Tag: M.W:100-200

In an article, author is Das, Deepankar, once mentioned the application of 920-66-1, Category: pyridazines, Name is 1,1,1,3,3,3-Hexafluoropropan-2-ol, molecular formula is C3H2F6O, molecular weight is 168.0378, MDL number is MFCD00011651, category is pyridazines. Now introduce a scientific discovery about this category.

Chiral bisoxazoline ligands designed to stabilize bimetallic complexes

Chiral bisoxazoline ligands containing naphthyridine, pyridazine, pyrazole, and phenol bridging units were prepared and shown to form bimetallic complexes with various metal salts. X-ray crystal structures of bis-nickel naphthyridine-bridged, bis-zinc pyridazine-bridged, and bis-nickel as well as bis-palladium pyrazole-bridged complexes were obtained.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 2231-57-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 2231-57-4, Name is Carbonothioic dihydrazide, SMILES is NNC(NN)=S, belongs to pyridazines compound. In a article, author is Khan, Abida, introduce new discover of the category.

Synthesis of novel N-substitutedphenyl-6-oxo-3-phenylpyridazine derivatives as cyclooxygenase-2 inhibitors

Some novel non-ulcerogenic N-substitutedphenyl-6-oxo-3-phenylpyridazines as COX-2 inhibitors have been developed (Supplementary material Appendix1). The novel aldehyde3was prepared by reacting 6-phenylpyridazin-3(2H)-one with 4-fluorobenzaldehyde. The aldehyde3was reacted with different hydrazines and thiazolidin-4-ones to obtain the novel N-substitutedphenyl-6-oxo-3-phenylpyridazine derivatives. These were assessed for their anti-inflammatory potential and gastric ulcerogenic effects. The molecular docking investigations were also undertaken. The spectroscopic data were coherent with the allocated structures of the compounds. The compounds4a(IC50= 17.45 nm;p< .05),4b(IC50= 17.40 nm;p <.05),5a(IC50= 16.76 nm;p< .05), and10(IC50= 17.15 nm;p< .05) displayed better COX-2 inhibitory activity than celecoxib (IC50= 17.79 nm;p< .05). These findings were consistent with the molecular docking investigations of4a,4b,5a, and10. Thein vivoanti-inflammatory profile of4a,4b,5a, and10was also superior to celecoxib and indomethacin. The compounds4b,5a, and10revealed no gastric ulcerogenic effects, wherein the compound4aproduced almost negligible gastric ulcerogenic effects than celecoxib and indomethacin. The compounds4a,4b,5a, and10have been postulated as promising non-ulcerogenic COX-2 inhibitors. Reference of 2231-57-4, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2231-57-4 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 103-85-5, Name is 1-Phenylthiourea, molecular formula is C7H8N2S. In an article, author is Qadir, Abdul,once mentioned of 103-85-5, COA of Formula: C7H8N2S.

GC-MS analysis of the methanolic extracts of Smilax china and Salix alba and their antioxidant activity

Smilax china L. (family Smilacaceae) and Salix alba L. (family Salicaceae) are plants that have been traditionally used to treat various ailments in Indian and Chinese medicine. A quantitative estimation of the methanolic extracts of these plants was performed by GC-MS analysis to obtain insight into its phytoconstituents responsible for therapeutic action. The antioxidant potential of the methanol extracts of Smilax china (MESC) and Salix alba (MESA) were assessed with DPPH by using a UV spectrophotometer at a wavelength of 517 nm. The prevailing compounds found in MESC were lactam sugars including 2,5-dimethyl-2,4-dihydroxy-3(2H)-furanon (1.40%), 1,5-anhydro-6-deoxyhexo-2,3-diulose (4.33%), and alpha-methyl-1-sorboside (1.80%); the two alkaloids found were 1,4-methane-4,4a,5,6,7,8,9,9a-octahydro-10,10-dimethyl cyclohepta[d] pyridazine (0.87%) and 1,3,7-trimethyl-2,6-dioxopurine(0.54%); terpenes included deltacadinene (0.39%), terpineol, ( +) -cedrol (22.13%), 3-thujanol (0.77%), and 9,10-dehydro-cycloisolongifolene (0.34%); fatty acids included cis-vaccenic acid (4.98%) and telfairic acid (1.10%); esters included 1,2,3-propanetriol diacetate (7.56%), 7-hexadecenoic acid, methyl ester (1.77%), eicosanoic acid, and methyl ester (0.95%); and glycerol included 1,2,3-propanetriol (28.75%). The interesting compounds found in MESA were reducing sugars like D-allose (4.40%) and pyrogallol (10.48%), alkaloids like caffeine (63.49%), and esters like methyl octadecanoate (0.53%). Both fractions revealed considerable antioxidant activity. The reported existing phenolic compounds and terpenes are responsible for the antioxidant activity of the plant extracts.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of 2,2,2-Trifluoroacetohydrazide1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, SMILES is NNC(=O)C(F)(F)F, belongs to pyridazines compound. In a article, author is Ghorbani-Vaghei, Ramin, introduce new discover of the category.

Preparation and characterization of nanomagnetic piperidinium benzene-1,3-disulfonate ionic liquid as a novel, green and heterogeneous catalyst and its use in the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and 1H-pyrazolo[1,2-a]pyridazine-5,8-diones under solvent-free conditions

The one-pot four-component synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones and 1H-pyrazolo[1,2-a] pyridazine-5,8-diones was carried out from the reaction between various aldehydes, malononitrile, hydrazine hydrate and phthalic anhydride or maleic anhydride at 110 degrees C in solvent-free conditions using piperidinium benzene-1,3-disulfonate nanomagnetic ionic liquid (NMIL) as a novel and reusable catalyst. Some advantages of the presented procedure are a significant reduction in cost, effective catalysis and reusability of the catalyst. NMIL was thoroughly characterized using Fourier transform infrared spectroscopy, X-ray diffraction, scanning and transmission electron microscopies, thermogravimetry, derivative thermogravimetry, Brunauer-Emmett-Teller analysis, vibrating sample magnetometry and energy-dispersive X-ray spectroscopy. The technique is developed as a suitable and safe method for the synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones and 1H-pyrazolo[1,2-a] pyridazine-5,8-diones making use of an efficient and reusable green catalyst.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1538-08-5. Application In Synthesis of 2,2,2-Trifluoroacetohydrazide.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 39825-33-7, Name is H-Ala-OiPr, SMILES is C[C@H](N)C(OC(C)C)=O, belongs to pyridazines compound. In a document, author is Rodriguez-Enriquez, Fernanda, introduce the new discover, HPLC of Formula: C6H13NO2.

Novel coumarin-pyridazine hybrids as selective MAO-B inhibitors for the Parkinson’s disease therapy

The 3-pyridazinylcoumarin scaffold was previously reported as an efficient core for the discovery of reversible and selective inhibitors of MAO-B, a validated drug target for PD therapy which also plays an important role in the AD progress. Looking for its structural optimization, novel compounds of hybrid structure coumarin-pyridazine, differing in polarizability and lipophilicity properties, were synthesized and tested against the two MAO isoforms, MAO-A and MAO-B (compounds 17a-f and 18a-f). All the designed compounds selectively inhibited the MAO-B isoenzyme, exhibiting many of them IC50 values ranging from sub-micromolar to nanomolar grade and lacking neuronal toxicity. The 7-bromo-3-(6-bromopyridazin-3-yl)coumarin (18c), the most potent compound of these series (IC50 = 60 nM), was subjected to further in vivo studies in a reserpine-induced mouse PD model. The obtained results suggest a promising potential for 18c as antiparkinsonian agent. Molecular modeling studies also provided valuable information about the enzyme-drug interactions and the potential pharmacokinetic profile of the novel compounds.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 39825-33-7 is helpful to your research. HPLC of Formula: C6H13NO2.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, molecular formula is C2H3F3N2O, belongs to pyridazines compound, is a common compound. In a patnet, author is Hatua, Kaushik, once mentioned the new application about 1538-08-5, HPLC of Formula: C2H3F3N2O.

Static second hyperpolarizability of diffuse electron compound M2X (M = Li, na; X = H, F): Ab-initio study of basis set effect and electron correlation

Present investigation reveals that diffuse electron compounds M2X predict large (10(6) a.u.) gamma(av) value. The basis set dependence of gamma(av) showed that the quality of basis function rather than its size is more important. Sadlej’s Pol basis set which is nearly four times less in size than aug-cc-pVQZ can give reliable estimate of gamma(cav). MP2 method in conjunction with large basis sets can give comparable results of gamma(av) that could be obtained from CCSD or CCSD(T). Higher order energy correction to MP2 leads to oscillatory behavior but inclusion of triple excitations to CCSD improves the magnitude of gamma(av). (C) 2017 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 1538-08-5. The above is the message from the blog manager. HPLC of Formula: C2H3F3N2O.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry, like all the natural sciences, COA of Formula: CH6N4S, begins with the direct observation of nature¡ª in this case, of matter.2231-57-4, Name is Carbonothioic dihydrazide, SMILES is NNC(NN)=S, belongs to pyridazines compound. In a document, author is Ju Feng-Yang, introduce the new discover.

Crystal structure of catena-poly[diaqua-(mu(2)-1,2-bis(4-pyridinyl)ethyane-kappa(2) N:N ‘)-(mu(2)-pyridazine-4,5-dicarboxylato-kappa O-2:O ‘)]dizinc(II) dihydrate, C12H12ZnN3O6

C12H12ZnN3O6, monoclinic, I2/a (no. 15), a = 17.6153(6) angstrom, b = 6.6922(2) angstrom, c = 24.1330(9) angstrom, beta = 107.899(4)degrees, V = 2707.22(17) angstrom(3), Z = 8, R-gt(F) = 0.0262, wR(ref)(F-2) = 0.0691, T = 293(2) K.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 2231-57-4. COA of Formula: CH6N4S.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5469-69-2, Name is 3-Amino-6-chloropyridazine, molecular formula is C4H4ClN3. In an article, author is Murineddu, Gabriele,once mentioned of 5469-69-2, Product Details of 5469-69-2.

Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1 receptor ligand antagonists

A series of sulfenamide and sulfonamide derivatives was synthesized and evaluated for the affinity at CB1 and CB2 receptors. The N-bornyl-S-(5,6-di-p-tolylpyridazin-3-yl)-sulfenamide, compound 11, displayed good affinity and high selectivity for CB1 receptors (K-i values of 44.6 nM for CB1 receptors and > 40 mu M for CB2 receptors, respectively). The N-isopinocampheyl-sulfenamide 12 and its sulfonamide analogue 22 showed similar selectivity for CB1 receptors with K-i values of 75.5 and 73.2 nM, respectively. These novel compounds behave as antagonists/inverse agonists at CB1 receptor in the [S-35]-GTP gamma S binding assays, and none showed adequate predictive blood-brain barrier permeation, exhibiting low estimated LD50. However, testing compound 12 in a supraspinal analgesic test (hot-plate) revealed that it was as effective as the classic CB1 receptor antagonist rimonabant, in reversing the analgesic effect of a cannabinoid agonist. (C) 2017 Elsevier Ltd. All rights reserved.

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Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Quality Control of H-Ala-OiPr, 39825-33-7, Name is H-Ala-OiPr, SMILES is C[C@H](N)C(OC(C)C)=O, belongs to pyridazines compound. In a document, author is Esme, A., introduce the new discover.

Spectroscopic (FT-IR, FT-Raman, UV-Vis) analysis, conformational, HOMO-LUMO, NBO and NLO calculations on monomeric and dimeric structures of 4-pyridazinecarboxylic acid by HF and DFT methods

In this study, the Fourier transform infrared (FT-IR) and Fourier transform Raman (FT-Raman) spectra of 4-pyridazinecarboxylic acid (4PCA) in solid phase were recorded and analyzed. Quantum chemical calculations of the optimized molecular structure, energies, conformational, UV-Vis, nonlinear optical (NLO) and natural bond orbital (NBO) analysis, molecular surfaces, Mulliken charges, and vibrational studies for 4PCA were performed using the ab initio Hartree-Fock (HF) and density functional theory (DFT/B3LYP) methods with 6-311++G(d,p) basis set. Obtained results on the geometric structure and vibrational frequencies are compared with observed data. The dimeric structure of 4PCA with DFT/B3LYP/6-311++G(d,p) level caused by the shifts of O-H and C=O bands in the vibrational spectra of 4PCA were also studied. Moreover, the spectroscopic and theoretical results were compared with the corresponding properties for monomeric and dimeric structures of 4PCA. The calculated highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energies also confirm that charge transfer occurs within the molecule. NBO analysis confirms the presence of intramolecular charge transfer and the hydrogen bonding interaction. The detailed vibrational assignments were performed with the HF and DFT calculations, and the potential energy distribution (PED) was obtained by the Vibrational Energy Distribution Analysis (VEDA4) program. (C) 2017 Published by Elsevier B.V.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 39825-33-7. Quality Control of H-Ala-OiPr.

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Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4949-44-4, Name is Ethyl 3-oxopentanoate, molecular formula is C7H12O3, belongs to pyridazines compound. In a document, author is Mosberger, Mathias, introduce the new discover, Quality Control of Ethyl 3-oxopentanoate.

Influence of Hetero-Biaryl Ligands on the Photo-Electrochemical Properties of [(ReNCS)-N-I((NN)-N-boolean AND)(CO)(3)]-Type Photosensitizers

A complete set of the symmetrical bidiazine (bdz) and asymmetrical pyridyldiazine (pydz) ligands, along with the known 2,2 ‘-bipyridyl (bpy) ligand, and their respective rhenium(I)-tricarbonyl-bromo and -thiocyonato complexes are presented. A bathochromic shift is observed with an increasing number of nitrogen atoms, caused by a stabilization of the diimine based LUMO. As expected from the energy gap law, this results in an increase in the non-radiative decay constant (k(nr)) along the line bpy-pydz-bdz. Interestingly, the increase in k(nr) for both pyridazine ligands (2-(pyridin-2-yl)pyridazine (pypdz) and 3,3 ‘-bipyridazine (bpdz)) is much less pronounced as compared to the other pydz resp. bdz ligands. This results in overall longer lifetime and quantum yield, at the increased spectral overlap with sunlight – both properties sought for in the creation of light-harvesting schemes in photochemistry.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4949-44-4. Quality Control of Ethyl 3-oxopentanoate.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem