Tag: M.W:100-200

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C4H2Cl2N2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1837-55-4, name is 3,5-Dichloropyridazine. In an article£¬Which mentioned a new discovery about 1837-55-4

BRIDGED PIPERIDINE DERIVATIVES

The present invention relates to a compound of formula (I), wherein Het Ar is a five or six membered hetaryl group, containing one, two or three heteroatoms, selected from N, O or S; R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, or lower alkoxy; R2 is lower alkyl substituted by halogen, -CH2-C3-6-cycloalkyl, substituted by one or two substituents, selected from lower alkyl substituted by halogen or halogen, or is lower alkenyl substituted by halogen; R3 is hydrogen, lower alkyl substituted by halogen, lower alkyl, halogen, C3-6-cycloalkyl or lower alkyl substituted by hydroxy; n is 1 or 2; for n = 2, R1 can be independent to each other; Y is CH or N; or to a pharmaceutically active acid addition salt thereof, to a racemic mixture or its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds may be used for the treatment of Alzheimer’s disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1837-55-4, help many people in the next few years.Formula: C4H2Cl2N2

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1138 – PubChem

 

Synthetic Route of 89089-18-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 89089-18-9, Name is 3-Bromo-6-chloropyridazine,introducing its new discovery.

NOVEL HETEROCYCLYL COMPOUNDS

The invention is concerned with novel heterocyclyl compounds of formula (I) wherein A, X, Y1, Y2, Y3, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR2 receptor, CCR5 receptor and/or CCR3 receptor and can be used as medicaments.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 89089-18-9, and how the biochemistry of the body works.Synthetic Route of 89089-18-9

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2820 – PubChem

 

Synthetic Route of 37444-46-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.37444-46-5, Name is Pyridazin-3-ylmethanol, molecular formula is C5H6N2O. In a article£¬once mentioned of 37444-46-5

SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 37444-46-5

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N339 – PubChem

 

Electric Literature of 932-22-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a Article£¬once mentioned of 932-22-9

Synthesis and photophysical properties of N-styrylazinones

(Chemical Equation Presented) N-Styrylazinones and 1-styrylbenzotriazine were synthesized, and their photophysical properties were investigated. (Z)- and/or (E)-N-Styrylazinones (or azine) 4 were prepared from the corresponding heterocycles 1 and benzaldehyde (3) by four methods. The absorption maxima of (Z)- and/or (E)-4a – 4j were measured in four solvents. Their absorption maxima showed a moderate dependence upon solvents. The absorption maxima of (Z)-isomers were blue-shifted as compared the corresponding (E)-isomers. Emission maxima, fluorescence band half-widths, 0,0 transition energies, Stokes shifts, and quantum yields of (Z)- and/or (E)-4a, 4b, 4d, 4e and 4j were measured in organic solvents. The fluorescence spectra show moderate solvatochroism. The fluorescence properties of N-styrylheterocycles vary with every heterocycles.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 932-22-9

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2305 – PubChem

 

1121-79-5, Name is 3-Chloro-6-methylpyridazine, belongs to pyridazine compound, is a common compound. Computed Properties of C5H5ClN2In an article, once mentioned the new application about 1121-79-5.

Identification, synthesis, and biological evaluation of 6-[(6 R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a ]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2 H)-one (AS1940477), a potent p38 MAP kinase inhibitor

Several p38 MAPK inhibitors have been shown to effectively block the production of cytokines such as IL-1beta, TNFalpha, and IL-6. Inhibitors of p38 MAP kinase therefore have significant therapeutic potential for the treatment of autoimmune disease. Compound 2a was identified as a potent TNFalpha production inhibitor in vitro but suffered from poor oral bioavailability. Structural modification of 2a led to the discovery of tetrahydropyrazolopyrimidine derivatives, exemplified by compound 3, with an improved pharmacokinetic profile. We found that blocking metabolism at the methyl group of the amine and constructing the tetrahydropyrimidine core were important to obtaining compounds with good biological profiles and oral bioavailability. Pursuing the structure-activity relationships of this series led to the discovery of AS1940477 (3f), with excellent cellular activity and a favorable pharmacokinetic profile. This compound represents a highly potent inhibitor of p38 MAP kinase with regard to in vivo activity in an adjuvant-induced arthritis model.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N645 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of 3-Phenyl-6-chloropyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 20375-65-9, Name is 3-Phenyl-6-chloropyridazine, molecular formula is C10H7ClN2

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application In Synthesis of 3-Phenyl-6-chloropyridazine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 20375-65-9

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2552 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 35857-89-7, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 35857-89-7, Name is 6-Chloropyridazine-3-carbonitrile, molecular formula is C5H2ClN3

Tungsten-catalyzed regioselective and stereospecific ring opening of 2,3-epoxy alcohols and 2,3-epoxy sulfonamides

The first catalytic, highly C3-selective, stereosepecific ring-opening reaction of 2,3-epoxy alcohols and 2,3-epoxy sulfonamides has been accomplished. This process was efficiently promoted by W-salts, and the developed method was applicable to various epoxides with diverse N-and O-nucleophiles affording the products in good to excellent yields (up to 95%) and generally with high regioselectivities (C3:C2 up to >99:1).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N982 – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Formula: C4H3ClN2O. Introducing a new discovery about 19064-67-6, Name is 6-Chloro-3-hydroxypyridazine

A pyridazinone female nuclear structure of the histone deacetylase inhibitors and its preparation and use (by machine translation)

A pyridazinone female nuclear structure of the histone deacetylase inhibitors and its preparation and use, said protease inhibitor having a structure of formula I shown, the formula I compound has excellent histone deacetylase inhibitory activity and anti-tumor cell multiplication, can be used for treating cancer. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C4H3ClN2O, you can also check out more blogs about19064-67-6

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N728 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C5H5ClN2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1121-79-5, name is 3-Chloro-6-methylpyridazine. In an article£¬Which mentioned a new discovery about 1121-79-5

Advances in the carbonylation of aryl halides using palladium catalysts

The palladium-catalyzed carbonylation of aryl halides is shown to be a versatile tool for the synthesis of various benzoic and heteroaromatic acid derivatives. Recent developments from our laboratories in this area are presented.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1121-79-5, help many people in the next few years.Formula: C5H5ClN2

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N650 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. name: 3-Methoxypyridazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 19064-65-4

N-phenyl-4-pyrazolo[1,5-6]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy

Glycogen synthase kinase 3 regulates glycogen synthase, the rate-determining enzyme for glycogen synthesis. Liver and muscle glycogen synthesis is defective in type 2 diabetics, resulting in elevated plasma glucose levels. Inhibition of GSK-3 could potentially be an effective method to control plasma glucose levels in type 2 diabetics. Structure-activity studies on a N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine series have led to the identification of potent and selective compounds with good cellular efficacy. Molecular modeling studies have given insights into the mode of binding of these inhibitors. Since the initial leads were also potent inhibitors of CDK-2/CDK-4, an extensive SAR was performed at various positions of the pyrazolo[1,5-b] pyridazin core to afford potent GSK-3 inhibitors that were highly selective over CDK-2. In addition, these inhibitors also exhibited very good cell efficacy and functional response. A representative example was shown to have good oral exposure levels, extending their utility in an in vivo setting. These inhibitors provide a viable lead series in the discovery of new therapies for the treatment of type 2 diabetes.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N269 – PubChem