Extended knowledge of 141-30-0

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CD73 INHIBITORS

The present invention provides 5-[5]-[2-cycloa Ikyl ]-6-pyridazin-3-yl ]- IH-pyrimidine-2,4-dione compounds, or pharmaceutically acceptable salts thereof, that inhibit the activity of CD73 and are useful in treating cancer. (Formula (I))

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New explortion of 3,5-Dichloropyridazine

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Electric Literature of 1837-55-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1837-55-4, Name is 3,5-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent£¬once mentioned of 1837-55-4

COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS

The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

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Discovery of 3,6-Dichloropyridazine

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Selective deoxygenation of heteroaromatic N-oxides with olefins catalyzed by ruthenium porphyrin

A new convenient method of deoxygenation of heteroaromatic N-oxides is described. Ruthenium porphyrin was used as a catalyst and this method expressed high yields for o-substituted pyridine N-oxides, quinoline N-oxide derivatives, acridine N-oxide, etc. under mild conditions. Moreover, nitro-, benzyloxy-, and ketone carbonyl groups, which can be affected by the usual deoxygenation methods such as catalytic hydrogenation or borane reduction, were retained.

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Brief introduction of 20375-65-9

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Synthesis of steroidal triply-bridged cyclophanes

Steroidal triply-bridged cyclophanes are synthesised using cholic acid derivatives as bridge units; cyclophane 3 moderately binds to organic guest molecules and enantio-selectively binds to N-Z-phenylalanine.

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Extended knowledge of 88491-61-6

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HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

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More research is needed about 4-Chloro-5-methoxypyridazin-3(2H)-one

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Retro-ene reaction, VI. Functionalization of 4,5-dihalopyridazin-6-ones using 1-acetyloxymethyl-4,5-dihalopyridazin-6-ones as the 1-o, 3-n, 5-o ene- adduct

Functionalization of 1-acetyloxymethyl-4,5-dihalopyridazin-6-ones via retro-ene reaction with some nucleophiles gave regioselectively only 5-halo- 4-substitutedpyridazin-6-ones.

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Extended knowledge of 6-Chloropyridazine-3-carbonitrile

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TRICYCLIC INDOLE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS

The present invention is directed to tricyclic indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.

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Properties and Exciting Facts About 3-Phenyl-6-chloropyridazine

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Reagent-controlled diastereoselective synthesis of (2S,3R)- and (2R,3R)-2,3-diaminobutanoic acid derivatives using proline-catalyzed alpha-hydrazination reaction

(2S,3R)- and (2R,3R)-2,3-Diaminobutanoic acid (Dab) derivatives were efficiently synthesized from Cbz-(R)-alanine using the proline-catalyzed diastereoselective alpha-hydrazination reaction and the SmI2-promoted reductive cleavage of the N-N bond as the key steps.

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The Absolute Best Science Experiment for 5-Chloropyridazine-3-carboxylic acid

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Angiotensin II receptor antagonists

Compounds are disclosed having the formula: STR1 The compounds of the invention are angiotensin II receptor antagonists.

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Brief introduction of 3-Chloro-6-methylpyridazine

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Quality Control of 3-Chloro-6-methylpyridazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1121-79-5, name is 3-Chloro-6-methylpyridazine. In an article£¬Which mentioned a new discovery about 1121-79-5

3-(3-PYRIMIDIN-2-YLBENZYL)-1,2,4-TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVES AS MET KINASE INHIBITORS

Compounds of the formula (I), in which R1, R2, R3, R3?, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumours.

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