Tag: M.W:100-200

Application of 141-30-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 141-30-0, Name is 3,6-Dichloropyridazine,introducing its new discovery.

A new series of 3-allylthio-6-(mono or disubstituted) aminopyridazines was synthesized by reacting 3-allylthio-6-chloropyridazine with several amines to develop new anticancer agents. These new compounds showed antiproliferative activities against lung cancer (A549), hepatoblastoma (Hep3b), prostate cancer (PC3), colon cancer (SW480) and cervical cancer (HeLa) cells in MTT assays, and could be promising candidates for chemotherapy of carcinomas. Compound 5 (3-allylthio-6-homopiperidinylaminopyridazine) showed higher potencies than 5-FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 5.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 141-30-0, and how the biochemistry of the body works.Application of 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1959 – PubChem

Synthetic Route of 932-22-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone,introducing its new discovery.

Lactam-lactim tautomeric structure of three hydroxypyridazine derivatives was investigated by infrared spectroscopy. The conclusion could be drawn that the molecules exist in oxo-enol tautomeric equilibrium in dioxane solution. The cyclic dimer intermolecular association of the molecules was supported by a charge distribution calculation.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 932-22-9, and how the biochemistry of the body works.Synthetic Route of 932-22-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2342 – PubChem

Related Products of 932-22-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a article，once mentioned of 932-22-9

The lipid peroxidation inhibiting piperazine and homopiperazine derivatives of the general formula (I) and the pharmaceutically acceptable acid addition salts thereof, Lip stands for hydrogen; C15 20 alkyl; C10 20 alkanoyl or C10 20 alkenoyl; trityl optionally substituted by halogen; adamantyl; 1- or 2-naphthyloxy or oxo-substituted tetrahydronaphthyloxy; or an amine protective group commonly used e.g. in the peptide chemistry;, A¹ and A² are selected independently from the group consisting of a single bond and C2 3 alkylene optionally substituted by hydroxy or oxo;, n is 1 or 2; and, Het represents, a group of the general formula (a), wherein, R¹ is amino or 1-pyrrolidinyl;, or a 4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl group of the formula (b); or a 4-amino-6,7-dimethoxy-2-quinazolinyl group of the formula (c); or a 4,7-diamino-6-phenyl-2-pteridinyl group of the formula (d); or a 2,7-diamino-6-phenyl-4-pteridinyl group of the formula (e); or a 2,4,7-triamino-6-pteridinylcarbonyl group of the formula (f); or a group of the general formula (g); wherein, X means oxygen, sulfur or nitrogen optionally substituted by lower alkyl,with the frist proviso that, when Het stands for a group of the general fromula (a) and both A¹ and A² mean single bonds then Lip may not be hydrogen;, with the second priviso that, when Lip is different from naphthyloxy or oxo-substituted tetrahydronaphthyloxy then A¹ means a single bond;, with the third proviso that, when Lip represents naphthyloxy or oxo-substituted tetrahydronaphthyloxy then A¹ may not be a single bond, as well as with the fourth proviso that, A¹ and A² cannot simultaneously stand for C2 3 alkylene optionally substituted by hydroxy or oxo.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 932-22-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2285 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 35857-89-7, name is 6-Chloropyridazine-3-carbonitrile, introducing its new discovery. name: 6-Chloropyridazine-3-carbonitrile

Pyruvate dehydrogenase kinases (PDKs) are overexpressed in most cancer cells and are responsible for aberrant glucose metabolism. We previously described bis(4-morpholinyl thiocarbonyl)-disulfide (JX06, 16) as the first covalent inhibitor of PDK1. Here, on the basis of the scaffold of 16, we identify two novel types of disulfide-based PDK1 inhibitors. The most potent analogue, 3a, effectively inhibits PDK1 both at the molecular (kinact/Ki = 4.17 × 103 M-1 s-1) and the cellular level (down to 0.1 muM). In contrast to 16, 3a is a potent and subtype-selective inhibitor of PDK1 with >40-fold selectivity for PDK2-4. 3a also significantly alters glucose metabolic pathways in A549 cells by decreasing ECAR and increasing ROS. Moreover, in the xenograft models, 3a shows significant antitumor activity with no negative effect to the mice weight. Collectively, these data demonstrate that 3a may be an excellent lead compound for the treatment of cancer as a first-generation subtype-selective and covalent PDK1 inhibitor.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 35857-89-7, and how the biochemistry of the body works.name: 6-Chloropyridazine-3-carbonitrile

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N945 – PubChem

Application of 66346-87-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 66346-87-0, 6-Chloro-5-methylpyridazin-3-amine, introducing its new discovery.

A nose drop containing the compound (I) represented by the formulawherein Ar1and Ar2are each an aromatic group, Ar1and Ar2optionally form a condensed cyclic group together with the adjacent carbon atom, ring B is a nitrogen-containing heterocycle, X and Y are each a bond, an oxygen atom or S(O)p (p is 0 to 2), NR4(R4is H or a lower alkyl group) or a divalent linear lower hydrocarbon group optionally having substituents and containing 1 to 3 heteroatoms, A is N or CR7(R7is H, a halogen atom, a hydrocarbon group, an acyl group or a hydroxy group optionally having substituents), R1, R2and R3are each H, a halogen atom, a hydrocarbon group, an acyl group or a hydroxy group optionally having substituents, and, R8is H, a hydroxy group optionally substituted by a lower alkyl group or a carboxyl group, provided that the nitrogen-containing heterocycle represented by ring B is not a heterocycle represented by the formulawherein n is 0 – 1, or a salt thereof or a prodrug thereof, exhibits a superior prophylactic or therapeutic effect on allergic rhinitis and the like.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 66346-87-0. In my other articles, you can also check out more blogs about 66346-87-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1085 – PubChem

Electric Literature of 141-30-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a article，once mentioned of 141-30-0

A photochemical method for the direct synthesis of 1H-pyrazoles from pyridazine N-oxides was developed. This chemistry features a regioselective approach to nonsymmetrically substituted pyridazine N-oxides. Herein, we highlight the first strategic use of photoinduced ring-opening reactions of 1,2-diazine N-oxides for the preparative synthesis of nitrogen heterocycles.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1862 – PubChem

Application of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent，once mentioned of 141-30-0

Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+-O-; X is O, S, -NH-, and -N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by a7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 141-30-0, and how the biochemistry of the body works.Application of 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1367 – PubChem

Electric Literature of 88511-47-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.88511-47-1, Name is Pyridazine-4-carboxamide, molecular formula is C5H5N3O. In a Article，once mentioned of 88511-47-1

The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel antibiotics. In the present study, we synthesized 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator. These efforts resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans, and in a mouse mammary gland infection model, without showing cytotoxicity. Don’t let the bad bugs bite: Staphylococcus aureus (blue) is notorious for causing antibiotic (yellow) resistant biofilm-related infections. The discovery of hamamelitannin as an antimicrobial potentiator led to an investigation of its structure-activity relationship. A potent and metabolically stable analogue (see structure, green) was identified that shows improved activity and drug-like properties.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 88511-47-1, and how the biochemistry of the body works.Electric Literature of 88511-47-1

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N456 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: Hexahydropyridazine dihydrochloride, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 124072-89-5, Name is Hexahydropyridazine dihydrochloride, molecular formula is C4H12Cl2N2

The present invention relates to new dithiinopyridazinedione derivatives, to processes for preparing them, to their use for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to crop protection compositions comprising these dithiinopyridazinedione derivatives.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: Hexahydropyridazine dihydrochloride, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 124072-89-5, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2168 – PubChem

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Computed Properties of C4H2Cl2N2In an article, once mentioned the new application about 141-30-0.

A series of A-ring pyrrole compounds of duocarmycin bearing 4′-methoxy- beta-heteroarylacryloyl groups were synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity against murine sarcoma 180 in mice. Most of the 4′-methoxy-beta- heteroarylacrylates displayed in vitro anticellular activity equivalent to that of 4′-methoxy-cinnamates. Among the 8-O-[(N-methylpiperazinyl)carbonyl] derivatives of 4′-methoxy-beta-heteroarylacrylates, compound 15b having a (4- methoxy-3,5-pyrimidinyl)acryloyl as segment-B (Seg-B) showed remarkably potent in vivo antitumor activity and low peripheral blood toxicity compared with the A-ring pyrrole derivatives having the trimethoxyindole skeleton in Seg-B, which were equal to 8-O-[(N-methylpiperazinyl)carbonyl] derivatives of 4′-methoxycinnamates. Moreover, these 8-O-[(N-methylpiperazinyl)carbonyl] derivatives of 4′-methoxy-beta-heteroarylacrylates had high aqueous solubility.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1597 – PubChem