Tag: M.W:100-200

Related Products of 39825-33-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 39825-33-7, Name is H-Ala-OiPr, SMILES is C[C@H](N)C(OC(C)C)=O, belongs to pyridazines compound. In a article, author is Wang, Tao, introduce new discover of the category.

In situ Synthesis, Crystal Structure and Photoluminescence of a Novel Coordination Polymer with (4,6,6)-Connected sqc111 Topology

Employing the mixed ligands to react with Cd(NO3)(2)center dot 4H(2)O afforded a new 3D coordination polymer [Cd-3(BPTC)(bmp)(2)(ox)(H2O)(4)] (1) (H4BPTC = biphenyl-3,3′,4,4′-tetracarboxylic acid, bmp = 3,6-bis(imidazol-1-yl)pyridazine, H(2)ox = oxalic acid), in which ox(2-) was from the in situ oxidation of ethanol. Compound 1 bears a novel trinodal (4,6,6)-connected net structure, and it is the first replica of the theoretically predicted sqc111 topology net. Moreover, the thermal and photoluminescent properties for 1 were also investigated.

Related Products of 39825-33-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 39825-33-7.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5469-69-2, Name is 3-Amino-6-chloropyridazine, molecular formula is C4H4ClN3. In an article, author is Ismail, Mahmoud F.,once mentioned of 5469-69-2, Formula: C4H4ClN3.

Dodecanoyl isothiocyanate and N ‘-(2-cyanoacetyl) dodecanehydrazide as precursors for the synthesis of different heterocyclic compounds with interesting antioxidant and antitumor activity

Dodecanoyl isothiocyanate 1 was utilized for the construction of thioureido, 2-thioxo-2,3-dihydroquinazolin-4(1H)-one, benzo[d]-1,3-thiazin-4(H)-one and 3-amino quinazolin-4(3H)-one derivatives 2, 3, 4, and 5 respectively. However, N-(2-cyanoacetyl) dodecanehydrazide 6 was also used as a key starting material for the construction of a variety of new pyrazolone, pyrazole, thiadiazole, pyridazine, chromeno[2,3-c]pyrazole, and dithiolane derivatives 7, 9, 12, 15, 18, and 20, respectively. The newly synthesized compounds were characterized by elemental analyses and spectral data (IR, H-1 NMR, and mass spectra). Some of the newly synthesized compounds bearing heterocyclic moieties were tested for antioxidant activity as reflected in their ability to inhibit oxidation in rat brain and kidney homogenates using 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) inhibition. Also, in vitro anticancer activity was examined using the standard (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) (MTT) method against a panel of two human tumor cell lines namely; hepatocellular carcinoma HepG2 and mammary gland breast cancer MCF-7. Compounds 12 and 16b exhibited the highest activities as antioxidant and antitumor agents. Meanwhile, compounds 7 and 20 showed moderate activities and the rest of the tested compounds showed weak activities. [GRAPHICS] .

Interested yet? Keep reading other articles of 5469-69-2, you can contact me at any time and look forward to more communication. Formula: C4H4ClN3.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Quality Control of 4-(Trifluoromethyl)benzoic acid, 455-24-3, Name is 4-(Trifluoromethyl)benzoic acid, molecular formula is C8H5F3O2, belongs to pyridazines compound. In a document, author is Zhao, Shixian, introduce the new discover.

Organometallic chemistry of bis(N-heterocyclic carbene) ligands containing a heteroarene spacer

Heteroarene-linked bis(N-heterocyclic carbenes) constitute an important family of ligands in transition metal chemistry and homogeneous catalysis. These ligands are used as multidentate ligands for the construction of mononuclear and multinuclear complexes that show unique physical properties and that are efficient catalysts for many organic transformations. A number of transition metal complexes of heteroarene-linked bis(N-heterocyclic carbene) ligands have been synthesized and structurally characterized in recent decades. In this review, we summarize the recent developments in metal complexes supported by heteroarene-linked bis(N-heterocyclic carbene) ligands and their applications. The ligands and their complexes are categorized by the linkers between the two NHCs, such as pyridine, bipyridine, phenanthroline, naphthyridine, pyrazole, thiophene, and pyridazine. (C) 2017 Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 455-24-3. Quality Control of 4-(Trifluoromethyl)benzoic acid.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

In an article, author is Aggarwal, Ranjana, once mentioned the application of 1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, molecular formula is C2H3F3N2O, molecular weight is 128.05, MDL number is MFCD00221440, category is pyridazines. Now introduce a scientific discovery about this category, Application In Synthesis of 2,2,2-Trifluoroacetohydrazide.

Synthesis and structural studies of 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b][3 ‘,4 ‘-f]pyridazines

Synthesis of a series of 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b][3′,4′-f]pyridazines (4) was accomplished by the oxidative intramolecular cyclization of 6-arylidenehydrazino-3-aryl-1,2,4-triazolo[4,3-b]pyridazine (3) using iodobenzene diacetate (IBD), as a green oxidant, in dichloromethane at room temperature. The compounds 3 and 4 were characterized by IR, NMR (H-1 and C-13), mass spectral data and elemental analyses. X-ray crystal analysis of sterically strained 3,6-di-(2′-fluorophenyl)-bis-1,2,4-triazolo-[4,3-b][3′,4′-f]pyridazine 4f and 3,6-di-(4′-fluorophenyl)-bis-1,2,4-triazolo-[4,3-b][3′,4’-f]pyridazine 4g indicated that pyridazine ring has twisted conformation leading to nonplanar tricyclic core. Both compounds crystallized in orthorhombic P2(1)2(1)2(1) space group, containing one single molecule per asymmetric unit. The studies reveal that the compound 4f is associated with weak, centrosymmetric F center dot center dot center dot F interactions (distance of 2.882(3) angstrom), with cis geometry, between adjacent molecules which are responsible for the formation of chains along a axis. Additionally, compounds 4 were screened for their cytotoxic activity against the human cervical carcinoma (HeLa) cell line using MTT assay, however, with not much significant activity. (C) 2019 Elsevier B.V. All rights reserved.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

Chemistry, like all the natural sciences, Category: pyridazines, begins with the direct observation of nature¡ª in this case, of matter.920-66-1, Name is 1,1,1,3,3,3-Hexafluoropropan-2-ol, SMILES is OC(C(F)(F)F)C(F)(F)F, belongs to pyridazines compound. In a document, author is Martinez-Gonzalez, Sonia, introduce the new discover.

Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors

PIM kinase family (PIM-1, PIM-2 and PIM-3) is an appealing target for the discovery and development of selective inhibitors, useful in various disease conditions in which these proteins are highly expressed, such as cancer. The significant effort put, in the recent years, towards the development of small molecules exhibiting inhibitory activity against this protein family has ended up with several molecules entering clinical trials. As part of our ongoing exploration for potential drug candidates that exhibit affinity towards this protein family, we have generated a novel chemical series of triazolo[4,3-b]pyridazine based tricycles by applying a scaffold hopping strategy over our previously reported potent pan-PIM inhibitor ETP-47453 (compound 2). The structure-activity relationship studies presented herein demonstrate a rather selective PIM-1 /PIM-3 biochemical profile for this novel series of tricycles, although pan-PIM and PIM-1 inhibitors have also been identified. Selected examples show significant inhibition of the phosphorylation of BAD protein in a cell-based assay. Moreover, optimized and highly selective compounds, such as 42, did not show significant hERG inhibition at 20 mu M concentration, and proved its antiproliferative activity and utility in combination with particular antitumoral agents in several tumor cell lines. (C) 2019 Elsevier Masson SAS. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 920-66-1. Category: pyridazines.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

In an article, author is Moslin, R., once mentioned the application of 88-17-5, Name is 2-(Trifluoromethyl)aniline, molecular formula is C7H6F3N, molecular weight is 161.1245, MDL number is MFCD00007718, category is pyridazines. Now introduce a scientific discovery about this category, SDS of cas: 88-17-5.

Identification of imidazo[1,2-b] pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling

As a member of the Janus (JAK) family of non-receptor tyrosine kinases, TYK2 mediates the signaling of pro-inflammatory cytokines including IL-12, IL-23 and type 1 interferon (IFN), and therefore represents an attractive potential target for treating the various immuno-inflammatory diseases in which these cytokines have been shown to play a role. Following up on our previous report that ligands to the pseudokinase domain (JH2) of TYK2 suppress cytokine-mediated receptor activation of the catalytic (JH1) domain, the imidazo[1,2-b] pyridazine (IZP) 7 was identified as a promising hit compound. Through iterative modification of each of the substituents of the IZP scaffold, the cellular potency was improved while maintaining selectivity over the JH1 domain. These studies led to the discovery of the JH2-selective TYK2 inhibitor 29, which provided encouraging systemic exposures after oral dosing in mice. Phosphodiesterase 4 (PDE4) was identified as an off-target and potential liability of the IZP ligands, and selectivity for TYK2 JH2 over this enzyme was obtained by elaborating along selectivity vectors determined from analyses of X-ray co-crystal structures of representative ligands of the IZP class bound to both proteins.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Sarris, Alexi J. C., once mentioned the application of 103-85-5, Name is 1-Phenylthiourea, molecular formula is C7H8N2S, molecular weight is 152.2168, MDL number is MFCD00004933, category is pyridazines. Now introduce a scientific discovery about this category, Formula: C7H8N2S.

Fast and pH-Independent Elimination of trans-Cyclooctene by Using Aminoethyl-Functionalized Tetrazines

The inverse-electron-demand Diels-Alder/pyridazine elimination tandem reaction, in which the allylic substituent on trans-cyclooctene is eliminated following reaction with tetrazines, is gaining interest as a versatile bioorthogonal process. One potential shortcoming of such currently used reactions is their propensity to proceed faster and more efficiently at lower pH, a feature caused by the nature of the tetrazines used. Here, we present aminoethyl-substituted tetrazines as the first pH-independent reagents showing invariably fast elimination kinetics at all biologically relevant pH values.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem