Tag: M.W:0-100

1632-76-4, 3-Methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 19; S-CS^-Dimethyl-lH-indol-l-yO-N’-CS-methoxy^-Cpyridazin-S- ylmethoxy)benzylidene)propanehydrazide; [0529] (a) 3-(Chloromethyl)pyridazine: To a stirred solution of 3- methylpyridazine (0.29 niL, 3.19 mmol) in CHCl3 (6 niL) at 60 0C was added trichloroisocyanuric acid (296 mg, 1.28 mmol) in several portions. The reaction mixture was heated for 2 hours and then absorbed directly onto silica gel. Purification on silica gel using EtOAc -hexane (0 to 80%) provided the product as a reddish oil (160 mg)., 1632-76-4

As the paragraph descriping shows that 1632-76-4 is playing an increasingly important role.

Reference£º
Patent; STEIN, Philip; DAINES, Robert; SPROUS, Dennis; O’GRADY, Harold; WO2010/132615; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

289-80-5, Pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

289-80-5, n-Butyllithium (2.76 mL, 6.9 mmol, 2.5 M in hexane) was added dropwise to a cooled (0 C) solution of diisopropylamine (0.97 mL, 6.9 mmol) in tetrahydrofuran (2 mL) under a nitrogen atmosphere. After stirring for 30 minutes the reaction mixture was cooled to-78 C and a solution of pyridazine (452 pL, 6.3 mmol) and tributyltin chloride (1.9 mL, 6.9 mmol) were added simultaneously while the temperature was kept below-70 C. The reaction mixture was stirred for 2 hours at-78 C ; subsequently, a saturated aqueous NH4C1 solution was added and the reaction mixture was extracted three times with ethyl acetate. The combined organic layers were dried (MgSO4) and evaporated to dryness. The crude product was purified by LCMS to give t’butylstannylpyridazine (197 mg, 0.53 mmol, 8% yield). This stannylpyridazine (183 mg, 0.49 mmol), (11ss,16alpha,17ss)-11-(4-bromophenyl)-17- cyclopropylcarbonyl-16-methylestra-4, 9-dien-3-one (100 mg, 0.20 mmol) and bis (triphenylphosphine) palladium (ll) chloride (3 mg, 0.004 mmol) were dissolved in dioxane (3 mL) under a nitrogen atmosphere. The reaction mixture was stirred overnight at 110 C and then cooled to room temperature. Water was added and the mixture was extracted three times with dichloromethane. The combined organic layers were dried through a phase separate filter and evaporated to dryness. Purification by LCMS followed by lyophilisation gave (11 p, 160, 17p)-17-cyclopropylcarbonyl-16-methyl-11- [4- (4-pyridazinyl) phenyl] estra- 4,9-dien-3-one (78 mg, 0.16 mmol, 79% yield).’H NMR (400 MHz, CDCl3) : 8 0.33 (s, 3H), 0.85-2. 84 (m, 26H), 4.48 (d, J= 7 Hz, 1H), 5.81 (s, 1H), 7.33-7. 37 (m, 2H), 7.60-7. 64 (m, 3H), 9.21 (dd, J = 5 and 1 Hz, 1H), 9.46 (dd, J = 3 and 1 Hz, 1H). The same title compound was also obtained using 4-tributylstannylpyridazine prepared according to the procedures described in Eur. J. Org. Chem. 2885-2896 (1998) and Tetrahedron Letters 38,5791-5794 (1997).

As the paragraph descriping shows that 289-80-5 is playing an increasingly important role.

Reference£º
Patent; AKZO NOBEL N.V.; WO2005/92912; (2005); A1;,
Pyridazine – Wikipedia
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20744-39-2, Pyridazin-4-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of primary amine (0.192 mmol) and triethylamine (0.480 mmol) in tetrahydrofuran (3 mE) at 0 C. were added phenyl chloroformate (0.096 mmol) and the reaction mixture stirred for 60 mm. at RT. The reaction mixture was quenched with water and the phenyl carbamate formed was extracted and the Intermediate 4J (25 mg, 0.096 mmol) in THF was added to the extract and the resulting solution was stirred at room temperature for 2 h. Reaction progress wasmonitored by TLC. The reaction mixture was quenched with water and extracted with ethyl acetate (3×5 mE) The combined organic layer was washed with 10% NaHCO3 (2×5 mE), water, dried over Na2SO4 and concentrated to afford crude product as off-white solid. The crude product wasther purified by preparative HPLC.

20744-39-2, 20744-39-2 Pyridazin-4-amine 298492, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; Velaparthi, Upender; Darne, Chetan Padmakar; Liu, Peiying; Wittman, Mark D.; Pearce, Bradley C.; Araujo, Erika M. V.; Dasgupta, Bireshwar; Nair, Jalathi Surendran; Janakiraman, Sakthi Kumaran; Rachamreddy, Chandrasekhar Reddy; Rao, Mettu Mallikarjuna; Karuppiah, Arul Mozhi Selvan Subbiah; Reddy, Bandreddy Subba; Nagalakshmi, Pulicharla; Bora, Rajesh Onkardas; Maheshwarappa, Shilpa Holehatti; Kumaravel, Selvakumar; Mullick, Dibakar; Sistla, Ramesh; (353 pag.)US9273058; (2016); B2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20744-39-2,Pyridazin-4-amine,as a common compound, the synthetic route is as follows.

Example 142-{[(4-Fluorophenyl)methyl]oxy}-4-(1 -methyl-1 H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-To a solution of methyl 2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1 H-pyrazol-4-yl)-5-(4- morpholinylmethyl)benzoate (may be prepared as described in Description 18; 144 mg, 0.33 mmol) in tetrahydrofuran (4 ml) was added lithium hydroxide (23.54 mg, 0.98 mmol) and water (1 ml). The mixture was stirred at room temperature for 18 hours then neutralised with 2M hydrochloric acid (0.79 ml, 1.59 mmol). The solvent was removed in vacuo and the residue redissolved in N,N-dimethylformamide (4 ml). Diisopropylethylamine (0.11 m, 0.66 mmol), 4-pyridazinamine (40.5 mg, 0.43 mmol), 1-hydroxy-7-azabenzotriazole (53.5 mg, 0.39 mmol) and EDC (94 mg, 0.49 mmol) were added and the solution was stirred for 3 hours. The solvent was removed in vacuo and the residue purified by MDAP to yield the title compound as a white solid. 57 mg.MS (electrospray): m/z, [M+H]+ = 5031 H NMR (400 MHz, DMSO-d6); 2.34 – 2.46 (4 H, m), 3.43 – 3.49 (2 H, m), 3.59 (4 H, t, J=4.14 Hz), 3.92 (3 H, s), 5.30 (2 H, s), 7.21 (2 H, t, J=8.91 Hz), 7.33 (1 H, s), 7.60 (2 H, dd, J=8.66, 5.65 Hz), 7.70 (1 H, s), 7.87 (1 H, s), 7.99 (1 H, dd, J=5.77, 2.76 Hz), 8.14 (1 H, s), 9.05 (1 H, d, J=5.77 Hz), 9.16 (1 H, d, J=1.76 Hz), 10.61 (1 H, s).

20744-39-2, As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James; WO2012/28629; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5469-70-5

Phenyl pyridazin-3-ylcarbamateTo a solution of 3-amino-6-chloropyridazine (19.2 g,148 mmol; CASNo. 5469-69-2) in EtOH (500 mL) was added 10% Pd catalyst on 1940 carbon (unreduced, 55% water). Triethylamine (50 mL) was added and the mixture was hydrogenated under 500 psi/mole for 1.9 h. The reaction was filtered and the ethanol was washed with aqueous NH4CI. The organic layer was concentrated to give pyridazin-3-amine as a white solid (11 g, 78% yield). MS (APCI 10V) AP+ 1 96.2. To a suspension of pyridazin-3-amine (5 g, 50 mmol) in THF (50 mL) and CH3CN (70 mL) was added pyridine (5.10 mL, 63.1 mmol) followed by phenyl chloroformate (6.95 mL, 55.2 mmol) slowly. The reaction was stirred overnight. The reaction was filtered to remove the precipitate. The filtrate was concentrated and then taken up in CH2CI2 which was then washed with water. The organic layer was dried using SPE phase separators and concentrated. The residue was purified by silica gel column chromatography (0-5% MeOH/CH2CI2). An undesired side product eluted first followed by the title compound which was concentrated to give a white solid (7.5 g, 70% yield). MS (APCI 10V) AP+1 216.12; 1H NMR (400 MHz, DMSO-d6) delta ppm 7.20 – 7.24 (m, 2 H) 7.25 – 7.28 (m, 1 H) 7.39 – 7.44 (m, 2 H) 7.64 – 7.69 (m, 1 H) 8.05 (dd, 1 H) 8.94 (dd, 1 H) 11.34 (s, 1 H).

As the paragraph descriping shows that 5469-70-5 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; LONG, Scott Allen; MEYERS, Marvin Jay; PELC, Matthew James; SCHWEITZER, Barbara Ann; THORARENSEN, Atli; WANG, Lijuan Jane; WO2010/58318; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

289-80-5, Pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The synthesis of 2 was similar to that of complex 1, but 3-nitrophthalic acid (H2npt) was used instead of H3btc. Reaction of AgNO3 (33.4 mg, 0.2 mmol), pyridazine (pdz)(16.0 mg, 0.2 mmol) and 1,3,5-benzene tricarboxylic (H3btc)(44.2 mg, 0.2 mmol) took place in H2O-DMF (N,N-Dimethylformamide)solvents (6 ml, v/v = 1:1) in the presence of ammonia(0.5 mL, 14 M) under ultrasonic treatment (160 W, 40 kHz,30 min) at 40 C. The resultant colourless solution was allowed slowly to evaporate at room temperature in the dark. The yellowcrystals of complex 1 were obtained after several days.The crystals were isolated by filtration and washed by deionized water and ethanol and dried in the air. And lightyellow crystals of 2 were obtained in 78% yield based on Ag. Elemental analysis: Anal. Calc. for Ag2C12H7N3O6: C, 28.545; H,1.397; N, 8.322. Found: C, 28.65; H, 1.41; N, 8.36%. Selected IR peaks (cm1): 3410 (m), 3085 (m), 2970 (w), 2849 (w), 1964 (w),1595 (s), 1519 (s), 1455 (s), 1372 (s), 1290 (s), 1156 (m), 1060(m), 965 (m), 920 (s), 819 (s), 787 (m), 748 (s), 710 (s), 684 (s),583 (w), 545 (w), 424(m)., 289-80-5

The synthetic route of 289-80-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Dan-Feng; Zhang, Ting; Dai, Si-Min; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; PA; (2014); p. 193 – 200;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1632-76-4,3-Methylpyridazine,as a common compound, the synthetic route is as follows.

To a solution of 3-methylpyridazine (4.60 g, 48.9 mmol) in acetic acid (30.0 mL) was added H202 (29.4 g,259 mmol, 29.4 mL, 30percent (w/w) in water). The mixture was heated at 120 00 for 6 h. The mixture wasallowed to cool to rt and poured in aqueous saturated NaHCO3 (500 mL) and extracted with DCM (5x 50 mL). The combined organic layer was dried over Na2SO4 and concentrated in vacuo to afford 6-methyl- pyridazine 1-oxide (2.22 g, 20.2 mmol, 41percent). LCMS: cal for [M+H} = 111.05, fd 111.2. 1H NMR shows a 1:1 mixture of both possible N-oxides.

1632-76-4, The synthetic route of 1632-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GRUeNENTHAL GMBH; NARDI, Antonio; RATCLIFFE, Paul; CRAAN, Tobias; HERTRAMPF, Thorsten; LESCH, Bernhard; STEINHAGEN, Henning; (70 pag.)WO2015/161924; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5469-70-5,3-Aminopyridazine,as a common compound, the synthetic route is as follows.

A round bottom flask was charged with pyridazin-3 -amine (10.11 mg, 0.106 mmol) and DMSO (0.204 ml) to give a solution. (P)-perfluorophenyl l-(5-fluoro-2-methoxy- 4-(3,3,3-trifluoropropyl)phenyl)-2-oxo-l,2-dihydroquinoline-6-sulfonate (0.050 g, 0.082 mmol) and THF (0.613 ml) were added. The flask was cooled in an ice-bath for 5 minutes, then LHMDS (1M in THF) (0.188 ml, 0.188 mmol) was added dropwise. The reaction was stirred for 15 minutes. The reaction was diluted with ethyl acetate and washed twice with IN HC1 solution. The organic layer was washed with brine, dried with sodium sulfate, filtered, and concentrated. The material was purified via column chromatography (RediSep Gold 40g, gradient elution 10-75% [3: 1 EtOAc/EtOH]: Heptane) to afford (P)-l-(5-fluoro-2-methoxy-4- (3,3,3-trifluoropropyl)phenyl)-2-oxo-N-( yridazin-3-yl)-l,2-dihydroquinoline-6-sulfonamide (0.036 g, 0.069 mmol, 84 % yield) as a white solid. NMR (400 MHz, DMSO-i) delta = 2.62 – 2.79 (m, 2 H) 2.89 – 3.04 (m, 2 H) 3.66 (s, 3 H) 6.67 (d, J=8.86 Hz, 1 H) 6.76 (d, J=9.59 Hz, 1 H) 7.30 – 7.40 (m, 2 H) 7.68 (dd, J=9.43, 3.73 Hz, 1 H) 7.84 (d, J=7.98 Hz, 1 H) 7.93 (d, J=9.23 Hz, 1 H) 8.18 (d, J=9.64 Hz, 1 H) 8.25 – 8.38 (m, 2 H) 14.49 (br. s., 1 H). m/z (ESI) 523.0 (M+H)+., 5469-70-5

The synthetic route of 5469-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WEISS, Matthew; MILGRAM, Benjamin C; MARX, Isaac E.; DINEEN, Thomas; (63 pag.)WO2017/106871; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.289-80-5,Pyridazine,as a common compound, the synthetic route is as follows.

General procedure: Pyridazine (1.0 eq.) and an alkyl halide (1.1 eq.) were added totoluene (15 mL) and placed in a closed vessel and exposed to irradiation for 5 h at 70 C in a sonicator until a precipitate was formed. The obtained solid was filtered and washed with ethyl acetate to afford the desired pyridazinium IL, 289-80-5

The synthetic route of 289-80-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Messali, Mouslim; Almtiri, Mohammed N.; Abderrahman, Bousskri; Salghi, Rachid; Aouad, Mohamed R.; Alshahateet, Solhe F.; Ali, Adeeb A-S.; South African Journal of Chemistry; vol. 68; (2015); p. 219 – 225;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20744-39-2, Pyridazin-4-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 292-{[(4-Fluorophenyl)methyl]oxy}-4-(1 -methyl-1 H-pyrazol-4-yl)-5-(4- morpholinylcarbonyl)-/V-4-pyridazinylbenzamide (E29) To a solution of (4-fluorophenyl)methyl 2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1 H- pyrazol-4-yl)-5-(4-morpholinylcarbonyl)benzoate (may be prepared as described inDescription 32; 191 mg, 0.35 mmol) in tetrahydrofuran (6 ml) was added lithium hydroxide (60 mg, 2.51 mmol) and water (1.5 ml). The mixture was stirred for 3 hours then quenched with 2M hydrochloric acid (1.26 ml, 2.51 mmol). The solvent was removed in vacuo and the residue was redissolved in N,N-dimethylformamide (6 ml) and diisopropylethylamine (0.12 ml, 0.70 mmol), 4-pyridazinamine (39.8 mg, 0.42 mmol), 1-hydroxy-7-azabenzotriazole (57.0 mg, 0.42 mmol) and EDC (100 mg, 0.52 mmol) were added. The reaction was stirred for 18 hours then the solvent was removed in vacuo and the residue purified by MDAP to yield the title compound as a white solid. 64 mg.MS (electrospray): m/z, [M+H]+ = 5171 H NMR (400 MHz, DMSO-d6); 2.74 – 3.13 (3 H, m), 3.35 – 3.75 (5 H, m), 3.86 – 3.96 (3 H, m), 5.33 (2 H, s), 7.15 – 7.29 (2 H, m), 7.43 (1 H, s), 7.50 – 7.66 (3 H, m), 7.74 (1 H, s), 7.94 – 8.07 (2 H, m), 8.95 – 9.10 (1 H, m), 9.20 (1 H, d, J=1.76 Hz), 10.69 (1 H, s)., 20744-39-2

The synthetic route of 20744-39-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James; WO2012/28629; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem