Simple exploration of 7145-62-2

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NOVEL PHENYLPYRROLE DERIVATIVE

The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof:

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Pyridazine | C4H4N2808 – PubChem

 

Properties and Exciting Facts About 3,6-Dichloropyridazine

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Immobilization of Fe(III) complexes of pyridazine derivatives prepared from biosorbents supported on zeolites

Immobilization of Fe(III) complexes of pyridazine derivatives was achieved in NaY zeolite, loaded with iron through the action of a robust biosorption mediator consisting of a bacterial biofilm, Arthrobacter viscosus, supported on the zeolite. The objective of this study is the preparation and characterization of new catalytic materials to be used in oxidation reactions under mild conditions. The biosorption of Fe(III) ions was performed starting from aqueous solutions with low concentrations of iron and the highest values of biosorption efficiency for Fe(III) were reached at the beginning of the contact period with the sorbents. The Fe(III) biosorption process was compared with the one of Cr(III) under the same experimental conditions, as this latter case has been well characterized. The sample used in the immobilization of Fe(III) complexes of pyridazine derivatives was prepared from an aqueous solution of 100.0 mgFe/L, without the competing effect of other metals. Fe(III) is retained in the zeolite by ion exchange and coordination with two different pyridazine derivative ligands, 3-ethoxy-6-chloropyridazine (A) and 3-piperidino-6-chloropyridazine (B). The resulting materials were fully characterized by different spectroscopic methods (EPR, FTIR and UV-vis), chemical analysis (CA), surface analysis (XRD and SEM) and thermogravimetric (TGA) analysis and the results indicated that the Fe(III) complexes of pyridazine derivatives were effectively immobilized in NaY inside the supercages, without any modifications of the morphology and structure of the zeolite. The EPR spectra of the Fe(III) complexes in Y zeolite show signals at g = 4.3 and 2.3, attributed to Fe(III) species coordinated to pyridazine derivative ligands.

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Discovery of 141-30-0

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TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE

Tetrahydroquinoline compounds of Formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

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Awesome and Easy Science Experiments about 3,6-Dichloropyridazine

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Photoredox-mediated Minisci C-H alkylation of N-heteroarenes using boronic acids and hypervalent iodine

A photoredox-mediated Minisci C-H alkylation reaction of N-heteroarenes with alkyl boronic acids is reported. A broad range of primary and secondary alkyl groups can be efficiently incorporated into various N-heteroarenes using [Ru(bpy)3]Cl2 as photocatalyst and acetoxybenziodoxole as oxidant under mild conditions. The reaction exhibits excellent substrate scope and functional group tolerance, and offers a broadly applicable method for late-stage functionalization of complex substrates. Mechanistic experiments and computational studies suggest that an intramolecularly stabilized ortho-iodobenzoyloxy radical intermediate might play a key role in this reaction system.

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Brief introduction of 3-Phenyl-6-chloropyridazine

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Total synthesis and determination of the absolute configuration of guadinomines B and C2

This article describes the determination of the absolute configurations of the guadinomines, which are novel cyclic guanidyl natural products that are inhibitors of the type III secretion system (TTSS) of bacteria. Any compound that interrupts the TTSS of bacteria is potentially an ideal anti-infectious drug. The reliable asymmetric synthesis of guadinomines has revealed their absolute configurations, which could not have been defined without this synthetic approach. Our report not only describes the asymmetric total synthesis of the title compounds, but also demonstrates the novel concise synthesis of tri-substituted piperazinone cores as optically pure forms. The novel feature of our method is an intramolecular SN2 cyclization that uses PPh 3 and I2 to construct the unique 5membered cyclic guanidine substructure.

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The important role of 6-Chloropyridazine-3-carbonitrile

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Electric Literature of 35857-89-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.35857-89-7, Name is 6-Chloropyridazine-3-carbonitrile, molecular formula is C5H2ClN3. In a Article£¬once mentioned of 35857-89-7

Geometry-Retentive C-Alkenylation of Lithiated alpha-Aminonitriles: Quaternary alpha-Alkenyl Amino Acids and Hydantoins

alpha-Amino nitriles tethered to alkenes through a urea linkage undergo intramolecular C-alkenylation on treatment with base by attack of the lithionitrile derivatives on the N?-alkenyl group. A geometry-retentive alkene shift affords stereospecifically the E or Z isomer of the 5-alkenyl-4-iminohydantoin products from the corresponding starting E- or Z-N?-alkenyl urea, each of which may be formed from the same N-allyl precursor by stereodivergent alkene isomerization. The reaction, formally a nucleophilic substitution at an sp2 carbon atom, allows the direct regioselective incorporation of mono-, di-, tri-, and tetrasubstituted olefins at the alpha-carbon of amino acid derivatives. The initially formed 5-alkenyl iminohydantoins may be hydrolyzed and oxidatively deprotected to yield hydantoins and unsaturated alpha-quaternary amino acids.

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Brief introduction of 3-Phenyl-6-chloropyridazine

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New synthetic routes to optically active alpha-quaternary alpha-aryl amino acid derivatives via the diastereoselective Stevens and Sommelet-Hauser rearrangements

The Stevens rearrangement of N-allylic alpha-aryl amino acid-derived ammonium salts and the Sommelet-Hauser rearrangement of N-benzylic alpha-alkyl amino acid-derived ammonium salts are shown to proceed with remarkably high levels of diastereoselectivity. The methods presented in this work provide new routes to optically active alpha-quaternary alpha-aryl amino acid derivatives. The Royal Society of Chemistry 2008.

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More research is needed about 3-Oxo-2,3-dihydropyridazine-4-carboxylic acid

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OXAZOLO [4 , 5-B] PYRIDINE COMPOUNDS AS NITRIC OXIDE SYNTHASE INHIBITORS

The compounds of formula (I) in which R1, R2, R3 and R4 have the meanings as given in the description, and the salts, N-oxides and salts of the N-oxide thereof are novel effective inhibitors of the inducible nitric oxide synthase.

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Discovery of 3,6-Dichloropyridazine

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Air-stable CpPd(NHC)Cl (NHC = N-heterocyclic carbene) complexes as highly active precatalysts for Kumada-Tamao-Corriu coupling of aryl and heteroaryl chlorides

A very straightforward one-pot method has been developed for preparation of air-stable CpPd(NHC)Cl complexes 1a-d. This new class of well-defined NHC-Pd complexes exhibits high catalytic activity in Kumada-Tamao-Corriu cross-coupling reaction involving various aryl and heteroaryl chlorides. Notably, the less sterically encumbered NHC ligand around Pd centre showed higher catalytic activity.

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Some scientific research about 3,6-Dichloropyridazine

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IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES

The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

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