Tag: M.W:100-200

Reference of 88-17-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 88-17-5, Name is 2-(Trifluoromethyl)aniline, SMILES is NC1=CC=CC=C1C(F)(F)F, belongs to pyridazines compound. In a article, author is Elie, Jonathan, introduce new discover of the category.

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

Haspin is a mitotic protein kinase required for proper cell division by modulating Aurora B kinase localisation and activity as well as histone phosphorylation. Here a series of imidazopyridazines based on the CHR-6494 and Structure Activity Relationship was established. An assessment of the inhibitory activity of the lead structures on human Haspin and several other protein kinases is presented. The lead structure was rapidly optimised using a combination of crystal structures and effective docking models, with the best inhibitors exhibiting potent inhibitory activity on Haspin with IC(50)between 6 and 100 nMin vitro. The developed inhibitors displayed anti-proliferative properties against various human cancer cell lines in 2D and spheroid cultures and significantly inhibited the migration ability of osteosarcoma U-2 OS cells. Notably, we show that our lead compounds are powerful Haspin inhibitors in human cells, and did not block G2/M cell cycle transition due to improved selectivity against CDK1/CyclinB.

Reference of 88-17-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 88-17-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 455-24-3, Name is 4-(Trifluoromethyl)benzoic acid, SMILES is C1=C(C=CC(=C1)C(O)=O)C(F)(F)F, in an article , author is Gao, Dan, once mentioned of 455-24-3, Application In Synthesis of 4-(Trifluoromethyl)benzoic acid.

Selective Synthesis in Microdroplets of 2-Phenyl-2,3-dihydrophthalazine-1,4-dione from Phenyl Hydrazine with Phthalic Anhydride or Phthalic Acid

Pyridazine derivatives are privileged structures because of their potential biological and optical properties. Traditional synthetic methods usually require acid or base as a catalyst under reflux conditions with reaction times ranging from hours to a few days or require microwave assistance to induce the reaction. Herein, this work presents the accelerated synthesis of a pyridazine derivative, 2-phenyl-2,3-dihydrophthalazine-1,4-dione (PDHP), in electrosprayed microdroplets containing an equimolar mixture of phenyl hydrazine and phthalic anhydride or phthalic acid. This reaction occurred on the submillisecond timescale with good yield (over 90 % with the choice of solvent) without using an external catalyst at room temperature. In sharp contrast to the bulk reaction of obtaining a mixture of two products, the reaction in confined microdroplets yields only the important six-membered heterocyclic product PDHP. Results indicated that surface reactions in microdroplets with low pH values cause selectivity, acceleration, and high yields.

Interested yet? Read on for other articles about 455-24-3, you can contact me at any time and look forward to more communication. Application In Synthesis of 4-(Trifluoromethyl)benzoic acid.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 4949-44-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 4949-44-4, Name is Ethyl 3-oxopentanoate, SMILES is CCC(CC(OCC)=O)=O, belongs to pyridazines compound. In a article, author is Ma, Jiani, introduce new discover of the category.

Detection and Identification of Reaction Intermediates in the Photorearrangement of Pyridazine N-Oxide: Discrepancies between Experiment and Theory

Photolysis of pyridazine N-oxide (PNO) results in the detection of a complex series of transient phenomena. On the ultrafast (fs) timescale, we could detect the decay of the first singlet excited state of PNO and the formation of a short-lived transient species, which, based on its time-resolved resonance Raman (TR3) spectrum, we assign to oxaziridine 1,2-diaza-7-oxa-bicyclo[4.1.0]hepta-2,4-diene. On a longer (hundreds of ns) timescale, this species rearranges to a ring-opened diazo compound, which we have also detected by time-resolved infrared and TR3 spectroscopy. In addition, we identify 1-oxa-3,4-diazepine as a long-lived species formed in the photochemistry of PNO. This species is formed via its oxirane isomer, which in turn is likely formed directly from the S I state of PNO via a conical intersection. The barrier determined experimentally for the decay of 1,2- diaza-7-oxa-bicyclo[4.1.0]hepta-2,4-diene (E-a = (7.1 +/- 0.5) kcal mol(-1)) is far larger than any barrier calculated by any method that includes dynamic electron correlation but very close to the barriers calculated at the RHF or CASSCF levels of theory. Many methods (B3LYP, MP2, and MP4) fail to give a minimum structure for 1,2-diaza-7-oxa-bicyclo[4.1.0]hepta-2,4-diene, while M06, M06-2X, MP3, CCSD, or CCSD(T) yield activation energies for its electrocyclic ring opening that are far too small. In addition, we note that several important geometric parameters, both of 1,2-diaza-7-oxa-bicyclo[4.1.0]hepta-2,4-diene and of the transition state of its ring opening reaction, clearly have reached no convergence, even at the fully optimized CCSD(T)/cc-pVTZ level of theory. We therefore suggest that the transient species described in this contribution might be excellent test molecules for further development of highly correlated and density functional theory methods.

Reference of 4949-44-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 4949-44-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 455-24-3, Name is 4-(Trifluoromethyl)benzoic acid, molecular formula is C8H5F3O2, belongs to pyridazines compound. In a document, author is Bruno, Rosaria, introduce the new discover, Recommanded Product: 455-24-3.

From Mononuclear Compounds to [2 x 2] Metallogrids: Ferromagnetically Coupled Systems Built by Nickel(II) and 3,6-Bis(2 ‘-pyridyl)pyridazine (dppn)

Mono-, di-, tri-, and tetranuclear compounds of nickel(II) of formula [Ni(dppn)(3)](NCS)(2).0.5dppn (1), [{Ni-(dppn)(NCS)}(2)(mu-dppn)(mu-NCS)]NCS (2), [Ni-3(dppn)(2)(N-3)(2)(mu-dppn)(2)(mu-N-3)(2)](ClO4)(2)center dot CH3CH2OH center dot 2H(2)O (3), and [Ni-4(mu-dppn)(4)(mu-N-3)(4)]Cl-4 center dot 5H(2)O (4) [dppn = 3,6-bis(2’-pyridyl)pyridazine] have been prepared and their structures determined by single crystal X-ray diffraction. Compound 1 is made up of mononuclear tris-chelated [Ni(dppn)(3)](2+) units, thiocyanate counterions, and dppn molecules of crystallization. 2 contains cationic dinuclear units, the six coordination around each metal center being achieved with a pyridazine-dppn and one end-on thiocyanate nitrogen as bridges, a didentate dppn ligand and a terminally bound N-thiocyanate. The electroneutrality in 2 is reached by free thiocyanato anions. 3 contains bent trinuclear cationic units where all nickel(II) ions exhibit a NiN6 chromophore with two bridging bis-didentate dppn and two end-on azide groups connecting the metal centers. Didentate dppn and monodentate azide ligands complete the six coordination at the peripheral nickel(II) ions. The charge in 3 is counterbalanced by perchlorate anions and ethanol and water molecules of crystallization are also present. 4 exhibits a [2 x 2] grid-type of nickel(II) ions where each pair of metal atoms are connected across a pyridazine-dppn fragment and one end-on azido group. Free chloride anions neutralize the positive charge of the grid and water molecules of crystallization are also present. Cryomagnetic susceptibility measurements on crushed crystals of 1-4, in the temperature range 1.9300 K, reveal the occurrence of a Curie law for 1 and overall ferromagnetic behavior for 2-4 [J = +4.52(2) (2), +1.32(1) (3), and +10.50(2) and +9.10(2) cm(-1) (4)]. The dominant ferromagnetic contribution across the single end-on thiocyanato (2) or azido bridges (3 and 4) versus the antiferromagnetic one through the pyridazine (2-4) is at the origin of this behavior. The values of the intramolecular ferromagnetic interactions in 3 and 4 were substantiated by DFT-type calculations. No ac signals were observed for 2-4 either in the lack of or under nonzero applied dc fields.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 455-24-3. Recommanded Product: 455-24-3.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Related Products of 920-66-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 920-66-1, Name is 1,1,1,3,3,3-Hexafluoropropan-2-ol, SMILES is OC(C(F)(F)F)C(F)(F)F, belongs to pyridazines compound. In a article, author is Huang, Wan-Yun, introduce new discover of the category.

Pyridazino[1,6-b]quinazolinones as new anticancer scaffold: Synthesis, DNA intercalation, topoisomerase I inhibition and antitumor evaluation in vitro and in vivo

A new anticancer N-containing heterocyclic scaffold was designed and 30 pyridazino[1,6-b]quinazolinone derivatives were synthesized and characterized. Antiproliferation evaluation in vitro against four human cancer cell lines including SK-OV-3(ovarian cell), CNE-2(nasopharyngeal cell), MGC-803(gastric cell) and NCI-H460(lung cell) indicated that most of them exhibited potent anticancer activity and the IC50 value of the most potent compound lowered to sub-mu M. DNA interaction assay indicated that compounds 4e, 4g, 6o, 6p, 8o can intercalate into DNA. Compounds 6 and 8 also demonstrated potent topoisomerase I (topo I) activity. Annexin VFITC/propidium iodide dual staining assay and cell cycle analysis indicated that 2-(4-bromophenyl)-4-((3-(diethylamino)propyl)amino) -10H-pyridazino [1,6-b]quinazolin- 10-one (8p) could induce arrest cell cycle at G2 phase and apoptosis in MGC-803 cells in a dose-dependent manner. The in vivo antitumor efficiency of compound 8p was also evaluated on MGC-803 xenograft nude mice, and the relative tumor growth inhibition was up to 55.9% at a dose of 20 mg/kg per two days. The results suggested that pyridazino[1,6-b]-quinazolinones might serve as a promising novel scaffold for the development of new antitumor agents.

Related Products of 920-66-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 920-66-1 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

In an article, author is Jia, Yunfei, once mentioned the application of 455-24-3, Formula: C8H5F3O2, Name is 4-(Trifluoromethyl)benzoic acid, molecular formula is C8H5F3O2, molecular weight is 190.12, MDL number is MFCD00002562, category is pyridazines. Now introduce a scientific discovery about this category.

Energetic 1H-Imidazo[4,5-d]pyridazine-2,4,7-triamine: A Novel Nitrogen-rich Fused Heterocyclic Cation with High Density

Fused heterocyclic energetic cation was rarely reported despite the development of energetic cation has attracted increasing attention in recent years. In this work, a new 1H-imidazo[4,5-d]pyridazine-2,4,7-triamine was synthesized in a one-step reaction, which was used as a cation to prepare 1H-imidazo[4,5-d]pyridazine-2,4,7-triamine perchlorate. Interestingly, when the synthesis was accomplished in different conditions, two crystal forms of perchlorate alpha-4 and beta-4 were obtained, which were further confirmed by X-ray single crystal diffraction, X-ray powder diffractograms, infrared and multinuclear NMR spectra. These salts showed high density (1.88-1.93 g cm(-3) at 293(2) K), moderate detonation performance (D, 8128-8437 m s(-1); P, 29.4-32.86 GPa) and good thermal stability (T-d: 272-274 degrees C). Compared with those known energetic perchlorates, the density and sensitivity (IS, 14-20 J; FS, 144-168 J) of 4 were also significantly improved. Through theoretical calculations and experiment results, the explanations for the differences in physicochemical properties of these two crystal forms were illustrated. Density overlap indicator (DORI) analysis was also employed to perform the necessary visualization and quantification of covalent and noncovalent interactions. It is evident that ionic bonds, hydrogen bonds, and pi-pi interactions are responsible for the high density and excellent performance of 1H-imidazo[4,5-d]pyridazine-2,4,7-triamine perchlorate, indicating that as-synthesized new material is a very promising cation in the construction of low-sensitivity high-energy compounds.

If you are interested in 455-24-3, you can contact me at any time and look forward to more communication. Formula: C8H5F3O2.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 2231-57-4, Name is Carbonothioic dihydrazide, formurla is CH6N4S. In a document, author is Daniels, Ruth E., introducing its new discovery. Recommanded Product: Carbonothioic dihydrazide.

Pyridazine-bridged cationic diiridium complexes as potential dual-mode bioimaging probes

A novel diiridium complex [(N<^>C<^>N)(2)Ir(bis-N<^>C)Ir(N<^>C<^>N)(2)Cl]PF6(N<^>C<^>N = 2-[3-tert-butyl-5-(pyridin-2-yl)phenyl]pyridine; bis-N<^>C = 3,6-bis(4-tert-butylphenyl) pyridazine) was designed, synthesised and characterised. The key feature of the complex is the bridging pyridazine ligand which brings two cyclometallated Ir(III) metal centres close together so that Cl also acts as a bridging ligand leading to a cationic complex. The ionic nature of the complex offers a possibility of improving solubility in water. The complex displays broad emission in the red region (lambda(em) = 520-720 nm, tau = 1.89 mu s, phi(em) = 62% in degassed acetonitrile). Cellular assays by multiphoton (lambda(ex) = 800 nm) and confocal (lambda(ex) = 405 nm) microscopy demonstrate that the complex enters cells and localises to the mitochondria, demonstrating cell permeability. Further, an appreciable yield of singlet oxygen generation (phi(Delta) = 0.45, direct method, by O-1(2) NIR emission in air equilibrated acetonitrile) suggests a possible future use in photodynamic therapy. However, the complex has relatively high dark toxicity (LD50 = 4.46 mu M), which will likely hinder its clinical application. Despite this toxicity, the broad emission spectrum of the complex and high emission yield observed suggest a possible future use of this class of compound in emission bioimaging. The presence of two heavy atoms also increases the scattering of electrons, supporting potential future applications as a dual fluorescence and electron microscopy probe.

If you are hungry for even more, make sure to check my other article about 2231-57-4, Recommanded Product: Carbonothioic dihydrazide.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is an experimental science, Application In Synthesis of 3-Amino-6-chloropyridazine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 5469-69-2, Name is 3-Amino-6-chloropyridazine, molecular formula is C4H4ClN3, belongs to pyridazines compound. In a document, author is Troitskaya-Markova, Nadezhda A..

Bis[1,2,5]oxadiazolo[3,4-c:3 ‘,4 ‘-e]pyridazine 4,5-dioxide as a synthetic equivalent of 4,4 ‘-dinitroso-3,3 ‘-bifurazan

The novel heterocyclic system, bis[1,2,5]oxadiazolo[3,4-c: 3′,4′-e]pyridazine 4,5-dioxide, was obtained along with other products in the course of oxidation of 3,3′-bi-1,2,5-oxadiazole4,4′-diamine. This compound acts as a synthetic equivalent of 4,4′-dinitroso-3,3’-bifurazan affording bis-diazene oxide derivative in the Kovacic reaction.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5469-69-2, in my other articles. Application In Synthesis of 3-Amino-6-chloropyridazine.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Synthetic Route of 1538-08-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, SMILES is NNC(=O)C(F)(F)F, belongs to pyridazines compound. In a article, author is Tonk, Rajiv K., introduce new discover of the category.

Therapeutic Potential of Cinnoline Core: A Comprehensive Review

Cinnoline or Benzo-pyridazine has its place in the family of fairly well-known benzfuseddiazine heterocycles. Because of its natural occurrence and synthetic exploration, cinnoline compounds validated its thought-provoking bioactivity through a number of research publications and patents during last few decades. A creative consideration has been rewarded to the synthesis of cinnoline based heterocyclic compounds, mostly due to their wide range of diverse pharmacological activities. The present review covers the principle approaches to the synthesis of cinnoline nucleus and almost all biological properties of 115 cinnoline derivatives reported during the last 65 years from natural and synthetic origin with 140 references.

Synthetic Route of 1538-08-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1538-08-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is an experimental science, Computed Properties of C7H6F3N, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 88-17-5, Name is 2-(Trifluoromethyl)aniline, molecular formula is C7H6F3N, belongs to pyridazines compound. In a document, author is Magyari, Jozef.

Synthesis, characterization, thermal properties and biological activity of diazine-ring containing hydrazones and their metal complexes

New coordination compounds have been synthesized by reacting Zn(II) and Co(II) nitrate or acetate in the presence of triethylamine with Schiff-base ligands containing diazine-ring, pyridine-2-carbaldehyde phthalazine-1-hydrazone,HzPYH, and di(2-pyridyl)ketone 3-chloro-pyridazine-6-hydrazone,HpDPKH. Complexes of[Co(HzPY)(2)]center dot 3.4H(2)O,[Zn(HzPY)(2)]and[Co(HpDPK)(2)]NO3 center dot H(2)Owere obtained. The crystal and the molecular structure of[Co(HzPY)(2)]center dot 3.4H(2)Owere determined using X-ray diffraction structure analysis. The compounds were characterized by elemental analysis, FT-IR and UV-Vis spectral data, conductivity and magnetic measurements, too. Except for the diamagnetic Co(III) compound with a nitrate counter-ion,[Co(HpDPK)(2)]NO3 center dot H2O, all the complexes are neutral-type. The magnetic moment of[Co(HzPY)(2)]center dot 3.4H(2)Oindicated a low-spin octahedral complex which is relatively rear amongst octahedral Co(II) complexes. Hence, its magnetic moment was measured in the temperature range of 3-300 K. To obtain products in the form of single crystals and/or to increase the yield, the reactions were carried out in solutions with different solvents or recrystallized from solvent mixtures. To determine the nature of the solvent (if any) in the crystalline products and to gain better insight into the decomposition mechanism, coupled TG-MS measurements were carried out. The desolvated compounds were stable at relatively high temperatures (> 200 degrees C). The cytotoxic, antiproliferative and efflux pump inhibitory effects of the compounds were tested in multidrug-resistant mouse T-lymphoma cells to study their effect on the suppression of MDR. The antibacterial activity of the compounds was also tested. The results of the antibacterial tests were analysed to understand better the effect of the central atoms and the structure on a specific activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 88-17-5, in my other articles. Computed Properties of C7H6F3N.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem