Top Picks: new discover of 3,6-Dichloropyridazine

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Synthetic Route of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent,once mentioned of 141-30-0

The invention relates to new dihydrothienopyrimidinesulphoxides of formula 1, as well as pharmacologically acceptable salts thereof, wherein X is SO or SO2, but preferably SO, and wherein R3 denotes an optionally substituted, mono- or bicyclic, unsaturated, partially saturated or saturated heterocycle or an optionally substituted, mono- or bicyclic heteroaryl and wherein R1 and R2 have the meanings stated in claim 1, as well as pharmaceutical compositions which contain these compounds. These new dihydrothienopyrimidinesulphoxides are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1492 – PubChem

 

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Phosphine oxide of the formula selected from the group consisting of STR1 wherein X is H, alkylthio of 1-4 carbon atoms, or STR2 Y is H, alkyl of 1-4 carbon atoms, Cl, Br, or STR3 Z is H, alkyl of 1-4 carbon atoms, or STR4 at least one of X, Y, and Z in the formula in which all three symbols appear is STR5 Q is H or Br; each of A and A’ is selected independently from H and alkyl of 1-4 carbon atoms, or A and A’ taken jointly is CH=CH–CH=CH; each of D and D’ is selected independently from H and CN, or D and D’ taken jointly is CH=CH–CH=CH; and each R is selected independently from alkyl of 1-4 carbon atoms, cycloalkyl of 5-6 carbon atoms, benzyl, phenyl, tolyl, and chlorophenyl.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1458 – PubChem

 

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A novel macrobicycle featuring an amidopyridine unit as a carboxylic acid binding site, and amide functionality to provide further hydrogen bonding interactions with suitable guests has been prepared. The ability of this novel macrobicycle to bind peptide derivatives has been investigated.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2766 – PubChem

 

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A process is described for the production of cyclohexanedimethanol by hydrogenation of a dialkyl cyclohexanedicarboxylate which comprises the steps of: (a) providing a hydrogenation zone containing a charge of a granular reduced manganese promoted copper catalyst; (b) forming a vaporous feed stream of a hydrogenatable material comprising a dialkyl cyclohexanedicarboxylate and from about 0.1 wt % up to about 15 wt % of an acidic material at a feed temperature which is in the range of from about 150 C. to about 350 C. and which is above the dew point of the feed stream and at a feed pressure which is in the range of from about 150 psia (about 10.34 bar) up to about 2000 psia (about 137.90 bar), said vaporous mixture having a known hydrogen-containing gas:dialkyl cyclohexanedicarboxylate ratio; (c) supplying the vaporous feed stream to the hydrogenation zone; (d) maintaining hydrogenation conditions in the hydrogenation zone which are effective to maintain the reaction mixture in contact with the catalyst above its dew point; (e) passing the vaporous feed stream through the hydrogenation zone: and (f) recovering from the hydrogenation zone a product stream comprising cyclohexanedimethanol.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2083 – PubChem

 

Awesome Chemistry Experiments For Pyridazine-3-carbonitrile

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Electric Literature of 53896-49-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.53896-49-4, Name is Pyridazine-3-carbonitrile, molecular formula is C5H3N3. In a article,once mentioned of 53896-49-4

Irradiation of 9 leads to hydrogen abstraction by N(1) and fragmentation to 8 from a triplet with ET ?78 kcal/mol. Irradiation of 2-acylpyridines (10) leads to abstraction by both nitrogen and oxygen (cf. eq 4), with the same Stern-Volmer kqtau for the two processes. Irradiation of 2-acylpyrazines (11) can lead to abstraction by either nitrogen (phi27 0.77 from 11b) or oxygen (phi11a 0.95 from 11f)- 3-Acylpyridazine 12d is unreactive on direct irradiation or triplet sensitization with sensitizer ET ?70 kcal/mol; it furnishes a small amount of 12a on sensitization by acetone. Ketone 18 is recovered unchanged from irradiation under all conditions used with 12d. These observations suggest a correlation between the photochemistry of each of these compounds and the energy of the npi* triplet of the heteroaromatic ring. The nature of the excited state(s) responsible for hydrogen abstraction by nitrogen and oxygen in these ketones is discussed.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N197 – PubChem

 

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Application of 141-30-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article,once mentioned of 141-30-0

Cyclic voltammetry and controlled-potential electrolysis have been employed to examine the electrochemical behavior of some mono- and dichlorinated pyrazines, quinoxalines, and pyridazines at carbon and mercury cathodes in either acetonitrile or dimethylformamide containing a tetraalkylammonium salt. Unsubstituted pyrazine and pyridazine each exhibit a single reduction wave, whereas unsubstituted quinoxaline shows three cathodic waves. For the chlorinated compounds, an additional wave is seen for the reduction of each carbon-chlorine bond. Depending on the potential of the cathode, bulk electrolyses of dichlorinated pyrazines or quinoxalines afford either the monochlorinated or fully dechlorinated product, whereas the monochlorinated analogues undergo reduction to the dechlorinated species. Electrolyses of chlorinated pyridazines give dark colored solutions, but the products (apparently polymeric) cannot be detected or identified by means of conventional GC, GC-MS, and HPLC techniques.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1829 – PubChem

 

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Electric Literature of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article,once mentioned of 141-30-0

For the first time, heterogeneous osmium tetroxide catalyzed asymmetric aminohydroxylation of olefins on polymer-supported ligands have been shown to proceed with comparable rate as in the case of homogeneous conditions.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1835 – PubChem

 

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 141-30-0, name is 3,6-Dichloropyridazine, introducing its new discovery. Recommanded Product: 141-30-0

The present invention relates to compounds that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1280 – PubChem

 

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Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine (1) with benzyl, aryl, and alkyl organozinc compounds led to selective mono-substitution of one of the chlorine atoms. The subsequent cross-coupling of the resulting monochlorides with RZnCl afforded unsymmetrical 3,6-carbon-disubstituted pyridazines.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1639 – PubChem

 

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The present disclosure describes compounds which are Akt kinase inhibitors useful for the treatment of cancer. The compounds disclosed herein are bivalent ligands capable of binding with both the kinase enzyme ATP binding domain and the kinase enzyme substrate binding domain.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1401 – PubChem