial and axial sites. Preliminary structural data for Cu(cppd)2Br2¡¤2H2O are consistent with a centrosymmetric tetragonally elongated octahedral copper atom similar to that in [Cu(cppd)2-(H2O)2][NO3]2. Comparable IR and UV/VIS data were obtained for Cu(cmppd)(cnge)2(NO3)2¡¤6H2O and [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4] and for Cu(cmppd)(cnge)Br2¡¤H2O and [Cu(cmppd)(cnge)Cl2]¡¤H2O, suggesting similar molecular structures. Intramolecular N-H … N hydrogen bonds occur between enge amino groups and pyridazine non-ligating nitrogens in the mixed-ligand complexes [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4] and [Cu(cmppd)(cnge)Cl2]¡¤H2O but not [Cu(cmppd)2(cnge)][BF4]2. That in [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4] differentiates between the two cnge ligands, their different roles being confirmed by the presence of two diagnostic vasym(NCN) doublets in its IR spectrum.

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Related Products of 89089-18-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 89089-18-9, molcular formula is C4H2BrClN2, introducing its new discovery.

AMINO OXAZINE DERIVATIVES

This invention relates to 5,6-dihydro-4H-[1,3]oxazin-2-ylamine compounds of the formula (I) wherein R1 to R5 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors and can be used as medicaments for the treatment or prevention of diseases such as diabetes.

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: pyridazine. Introducing a new discovery about 115514-66-4, Name is 4-Bromopyridazine

Optimized scale up of 3-pyrimidinylpyrazolo[1,5-a]pyridine via Suzuki coupling; A general method of accessing a range of 3-(hetero)arylpyrazolo[1,5-a] pyridines

We have developed an improved synthesis of 3-(hetero)aryl pyrazolo[1,5-a]pyridines (such as 3-(2,5-dichloropyrimidin-4-yl)pyrazolo[1,5-a] pyridine (8)) via an optimized synthesis and Suzuki coupling of 3-pyrazolo[1,5-a]pyridine boronic ester 10. These conditions are applicable to both high throughput chemistry and large scale synthesis of these medicinally important compounds. The scope of this chemistry has been further extended to include the synthesis and coupling of a novel boronic ester, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b] [1,3]oxazine (43).

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Application of 17645-17-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.17645-17-9, Name is 6-Chloro-N3-methylpyridazine-3,4-diamine, molecular formula is C5H7ClN4. In a Patent£¬once mentioned of 17645-17-9

Thiazolidinone compounds and composition for angina pectoris comprising the compounds as an active ingredient

A thiazolidinone compound represented by general formula (I) or a pharmacoligically acceptable salt thereof, STR1 wherein W represents sulfur or oxygen and X represents –N(R1)–, or alternatively X represents sulfur or oxygen and W represents –N(R1)–, and R1 represents hydrogen, alkyl or substituted alkyl; R2 and R3 are the same or different from each other, and each represents hydrogen, alkyl, substituted alkyl, aryl, or 5- or 6-membered heteroaryl; R4 represents hydrogen, alkyl or substituted C1 -C4 alkyl; R5 represents substituted cycloalkyl which may contain nitrogen, provided the substituents include –B–ONO2 (wherein B represents a single bond or alkylene) as the indispensable member and alkyl groups as optional members; and A represents a single bond or alkylene, has an excellent anti-anginal effect and thus is useful as an angina pectoris remedy or preventive.

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: pyridazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 65202-50-8, name is Methyl 6-chloropyridazine-3-carboxylate. In an article£¬Which mentioned a new discovery about 65202-50-8

NEW COMPOUNDS

The present invention provides certain compounds according to formula (I) which are inhibitors of SSAO activity wherein V, W, X, Y, Z, R1 and R2 are as defined in the specification.

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Reference of 932-22-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 932-22-9, molcular formula is C4H2Cl2N2O, introducing its new discovery.

N-Nitration of Secondary Amines with 4-Chloro-5-methoxy-2-nitropyridazin-3-one

N-Nitration of 4-chloro-5-substituted-pyridazin-3-one with copper nitrate trihydrate in acetic anhydride gave the corresponding 4-chloro-2-nitro-5-substituted-pyridazin-3-one. 4-Chloro-5-alkoxy-2-nitropyridazin-3-ones such as 5-methoxy (2b) and 5-ethoxy (2d) derivatives showed excellent nitro group transfer potentiality. N-Nitration of some secondary amines with 2b gave the corresponding N-nitramines under mild neutral condition in good yields.

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