Tag: M.W:100-200

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C5H5BrN2O, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 17321-29-8, Name is 3-Bromo-6-methoxypyridazine, molecular formula is C5H5BrN2O

New sulfones were synthesized; these are analogues of bis-(4-aminophenyl)sulfone (DDS) but contain, instead of one benzene nucleus, a heterocycle that is a pyrimidine, pyrazine or pyridazine nucleus.This was substituted with amine, methoxy, methyl groups or halogens in order to obtain long-acting drugs, similarly to those obtained in the field of sulfonamides.The synthesis was accomplished by reaction of sodium p-amino- or p-acetamidobenzenesulfinate with the corresponding halodiazine; only the p-aminophenyl 3-aminopyridazin-6-yl sulfone was obtained by acid hydrolysis.The compounds showed good antitubercular activity in vitro.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Formula: C5H5BrN2O, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 17321-29-8

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2546 – PubChem

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. COA of Formula: C4H2Cl2N2In an article, once mentioned the new application about 141-30-0.

1,2,4,5-Tetrazines and 1,2,4-triazines tethered to tryptamine via the ethylamine side chain undergo intramolecular inverse electron demand cycloadditions to produce adducts with the [ABazaCE]-ring skeleton of the Aspidosperma alkaloids. (C) 2000 Elsevier Science Ltd.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1616 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C4H2Cl2N2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

Glycogen synthase kinase 3 regulates glycogen synthase, the rate-determining enzyme for glycogen synthesis. Liver and muscle glycogen synthesis is defective in type 2 diabetics, resulting in elevated plasma glucose levels. Inhibition of GSK-3 could potentially be an effective method to control plasma glucose levels in type 2 diabetics. Structure-activity studies on a N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine series have led to the identification of potent and selective compounds with good cellular efficacy. Molecular modeling studies have given insights into the mode of binding of these inhibitors. Since the initial leads were also potent inhibitors of CDK-2/CDK-4, an extensive SAR was performed at various positions of the pyrazolo[1,5-b] pyridazin core to afford potent GSK-3 inhibitors that were highly selective over CDK-2. In addition, these inhibitors also exhibited very good cell efficacy and functional response. A representative example was shown to have good oral exposure levels, extending their utility in an in vivo setting. These inhibitors provide a viable lead series in the discovery of new therapies for the treatment of type 2 diabetes.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Computed Properties of C4H2Cl2N2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1920 – PubChem

Reference of 18591-82-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.18591-82-7, Name is 6-Methylpyridazin-3-amine, molecular formula is C5H7N3. In a Patent，once mentioned of 18591-82-7

The invention concerns pharmaceutically useful N-heterocyclyl sulphonamide derivatives, their pharmaceutically acceptable salts, processes for their manufacture, their use for antagonising one or more actions of endothelin in a human or other warm-blooded animal, their use in methods of treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N205 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of 3,6-Dichloropyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Safety of 3,6-Dichloropyridazine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1333 – PubChem

Electric Literature of 59772-58-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.59772-58-6, Name is 6-Aminopyridazine-3-carboxylic acid, molecular formula is C5H5N3O2. In a Article，once mentioned of 59772-58-6

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 59772-58-6

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N820 – PubChem

Reference of 20375-65-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.20375-65-9, Name is 3-Phenyl-6-chloropyridazine, molecular formula is C10H7ClN2. In a Article，once mentioned of 20375-65-9

We report new 3D fragment descriptors to model parameters and properties of stereoisomeric molecules and conformers. New 3D fragment descriptors have been applied to discriminate between stereoisomers in predictive QSPR modeling of the standard free energy (?G) for the 1:1 inclusion complexation of 76 chiral guests with beta-cyclodextrin (beta-CD) and 40 chiral guests with 6-amino-6-deoxy-beta-cyclodextrin (am-beta-CD) in water at 298 K. The in-house software, mfSpace (Molecular Fragments Space), was used for QSPR modeling, generation and coding of the 3D fragment descriptors. The program implements the Singular Value Decomposition for Multiple Linear Regression analysis as machine learning method. We used ensemble modeling techniques which include the generation of many individual models, the selection of the most relevant ones and followed by their joint application to test compounds, i.e., applying a consensus model for average predictions. The models based on 2D and 3D fragment descriptors provide the best predictions in external fivefold cross-validation: root mean squared error RMSE = 1.1 kJ/mol and determination coefficient Rdet2 = 0.918 (beta-CD), RMSE = 0.89 kJ/mol and Rdet2 = 0.910 (am-beta-CD).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 20375-65-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2745 – PubChem

Electric Literature of 932-22-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a Article，once mentioned of 932-22-9

Amyloid plaques, which are primarily composed of aggregated amyloid-beta (Abeta) peptide, are the neuropathological hallmarks of Alzheimer’s disease (AD). Fluorescent markers containing 2-styrylpyridazin-3(2H)-ones were developed to detect intracellular aggregated Abeta peptides. Nine compounds exhibited a greater than 10-fold increase of in emission spectra before and after mixing with Abeta aggregates compared with before mixing. Among these compounds, compound 9n exhibited the highest affinity for Abeta aggregates (Kd = 1.84 muM) and selectively stained both aggregated intracellular Abeta and Abeta plaques in the transgenic AD model mice (APP/PS1). These preliminary results indicate that 2-styrylpyridazin-3(2H)-one derivatives are promising alternative fluorescence imaging agent for the study of AD.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 932-22-9. In my other articles, you can also check out more blogs about 932-22-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2347 – PubChem

1442437-21-9, Name is 4-Hydroxy-6-oxo-1,6-dihydropyridazine-3-carboxylic acid, belongs to pyridazine compound, is a common compound. Computed Properties of C5H4N2O4In an article, once mentioned the new application about 1442437-21-9.

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNalpha, by acting on Tyk-2 to cause signal transduction inhibition.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2012 – PubChem

Electric Literature of 13327-27-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.13327-27-0, Name is 6-Methylpyridazin-3(2H)-one, molecular formula is C5H6N2O. In a Article，once mentioned of 13327-27-0

Following a ligand-based drug design approach, a potent mixed formyl peptide receptor 1 (FPR1) and formyl peptide receptor-like 1 (FPRL1) agonist (14a) and a potent and specific FPRL1 agonist (14x) were identified. These compounds belong to a large series of pyridazin-3(2H)-one derivatives substituted with a methyl group at position 6 and a methoxy benzyl at position 4. At position 2, an acetamide side chain is essential for activity. Likewise, the presence of lipophilic and/or electronegative substituents in the position para to the aryl group at the end of the chain plays a critical role for activity. Affinity forFPR1 receptors was evaluated by measuring intracellular calcium flux in HL-60 cells transfected with FPR1, FPRL1, and FPRL2. Agonists were able to activate intracellular calcium mobilization and chemotaxis in human neutrophils. Themost potent chemotactic agent (EC50 =0.6 muM) was the mixed FPR/FPRL1 agonist 14h.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 13327-27-0, and how the biochemistry of the body works.Electric Literature of 13327-27-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N302 – PubChem