Tag: M.W:100-200

In an article, author is Gaikwad, Dattatraya D., once mentioned the application of 920-66-1, Safety of 1,1,1,3,3,3-Hexafluoropropan-2-ol, Name is 1,1,1,3,3,3-Hexafluoropropan-2-ol, molecular formula is C3H2F6O, molecular weight is 168.0378, MDL number is MFCD00011651, category is pyridazines. Now introduce a scientific discovery about this category.

Synthesis and anti-proliferative activity studies of 2-(2-(trifluoromethyl)-6-(substituted)imidazo[1,2-b]pyridazin-3-yl)-N-(substituted)acetamide derivatives

A series of novel imidazo[1,2-b]pyridazin-3-yl acetamide derivatives (9a-9j) were synthesized from a 3,6-dichloropyridazine. We have developed a simple strategy for the synthesis of functionally diverse imidazole, and pyridiazine derivatives were reported via a series of steps. The work involves bicyclic imidazo-pyridazine ring formation, halogenation, cynation, hydrolysis, peptide coupling, and Buchwald reaction. The structure of the synthesized compounds was confirmed by IR, H-1 NMR, C-13 NMR,F-19 NMR, mass spectra, and elemental analysis, and purity is checked by HPLC. All synthesized compounds were screened for anticancer activity against A-549 and Du-145 cancer cell lines by MTT assay. The preliminary bioassay suggests that most of the compounds show anti-proliferation with different degrees; doxorubicin was used as positive control. The synthesized compound shows IC50 values in the range of 1.74 mu M to 16.17 mu M in both cell lines. The compounds 9e, 9g, and 9h were active compared with doxorubicin in both the cell lines. The compounds having cyclopentyl ring are active compared with higher and lower carbon analogues.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

103-85-5, Name is 1-Phenylthiourea, molecular formula is C7H8N2S, belongs to pyridazines compound, is a common compound. In a patnet, author is Nief, Olfat A., once mentioned the new application about 103-85-5, Category: pyridazines.

Synthesis, Characterization of Poly Heterocyclic Compounds, and Effect on Cancer Cell (Hep-2) In vitro

A synthesis series of new heterocyclic derivatives (A(2)-A(7)) (pyrrole, pyridazine, oxazine and imidazol) derived from 4-acetyl-2,5-dichloro-1-(3,5-dinitrophenyl)-1H-pyrrole-3-carboxylate(A(1)) have been synthesised. Synthesis of compound (A(2)) by the reaction of starting material (A(1)) with hydroxyl amine hydrochloride in the presence of pyridine. Compound (A(2)) was reacted with hydrazine hydrate in dry benzene to give (A(3)) derivative. The compound) A(3)) deals with sodium nitrite to give diazonium salt, and the reaction diazonium salt with ethyl acetoacetate to produce compound (A(4)). To a mixture of compound (A(4)) and hydroxyl amine with sttired to yield (A(5)). Compound (A(6)) was prepared by reaction compound (A(4)) with thiosemicarbazide in presence of drops of acetic acid. Synthesis of 1compound (A(7)) by reaction compound (A(6)) with ethyl chloro acetate. The reactions have been monitored by TLC and the synthesized compounds were characterized using spectrophotometric methods FT-IR, 1H NMR. The biological effects of the prepared compounds on the cancer cells were studied in vitro. The results indicated that these Synthesized compounds (A(1)-A(7)) inhibited1 the cancer1 cells1 efficiently, the compound (A(6)) was activity inhibited on the cancer cells.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 103-85-5, Name is 1-Phenylthiourea, SMILES is S=C(N)NC1=CC=CC=C1, in an article , author is Jia, Bin, once mentioned of 103-85-5, Quality Control of 1-Phenylthiourea.

New bipolar host materials based on methyl substituted pyridazine for high- performance green and red phosphorescent OLEDs

In this work, two host materials, namely DAMP and DCMP were designed and synthesized based on 4,5-dimethylpyridazine and triphenylamine or carbazole. These two compounds exhibit good thermal stability, suitable highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels and balanced carrier transport properties. Green phosphorescent organic light-emitting devices (PhOLEDs) based on DAMP and DCMP exhibit excellent performance with the maximum external quantum efficiencies (EQEs) of 19.5% and 22.2%, respectively. At the luminance of 1000 cd/m(2), the EQE of the device based on DCMP can still reach to 21.4%. Besides, red PhOLEDs hosted by DAMP and DCMP also showed satisfied performance, with the maximum EQE of 15.3% and 20.0%, respectively. These results suggest that DAMP and DCMP are promising host materials for green and red PhOLEDs.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Related Products of 50681-25-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a article, author is Lyu, Xue-Li, introduce new discover of the category.

Visible-Light-Induced Copper-Catalyzed Decarboxylative Coupling of Redox-Active Esters with N-Heteroarenes

Herein we report a protocol for visible-light-induced copper-catalyzed decarboxylative coupling reactions between N-heteroarenes and redox-active esters. Various N-hydroxyphthalimide esters reacted with isoquinoline, quinoline, pyridine, pyrimidine, quinazoline, phthalazine, phenanthridine, and pyridazine to give the corresponding products in modest to excellent yields. The reactions proceed under mild conditions and have a broad scope and high functional group tolerance. Mechanistic studies revealed that the catalytic behavior of Cu-I photocatalyst generated in situ was consistent with that of preformed [Cu(dmp)(xantphos)]BF4.

Related Products of 50681-25-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 50681-25-9.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, formurla is C5H4N2O2. In a document, author is Saldia, Marianela, introducing its new discovery. SDS of cas: 50681-25-9.

Electronic and Photophysical Properties of Re-I(CO)(3)Br Complexes Modulated by Pyrazolyl-Pyridazine Ligands

The direct reaction of a series of substituted (1H-pyrazol-1-yl)pyridazine (L-I: 6-(1H-pyrazolyl)pyridazine; L-II: 3-chloro-6-(1H-pyrazole-1-yl)-pyridazine; L-III: 6-(1H-3,5-dimethylpyrazolyl)pyridazine-3-carboxylic acid; L-IV: 3,6-bis-N-pyrazolyl-pyridazine; and L-V: 3,6-bis-N-3-methylpyrazolyl-pyridazine) with the bromotricarbonyl(tetrahydrofuran)rhenium(I) dimer leads to the monometallic complexes [(L-X)Re(CO)(3)Br] (I-V), which displays a nonregular octahedral geometry around the Re-I center and a fac-isomerism for the carbonyl groups, whereas pyridazine and pyrazolyl rings remain highly coplanar after coordination to rhenium. Cyclic voltammetry shows one irreversible oxidation and one irreversible reduction for each compound as measured in N, N-dimethylformamide. Oxidation ranges from 0.94 V for III to 1.04 V for I and have been attributed to the Re-I/Re-II couple. In contrast, the reductions are ligand centered, ranging from -1.64 V for II to -1.90 V for III and V. Density functional theory calculations on the vertical one electron oxidized and one electron reduced species, using the gas-phase optimized geometry for the neutral complex confirm this assignment. Compounds I-V show two absorption bands, one around 410 nm (metal-to-ligand charge transfer (MLCT), Re-d pi -> pi*) and the other at similar to 300 nm (intraligand, pi -> pi*). Excitation at 400 nm at 77 K leads to unstructured and monoexponential emission with large Stokes shift, whose maxima vary between 570 (III) and 636 (II) nm. The quantum yields for these emissions in solution are intensified strongly going from air to argon equilibrated solution. Singlet oxygen quantum yields change from 0.03 (III) to 0.21 (IV). These data are consistent with emission from (MLCT)-M-3. The emission undergoes a bathochromic shift when R-1 is a pi-donating group (Cl or N-pyrazolyl) and a hypsochromic shift for a pi-acceptor (COOH). The bimolecular emission quenching rate constant by triethylamine (TEA) for II, IV, and V is 1.09, 0.745, and 0.583 x 10(8) M-1 s(-1), respectively. Photolysis in dichloromethane-CO2 saturated solution with TEA as a sacrificial electron donor leads in all cases to formic acid generation.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Synthetic Route of 5469-69-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 5469-69-2, Name is 3-Amino-6-chloropyridazine, SMILES is C1=C(N=NC(=C1)Cl)N, belongs to pyridazines compound. In a article, author is Mohamed, Khaled S., introduce new discover of the category.

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL HETEROCYCLES AS ANTIPYRINE DERIVATIVES

Novel antipyrine derivatives bearing pyran, pyridopyrimidine, chromene, benzothiazole, indole, pyrazole and pyridazine moieties were synthesized by using 2-cyano-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide (1) as a staring material. The newly synthesized compounds were evaluated for their antimicrobial activities based on inhibition diameter zone against Gram-positive and Gram-negative bacteria.

Synthetic Route of 5469-69-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 5469-69-2 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Electric Literature of 50681-25-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a article, author is Rizk, Sameh A., introduce new discover of the category.

Design, Regiospecific Green Synthesis, Chemical Computational Analysis, and Antimicrobial Evaluation of Novel Phthalazine Heterocycles

Phthalazines have received considerable attention for their wide antimicrobial activity. Regiospecific nucleophilic attack of 4-benzylphthalazin-1-ol by the 1-oxo rather than the aza group on different alkyl halides gave novel phthalazine heterocyclic derivatives. Moreover, a variety of nucleosides bonded to electron-withdrawing groups were synthesized using 4-benzylphthalazine-1-ol. The density functional theory has been used to investigate the electronic structure of the synthesized compounds. All of the synthesized derivatives showed remarkable activity when tested against Gram-positive and Gram-negative bacteria, Aspergillus niger, and Candida albicans. The reactivity of these nucleosides was expected to arise from their bonding with the lone pair of N-atom of the macromolecules of bacteria. These bonding were expected to inhibit the enzyme by forming highly stable complex with lower highest occupied molecular orbital energy. The structures of these synthesized derivatives were established by Fourier transform infrared, H-1-NMR, and C-13-NMR spectroscopic evidence.

Electric Literature of 50681-25-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 50681-25-9.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, formurla is C5H4N2O2. In a document, author is Pinto-Pacheco, Brismar, introducing its new discovery. SDS of cas: 50681-25-9.

Fluorescence Quenching Effects of Tetrazines and Their Diels-Alder Products: Mechanistic Insight Toward Fluorogenic Efficiency

Inverse electron demand Diels-Alder reactions betweens-tetrazines and strained dienophiles have numerous applications in fluorescent labeling of biomolecules. Herein, we investigate the effect of the dienophile on the fluorescence enhancement obtained upon reaction with a tetrazine-quenched fluorophore and study the possible mechanisms of fluorescence quenching by both the tetrazine and its reaction products. The dihydropyridazine obtained from reaction with a strained cyclooctene shows a residual fluorescence quenching effect, greater than that exerted by the pyridazine arising from reaction with the analogous alkyne. Linear and ultrabroadband two-dimensional electronic spectroscopy experiments reveal that resonance energy transfer is the mechanism responsible for the fluorescence quenching effect of tetrazines, whereas a mechanism involving more intimate electronic coupling, likely photoinduced electron transfer, is responsible for the quenching effect of the dihydropyridazine. These studies uncover parameters that can be tuned to maximize fluorogenic efficiency in bioconjugation reactions and reveal that strained alkynes are better reaction partners for achieving maximum contrast ratio.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Name: 3-Amino-6-chloropyridazine, 5469-69-2, Name is 3-Amino-6-chloropyridazine, SMILES is C1=C(N=NC(=C1)Cl)N, belongs to pyridazines compound. In a document, author is El-Sayed, Hassan A., introduce the new discover.

Cyanoacetic acid hydrazide: An efficient access for the synthesis of multi-functional azine and azole derivatives

Herein, the synthesis of nitrogen-containing heterocyclic scaffolds from heterocyclization of cyanoacetic acid hydrazide derivatives is described. Thiosemicarbazide derivative 1a undergoes base-mediated cyclization producing pyrazole derivative of type 2. The triazolopyridine 5 was obtained by double cyclization of 1a and benzylidene malononitrile. Compound 1b condensed with ethyl chloroformate to furnish pyrazolooxazine 8. Compound 1b was added to benzoyl isothiocyanate under thermal condition to form oxadiazine derivative 10 while, keeping the above reactant under room temperature to form acyclic derivative 11. Using CS2 as a cyclizing agent for compound 1b yielded pyrazole derivative 13. Treatment of 1b with I-2 resulted in oxidative cyclization producing pyridazine derivative 14. Compound 1c cyclized with benzoyl isothiocyanate forming triazolothiazine derivative 18. While using cinnamoyl isothiocyanate, the acyclic product 22 was obtained. Compound 1c was condensed with formaldehyde leading to oxadiazole derivative 25.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5469-69-2. Name: 3-Amino-6-chloropyridazine.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is an experimental science, Safety of Ethyl 3-oxopentanoate, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 4949-44-4, Name is Ethyl 3-oxopentanoate, molecular formula is C7H12O3, belongs to pyridazines compound. In a document, author is Ewida, Menna A..

Imidazo[2 ‘,1 ‘:2,3]thiazolo[4,5-d]pyridazinone as a new scaffold of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study

New series of thiazolo [4,5-d] pyridazin and imidazo [2′,1′:2,3]thiazolo [4,5-d]pyridazin analogues were designed, synthesized and evaluated for their in vitro DHFR inhibition and antitumor activity. Compounds 13 and 43 proved to be DHFR inhibitors with IC50 0.05 and 0.06 mu M, respectively. 43 proved lethal to OVCAR-3 Ovarian cancer and MDA-MB-435 Melanoma at IC50 0.32 and 0.46 mu M, respectively. The active compounds formed hydrogen bond at DHFR binding site between N-1-nitrogen of the pyridazine ring with Glu30; the carbonyl group with Trp24, Arg70 or Lys64; pi-cation interaction with Arg22 and pi-pi interaction with Phe31 residues. Ring annexation of the active 1,3-thiazole ring analogue 13 into the bicyclic thiazolo [4,5-d]pyridazine (18,19) or imidazo [2,1-b] thiazoles (23-25) decreased the DHFR inhibition activity; while the formation of the tricyclic imidazo [2′,1’:2,3]-thiazolo [4,5-d]pyridazine (43-54) increased potency. The obtained model could be useful for the development of new class of DHFR inhibitors.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4949-44-4. Safety of Ethyl 3-oxopentanoate.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem