Tag: M.W:100-200

Related Products of 21778-81-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Synthesis of Indole- and Pyrrole-Fused Seven-Membered Nitrogen Heterocycles via Acid-Base Switchable Cyclization Involving Cleavage of Amide C-N Bonds. Author is Hao, Yanke; Zhou, Pan; Niu, Kaikai; Song, Hongjian; Liu, Yuxiu; Zhang, Jingjing; Wang, Qingmin.

The method for synthesis of indole- and pyrrole-fused seven-membered nitrogen heterocycles I [R = H, Br; R1 = H; RR1 = -CH=CHCH=CH-, -CH=C(OMe)CH=CH-, -CH=CHC(Br)=CH-, etc.; R2 = H, Me, 3-(trifluoromethyl)phenyl, ethyloxidanyl; R3 = H, Me; R4 = Me, 4-methylphenyl, thiophen-2-yl, etc.], 2-tosyl-1,2,3,4-tetrahydro-5H-[1,5]diazocino[3,2,1-hi]indol-5-one and II (R5 = H, OMe; R6 = Me, 2-fluorophenyl, thiophen-2-yl, etc.) by means of acid-base switchable cyclization reactions have been reported. The reactions involved cleavage of amide C-N bonds, chemoselective N-1 or C-3 acylation, and 1,4-Michael addition This method could be used to construct two different kinds of seven-membered rings in one step from the same starting material without the need for a transition-metal catalyst.

There are many compounds similar to this compound(21778-81-4)Related Products of 21778-81-4. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and biological evaluation of indoles, published in 2015, which mentions a compound: 21778-81-4, Name is 5-Methoxy-1H-indole-2-carbaldehyde, Molecular C10H9NO2, Computed Properties of C10H9NO2.

Objective of this research was to synthesize and characterize indole derivatives Indole nucleus has antimicrobial activities. Different kind of indole ring derivatives were synthesized such as 3-((E)-2-nitrovinyl)-1H-indole, 2-(1H-indol-3-yl)ethanamine, N-(2-(1H-indol-3-yl)ethyl)benzamide, Me 2-(3-(2-(benzamido)ethyl)-1H-indol-1-yl)acetate, 2-(3-(2-(benzamido)ethyl)-1H-indol-1-yl)acetic acid, N-(2-(1-((2,3-dihydro-1H-inden-5-yl-carbamoyl)methyl)-1H-indol-3-yl)ethyl)benzamide, e.g., I [R = 4-indanyl, 5-indanyl]. Antifungal activity of compounds I [R = 4-indanyl, 5-indanyl] were also studied.

There are many compounds similar to this compound(21778-81-4)Computed Properties of C10H9NO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Name: 5-Methoxy-1H-indole-2-carbaldehyde. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Convenient synthesis of tetrahydro-γ-carbolines and tetrahydroquinolines through a chemo- and regioselectivity switch by a Bronsted acid catalyzed, one-pot, multicomponent reaction. Author is Cheng, Hong-Gang; Chen, Cai-Bao; Tan, Fen; Chang, Ning-Jie; Chen, Jia-Rong; Xiao, Wen-Jing.

An efficient, one-pot, multicomponent reaction of aldehydes, p-methoxyaniline, and 2-vinylindoles was developed. This approach provides a practical approach to synthetically and biol. significant tetrahydro-γ-carboline and tetrahydroquinoline derivatives in good yields through a chemo- and regioselectivity switch, which can be tuned by simply changing the substituent on the indole component under identical reaction conditions.

There are many compounds similar to this compound(21778-81-4)Name: 5-Methoxy-1H-indole-2-carbaldehyde. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride, is researched, Molecular C4H9ClFN, CAS is 136725-55-8, about Facile and efficient syntheses of novel (S)- and (R)-3-fluoropyrrolidines and 3,3-difluoropyrrolidine, the main research direction is fluoropyrrolidine enantiomeric synthesis; difluoropyrrolidine enantiomeric; pyrrolidine fluoro difluoro.Quality Control of (R)-(-)-3-Fluoropyrrolidine Hydrochloride.

Novel enantiomeric 3-fluoropyrrolidines and 3,3-difluoropyrrolidine were obtained in high yield starting from the enantiomerically pure and com. available (2S,4R)-4-hydroxyproline. Spray-dried potassium fluoride and diethylaminosulfur trifluoride were used to introduce one or two fluorine atoms, resp.

There are many compounds similar to this compound(136725-55-8)Quality Control of (R)-(-)-3-Fluoropyrrolidine Hydrochloride. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Formula: C10H9NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Asymmetric organocatalytic N-alkylation of indole-2-carbaldehydes with α,β-unsaturated aldehydes: one-pot synthesis of chiral pyrrolo[1,2-a]indole-2-carbaldehydes. Author is Hong, Liang; Sun, Wangsheng; Liu, Chunxia; Wang, Lei; Wang, Rui.

Diphenylprolinol trimethylsilyl ether-catalyzed asym. aza-Michael addition/aldol addition of indole-2-carboxaldehyde with unsaturated aldehydes is described. A series of chiral pyrrolo[1,2-a]indole-2-carbaldehydes were obtained in good yields with excellent stereoselectivities.

There are many compounds similar to this compound(21778-81-4)Formula: C10H9NO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Name: (R)-(-)-3-Fluoropyrrolidine Hydrochloride. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride, is researched, Molecular C4H9ClFN, CAS is 136725-55-8, about Scalable Process Design for a PDE10A Inhibitor Consisting of Pyrazolopyrimidine and Quinoxaline as Key Units. Author is Yamagami, Takafumi; Kobayashi, Ryo; Moriyama, Noriaki; Horiuchi, Hideki; Toyofuku, Eiji; Kadoh, Yoichi; Kawanishi, Eiji; Izumoto, Shinichi; Hiramatsu, Hajime; Nanjo, Takehiro; Sugino, Masuhiro; Utsugi, Masayuki; Moritani, Yasunori.

In this study, research and development for the synthetic process of a PDE10A inhibitor are described; in particular, an efficient regioselective construction of the quinoxaline unit, a cost-effective pyrazolo[1,5-a]pyrimidine formation, and a cost-saving approach in a nucleophilic aromatic substitution (SNAr) reaction by introducing oxazolidinone as an electron-withdrawing group to a chloropyrazolo[1,5-a]pyrimidine core are key points. The newly developed process has been successfully scaled up to 40 kg. Furthermore, a one-pot tandem reaction from aminopyrazole to dichloropyrazolo[1,5-a]pyrimidine by activating malonic acid with POCl3 was discovered. The finding contributed to avoiding isolation of the hygroscopic pyrazolo[1,5-a]pyrimidin-5(4H)-one intermediate, which caused complicated filtration and drying processes observed in the first scale-up campaign.

There are many compounds similar to this compound(136725-55-8)Name: (R)-(-)-3-Fluoropyrrolidine Hydrochloride. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Catalytic Asymmetric [3 + 2] Annulation via Indolyl Copper-Allenylidene Intermediates: Diastereo- and Enantioselective Assembly of Pyrrolo[1,2-a]indoles.Application of 21778-81-4.

A catalytic asym. decarboxylative [3 + 2] annulation via indolyl copper-allenylidene amphiphilic intermediates has been developed. This protocol offers a straightforward method for the synthesis of biol. important pyrrolo[1,2-a]indoles bearing contiguous quaternary and tertiary stereogenic centers with excellent diastereo- and enantioselectivities (up to >20:1 dr and >99% ee). In addition, the diversity-oriented synthesis of pyrrolo[1,2-a]indoles was achieved via versatile transformations of the alkyne-containing cycloadducts.

There are many compounds similar to this compound(21778-81-4)Application of 21778-81-4. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Recommanded Product: 21778-81-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Synthesis of carbazole derivatives. III. Synthesis of new pyrrolidino[3,4-c]carbazoles by intramolecular Michael addition. Author is Mahboobi, Sioavosh; Kuhr, Sabine; Koller, Markus.

The authors have reported on the synthesis of carbazoles by inter- and intramol. Michael addition Ellipticine derivatives are related to these compounds, and especially those with 9-methoxy- and 9-hydroxy substituents exhibit appreciable antitumor and antileukemic activity. Therefore, the authors have prepared the tetrahydrocarbazoles I (R1 = OMe, R2 = H; R1 = H, R2 = OMe), starting from N-benzyl-2-formyl-5-methoxyindole and N-benzyl-2-formyl-7-methoxyindole, resp.

There are many compounds similar to this compound(21778-81-4)Recommanded Product: 21778-81-4. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ) is researched.Computed Properties of C10H9NO2.Liu, Hailong; Zhang, Lei; Zhao, Fei; Liu, Hong published the article 《Three-Step One-Pot Synthesis of 1,4-Dihydropyrazolo[4,3-b|indoles Using Copper Catalysis》 about this compound( cas:21778-81-4 ) in European Journal of Organic Chemistry. Keywords: dihydropyrazoloindole preparation; formylindole hydrazine cyclization microwave irradiation copper catalyst. Let’s learn more about this compound (cas:21778-81-4).

A convenient three-step one-pot copper-catalyzed method has been developed for the preparation of pyrazolo[4,3-b]indoles, new indole-based compounds with potential biol. activity. Treatment of various hydrazines, including alkyl hydrazines, with indole-2-carbaldehydes generated the corresponding products in moderate to good yields without protection of the indole N-1 moiety. In addition, LiOH was used as a base in the copper-catalyzed coupling reaction. Microwave heating was used to accelerate the iodination of indoles and the C-N bond formation.

There are many compounds similar to this compound(21778-81-4)Computed Properties of C10H9NO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Cooperative N-heterocyclic Carbene and Iridium Catalysis Enables Stereoselective and Regiodivergent [3 + 2] and [3 + 3] Annulation Reactions, the main research direction is pyrroloindole preparation enantioselective diastereoselective regioselective; indolyl allyl carbonate enal cyclization carbene iridium catalyst; formylcyclopropane enal cyclization carbene iridium catalyst; pyridineindole preparation enantioselective diastereoselective regioselective; enal indolyl allyl carbonate cyclization carbene iridium catalyst.Product Details of 21778-81-4.

A cooperative N-heterocyclic carbene (NHC)/iridium catalysis has been developed to achieve highly stereoselective and regiodivergent [3 + 2] and [3 + 3] annulation reactions of 2-indolyl allyl carbonates I (R = H, Me; R1 = H, OMe, Me, F, Cl; R1 = H, OMe, Cl) with enals R3CH=CHCHO (R1 = Ph, hexyl, 4-chlorophenyl, furan-2-yl, etc.). The use of the NHC catalyst has introduced switchable homoenolate and enolate intermediates from the common enal precursor via a simple adjustment of reaction conditions in a predictable manner. This protocol furnishes two types of biol. important products, pyrrolo[1,2-a]indoles II and pyridine[1,2-a]indoles III, with high diastereo- and enantioselectivities (up to >20:1 dr and >99% ee). Notably, all four stereoisomers of these products with two vicinal stereocenters could be afforded through permutations of the enantiomers of the two chiral catalysts. Mechanistic investigations and further computational d. functional theory calculations give an explanation of the origin of the regioselectivity. In addition, the NHC-enolate intermediate generated from formylcyclopropanes IV (R4 = Ph, tert-Bu, naphthalen-2-yl, etc.) was also compatible in this cooperative catalytic system and thus the arsenal of optically pure pyrrolo[1,2-a]indole products V was enriched.

There are many compounds similar to this compound(21778-81-4)Product Details of 21778-81-4. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem