Tag: M.W:100-200

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 6-Chloro-4-methylpyridazin-3-amine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 64068-00-4

TRIAZOLO COMPOUNDS

The present invention relates to compounds of formula (I) and its use for the treatment of neurological disorders.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1041 – PubChem

 

Reference of 141-30-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 141-30-0, 3,6-Dichloropyridazine, introducing its new discovery.

Highly selective and sensitive determination of copper ion based on a visual fluorescence method

A novel ratiometric fluorescence sensor for rapid and on-site visual detection of Cu2+ was designed and synthesized by integrating yellow-emission rhodamine fluorophore (RL) and red-emission CdTe@SiO2 QDs. The as-prepared nanohybrid fluorescence sensor shows dual-emissions at 537 nm and 654 nm under a single excitation at 500 nm in the presence of Cu2+. Owing to the strong chelating ability of RL toward Cu2+, the yellow fluorescence of RL could be selectively enhanced while the red fluorescence of CdTe QDs is almost unchanged, leading to an obvious fluorescence color change from red to yellow, which could be used for visual and ratiometric detection of Cu2+. This nanohybrid sensor exhibits excellent selectivity, sensitivity and anti-interference to Cu2+ detection and the detection limit is as low as 8.4 nM. Additionally, a simple device test strip for rapid and on-site detection of Cu2+ has been designed by immobilizing the RL-CdTe@SiO2 QDs on a common filter paper. This simple and effective paper-based sensor has a visual detection limit of 0.5 muM, showing its promising application for on-site and rapid sensing of Cu2+ in pollution water.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 141-30-0. In my other articles, you can also check out more blogs about 141-30-0

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1641 – PubChem

 

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Safety of 3,6-DichloropyridazineIn an article, once mentioned the new application about 141-30-0.

Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors

Background: Since brain neurotransmitter levels are associated with the pathology of various neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) plays a critical role in balancing these neurotransmitters in the brain. MAO isoforms appear as promising drug targets for the development of central nervous system agents. Pyridazinones have a broad array of biological activities. Here, six pyridazinone derivatives were synthesized and their human monoamine oxidase inhibitory activities were evaluated by molecular docking studies, in silico ADME prediction and in vitro biological screening tests. Methods: The compounds were synthesized by the reaction of different piperazine derivatives with 3 (2H)-pyridazinone ring and MAO-inhibitory effects were investigated. Docking studies were conducted with Maestro11.8 software. Results: Most of the synthesized compounds inhibited hMAO-B selectively except compound 4f. Compounds 4a?4e inhibited hMAO-B selectively and reversibly in a competitive mode. Compound 4b was found as the most potent (ki = 0.022 ¡À 0.001?muM) and selective (SI (Ki hMAO-A/hMAO-B) = 206.82) hMAO-B inhibitor in this series. The results of docking studies were found to be consistent with the results of the in vivo activity studies. Compounds 4a?4e were found to be non-toxic to HepG2 cells at 25?muM concentration. In silico calculations of ADME properties indicated that the compounds have good pharmacokinetic profiles. Conclusion: It was concluded that 4b is possibly recommended as a promising nominee for the design and development of new pyridazinones which can be used in the treatment of neurological diseases. Graphic abstract: [Figure not available: see fulltext.].

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1839 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 5-Chloropyridazin-4-amine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 53180-92-0, Name is 5-Chloropyridazin-4-amine, molecular formula is C4H4ClN3

Synthetic method 5-chloro -4-aminopyridazine (by machine translation)

The invention relates to the technical field, of chemical synthesis 5 – and particularly discloses,aminopyridazine-3,6 -aminopyridazine as a starting material, and a synthetic route, of 4 -aminopyridin, chloro N – obtained by hydrogenation dechlorination (NCS) to yield, amino pyridazine key intermediate 5 – with .5 – chlorine – 4 4-aminopyridazine as an important intermediate, for drug synthesis, in particular to commercialized mass production, of the synthetic route, of the present invention for the first time to obtain. chlorine – 4 4-aminopyridazine, in a high yield and. high purity for the first time, 5 . (by machine translation)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 5-Chloropyridazin-4-amine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 53180-92-0, in my other articles.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N711 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: Methyl 6-chloropyridazine-3-carboxylate, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 65202-50-8, Name is Methyl 6-chloropyridazine-3-carboxylate, molecular formula is C6H5ClN2O2

PYRIMIDINE AND PYRAZINE HDAC1,2 INHIBITORS

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: Methyl 6-chloropyridazine-3-carboxylate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 65202-50-8, in my other articles.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2428 – PubChem

 

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. category: pyridazineIn an article, once mentioned the new application about 141-30-0.

Facile access to mono-cinchona alkaloid-derived ligands

Two facile accesses to mono-cinchona alkaloid-derived ligands, by conventional heating conditions and solvent-free microwave irradiation, are described. 1,4-Dichlorophthalazine (PHAL) or 3,6-dichloropyridazine (PYDZ) reacted with quinine (QN), cinchonine (CN), or cinchonidine (CND) by using CaH2 as acid-bonding reagent in DMF at 90-100C to provide mono-cinchona alkaloid-derived ligands 2a-f (87-95%) in 1.5 h. However, the coupling reactions were performed under solvent-free microwave conditions to yield 2a-f (64-89%) within 15 min. Copyright Taylor & Francis Group, LLC.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1945 – PubChem

 

Related Products of 141-30-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent£¬once mentioned of 141-30-0

Use of Mc4 Receptor Agonist Compounds

This invention relates to the use of an MC4 receptor agonist compound for the manufacture of a medicament for the treatment of lower urinary tract dysfunction.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 141-30-0. In my other articles, you can also check out more blogs about 141-30-0

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1325 – PubChem

 

1837-55-4, Name is 3,5-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Safety of 3,5-DichloropyridazineIn an article, once mentioned the new application about 1837-55-4.

Suzuki-Miyaura coupling

The Suzuki-Miyaura coupling (SMC) is the most commonly used carbon-carbon bond forming reaction in the pharmaceutical industry. Its popularity in industry comes from its ability to carry out a wide range of C(sp2)-C(sp2) couplings and to therefore generate a broad range of biaryl motifs in a straightforward manner while displaying a high level of functional group tolerance. The high success rate of the reaction has been driven by the enormous amount of research that has been carried out in developing new ligands and reaction conditions, and it is now the case that the majority of potential substrates can be coupled if the right conditions are chosen. With the huge number of conditions available, the decision as to which to pick with a difficult SMC reaction can be difficult to make. This chapter will detail the best approaches to use for the coupling of challenging substrates as well as highlighting the main issues that can prevent successful reaction. The side reactions encountered with heterocyclic boronates will be discussed in detail and approaches to avoid the issues will be examined. The power of the SMC reaction in allowing selective coupling in dihalogenated systems will also be detailed, and a range of industry examples will be detailed to illustrate the points made.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1189 – PubChem

 

Related Products of 20375-65-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.20375-65-9, Name is 3-Phenyl-6-chloropyridazine, molecular formula is C10H7ClN2. In a Article£¬once mentioned of 20375-65-9

Complexation of chiral di (N-Protected alpha-Amino)-beta-diketones with some transition metals

Chiral Di (N-protected a-amino)-b-diketones and its transition metal complexes have been synthesized. Di(N-protected a-amino)-b- diketones were prepared by reaction of activation of N-protected- a-amino acids (imidazolide) with a-diazoketones derived from natural amino acids in presence of lithium diisopropyl amid in tetrahydrofuran as a solvent at -78 C and treatment the product with rhodium acetate to remove diazo group. The synthesized compounds were characterized by analytical techniques viz: IR, NMR and elemental analysis. The thermal stability of the newly synthesized metal complexes have been studied.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 20375-65-9

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2735 – PubChem

 

Application of 141-30-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article£¬once mentioned of 141-30-0

Model Studies toward the Total Synthesis of Thebaine by an Intramolecular Cycloaddition Strategy

Three model compounds required for an approach to thebaine by intramolecular [4+2] cycloaddition were prepared. In the first two cases the anticipated cycloaddition products were obtained under thermal conditions. Thermolysis of the third, more advanced model compound, afforded products resulting from rearrangements and/or elimination. A study of analogous intra- and intermolecular reactions using benzofuran as dienophile and various electron-poor and electron-rich dienes (pyridazines, pyranones, Danishefsky diene) was undertaken.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 141-30-0. In my other articles, you can also check out more blogs about 141-30-0

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1776 – PubChem