New explortion of 5-Methoxypyridazin-3(2H)-one

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A large scale synthesis of 3-chloro-5-methoxypyridazine

A large scale synthesis of 3-chloro-5-methoxypyridazine was developed (18 moles) that relies on the protection of the pyridazinone nitrogen of 4,5-dichloro-3(2H)-pyridazinone as the tetrahydropyranyl derivative 2. The 5-chloro position of the protected pyridazinone was selectively displaced with methoxide to give 3 followed by catalytic hydrogenation of the 4-chloro group to give 4. Removal of the protecting group with acid followed by phosphorous oxychloride treatment gave the target compound 6 in good yield. This route is superior to the previously described synthesis of this compound.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N522 – PubChem

 

Awesome Chemistry Experiments For 89089-18-9

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89089-18-9, Name is 3-Bromo-6-chloropyridazine, belongs to pyridazine compound, is a common compound. category: pyridazineIn an article, once mentioned the new application about 89089-18-9.

BIOLOGICALLY ACTIVE AMIDES

The present invention is directed to biologically active amides which are ligands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from certain disorders which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, this invention also provides uses of a compound of the invention for the manufacture of a medicament for treating a subject suffering from certain disorders

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Final Thoughts on Chemistry for 4-Chloro-3,5-dimethoxypyridazine

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Application of 63910-48-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.63910-48-5, Name is 4-Chloro-3,5-dimethoxypyridazine, molecular formula is C6H7ClN2O2. In a article£¬once mentioned of 63910-48-5

Studies on Syntheses and Reaction of Methoxypyridazines. I. Methoxylation of 3,4,5-Trichloropyridazine

The reaction of 3,4,5-trichloropyridazine (1) with 1 eq amount of NaOMe resulted in the formation of three dichloromonomethoxypyridazines (2, 3-OMe; 3, 4-OMe; 4, 5-OMe) in the ratio of 1:3:6.The 4-OMe compound 3 was isolated from the reaction mixture and the 3-OMe compound 2 was syntesizsed independently.Further methoxylation of 2, 3 and 4 was also investigated in order to prepare various substituted pyrazines.Keywords – 3,4,5-trichloropyridazine; methoxylation; dichloromonomethoxypyridazine; monochlorodimethoxypyridazine; pyridazinone; 3,4,5-trimethoxypyridazine

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New explortion of 141-30-0

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 141-30-0, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 141-30-0, name is 3,6-Dichloropyridazine. In an article£¬Which mentioned a new discovery about 141-30-0

SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS

The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against c-Met and are useful in treating disorders related to abnormal protein kinase activities such as cancer

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Properties and Exciting Facts About 3,6-Dichloropyridazine

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PYRROLO[1,2-A]PYRAZINE DERIVATIVES AS 5HT1A LIGANDS

This invention relates to the use of compounds of formula I wherein R 1, R 2, R 3, X, m and n are defined as in the specification, and their pharmaceutically acceptable salts, for the treatment of disorders of the serotonin system.

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Extended knowledge of 932-22-9

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Reference of 932-22-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a Article£¬once mentioned of 932-22-9

Synthesis of 1-[(pyrazol-3-yl)methyl]pyridazin-6-ones

This paper presents the synthesis of 1-[(pyrazol-3-yl)methyl]pyridazin-6-ones from ethyl 4-(4,5-dichloro-6-oxopyridazin-1-yl)-3-oxobutanoate.

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The important role of 141-30-0

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, HPLC of Formula: C4H2Cl2N2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 141-30-0

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C4H2Cl2N2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

PROCESS FOR PRODUCING 3-AMINO-6-CHLOROPYRIDAZINE

A process for producing 3-amino-6-chloropyridazine, characterized in that 3,6-dichloropyridazine is reacted with ammonia in the presence of a water-soluble C5-C1000 polyether.

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Some scientific research about 20375-65-9

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C10H7ClN2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 20375-65-9, in my other articles.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C10H7ClN2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 20375-65-9, Name is 3-Phenyl-6-chloropyridazine, molecular formula is C10H7ClN2

Synthesis and chiroptical properties of helical polyallenes bearing chiral amide pendants

Two allene derivatives, l- and d-N-(1-(octylamino)-1-oxopropan-2-yl)-4-(propa-1,2-dien-1-yloxy)benzamide (l-1 and d-1), bearing chiral amide pendants were designed and synthesized. Living polymerizations of l-1 and d-1 with allylnickel complex as a catalyst afforded poly-l-1m and poly-d-1m with controlled molecular weights and narrow molecular weight distributions. These polymers were found to possess a stable helical conformation with a preferred handedness in aprotic solvents on the basis of their circular dichroism (CD) spectra and specific rotation as well as computer simulation. The helical conformation of the polymers was revealed to be stabilized by elongation of the repeating unit until the degree of the polymerization reaches 80. The slightly influence of temperature on the CD spectra of poly-l-1100 in CHCl3 indicated the helical conformation was quite stable at least in the range of 0-55 C. Although poly-l-1100 showed similar CD spectra in different aprotic solvents, remarkable decrease was observed upon the addition of protic solvents such as methanol due to the weakened hydrogen bonding interactions between the adjacent repeating units. The poly-l-1100 behaves as a pH-responsive property; the helical structure of the main chain can be transformed to random coil by addition of trifluoroacetic acid to the THF solution which again switches back to helical conformation by neutralization with triethylamine. It was confirmed that the copolymerization of l-1 and d-1 obeyed the majority rule as supported by the nonlinear correlation between the enantiomeric excess of monomer 1 with the CD intensities of the generated copolymers. Atomic force microscope (AFM) and scanning electron microscope (SEM) studies revealed poly-l-1100 self-assembled into well-defined helical fibrils with distinct handedness.

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Discovery of 3-Chloropyridazine

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SUBSTITUTED PYRIDAZINE DERIVATIVES WHICH HAVE HISTAMINE H3 ANTAGONIST ACTIVITY

The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.

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The Absolute Best Science Experiment for 3-Phenyl-6-chloropyridazine

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Computed Properties of C10H7ClN2. Introducing a new discovery about 20375-65-9, Name is 3-Phenyl-6-chloropyridazine

Direct Optical Resolution of Carboxylic Acids by Chyral HPLC on Tris(3,5-dimethylphenylcarbamate)s of Cellulose and Amylose

A variety of racemic carboxylic acids have been for the first time directly resolved by normal-phase, high-performance liquid chromatography using a hexane-2-propanol eluting system containing a small amount (ca. 1percent) of a strong carboxylic acid, like formic acid, trichloroacetic acid, and trifluoroacetic acid.

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Pyridazine | C4H4N2719 – PubChem