Tag: M.W:0-100

289-80-5, Pyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of the corresponding [1,2,3]triazolo[1,5-a]pyridine 1 in anhydrous toluene at -40 C under an argon current, a solution of 1.6 n-BuLi in hexane (1.1 equiv) was added with stirring; a deep red color developed. The mixture was kept at -40 C for 4 h. The azine (1.1equiv) in dry toluene solution was added and the mixture was kept inthe cold bath at -40 C for 2 h. The solution was treated with a saturateds olution of NH4Cl followed by aq KMnO4 solution for 30 min at r.t. The mixture was filtered over Celite, the organic and aqueous layers were separated, the aqueous layer was extracted with CH2Cl2, the combined organic extracts were dried (Na2SO4), and the solution was filtered and concentrated to give the crude product.

289-80-5, The synthetic route of 289-80-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adam, Rosa; Abarca, Belen; Ballesteros, Rafael; Synthesis; vol. 49; 22; (2017); p. 5059 – 5066;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

504-30-3, Pyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17; 2-f4-((1R.2R)-2-ir(2SV2-MethylPyrrolidin-1-vnmethyl)cvclopropyhphenvnpyridazin-; A solution of the product from Example 4A (47 mg, 0.16 mmol;1-[2-(4- bromo-phenyl)-(1 R, 2R)-cyclopropylmethyl]-(2S)-2-methyl-pyrrolidine), 3(2H)- pyridazinone (CAS No. 504-30-3, 20 mg, 0.2 mmol), copper iodide (1.5 mg, 0.008 mmol), N.N’-trans-dimethyl-cyclohexane-i^-diamine (2.3 mg, 0.016 mmol) and potassium phosphate (75 mg, 0.35 mmol) in a mixture of toluene and isopropanol (4 ml, 1:1) was heated to 1100C in a screw capped vial for 16 hours. The mixture was cooled to ambient temperature, treated with H2O and extracted with ethyl acetate (2 x 25 ml_). The organic layer was separated, washed with brine and dried with magnesium sulfate. After filtration, the organic layer was concentrated under reduced pressure and the resulting oil was purified on silica gel with 1 % to 3% methanol (containing 10 % concentrated NH4OH) in dichloromethane to provide the title compound. 1H NMR (300 MHz, CD3OD) delta 1.07 (m. 1H), 1.14 (m, 1H), 1.26 (d, J=6 Hz1 3H), 1.40 (m, 1H), 1.58 (m, 1H), 1.90(m, 3H), 2.13 (m, 1H), 2.58 (m, 1H), 2.70 (q, J=9 Hz, 1H), 2.89 (m, 1H), 3.14 (dd. J=12 Hz, J=6 Hz1 1H), 3.44 (m, 1 H), 7.07 (d, J=9 Hz, 1 H)1 7.24 (d, J=9 Hz1 2H), 7.44 (d, J=9 Hz, 2H), 7.47 (m, 1H), 8.03 (m, 1H). MS (DCI-NH3) m/z 310 (M+H)+., 504-30-3

As the paragraph descriping shows that 504-30-3 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; WO2007/150010; (2007); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.289-80-5,Pyridazine,as a common compound, the synthetic route is as follows.

The synthesis of 3 was similar to that of complex 1, but pyromellitic acid (H4pma) was used instead of H3btc. Reaction of AgNO3 (33.4 mg, 0.2 mmol), pyridazine (pdz)(16.0 mg, 0.2 mmol) and 1,3,5-benzene tricarboxylic (H3btc)(44.2 mg, 0.2 mmol) took place in H2O-DMF (N,N-Dimethylformamide)solvents (6 ml, v/v = 1:1) in the presence of ammonia(0.5 mL, 14 M) under ultrasonic treatment (160 W, 40 kHz,30 min) at 40 C. The resultant colourless solution was allowed slowly to evaporate at room temperature in the dark. The yellowcrystals of complex 1 were obtained after several days.The crystals were isolated by filtration and washed by deionized water and ethanol and dried in the air. And clear yellowish crystals of 3 were obtained in 81% yield based on Ag. Elementalanalysis: Anal. Calc. for Ag2C9H5N2O4: C, 25.684; H, 1.197; N,6.656. Found: C, 25.59; H, 1.28; N, 7.06%. Selected IR peaks(cm1): 3410 (m), 3072 (w), 3010 (w), 1576 (s), 1481 (m), 1411(s), 1315 (m), 1264 (m), 1131 (m), 1054 (w), 972 (m), 920 (w),857 (m), 805 (m), 767 (m), 670 (m), 576 (w), 525 (m), 435(m)., 289-80-5

As the paragraph descriping shows that 289-80-5 is playing an increasingly important role.

Reference£º
Article; Wang, Dan-Feng; Zhang, Ting; Dai, Si-Min; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; PA; (2014); p. 193 – 200;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under an atmosphere of nitrogen, a 25 mL dry Schlenk flask was placed with Cu(acac)2 (1.6 mg, 0.01 mmol) and ligand A (2.6 mg, 0.012 mmol). Anhydrous MeOH (1.0 mL) was added, and the mixture was magnetically stirred at 20 C for 15 min. Then a solution of 1-phenylprop-2-yn-1-yl acetate 2a (0.24 mmol), 2-aminopyridine 1a (0.2 mmol) and diisopropylethylamine (0.07 mL, 0.4 mmol) in MeOH (0.5 mL) were added dropwise. The reaction flask was kept at room temperature for 6 h. After 1a was completely consumed as monitored by TLC, H2O (10 mL) was added to quench the reaction. The resulting mixture was then extracted three times with diethyl ether (10 mL*3). The combined organic layer was dried over Na2SO4. After evaporation of the volatile solvent under reduced pressure, the residue was purified by flash chromatography on silica gel to afford pure 3a (39 mg, 0.19 mmol) as a brown oil in a yield of 94%., 5469-70-5

The synthetic route of 5469-70-5 has been constantly updated, and we look forward to future research findings.

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Article; Cheng, Cang; Ge, Luo; Lu, Xuehe; Huang, Jianping; Huang, Haocheng; Chen, Jie; Cao, Weiguo; Wu, Xiaoyu; Tetrahedron; vol. 72; 43; (2016); p. 6866 – 6874;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20744-39-2, Pyridazin-4-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Aniline (62mul, 0.68 mmol), 2,4-dichloropyridine (100 mg, 0.68 mmol), cesium carbonate (442 mg, 1.36 mmol), xantphos (47 mg, 0.08 mmol) and Pd(OAc)2 (12 mg, 0.05 mmol) were combined in a microwave tube, sealed and purged with nitrogen. Dioxane (3 mL) was then added and the reaction solution degassed with nitrogen prior to heating at 100C for 30 minutes. The reaction mixture was then filtered and the filtrate was purified by reverse phase chromatography, utilizing a 20-65% gradient over 9 mins, with 0.5% ammonia as modifier to afford 4-chloro-N-phenyl-pyridin-2-amine, 20744-39-2

As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.

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Article; Burton, Rebecca J.; Crowther, Mandy L.; Fazakerley, Neal M.; Fillery, Shaun M.; Hayter, Barry M.; Kettle, Jason G.; McMillan, Caroline A.; Perkins, Paula; Robins, Peter; Smith, Peter M.; Williams, Emma J.; Wrigley, Gail L.; Tetrahedron Letters; vol. 54; 50; (2013); p. 6900 – 6904;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-methyl-8-morpholino-6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxylic acid (23.0 mg, 0.057 mmol) and 3-aminopyridazine (16.0 mg, 0.170 mmol) were dissolved in MeCN (1.2 mL). HATU (32.0 mg, 0.085 mmol) and pyridine (0.014 mL, 0.170 mmol) were added and the vial was sealed and heated to 50 C for 1 h, then to 80 C for 2 h. The reaction was cooled to room temp and bicarb (2 mL) and water (1 mL) were added. The mixture was extracted with EtOAc (3×5 mL) but there was precipitate in the organic layer. The solid was collected by filtration and washed with diethyl ether, and dried in vacuo to give 2-methyl-8-morpholino-N-(pyridazin-3-yl)-6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxamide (8.0 mg, 29%). MS (ESI) calcd for C23H20F3N702: 483.16; found: 484 [M+H], 5469-70-5

5469-70-5 3-Aminopyridazine 230373, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; WO2013/59587; (2013); A1;,
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Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5469-70-5,3-Aminopyridazine,as a common compound, the synthetic route is as follows.

A flask was charged with perfluorophenyl 1-(4-bromo-2-methoxyphenyl)-2-oxo-1,2-dihydroquinoline-6-sulfonate (3.33 g, 5.78 mmol) and pyridazin-3-amine (0.659 g, 6.93 mmol). A septum was attached and THF (28.9 ml) was added. The mixture was cooled to 0 C. and a THF solution of lithium bis(trimethylsilyl)amide (12.13 ml, 12.13 mmol, 1 M) was added dropwise to give a brown solution. The solution was maintained at 0 C. for 20 min. The reaction mixture was partitioned between 1 N HCl (200 mL) and EtOAc (200 mL), the layers were separated and the aqueous layer was extracted with DCM (100 mL) and EtOAc (200 mL). The combined organic layers were dried (Na2SO4) and concentrated to provide 1-(4-bromo-2-methoxyphenyl)-2-oxo-N-(pyridazin-3-yl)-1,2-dihydroquinoline-6-sulfonamide (3.39 g, 6.96 mmol, 120% yield) as a light yellow foam. Although contaminated with solvent, the product was of sufficient purity for use in the next step. m/z (ESI) 485.1 (M-H)-.

5469-70-5, As the paragraph descriping shows that 5469-70-5 is playing an increasingly important role.

Reference£º
Patent; Amgen Inc.; Weiss, Matthew; Boezio, Alessandro; Boezio, Christiane; Butler, John R.; Chu-Moyer, Margaret Yuhua; Dimauro, Erin F.; Dineen, Thomas; Graceffa, Russell; Guzman-Perez, Angel; Huang, Hongbing; Kreiman, Charles; La, Daniel; Marx, Isaac E.; Milgrim, Benjamin Charles; Nguyen, Hanh Nho; Peterson, Emily; Romero, Karina; Sparling, Brian; US9212182; (2015); B2;,
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Pyridazine | C4H4N2 – PubChem

1632-76-4, 3-Methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: 6-methylpyridazine-3-carbonitrile (2)To a stirring solution of 3-methylpyridazine (1.1 g, 11.80 mmol) in dichloromethane (20 mL) was added AICI3(0.05 g) followed by trimethylsilylcyanide (2.1 g, 21.1 mmol). After 20 min, a solution of p-toluenesulfonyl chloride (3.8 g, 20.1 mmol) in dichloromethane (5 mL) was added slowly and the solution was stirred for 16 h. The solvent was removed in vacuo and ethanol (10 ml) was added and stirred for 15 min, then filtered to give a white solid. The solid was dissolved in THF (200 mL) and DBU (1.6 mL, 10.5 mmol) was added. After 1 h, the solvent was removed in vacuo and the residue was partitioned between hexane and saturated aqueous NH4C1. The aqueous phase was basified with solid a2C03, and then extracted with EtOAc (100ml*2). The combined ethyl acetate phases was dried over MgS04, filtered and concentrated to give compound 2 as a white solid.

1632-76-4, The synthetic route of 1632-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; MCCOMAS, Casey, C.; REGER, Thoma, S.; QI, Changhe; WO2014/150114; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20744-39-2, Pyridazin-4-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20744-39-2, To a microwave reaction tube were added 12c (250 mg, 0.273 mmol), pyridazin-4-amine (39.0 mg, 0.410 mmol), DIPEA (0.191 mL, 1.093 mmol), HATU (125 mg, 0.328 mmol) and DMF (15 mL). The mixture was heated to 100 C for 2 hrs under microwave. The mixture was cooled to room temperature and purified by MADP (acidic mobile phase) to give the title compound (30.5 mg, 0.079 mmol, 28.9 % yield) as a yellow solid. LCMS: 375.2 [M+H]+. 1H NMR (400 MHz, DMSO-d6): delta 10.72 (s, 1H), 9.19 (br., 1H), 9.05 (d, J= 5.6 Hz, 1H), 8.01 (d, J= 3.6 Hz, 1H), 7.48 (d, J= 6.8 Hz, 2H), 7.34 (d, J= 6.8 Hz, 3H), 7.19 (d, J= 8.8 Hz, 1H), 6.85 (br., 1H), 6.75 (d, J= 8.8 Hz, 1H), 5.15 (s, 2H), 3.22 (br., 4H), 1.96 (br., 4H). 13C NMR (101 MHz, CDCl3): delta 165.1, 151.5, 147.9, 143.7, 143.6, 137.6, 135.3, 129.6, 129.3, 128.8, 120.7, 117.1, 114.9, 114.1, 114.0, 73.1, 48.1, 25.5. HRMS (ESI): m/z calcd for C22H22N4O2 [M+H]+ 375.1821, found [M+H]+ 375.1816.

As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.

Reference£º
Article; Ding, Xiao; Stasi, Luigi Piero; Dai, Xuedong; Long, Kai; Peng, Cheng; Zhao, Baowei; Wang, Hailong; Sun, Changhui; Hu, Huan; Wan, Zehong; Jandu, Karamjit S.; Philps, Oliver J.; Chen, Yan; Wang, Lizhen; Liu, Qian; Edge, Colin; Li, Yi; Dong, Kelly; Guan, Xiaoming; Tattersall, F. David; Reith, Alastair D.; Ren, Feng; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 212 – 215;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5469-70-5,5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A microwave tube was charged with 6′-bromo-8′-chloro-2’H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione 3 (1.00 eq.), amine (1.00 eq.), Cs2CO3 (2.00 eq.), Pd2(dba)3 (0.10 eq.), xantphos (0.10 eq.) and 1,4-dioxane (4 mL). The reaction mixture was heated under microwave irradiation at 130 C for 30 min, concentrated under reduced pressure, and purified by flash column chromatography (silica gel, DCM ramping to DCM/CH3OH = 9:1) to yield the desired product.

As the paragraph descriping shows that 5469-70-5 is playing an increasingly important role.

Reference£º
Article; Abdelaziz, Ahmed M.; Basnet, Sunita K.C.; Islam, Saiful; Li, Manjun; Tadesse, Solomon; Albrecht, Hugo; Gerber, Cobus; Yu, Mingfeng; Wang, Shudong; Bioorganic and Medicinal Chemistry Letters; vol. 29; 18; (2019); p. 2650 – 2654;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem